• Title/Summary/Keyword: Diagnostic Tool

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A Study on the Development of Diagnostic Tools for Sasang Constitutional Patterns (사상체질병증 진단도구 개발 연구)

  • Lee, Hyeri;Lee, Jun-Hee
    • Journal of Sasang Constitutional Medicine
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    • v.33 no.3
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    • pp.95-126
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    • 2021
  • Objectives The purpose of this study was to develop diagnostic tools for Sasang Constitutional patterns based on the middle classification of the Sasang Constitutional patterns. Methods Diagnosis and assessment indicators of Soeumin, Soyangin, Taeeumin, and Taeyangin patterns were extracted based on the 『Clinical Practice Guideline for Sasang Constitutional Medicine Symptomatology』 and 『Donguisusebowon』. An online survey was conducted on the 'importance of diagnosis and assessment indicators' by the Sasang Constitutional Medicine expert group. Results Based on the expert consultation results, the importance weight for each diagnosis and assessment indicators symptom was calculated, and the importance was ranked to develop diagnostic tools for Soeumin, Soyangin, Taeeumin, and Taeyangin patterns. Diagnostic tool consisted of 58 questions for Soeumin patterns, 68 questions for Soyangin patterns, 81 questions for Taeeumin patterns, and 42 questions for Taeyangin patterns. The final total score was calculated by reflecting each response score and the weight of each question. Conclusions The developed 'Diagnostic Tools for Sasang Constitutional patterns' can be used to make an effective and objective diagnosis in the clinical site. In the future, if the reliability and validity of these diagnostic tools are tested through clinical study, it will be possible to improve clinical applicability and contribute to standardization of diagnosis.

A New Cancer Cell Detection Method Using an Infectivity-enhanced Adenoviral Vector

  • Uchino, Junji;Takayama, Koichi;Nakagaki, Noriaki;Shuo, Wang;Hisasue, Junko;Nakatom, Keita;Ohta, Keiichi;Hirano, Ryosuke;Tashiro, Naoki;Miiru, Izumi;Fujita, Masaki;Watanabe, Kentaro;Nakanishi, Yoichi
    • Asian Pacific Journal of Cancer Prevention
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    • v.13 no.11
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    • pp.5551-5556
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    • 2012
  • Cytological examination is widely used as a diagnostic tool because of the ease of collecting cells from the involved area. However, the diagnostic yield of cytological examination is unsatisfactory; the reasons include sampling error, poorly prepared samples, small numbers of malignant cells, and low grades of cellular atypia. In this study, we focused on the high infectivity of adenovirus towards epithelial cells and applied the luciferase-expressing adenoviral vector to a new cancer cell detection tool. In addition, adenoviral infectivity was enhanced by modifying viral fiber proteins. The sensitivity of the diagnostic tool was tested using the NCI-H1299 lung cancer cell line, and validated in body fluid samples from cancer patients with a variety of etiology. Results showed that the adenovirus efficiently transfected NCI-H1299 with high sensitivity. Only 10 cancer cells were sufficient for detection of luciferase signals. In body fluid samples, the adenovirus confirmed the diagnosis for malignant and benign cancer, but not in non-epithelial cell derived samples. This study provides proof-of-concept for a more reliable and sensitive diagnostic tool for epithelium-derived cancer.

The FMD Diagnostic Kit as a Boundary Object and Boundary Making: Conflicts and Negotiations Between the State-centered and Decentralized Sociotechnical Orders (경계물과 경계만들기로서 구제역 간이진단키트: 국가기술중심주의와 분권주의의 충돌)

  • Kim, Kiheung
    • Journal of Science and Technology Studies
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    • v.18 no.2
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    • pp.307-342
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    • 2018
  • This article is to discuss about a debate on controlling and handling rights of diagnostic instruments for the outbreak of Foot-and-Mouth Disease(FMD) in South Korea between 2010 and 2011. The epidemic of FMD caused catastrophic shockwave to the whole Korean society and there was fierce debate what was the best diagnostic tool for the disease and who owned the controlling power. The central government insisted to have the power of controlling the diagnostic tool to maintain the nation-centered disease control while local governments and civil organisations attempted to take over the controlling power of the diagnostic tools. In this article the concept of boundary objects which was suggested by an American STS academic, Susan Leigh Star and her colleagues. The boundary object could be the useful concept for capturing the whole process of constructing and imposing meanings and social orders in the diagnostic tool, called the portable antibody/antigen diagnostic kit. The constructing process of this boundary object must be understood with relation to boundary making activities between different social groups.

