• 대한정형외과학회지
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• 제55권5호
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• pp.359-365
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• 2020

소아 고관절 이형성증은 비구 또는 근위 대퇴골, 혹은 양쪽 모두를 포함하는 고관절의 부적절한 발달을 지칭하는 광범위한 개념이다. 초음파적 검사로 영아기의 고관절 탈구 진단이 간과되거나 수술적인 치료가 필요한 경우는 감소하고 있으나 모든 고관절 이형성증을 찾아내지는 못하고 있다. 아탈구가 없는 고관절 이형성증은 우연히 진단되며, 40대 이후 여자에서 퇴행성 관절염과 강한 연관성을 가진다. 아탈구를 동반한 고관절 이형성증은 아탈구의 정도에 따라 증상이 다양한 시기에 걸쳐 나타나며, 특히 여성에서 임신 중 발현되는 경우가 많다. 신생아에 대한 정확한 이학적 검사와 조기 치료는 이 질환의 양호한 결과를 위해 매우 중요하다. 진단의 간과를 막고 조기 치료의 기회를 제공하기 위해 저자는 고관절 이형성증이 의심스러운 2세 이하 영아 모두에게 고관절 검사를 추천한다. 본 연구에서는 고관절 이형성증의 진단 및 초기 치료에 대해 고찰해 보고자 한다.

• 한국발생생물학회지:발생과생식
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• 제25권4호
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• pp.257-268
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• 2021

Phthalates and their metabolites are well-known endocrine disrupting chemicals. Di-(2-ethylhexyl) phthalate (DEHP) has been widely used in industry and the exposing possibility to adult is high. In this study, DEHP was treated (133 ㎍/L and 1,330 ㎍/L in drinking water) according to the OECD test guideline 443 to mature female mice and their adrenal gland were examined for histological characteristics and steroidogenic gene expression. The wet weight of the adrenal gland was increased in all administrated groups compared to control. The diameter of zona fasciculata (ZF) was increased by DEHP in both outer ZF and inner ZF but there was no difference in morphology of the cells and arrangements into zona between groups. In addition, the arrangement of extracellular matrix was not different between control and DEHP groups. CYP11B1 was mainly localized at ZF and the intensity was not different between groups. DAX1 was localized in zona glomerulosa (ZG) and ZF, and its expression levels were decreased by DEHP administration. Its level was lower in DEHP133 group than DEHP1330 group. On the other hand, CYP17A1 was localized in ZG of DEHP1330 group. These results suggest that chronic low-dose DEHP exposing may modify the microstructure and function of the adrenal cortical cortex.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• 제34권2호
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• pp.141-149
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• 2023

Objectives: Most developmental screening tests have been built as parent-performed questionnaires. However, they often do not guide parents on how to answer the questionnaire. This study aimed to develop easily applicable parent guidelines. Methods: We implemented the Delphi procedure with 20 panelists. The development of the initial questionnaire was based on the results of two surveys of parents and experts provided by a policy research report that investigated the item adequacy of the Korean Developmental Screening Test. Round one included 33 items comprising all possible measurements in six categories that were identified as difficult to understand or confusing. Round two merged and modified some items and included 32 items. We defined consensus as a median agreement value of one or less and convergence and stability values of 0.5 or less. The subjective usefulness of the parent guidelines was examined based on their previous test experiences. Results: Consensus was reached after the second round, reflecting the items with the highest level of accuracy in each category. Of the 167 parents who participated in the survey, 113 (67.7%) affirmed the usefulness of the guidelines, while 10 (6.0%) answered that they were not useful. Items that recommended a different scoring strategy in answering the questionnaire from their previous measurements were found to be more useful by the parents. Conclusion: The parent guidelines, composed of five bullet points, drew on the consensus of the experts. Further studies are required to assess whether these guidelines improve the accuracy of screening tests in clinical settings.

• 한국발생생물학회:학술대회논문집
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• 한국발생생물학회 2003년도 제3회 국제심포지움 및 학술대회
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• pp.110-110
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• 2003

