• Molecules and Cells
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• 제26권2호
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• pp.107-112
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• 2008

Invasion mechanisms of pathogens and counteracting defense mechanisms of plants are highly diverse and perpetually evolving. While most classical studies of plant defense have focused only on defense-specific factor-mediated responses, recent work is beginning to shed light on the involvement of non-stress signal components, especially growth and developmental processes. This shift in focus links plant resistance more closely with growth and development. In this review, we summarize our current understanding of how pathogens manipulate host developmental processes and, conversely, of how plants deploy their developmental processes for self-protection. We conclude by introducing our recent work on UNI, a novel R protein in Arabidopsis which mediates cross-talk between developmental processes and defense responses.

• Molecules and Cells
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• 제42권6호
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• pp.441-447
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• 2019

RAS gene mutations are frequently found in one third of human cancers. Affecting approximately 1 in 1,000 newborns, germline and somatic gain-of-function mutations in the components of RAS/mitogen-activated protein kinase (RAS/MAPK) pathway has been shown to cause developmental disorders, known as RASopathies. Since RAS-MAPK pathway plays essential roles in proliferation, differentiation and migration involving developmental processes, individuals with RASopathies show abnormalities in various organ systems including central nervous system. The frequently seen neurological defects are developmental delay, macrocephaly, seizures, neurocognitive deficits, and structural malformations. Some of the defects stemmed from dysregulation of molecular and cellular processes affecting early neurodevelopmental processes. In this review, we will discuss the implications of RAS-MAPK pathway components in neurodevelopmental processes and pathogenesis of RASopathies.

• 한국균학회소식:학술대회논문집
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• 한국균학회 2014년도 춘계학술대회 및 임시총회
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• pp.39-39
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• 2014

In a homothallic filamentous fungus Aspergillus nidulans, sexual and asexual developments are largely affected by the genetic and environmental factors. To regulate the complex subsets of genes involved in the developmental processes accurately, tight regulations of transcription factors are required. The forkhead type transcription factors are the class of regulators that function in a broad spectrum of cellular and developmental processes in many species from yeast to human. Here, we identified the fkhA and fkhB genes that encode a conserved forkhead transcription factors. The fkhA deletion resulted in the complete loss of fruiting body formation under all conditions favoring sexual development, suggesting that the fkhA gene is required for sexual development in A. nidulans. Overexpression of fkhA resulted in enhanced formation of fruiting bodies under induction condition not only in the normal condition but also in the condition of presence of 0.6 M KCl, which strongly inhibits sexual development. To know the function of the fkhB gene, we also generated fkhB knock-out strain in A. nidulans. Deletion of fkhB resulted in abnormal conidiophore formation under standard conditions and delayed sexual development process, suggesting that the fkhB gene plays an important role in conidiophore morphogenesis Taken together, these results suggest that the fkhA gene is necessary and sufficient for regulating sexual development and the fkhB gene is a transcription factor related in asexual developmental process in A. nidulans.

• Molecules and Cells
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• 제43권7호
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• pp.600-606
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• 2020

Numerous physiological processes in nature have multiple oscillations within 24 h, that is, ultradian rhythms. Compared to the circadian rhythm, which has a period of approximately one day, these short oscillations range from seconds to hours, and the mechanisms underlying ultradian rhythms remain largely unknown. This review aims to explore and emphasize the implications of ultradian rhythms and their underlying regulations. Reproduction and developmental processes show ultradian rhythms, and these physiological systems can be regulated by short biological rhythms. Specifically, we recently uncovered synchronized calcium oscillations in the organotypic culture of hypothalamic arcuate nucleus (ARN) kisspeptin neurons that regulate reproduction. Synchronized calcium oscillations were dependent on voltage-gated ion channel-mediated action potentials and were repressed by chemogenetic inhibition, suggesting that the network within the ARN and between the kisspeptin population mediates the oscillation. This minireview describes that ultradian rhythms are a general theme that underlies biological features, with special reference to calcium oscillations in the hypothalamic ARN from a developmental perspective. We expect that more attention to these oscillations might provide insight into physiological or developmental mechanisms, since many oscillatory features in nature still remain to be explored.

• 한국식물학회:학술대회논문집
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• 한국식물학회 1987년도 식물생명공학 심포지움 논문집 Proceedings of Symposia on Plant Biotechnology
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• pp.117-132
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• 1987

Plants are inherited spatial and temporal coordination systems in their growth and differentiation processes which are precisely governed by the two interlocked control systems; autogenous and environmental. Looking into the overall course of plant development from molecular to organismal level, it can be comparable to a concerto for plant hormones, environmental stimuli and plant genomic orchestra conducted by an unidentified virtuoso. Some of the recent significant attempts to puzzle out the mystery of the life processes of plant development are briefly reviewed. The revolutionary advances in understanding the mystic processes are contemporarily achieved by the application of various molecular techniques. The characterization of plant genomes is now attained through recombinant DNA approaches, and the sensitive detection of specific gene products during the plant development is perimitted by the immunochemical procedures. However, along with the recognition of underlying molecular events such as developmental changes in gene expression and hormone-receptor interrelation associated with tissue sensitivity to hormones, more emphasis should be placed upon the physiological approaches of organismal level for the understanding the correlative systems of the developmental processes of plants as intact eukaryotic organisms.

