• Biomolecules & Therapeutics
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• v.32 no.2
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• pp.183-191
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• 2024

The Unfolded Protein Response (UPR) serves as a critical cellular mechanism dedicated to maintaining protein homeostasis, primarily within the endoplasmic reticulum (ER). This pathway diligently responds to a variety of intracellular indicators of ER stress with the objective of reinstating balance by diminishing the accumulation of unfolded proteins, amplifying the ER's folding capacity, and eliminating slow-folding proteins. Prolonged ER stress and UPR irregularities have been linked to a range of neuropsychiatric disorders, including major depressive disorder, bipolar disorder, and schizophrenia. This review offers a comprehensive overview of the UPR pathway, delineating its activation mechanisms and its role in the pathophysiology of neuropsychiatric disorders. It highlights the intricate interplay within the UPR and its profound influence on brain function, synaptic perturbations, and neural developmental processes. Additionally, it explores evolving therapeutic strategies targeting the UPR within the context of these disorders, underscoring the necessity for precision and further research to effective treatments. The research findings presented in this work underscore the promising potential of UPR-focused therapeutic approaches to address the complex landscape of neuropsychiatric disorders, giving rise to optimism for improving outcomes for individuals facing these complex conditions.

• Journal of the Korean association of regional geographers
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• v.23 no.1
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• pp.168-177
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• 2017

In order to reveal formation factors and developmental processes of tafoni this study was conducted with petrological analysis including microscopic observation, measurement of water content and water analysis at Golgulsa temple in Gyeongju, South Korea. The direction of the entrance to tafoni at Golgulsa temple tends to coincide with the direction of slope, and this is thought to be related to the direction of wind flow and water supply. Tafoni's initial developmental processes is judged to have grown as a result of a breakaway of rock fragments along with beddings and cracks in rock. Then, tafoni have been enlarged along at the spots that sufficiently accommodate water supply depending on the direction of wind. The results of water analysis of the stagnant water in gnamma implies that a high meltage of Na and Cl compared to other inland areas can be from the adjacent shore. The effects of such saline substances on rock weathering and development of taponi are currently under way through electronic microscopy and geochemical analysis.

• Journal of the Economic Geographical Society of Korea
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• v.17 no.1
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• pp.1-27
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• 2014

This paper aims at exploring the multi-scalar processes through which the Gumi Industrial Complex was developed in the late 1960s and the early 1970s. Existing studies, influenced by the "Developmental State Thesis", tend to see the industrialization processes of South Korea either by focusing on the socio-politico-economic processes at the national scale or in terms of the plan rationality of the national bureaucrats. This paper, however, denies this perspective on the basis of the strategic relational approach to the state and the multi-scalar perspective. In particular, it argues that the state actions for national industrialization have been the outcome of complex interactions, conflicts and negotiations among social forces, acting in and through the state, and at diverse geographical scales. This paper attempts to empirically prove this argument on the basis of a case study on the construction processes of Gumi Industrial Complex. The development of Gumi Industrial Complex cannot be solely explained in terms of either the plan rationality of the national bureaucrats or the political motivation related to the fact that Gumi was the hometown of President Park Jung-Hee. This paper argues that the development of Gumi Industrial Complex was heavily influenced by the role of the following actors; place-dependent local actors in Gumi and the multi-scalar agents, such as the Korean-Japanese businessmen and the national parliament members elected in the Gumi electoral district.

• Parasites, Hosts and Diseases
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• v.54 no.5
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• pp.653-658
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• 2016

This investigation aimed to evaluate the differential expression of HoxB7 and notch genes in different developmental stages of Echinococcus granulosus sensu stricto. The expression of HoxB7 gene was observed at all developmental stages. Nevertheless, significant fold differences in the expression level was documented in the juvenile worm with 3 or more proglottids, the germinal layer from infected sheep, and the adult worm from an experimentally infected dog. The notch gene was expressed at all developmental stages of E. granulosus; however, the fold difference was significantly increased at the microcysts in monophasic culture medium and the germinal layer of infected sheep in comparison with other stages. The findings demonstrated that the 2 aforementioned genes evaluated in the present study were differentially expressed at different developmental stages of the parasite and may contribute to some important biological processes of E. granulosus.

• English Language & Literature Teaching
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• no.6
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• pp.35-47
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• 2000

This study questions the validity of Crosslinguistic Influence (CLI) in EFL Learning. A ten-minute grammaticality judgement test involving resumptive pronouns in English relative clauses was given to 15 female subjects. The research results, which were analysed in terns of language transfer and universalist arguments, support the existence of a universal process that guides L2 learning, and some common developmental patterns between the two processes of L1 and L2 learning. Hence, the universalist view should be given at least equal Weight as the CLI approach.