The high incidence of polyspermic fertilization is one of the major causes lowering the overall efficiency of porcine IVF. The common procedure for IVF involves the co-culture of both gametes in the medium drop, which increases sperm concentration and incidence of polyspermy. Therefore, the present study was carried out to increase the efficiency of porcine IVF by reducing polyspermy using a modified swim-up method. This method modifies conventional swim-up washing by placing oocytes directly at the time of washing. Sperm pellet was prepared in the tube and mature oocytes were placed on cell strainer with $70 \mu m$ pore size (Falcon 2350) at the top of the tube. After insemination, the oocytes were stained for examination. Also, the developmental potential of fertilized embryos was measured to evaluate for the feasibility of this method. While having similar penetration rates in both methods ($86.67 \pm 2.36% to 83.33 \pm 1.36%$), there was a significant reduction of polyspermy in modified swim-up method ($17.50 \pm 1.60%$) compare to the control ($44.1 \pm 3.70%$ (p<0.05). Subsequent culture showed higher rate of blastocyst formation in modified swim-up method (20.44$\pm$0.99%) than the control ($15.73 \pm 3.26%$) (P<0.05), even though there was no significant difference. These results suggest that, by controlling the number of spermatozoa reaching the oocytes, porcine oocytes might be protected from polyspermy in vitro. Also, the developmental potential of the fertilized embryos using this method could be improved by increasing the pool of spermatozoa with better quality. Further optimization of the procedure required to implicate this method in routine porcine IVF.

• Toxicological Research
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• 제21권1호
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• pp.23-29
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• 2005

A developmental study of CONP01, a new antiarthritic agent, was conducted in Sprague-Dawley rats. Dosage of CONP01 0, 111, 333, and 1000 mg/kg/day were administered to dams orally from day 6 to day 16 of gestation. Two-third of dams per group were subjected to caesarean section on day day 20 of pregnancy for examination of their fetuses, and the remaining one-third of dams per group were allowed to deliver naturally for postnatal examination of their offspring. There was no change in the dams body weights, food consumptions, specific clinical sings and gross findings. There was significant decrease only in the absolute and relative weights of right ovary in 111 mg/kg treatment group, when compared with the vehicle control, whereas other organ weights were not changed. Moreover, no increase in the frequencies of external, visceral and skeletal malformation of fetuses were observed in the treated groups. These results suggest that the oral NOAEL (no observed adverse effect level) of CONP01 may be over 1,000 mg/kg in dams and fetuses of rats.

• 한국산학기술학회논문지
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• 제11권9호
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• pp.3390-3397
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• 2010

본 연구의 목적은 지역사회 아동을 대상으로 발달지연 선별검사 중 부모-보고형 검사인 Korean-Ages and Stages Questionnaires(K-ASQ)의 타당도와 효용성을 알아보고자 하였다. 연구방법에서 연구대상은 선별검사에 동의한 229명 아동의 부모들과 유전적 질환 혹은 선천적 발달 지연이 보고되지 않은 3~5세 아동들이었다. 연구결과 K-ASQ는 민감도 0.41%, 특이도 0.76%, 과다의뢰율 0.14%, 과소의뢰율 0.21%이였으며, 지연발달과 정상발달 예측율은 지연 발달에서는 K-ASQ 0.70%, 정상발달 예측율은 K-ASQ 0.77%로 나타났다. K-ASQ의 타당도는 정상아동을 정상으로 선별하는 특이도가 민감도보다 높았으며, 지연발달과 정상발달 예측율에서도 K-ASQ는 70% 이상으로 임상에서 아동발달 선별에 유용하게 사용될 수 있을 것이다.

• 한국생활과학회지
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• 제21권1호
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• pp.71-82
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• 2012

The purpose of this study is to examine perceptive change in attitude toward infancy and early childhood among university students' who were exposed to a human development lecture on infancy and early childhood. This study aims to investigate the significance of education in shaping attitudes related to child development and the importance of infancy and early childhood as developmental stages. This study also seeks to provide basic data for expanding and systematizing relevant educational programs. Fifteen university students who attended a lecture on human development were divided into four groups with three groups containing 4 members and one group containing 3 members. The following results were obtained: 1) Before attending the lecture on human development, students perceived infancy as a period dominated by feelings of helpless, indifference, and a general lack of knowledge or ability to interact with their environment; 2) Before attending the lecture on human development, students perceived early childhood as an initial period of transition that can potentially influence one's future; 3) After attending the lecture, students were better able to rationalize the developmental importance of infancy and early childhood. 4) After attending the lecture, students displayed broader understanding of the importance of early childhood on human development. This study also discusses the necessity for continuous and systematic provision of programs to help adults develop a positive perception of infancy and early childhood as a developmental process related to parenting skills.

