• The Korean Journal of Cytopathology
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• v.9 no.1
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• pp.69-78
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• 1998

There is a lot of difficulty in the diagnosis of follicular lesions of the thyroid by fine needle aspiration cytology(FNAC). The main purpose of this report is offering more guidance regarding the cytologic appearance to distinguish follicular neoplasm from nodular golfer and laying stress on the presence of mixed group. The histologic and cytologic findings of 23 follicular neoplasms and 13 nodular (adenomatous) getters were reviewed. Histologic specimens were classified into the microfollicular(MIF), mixed(MIX), and nodular getter(NG) groups. The comparison of histologic patterns with histologic diagnosis revealed that all the lesions with predominantly microfollicular, trabecular, or solid pattern were follicular carcinoma and all the lesions with predominantly macrofollicular pattern were nodular goiter. The distinguishing cytologic features for the MIF group were irregular cell arrangement in cell groups(100%, p=0.00001), absence of atrophic follicular cells(100%, p=0.0007), abundant microfollicles(100%, 0=0.002), pleomorphic nuclei(100%, p=0.002), not predominant syncytial smear pattern(100%, p=0.002), heterochromatin(100%, p=0.032), absence of macrofollicles(100%, p=0.038), scant colloid(100%, 0=0.04), clear back-ground(83%, p=0.00006), and uniform sized follicles(83%, p=0.014). And regular cell arrangement(honeycomb appearance) in cell groups(85%, p=0.0000), atrophic change of follicular cells(69%, p=0.0002), syncytial smear pattern(54%, p=0.000), monomorphic nuclei(85%, p=0.008), and hemorrhagic background(100%, p=0.027) were characteristic features of the NG group. Seventeen out of 36 cases(47%) were the MIX group composed of combined cytologic features of the MIF and NG groups. Therefore the frequent presence of the MIX group is considered to be main cause of the difficulty in the diagnosis of follicular lesions by FNAC. The mixed morphologic feature may support the hypothesis of a biologic 'continuum' between nodular goiter and follicular neoplasm of thyroid gland.

• The Journal of Korean Obstetrics and Gynecology
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• v.28 no.1
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• pp.102-112
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• 2015

Objectives: This study was performed to obtain reference data of traditional Korean medicine diagnostic methods for the practical usage in women infertility. Methods: The study involved 38 female patients of age 20-38 years that had diagnosed of infertility. All the subjects answered to pattern identification questionnaire and Questionnaire for the Sasang Constitution Classification (QSCC II). Pattern identification scores and constitution types have been analyzed with variables of infertility factors and age. Statistical analysis was performed by adopting descriptive and inferential tests. Results: In pattern identification questionnaire analysis, the patterns were observed in order of frequency: liver stasis; blood deficiency; kidney-yang deficiency; kidney-yin deficiency; damp-heat; blood stasis; and phlegm. The group, less than 35 years old, had the higher average score of liver stasis (p<0.05). Also, the group with tubal and peritoneal factors, had the higher average score of blood deficiency (p<0.05). In QSCC II analysis, So-yang type had the higher average score of liver stasis, kidney-yang deficiency, and kidney-yin deficiency. So-eum type had the higher average score of liver stasis, kidney-yang deficiency, kidney-yin deficiency, and blood deficiency. While, Tae-um type had the higher average score of liver stasis and phlegm. Conclusions: We would accumulate the clinical data for the practical usage of traditional Korean medicine diagnostic methods in women infertility.

• Investigative Magnetic Resonance Imaging
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• v.10 no.2
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• pp.63-69
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• 2006

Purpose : Marrow edema and fatty degeneration of the hip joint bones could be initial and late signs in hip joint and its bone diseases respectively, which might be differentiated from age-related marrow conversion pattern. So authors have investigated normal marrow conversion pattern of the femur and acetabulum around the hip joints. Materials and methods : Three coronal MR images of 288 hip joint bones in 144 subjects, aged 2 days to 76 years divided to 8 groups every 10 years, were retrospectively analysed for the location and appearance of the converted yellow marrow. The converted yellow marrow were divided to head, neck, and trochanter in the proximal femur and below and above 50% in acetabulum of the hip. Results : The most common type of marrow conversion is the converted yellow marrow in the entire proximal femur and below 50% of acetabulum of the hip. We observed the start of marrow conversion in just before and after 2 years old and stopped at just before and after 20 years old. Conclusion : The understanding of age-related marrow conversion pattern of the hip joint bones would provide some information for differentiation from pathologic condition of them such as edema, fatty degeneration, metastasis, or leukemia.

