• Title/Summary/Keyword: Developmental study

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Cytotec Induced Embryotoxicity in Developing Mus musculus

  • Naeem, Khadija;Ahmad, Naveed;Asmatullah, Asmatullah
    • Asian-Australasian Journal of Animal Sciences
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    • v.23 no.10
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    • pp.1282-1290
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    • 2010
  • The study was carried out to assess the developmental abnormalities induced by Cytotec in mice during intrauterine life. Pregnant mice were exposed to a single dose of 0, 0.02, 0.04, 0.06, 0.08 and $0.1{\mu}g$/g BW on day 8 of gestation. Fetuses were recovered on day 18 of gestation. These fetuses were subjected to morphological and morphometric studies. Morphological studies showed abnormalities like anophthalmia, microophthalmia, micromelia and syndactyly. In addition to these, resorptions were also encountered in the higher dose groups. Morphometric analysis showed an overall reduction in body weight, crown rump length, brain and eye circumference, pinna and snout size, length of fore and hind limb and tail size with a significant difference (p<0.001) compared to controls. The outcomes of histological studies revealed some brain defects like hydrocephaly, enlarged third ventricle and undifferentiated ectoneural cells and abnormalities of the heart included right auricle thrombosis and degeneration of trabecular zone.

The expression and function of FGF-8 in limb development and regeneration of mexican axolotl, Ambystoma mexicanum

  • Han, Man-Jong;Kim, Won-Sun
    • Proceedings of the Korean Society of Developmental Biology Conference
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    • 1998.07a
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    • pp.57-58
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    • 1998
  • From the present study, following conclusions can be drawn: 1. lide in other species, axolotl FGF-8 is proposed to play a similar role in the early phase of limb development. However, the mechanism of its expression might be somewhat different from amniotes considering its characteristic mesenchymal expression. 2. In the regenerating axolotl limbs, Fgf-8 expression profile suggests that it is involved in wound gealing, dedifferentiation, and blastema formation. 3. Exoggenously supplied FGF-8 can accelerate blastema formation and concomitantly increase the Msx-1 expression level at the early stage of limb regeneration. Furthermore, it can partially substitute for nerve factor(s) as has been indicated by the induction of blastema formation in the denervated regenerates after FGF-8 application. 4. The unique expression feature of Fgf-8 in hte mesenechymal tissue of the regenerating axolotl limb might be casually related to its remarkable regeneration capacity of urodele.

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Effects of Various Kinds and Concentrations of Cryoprotectants on Viabilities of Ultrarapidly Frozen 4-cell Mouse Embryos and Morulae (생쥐 4세포기 및 상실배기 수정란의 초급속동결에 있어서 동결보호제의 종류와 농도가 생존성에 미치는 영향)

  • 임준호;신상태;강만종;한용만;이경광
    • Journal of Embryo Transfer
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    • v.11 no.1
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    • pp.35-40
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    • 1996
  • This study was carried out to select the best cryoprotectant and to establish optimal concentration of the cryoprotectant in ultrarapid freezing of mouse 4-cell embryos and morulae, respectively. We investigated survival of ultrarapid frozen embryos according to various cryoprotectants such as glycerol, ethylene glycol, propylene glycol and dimethyl sulfoxide (DMSO). Suvival of the embryos frozen at different concentrations (3.0, 4.0 and 5.0 M) of indivisual cryoprotectant was also tested. Preimplantation developmental rate (96.3%, 83/86) of 4-cell mouse embryos treated with 4.0 M ethylene glycol after ultrarapid freezing and thawing was higher than those of other cryoprotectants (glycerol, propylene glycol and DMSO). In the ultrarapid freezing of mouse morulae, the highest developmental rate (98.8%, 89 /90) of the embryos to blastocysts was shown in the group of 5.0 M glycerol. Thus, these results demonstrate that 4.0 M ethylene glycol and 5.0 M glycerol are optimal for ultrarapid freezing of 4-cell mouse embryos and morulae, respectively.

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Developmental salivary gland defect with extra-osseous course of the inferior alveolar nerve (하치조신경을 포함하는 발육성 타액선골결손)

  • Han Jin-Woo;Choi Hang-Moon
    • Imaging Science in Dentistry
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    • v.34 no.3
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    • pp.171-174
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    • 2004
  • The present study reports a case of developmental salivary gland defect. On panoramic examination, large radiolucent lesion surrounded by a sclerotic wall was noted in the right posterior mandible. On CT examination, large lingual bone concavity with extra-osseous course of the inferior alveolar nerve bundle was detected. In atypical cases, it is suggested that confirmatory imaging using CT or MRI should be taken.

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A STUDY ON DEVELOPMENT OF CROWN PERMANENT TEETH BY OBLIQUE CEPHALOGRAM (OBLIQUE CEPHALOGRAM에 의(依)한 영구치(永久齒) 치관(齒冠) 발육(發育)에 관(關)한 고찰(考察))

  • Cha, Moon-Ho;Kim, Jin-Tae
    • Journal of the korean academy of Pediatric Dentistry
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    • v.3 no.1
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    • pp.48-51
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    • 1976
  • Surveying the developmental degree of the crowns of mandibular first bicuspid in 566 korean children (264 males and 302 females) from 3 to 7 years of age by oblique cephalogram, the author got to the following results. 1. The developmental degree of the tooth crown of mandibular first bicuspid was earlier in female than in male. 2. The period of complete development of the crown of mandibular first bicuspid was 7 year 1 month in male and 6 year 3 month in female. 3. There was no significant difference in the period of complete development of the tooth crown compared with that of Japanese and American children.