• Proceedings of the Botanical Society of Korea Conference
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• 1987.07a
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• pp.81-101
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• 1987

In an attempt to revies the informations about genes involved in symbiotic nitrogen fixation, developmental processes in which host plant interact with microbe during nodule formation were introduced first. The structure, function and regulation of the genes discussed were mainly about microbial genes; those involved in the process of nodule formation (nod-genes) and of nitrogen fixation (nif-genes). Informations about the host genes involved in the symbiosis were discussed briefly.

• Reproductive and Developmental Biology
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• v.32 no.4
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• pp.229-235
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• 2008

Silencing of Dicer1 by siRNA did not inhibit development up to the blastocyst stage, but decreased expression of selected transcription factors, including Oct-4, Sox2 and Nanog, suggesting that Dicer1 gene expression is associated with differentiation processes at the blastocyst stage (Cui et al., 2007). In order to get insights into genes which may be linked with microRNA system, we compared gene expression profiles in Gapdh and Dicer1 siRNA-microinjected blastocysts using the Applied Biosystem microarray technology. Our data showed that 397 and 737 out of 16354 genes were up- and down-regulated, respectively, following siRNA microinjection (p<0.05), including 24 up- and 28 down-regulated transcription factors. Identification of genes that are preferentially expressed at particular Dicer1 knock down embryos provides insights into the complex gene regulatory networks that drive differentiation processes in embryos at blastocyst stage.

• Journal of Plant Biotechnology
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• v.42 no.1
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• pp.1-5
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• 2015

The biological roles of glycogen synthase kinase 3 (GSK3) proteins have long been extensively explored in eukaryotic organisms including fungi, animals and plants. This gene family has evolutionary well conserved kinase domain and shares similar phosphorylation properties to their substrate proteins. However, their specific biological roles are surprisingly distinct in different organisms. GSK3s play key role in key regulating the cytoskeleton and metabolic processes in animal systems, but plant GSKs are involved in quite different processes, such as flower development, brassinosteroid signaling, abiotic stresses, and organogenesis. In particular, recent studies have reported the critical multiple functions of BIN2 and its related paralogues plant GSK3s during organogenesis via connecting hormonal or developmental programs. In this review, we outline the recent understanding in the versatile functions related in physiological and biochemical relevance, which are mediated by plant GSK3s in various cellular signaling.

• Genes and Genomics
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• v.40 no.11
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• pp.1199-1211
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• 2018

Soil acidification is one of major problems limiting crop growth and especially becoming increasingly serious in China owing to excessive use of nitrogen fertilizer. Only the STOP1 of Arabidopsis was identified clearly sensitive to proton rhizotoxicity and the molecular mechanism for proton toxicity tolerance of plants is still poorly understood. The main objective of this study was to investigate the transcriptomic change in plants under the low pH stress. The low pH as a single factor was employed to induce the response of the wheat seedling roots. Wheat cDNA microarray was used to identify differentially expressed genes (DEGs). A total of 1057 DEGs were identified, of which 761 genes were up-regulated and 296 were down-regulated. The greater percentage of up-regulated genes involved in developmental processes, immune system processes, multi-organism processes, positive regulation of biological processes and metabolic processes of the biological processes. The more proportion of down-regulation genes belong to the molecular function category including transporter activity, antioxidant activity and molecular transducer activity and to the extracellular region of the cellular components category. Moreover, most genes among 41 genes involved in ion binding, 17 WAKY transcription factor genes and 17 genes related to transport activity were up-regulated. KEGG analysis showed that the jasmonate signal transduction and flavonoid biosynthesis might play important roles in response to the low pH stress in wheat seedling roots. Based on the data, it is can be deduced that WRKY transcription factors might play a critical role in the transcriptional regulation, and the alkalifying of the rhizosphere might be the earliest response process to low pH stress in wheat seedling roots. These results provide a basis to reveal the molecular mechanism of proton toxicity tolerance in plants.

• Development and Reproduction
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• v.4 no.1
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• pp.7-12
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• 2000

At fertilization, sperm penetrates into oocyte, male and female pronuclei are fused together, and mitotic division follows. However, little information is available on the interactive roles and dynamic processes between cytoplasmic and nuclear components during the pronuclear formation, migration and cell division. The assisted reproductive technologies such as, intracytoplasmic sperm injection (ICSI) and round spermatid injection(ROSI) could provides new treatments for the male infertility as well as tools for the study of basic mechanism during fertilization. Nuclear transfer can also provide a mechanism on the interactive roles between nucleus and cytoplasm since the process includes nuclear reprogrammming of differentiated cells in the enucleated oocytes. Recently, I have investigated developmental processes in porcine oocytes following fertilization parthenogenesis, ICSI, ROSI and nuclear transfer using indirect immunocytochemical and electron microscopic studies. The results could provide an insight into biological questions related with epigenesis as well as strategies for the enhancement of embryology in general such as ICSI and nuclear transfer.