Autonomic Conditions in Allergic Rhinitis Depending on Various Pattern Identifications (알레르기 비염 환자의 변증별 자율신경계 특성 분석 연구)

  • Choi, Eun-Ji;Jang, Soobin;Lee, Kyu-Jin;Yun, Young-Hee;Choi, In-Hwa;Ko, Seong-Gyu
    • The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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    • v.27 no.4
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    • pp.110-120
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    • 2014
  • Objectives : We performed a clinical study to investigate autonomic conditions in persistent allergic rhinitis depending on various pattern identifications and the availability of heart rate variability (HRV) as a pattern identification diagnostic tool. Methods : 32 patients with persistent allergic rhinitis were asked to interview with doctor of Korean Medicine and perform the four pattern questionnaires (Cold-Heat Pattern, Phlegm Pattern, Yin Deficiency pattern, bloodstasis pattern). Then, they were examined their autonomic conditions with heart rate variability test. Results : Patients were classified as three pattern groups (Lung-stomach heat, Lung qi deficiency cold, Lung-spleen qi deficiency) by doctor. In the Lung qi deficiency cold group, Total power of the HRV (TP) and the power of the low frequency component (LF) significantly higher than in the Lung-stomach heat or Lung-spleen qi deficiency group (P < 0.05). Also, Patients were classified as 8 pattern groups (Cold/Heat, Phlegm/Non-phlegm, Yin deficiency/Non-yin deficiency, Bloodstasis/Non-bloodstasis) by four pattern questionnaires. Only in the Yin deficiency group, the power of the low frequency component (LF) significantly lower than in the Non-yin deficiency group (P < 0.05). There were not any significant differences in the rest groups. Conclusions : The result may provide that HRV doesn't reflect well the differences in the various pattern groups, and the HRV's availability is low. Continuous studies are needed to develop the objective and standardized pattern identification diagnostic tool for allergic rhinitis.

The importance of probing in diagnosing the periodontal diseases (임상가를 위한 특집 1 - 치주질환 진단에 있어서 탐침의 중요성)

  • Park, Junseok;Ku, Young
    • The Journal of the Korean dental association
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    • v.50 no.8
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    • pp.460-464
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    • 2012
  • Periodontitis is the most prevalent noncontagious disease. Periodontal probing for measuring probing depth (PD) and clinical attachment level (CAL) has been an important diagnostic tool to determine the presence and severity of periodontal diseases. For probing reproducibility, adroit probe handling with constant force is required.

Plain Abdominal Radiography in Infants and Children (영유아 및 소아의 단순복부 X-선 사진)

  • Lee, Hee-Jung
    • Pediatric Gastroenterology, Hepatology & Nutrition
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    • v.14 no.2
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    • pp.130-136
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    • 2011
  • Plain X-ray radiographs are the first line of investigation taken in the diagnosis of abdominal pathology and are considered an important diagnostic tool to provide guidelines for further imaging studies and comprehensive therapeutic management. Although most abdominal pathology demonstrates non-specific radiologic findings, the plain abdominal radiography is very useful in specific diseases, including certain gastrointestinal anomalies. This review provides image findings of normal plain abdominal radiography and some common abdominal pathology in infants and children.

A Study on the Statistical Analysis of HDPE films` Breakdown Strength using Weibull Statistical Function (Weibull통계함수를 이용 HDPE필름 절연파괴강토 통계적해석에 관한 연구)

  • 강무성;오재형;박대희
    • Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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    • 1997.11a
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    • pp.106-108
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    • 1997
  • In this paper, the breakdown strength of Pure HDPE(High density polyethylene) films and aged HDPE films were evaluated using 2-parameter Weibull distribution function. The result show that both were fitted 2-parameter Weibull distribution. This method could be used to be the diagnostic tool to evalute the insulation performance and endurance under the multiple stresses.

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Non-linearity Testing of D/A Converters Applying Walsh Function (Walsh 함수를 적용한 D/A 컨버터의 비선형 시험)

  • Lee, Hae-Ki;Lee, Chun-Mo
    • Proceedings of the KIEE Conference
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    • 2002.06a
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    • pp.161-165
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    • 2002
  • The paper presents a diagnostic tool for analyzing the bit intermodulation in D/A converter. Bit intermodulation cause linearity errors which degrade the performance of the converter. A linear transformation of the Walsh transform of the integrated non-linearity diagram is shown to be sufficient to extract the bit intermodulation terms and their noise sensitivity. Practical applicability of the proposed method is shown by measurement.

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Clinical Application of $^{18}F-FDG$ PET in Salivary Gland Cancer (타액선암(Salivary Gland Cancer)에서 $^{18}F-FDG$ PET의 임상 이용)

  • Yang, You-Jung
    • Nuclear Medicine and Molecular Imaging
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    • v.42 no.sup1
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    • pp.14-16
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    • 2008
  • Salivary gland tumors are relatively rare, constituting 3% of all head and neck neoplasms. In patients with salivary gland malignancies, $^{18}F-FDG$ PET is clinically useful in initial staging, histologic grading, and monitoring after treatment. According to clinical research data hitherto, $^{18}F-FDG$ PET is expected to be an effective diagnostic tool in the management of salivary gland tumors.

Constant Error Variance Assumption in Random Effects Linear Model

  • Ahn, Chul-Hwan
    • Communications for Statistical Applications and Methods
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    • v.2 no.2
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    • pp.296-302
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    • 1995
  • When heteroscedasticity occurs in random effects linear model, the error variance may depend on the values of one or more of the explanatory variables or on other relevant quantities such as time or spatial ordering. In this paper we derive a score test as a diagnostic tool for detecting non-constant error variance in random effefts linear model based on the model expansion on error variance. This score test is compared to loglikelihood ratio test.

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