• Journal of Physiology & Pathology in Korean Medicine
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• v.24 no.3
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• pp.390-400
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• 2010

This study is aimed to test physiological and hematological actions of Rheum palmatum through clinical pilot study optimized for usual oriental medicine prescription. Thirty-one cases were finally collected and the sample extract 100 $m{\ell}$ of Rheum palmatum (ERP) was administered two times in a day during 3 days and checked with blood CBC test, urinalysis, liver function test, abdominal X-ray as well as general diagnostic process of oriental medicine; pattern identification, assessment of shapes and constitution. The total toxic effective rate of ERP was 9.68% in 3 cases of the whole in case of consistent uneasy state in the subjective symptomatic assessment and aggravation of blood and urine examination. The relevant diagnostic factors were so-eum constitution and essence type subject, carapaces species, lung type in the aspect of Jisan shape theory. On the other hand, the positive effective rate of ERP was 29.03% manifesting improvement of vital signs or present illness and no abnormal changes of blood chemistry and urinalysis and simple abdomen radiology. The relevant diagnostic factors were tae-eum constitution, energy type subject, aves species, heart and liver type in Jisan's shape theory. And the other cases were manifesting no specific change through the administration of ERP. The ratio of the numbers of decrease and increase was 44:5 in the tenderness and hardness of abdominal palpation. But if the pattern identification doesn't comply with the aim of rhubarb application despite of constipation and abdominal pain, the tendeness and biochemical report was shown in abnormal change. The mean number of diarrhea by ERP was $16.77{\pm}6.95$ during 3 days after administration, and the frequent areas of abdominal pain were lower>middle>upper in order, and it meant the target site of ERP too. Besides, the toxic reaction against ERP was expressed highly in case of decrease in blood cell count and hemoglobin, hematocrit having blood deficiency syndrome. Likewise, the toxicity of ERP was influenced by pattern identification manifesting present disease condition and diagnostic factors of four constitutions, Jisan's shape theory collaterally. In conclusion, evaluation of herbal toxicity in order for using as a clinical guideline, various diagnostic pattern information and shape features like the above should be studied together with other pharmacologic toxicology test for the future.

• The Journal of Internal Korean Medicine
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• v.35 no.2
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• pp.157-174
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• 2014

Objectives : The aims of this study were to evaluate the diagnostic values of tongue coating thickness and sterno-costal angle as the quantitative diagnostic indicators in functional dyspepsia. Methods : We surveyed 60 functional dyspepsia patients recruited by the clinical trial, 'Clinical Trial for Evaluation on Availability of tongue diagnosis system (CTS-1000) : a Pilot study'. The patients were classified into three groups according to Rome III criteria for functional dyspepsia, and categorized into five groups according to Instrument of pattern identification for functional dyspepsia. Nepean dyspepsia index-Korean version (NDI-K) score, tongue coating thickness (percentage of tongue coating by tongue diagnosis system (CTS-1000), and weight of tongue coating by microbalance), sterno-costal angle, duration of illness and body mass index (BMI) were investigated. Results : Among the 5 types by instrument of pattern identification for functional dyspepsia, a significant difference of percentage of tongue coating was found. Percentage of tongue coating and weight of tongue coating showed significant correlation with total NDI-K score. Sterno-costal angle showed strong positive correlation with BMI and also showed significant difference between the non-overweight (BMI<23, n=32) and overweight ($BMI{\geq}23$, n=28) groups. Conclusions : Tongue coating thickness showed its potential as a new quantitative diagnostic indicator of functional dyspepsia. Further studies on the sterno-costal angle are anticipated to evaluate its potential as a new quantitative diagnostic indicator.

• The Journal of Korean Medicine
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• v.33 no.4
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• pp.1-8
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• 2012

Objectives: The purpose of this study was to specify major tongue diagnostic indicators and evaluate their significance in discriminating pattern identification subtypes in stroke patients. Methods: This study used a community based multi-center observational design. Participants (n=1,502) were stroke patients admitted to 11 oriental medical university hospitals between December 2006 and February 2010. To determine which tongue indicator affected each pattern identification, a decision tree analysis of the chi-square automatic interaction detector (CHAID) algorithm was performed. The chi-squared test was used as the criterion in splitting data with a p-value less than 0.05 for division, which is the main procedure for developing a decision tree. The minimum sample size for each node was specified as n =10, and branching was limited to two levels. Results: From the 9 tongue diagnostic indicators, 6 major tongue indicators (red tongue, pale tongue, yellow fur, white fur, thick fur, and teeth-marked tongue) were identified through the decision tree analysis. Furthermore, each pattern identification was composed of specific combinations of the 6 major tongue indicators. Conclusions: This study suggests that the 6 tongue indicators identified through the decision tree analysis can be used to discriminate pattern identification subtypes in stroke patients. However, it is still necessary to re-evaluate other pattern identification indicators to further the objectivity and reliability of traditional Korean medicine.