• Journal of Ecology and Environment
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• 제30권4호
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• pp.347-356
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• 2007

The structure and dynamics of Korean red pine stands established in the riparian zone were studied in the Tsang stream in Mt. Seorak National Park, in east-central Korea. Pine stands were classified into four successional stages, the initial, establishing, competitive, and stabilizing stages, based on the age distribution of a dominant tree, Pinus densiflora, the vegetation stratification, and the microtopography of the riverine environment. The stages usually corresponded to disturbance frequencies, depending on the horizontal and vertical distances from the watercourse. Stands of the initial and establishing stages lacked tree or subtree layers, or both. As stands progressed through the developmental stages, soil particle size became finer and moisture retention capacity was improved. The stand ordination reflected the developmental stage, and the species ordination differentiated species specializing in relatively dry and wet habitats. The results of the analysis of vegetation dynamics provided ecological information which will be useful for understanding the developmental processes of vegetation established in riparian zones. Species diversity indices usually increased across developmental stages, following the typical pattern for successional processes. We discuss the importance and necessity of riparian vegetation in Korea, where most riparian forests have disappeared due to excessive human land use.

• 아동학회지
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• 제26권5호
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• pp.185-204
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• 2005

This paper demonstrated how application of evolutionary knowledge to developmental perspectives enhances understanding of human ontogeny. Evolutionary Developmental Psychology (EDP) explains human behavior through evolutionary principles and focuses on ontogeny rather than phylogeny. In this paper, the authors review concepts of evolution, adaptations, and the processes of evolution from EDP perspectives. The definition and basic assumptions of EDP are introduced, followed by explanations of how evolution happens in ontogeny by looking at developmental systems approaches, concepts of ontogenetic and deferred adaptations, evolution of childhood, and brain plasticity. Possible pathways of evolution in ontogeny are also discussed. Finally, some research methodology for applying EDP to child development is suggested with specific hypotheses and studies.

• Parasites, Hosts and Diseases
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• 제42권4호
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• pp.151-157
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• 2004

Developmental surface ultrastructure of Macroorchis spinulosus was studied by scanning electron microscopy. One-day-old juvenile fluke was leaf-shaped and bent ventrally. Body surface was covered densely with peg-like spines and with cobblestone-like cytoplasmic processes. Ciliated sensory papillae were concentrated around oral sucker. Several unciliated sensory papillae occurred equidistantly on oral sucker and acetabulum. The ciliated papillae appeared in two longitudinal lines symmetric bilaterally on dorsal surface. On adult flukes, tegumantal spines became wider in middle of the body surface. The cytoplasmic processes differentiated into more fine velvety form. It is likely that the differentiated fine cytoplasmic processes are an increased absorptive surface to adult M. spinulosus. It is suggested that single pointed tegumental spines on anterior half of the body may be supportive for this fluke to migration.

• The Journal of Asian Finance, Economics and Business
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• 제5권3호
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• pp.195-206
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• 2018

Paying close attention to those new to an organization, whether fresh or experienced, whose primary interest is in (re)socialization, the current study intends to (1) further the concept of mentoring from a bilateral relationship to a community and culture fostered by developmental networks, (2) propose an integrated conceptual framework for organizational socialization, and (3) suggest implications for practice and future research. This study reviews, analyzes, and integrates research assets and subsequently re-conceptualizes the aggregate information as valid propositions and a conceptual framework. The findings include (1) 11 propositions regarding the relationships among network characteristics (embeddedness, diversity), developmental functions (career support, psychosocial support, and role modeling), and socialization outcomes (learning and attitudinal outcomes); and (2) an integrated conceptual framework that depicts a comprehensive mechanism through which developmental networks conduce to organizational socialization of newcomers. Implications are that developmental networking must be an individual's fundamental competency and an essential part of organizational onboarding processes, and imperative for both members' career development and innovative organizational culture. By integrating research assets on the developmental phenomenon into conceptualizations, this study furthers the concept of mentoring to organizational culture and stimulates a substantive discourse for theory-building towards organizational socialization from the developmental network perspective.

• 재활복지
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• 제15권4호
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• pp.27-47
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• 2011

본 논문은 발달장애인의 역량강화를 통해 지역사회로의 자연스러운 전환을 목표로 한 전환과정과 프로그램을 개발하기 위한 연구이다. 연구목적을 달성하기 위하여 문헌연구, 관련 프로그램 사례조사, 전문가 심층면접 방법을 활용하였으며 연구의 결과는 다음과 같다. 첫째, 현재 발달장애인들을 고려한 전환과정은 지나치게 제한되어 있고 이들의 특성을 고려하지 못하고 있다. 둘째, 발달장애인을 위한 새로운 고등교육프로그램이 새로운 전환과정으로 시작되고 있으나 중등학교와 연계가 부족하다. 셋째, 중등학교 이후 발달장애인을 위한 대학프로그램에서 중요하게 고려되어야 하는 요인은 자기인지와 자기이해이다. 이 결과를 중심으로 한국에서 발달장애인을 위한 대학 내 전환과정과 프로그램을 제안하면 첫째, 발달장애인을 위한 중등학교 이후 전환과정은 최소한 발달장애인의 특성과 자기이해와 자기인지가 이루어질 수 있도록 주류화교육이 이루어져야 하며, 이를 고려할 때 대학 내에서의 전환과정 구성은 하나의 대안이 될수 있다. 둘째, 대학 내 구성되는 고등교육프로그램은 다음과 같은 측면이 고려되어 구성될 필요가 있다. ① 대학 내의 많은 고등교육 관련 프로그램의 지원을 받을 수 있도록 연계되거나 지원망이 구축될 필요가 있다. ② 대학 내의 모든 프로그램에 발달장애학생들이 참여할 수 있도록 문호가 개방되어야 한다. ③ 대학 내의 전문 인력들이 필요에 따라 참여할 수 있도록 인적구성이 체계화되고 연계될 수 있어야 한다. ④ 대학 내의 비장애학생들이 발달장애학생들의 프로그램에 참여할 수 있도록 통합학습이나 활동이 자연스럽게 이루어질 수 있도록 해야 한다.