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Perceptual development in the categorization of pitch accent contrasts in children and adults

  • Kim, Jung-Sun
    • Phonetics and Speech Sciences
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    • v.3 no.3
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    • pp.11-18
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    • 2011
  • This paper examines the categorical labeling of lexical pitch accent contrasts in North Kyungsang and South Cholla Korean listeners. It focuses specifically on investigating whether the pitch accent perception of adults and children has a dialect-specific effect. To evaluate the development of perceptual identification, slopes, intercepts, and positions at categorical boundaries were computed using a logistic regression function. The results showed that differences in slopes and intercepts were significant between North Kyungsang child and adult listeners, but the same was not the case for the positions at boundaries. As far as South Cholla child and adult listeners were concerned, there was a significant difference in slopes, but not intercepts and positions at boundaries. In the present study, the comparison of intercepts and slopes at the boundaries indicated developmental differences between North Kyungsang adult and child listeners. This improvement in categorical proportion seems to be a result of developmental changes in categorical perception. For South Cholla adult and child listeners, however, perception of the non-native contrast becomes less categorical.

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Development of the Short-Horned Grasshoppers, Oxya sinuosa, at the Constant Temperature (恒溫條件下에서의 우리벼메뚜기 ( Oxya sinuosa ) 의 發育)

  • Joo, Eun-Young
    • The Korean Journal of Ecology
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    • v.14 no.1
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    • pp.9-13
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    • 1991
  • The short-horned grasshoppers, Oxya sinuosa Mistshenko, were reared in the growth cabinet exposed alternately to 16 hours of artificial light (510${\pm}$240 lux) and 8 hours of darkness under the condition of constant temperature of 30${\circ}C$ and 65${\pm}$3% in relative humidity. The results obtained in this study are summarized as follows. Both female and male grasshoppers had seven instars. In the larval developmental stages of female and male, the third stage was shorter than the other stages, and the longest stage was the seventh. The total developmental period of females and males were approximately 80.17 and 63.5 days, respectively. The survivorship curve at the temperature of 30${\circ}C$ shows straight line.

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The Expression of ultraspiracle Gene Product during Development of Drosophisa melanogaster (노랑초파리 발생과정에서의 ultraspiracle 유전자 산물의 발현)

  • 김세재;정기화이정주
    • The Korean Journal of Zoology
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    • v.38 no.2
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    • pp.220-229
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    • 1995
  • uftraspirocle (usa) gene product (Uspl is a member of the superfamilv of steroid hormone receptors in Drosophila melonogaster which mediate the hormone action by heteromerization with ecdvsone receptor (EcR). Based on the genetic and molecular characterization of usp, it has been proposed that Usp funtions in at least three significant developmental pathway: embrvogenesis, eve morphogenesis, and female reproduction. In this study, the expression patterns of Usp were investigated by immunohistochemistrv in individual tissues from diHernt developmental stases of Drosophila. Usp is localized in the nucleus with ubiquitous distribution throughout development. Usp expression is detected throughout embrvogenesis. Usp is expressed in imaginal and lanral tissues from late third instar 18nra. The expression pattern of Usp is overlapped by those of EcR. Also Usp is expressed in differentiating adult reproductive organs. This result suggests that Usp is not a transcriptional regulatory factor modulating hormonal response during development, but also play some roles in female and male reproduction of Drosophila.

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Definition of the Diversity Education in Japan

  • YANO, Natsuki;OTA, Mamiko;HAN, Changwan
    • Proceedings of the Korea Contents Association Conference
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    • 2016.05a
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    • pp.389-390
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    • 2016
  • Since the Salamanca statement in 1994, inclusive education became the worldwide issue in the field of educational policy. Inclusive education is defined that equality and comprehensive education in the classroom to learning together regardless of whether with disability or not (Han et al, 2013). Inclusive education is the educational system and consist of the three domains; guarantee of rights, improvement in environment and reform in curriculum (Han et al, 2015). Diversity education has been positioned as an educational method in inclusive education. Diversity in classroom is very wide ranging; nationality, gender, culture, race, ethnicity, disability, age and religion. Diversity education is the educational method to providing the appropriate education for the children's diversity on the assumption that appreciate to the diversity. In recent years, the main purpose of inclusive education is to encompass children with disabilities. However, developmental disabilities that has no intellectual delay become a new challenge in education in addition to the physical and mental disability. This study aims to definition of the diversity education as the educational method in Japan.

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Developmental trends of children's emotional intelligence (유아 정서지능 발달에 관한 연구)

  • Kim, Kyoung Hoe;Kim, Kyoung Hee
    • Korean Journal of Child Studies
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    • v.21 no.4
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    • pp.21-34
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    • 2000
  • This investigation of developmental trends in children's emotional intelligence used the Emotional Intelligence Rating Scale for Preschool Children(Kim, 1998) to study 973 children. Significant age differences were found in 5 factors: 'utilization of emotion', 'regulation of emotion', 'handling of relationship between child and teacher' and 'handling of relationship with peers'. Children's emotional intelligence scores increased with age in 3 factors: 'utilization of emotion', 'empathy', and 'regulation of emotion'. Sex differences were found in 5 factors: 'utilization of emotion', 'empathy', 'appraisal and expression of self emotion', 'regulation of emotion', and 'handling of relationship between child and teacher'. In all factors, the scores of girls were higher than those the scores of boys.

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