• 대한치과교정학회지
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• 제9권1호
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• pp.23-35
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• 1979

The present study has the purpose of investigating various growth and developmental aspects of rabbit snout with the aid of metallic implantation and of improving on the indirect method of growth and developmental studies of its skull. Sixty-eight growing albino rabbits were used. A head holder, film holder, cephalometer, metallic implanting device and implant materials were designed and constructed by the author. Eight metallic pins were implanted with a metallic implanting device in the rabbit snout under general anesthesia. Two metallic pins were implanted on each side of the interfrontal suture and another two were put on each side of the internasal suture near the frontonasal suture. Serial cephalograms were taken with a two-week interval, using the head holder, film holder and cephalometer. Eight items of linear measurement were obtained from the film. On the base of the results of the study, the following conclusions are obtained: 1. The metallic implant method is better than the other indirect methods for growth and developmental studies of the rabbit skull. 2. Most of the vertical growth of the rabbit snout is due to sutural growth at the frontonasal suture and the horizontal growth is at the interfrontal and the internasal suture. 3. The vertical growth of the rabbit snout is greater than the horizontal growth. 4. The horizontal growth of the rabbit snout is greater at the nasal bone than at the frontal bone. 5. The amount of vertical growth of the rabbit snout is almost same at inner and outer side of the interfrontal and internasal suture line, 6. Growth rate of the sutural growth of the rabbit snout tends to decrease by the growth of the rabbit. 7. Implant materials do not disturb growth and development of the rabbit snout, except a slight trauma effect during the first week of metallic implantation.

• 대한가정학회지
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• 제33권4호
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• pp.173-188
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• 1995

This study examined the characteristics of the relationship of HOME, sociodemographic variables and children's verbal ability at age four, five, six, Expecially this study investigated causal relationships amoong the variables which are supposed to affect children's verbal ability by children's age and sex. The subject of this study were 180 children and their mothers. Instruments included inventory of home stimulation(HOME), inventory of socio-demographic variables, inventory of the children's verbla ability. The results obtained from this study were as follows : 1. For the most part, HOME and socio-demographic variables had a significant positive correlation with children's verbal ability. 2. The variables that significantly predicted children's verbal ability differed according to children's age and sex. That is, play materials, breadth of experience and economic status of the home were predictive of boy's verbal ability at age four, while aspects of physical environment, breadth of experience were predictive at age five, fostering maturity and independence, parent's education were predictive at age six. And developmental stimulation and breadth of experience were predictive of girl's verbal ability at age four, while developmental stimulation, economic status of the home were predictive at age five, developmental stimulation and play materials were predictive at age six. 3. the results of the analysis of the causal model showed that the kind of variables that affected children's verbal ability directly differed according to children's age and sex. That is, indirect stimulation and direct stimulation affected boy's verbal ability directly at age four and five, while indirect stimulation and parent's education affected boy's verbal ability at age six. And indirect stimulation, direct stimulation, emotional climate of the home affected girl's verbal ability directly at age four, while direct stimulation, economic status of the home, indirect stimulation affected directly at age five, parent's education, indirect stimulation and direct stimulation affected girl's verbal ability at age six. 4. Another causal model of the HOME, socio-demographic variables affecting children's verbal ability showed that total HOME scores more significantly affected boys and girl's verbal ability directly than socio-demographic variables at all ages.

• 한국응급구조학회지
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• 제5권1호
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• pp.7-14
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• 2001

The purposes of this study which was conducted by inquiring into some curricula for Emergency Medical Dispatchers(EMDs) are to introduce a curriculum into Korea and develop a textbook for training of the EMDs in Korea. The conclusions from this study were summarized as follows; (1) There are some professional demands in our Emergency Medical Dispatch field therefore, now it is necessary to set up an education system for the EMDs in Korea and give them a suitable name to this change. (2) Some historical turning points which are condensed from the developmental process in the USA. including "Medical Self Help" with no formal dispatch protocols, Medical Priority Dispatch System, Practice Standard, Dispatch Protocols will serve as a good reference for establishing and education system for the EMDs. (3) To effectively train the EMDs in Korea, we needed to be introduced to Emergency Medical Dispatch : National Standard of Curriculum from the U.S. Department of Transportation & the National Highway Traffic Safety Administration which is made up Basic Emergency Medical Concepts, Information Gatherin & Dispatch, Introduction to the Emergency Medical Dispatch Protocol Reference System(EMDPRS) & 32 Chief Complaint Types. (4) The introduced curriculum closely related to the medical director, the direct indirect medical control, the scope of practice in the USA, should be revised for the Emergency Medical Service System of Korea. But to reduce the developmental process & time, it is necessary to postpone the consideration on these factors until publishing a new textbook. (5) This study which gives the cornerstone about some developmental methods on textbook for EMDs will be helpful to build up an education system for EMDs such as Curriculum, EMD Certification, National Academy of Emergency Medical Dispatch to fit the Emergency Medical Service System of Korea in the future.