• Journal of Physiology & Pathology in Korean Medicine
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• v.27 no.2
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• pp.167-172
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• 2013

In order to establish the diagnostic indices of skin diseases, some physiological and pathological concepts of interstices(腠理) were researched based on , and western dermatology with etymological analysis. As physiological indices for diagnosis of skin diseases, measurement of epidermis and dermis using ultrasonogram in the zhongwan and dachui's location. And for grading looseness and fineness of interstices with 3 unsound groups, measuring numbers and sizes of sweat pores in each point's 1 cm diameter circular area using comparative method and palpation assessment. Another index is superficial temperature. As pathological indices for diagnosis, validating volumes of dead skin cells and grading degrees of atrophy and degeneration of skin lesion. And as supplementary measures, absorptive degrees of cosmetics on face should be recorded according to 3 grades. These diagnostic indices can contribute to establishment of standard pattern identification and prescription of skin diseases through converting anatomical cognizance into classical concepts of interstices objectively.

• Journal of The Korean Astronomical Society
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• v.42 no.3
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• pp.33-37
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• 2009

We propose a diagnostic that can resolve the planet/binary degeneracy of central perturbations in caustic-crossing high-magnification microlensing events. The diagnostic is based on the difference in the morphology of perturbation inside the central caustics induced by a planet and a wide-separation binary companion. We find that the contours of excess exhibit a concentric circular pattern around the caustic center for the binary-lensing case, while the contours are elongated or off-centered for the planetary case. This difference results in the distinctive features of the individual lens populations in the residual of the trough region between the two peaks of the caustic crossings, where the shape of the residual is symmetric for binary lensing while it tends to be asymmetric for planetary lensing. We determine the ranges of the planetary parameters for which the proposed diagnostic can be used. The diagnostic is complementary to previously proposed diagnostics in the sense that it is applicable to caustic-crossing events with small finite-source effect.

• The Transactions of The Korean Institute of Electrical Engineers
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• v.58 no.7
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• pp.1424-1434
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• 2009

DNA computing-inspired pattern classification based on the hypernetwork model is a novel approach to pattern classification problems. The hypernetwork model has been shown to be a powerful tool for multi-class data analysis. However, the ordinary hypernetwork model has limitations, such as operating sequentially only. In this paper, we propose a efficient implementing method of DNA computing-inspired pattern classifier using GPU. We show simulation results of multi-class pattern classification from hand-written digit data, DNA microarray data and 8 category scene data for performance evaluation. and we also compare of operation time of the proposed DNA computing-inspired pattern classifier on each operating environments such as CPU and GPU. Experiment results show competitive diagnosis results over other conventional machine learning algorithms. We could confirm the proposed DNA computing-inspired pattern classifier, designed on GPU using CUDA platform, which is suitable for multi-class data classification. And its operating speed is fast enough to comply point-of-care diagnostic purpose and real-time scene categorization and hand-written digit data classification.

• The Korean Journal of Cytopathology
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• v.9 no.2
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• pp.187-191
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• 1998

Alveolar soft part sarcoma(ASPS) is a rare malignant neoplasm with a distinct clinicopathologic entity of which fine needle aspiration(FNA) cytologic findings have been described in only a few reports. Although patients usually present with an isolated soft-tissue mass in the extremity, metastasis can occur in about 13 % of total cases and the most frequent metastatic site is the lung. We have recently experienced a FNA cytologic case of ASPS in the lung. A 23-year-old female patient was admitted to this hospital due to 2-month-history of cough She had been good in health before the visit. Chest computed tomography revealed multiple, variable sized, bilateral pulmonary nodules. Physical examination and other staging work up revealed no other lesions except for pulmonary nodules. A percutaneous transthoracic FNA was performed from the pulmonary nodules. The smear was cellular and most cells were arranged singly. In addition, a few clusters lined by thin-walled vasculature with a pseudoalveolar pattern were present. Some of the tumor cells were large and polygonal lo oval with abundant granular or vacuolated cytoplasm. Most cells were naked nuclei showing finely granular chromatin pattern with prominent central nucleoli.