• 한국발생생물학회:학술대회논문집
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• 한국발생생물학회 2002년도 전기 제14차 학술대회 논문집
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• pp.44-44
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• 2002

• 한국발생생물학회:학술대회논문집
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• 한국발생생물학회 2001년도 전기 제11차 학술대회 논문집
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• pp.55-56
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• 2001

Gelatin zymograms of bFF and bS showed GA110 and 62 kDa gelatinses in adsition to several minor ones. Of these, GA110 gelatinase was abolished by treating bFF or bS with bOF and interestingly, its enzymatic activity was enhanced by adding EDTA to bFF or bS before zymographic analyses. Experiments using specific inhibitors of MMPs indicated that GA110 and 62 kDa proteins were indeed gelatinases. Immunoblotting experiments using an antibody against human MMP-2 showed that both GA110 and 62 kDa were an MMP-2 isoform and active MMP-2, respectively. The results suggest that the interaction between bFF and bOF can occur at the time of fertilization.

• Korean Journal of Radiology
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• 제22권8호
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• pp.1379-1396
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• 2021

Rare neurovascular diseases (RNVDs) have not been well-recognized in Korea. They involve the central nervous system and greatly affect the patients' lives. However, these diseases are difficult to diagnose and treat due to their rarity and incurability. We established a list of RNVDs by referring to the previous literature and databases worldwide to better understand the diseases and their current management status. We categorized 68 RNVDs based on their pathophysiology and clinical manifestations and estimated the prevalence of each disease in Korea. Recent advances in genetic, molecular, and developmental research have enabled further understanding of these RNVDs. Herein, we review each disease, while considering its classification based on updated pathologic mechanisms, and discuss the management status of RNVD in Korea.

• 대한장애인치과학회지
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• 제15권1호
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• pp.89-93
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• 2019

본 증례 보고는 기관 삽관 경험이 있는 조산아에서 상악 유전치의 발육장애가 나타난 증례이다. 본 증례들에서는 기관 삽관으로 인해 치관 형태 이상, 법랑질 결함, 맹출 지연이 나타났다. 또한 치배의 변위로 인한 맹출 경로 이상, 치근 만곡, 후속 영구치의 비정상적인 치근 형성도 나타났다. 이환 치아에 대해서는 예방적 수복치료 및 관리, 적절한 시기에 발치를 고려해야 한다. 소아치과의사는 삽관 경험이 있는 조산아에서 나타날 수 있는 상황에 대해 이해하고, 적절한 개입을 통해 구강 건강 증진을 도모해야 한다.

• 대한상한금궤의학회지
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• 제15권1호
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• pp.1-52
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• 2023

Objective : The objective of this study was to explore the meaning of Mai (脉) in the fifteen letters provisions of Gangpyeong-Shanghanlun through the comparative analysis of 10 cases and paleography. Methods : We have collected 10 cases that have been diagnosed and treated by Gangpyeong-Shanghanlun Mai (脉) provision. And then, comparative analysis has been done among those 10 cases. Based on result of case analysis, paleographic meaning of each Mai (脉) have been studied to redefine Gangpyeong-Shanghanlun Mai (脉)'s meaning. Results : After administration of Mai (脉) provision's herbal medicine, all 10 patients recovered their mobility problem and pain. From this result, we could fomulate the hypothesis that Mai (脉) in Gangpyeong-Shanghanlun could mean mobility problems. After through further paleography studies, we could elaborate each Mai (脉)'s clinical meaning and related diseases. Conclusions : Mai (脉) in Gangpyeong-Shanghanlun could mean mobility problems caused by various diseases, which include musculoskeletal pain, neuropathy, syncope, fatigue, developmental disability and major depressive disorder.

• 한국전문물리치료학회지
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• 제6권2호
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• pp.77-86
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• 1999

Developmental dysplasia or dislocation of the hip is the most pronounced form of a condition in which the femoral heads tends progressively to leave the acetabulum. In the young child the variability of findings and course suggest a spectrum of conditions in which there are a number of common features: restriction of movement, particularly of abduction in flexion; shortening; and abnormal radiology, including a sloping or dysplastic acetabulum and delay in the appearance of the upper femoral epiphysis. It is vital to make the diagnosis of a congenital dislocation as soon after birth as possible. Conservative treatment with an abduction brace before the child run begins to walk is completely adequate, but after the age of 4 even surgical repositioning is difficult and after the age of 7 it is almost impossible. The aim of the study was to gain insight into the value of physical therapy of developmental dysplasia or dislocation after operation.

• 대한음성언어의학회:학술대회논문집
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• 대한음성언어의학회 2006년도 제25회 학술대회
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• pp.152-152
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• 2006

• The Korean Journal of Pain
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• 제11권1호
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• pp.134-137
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• 1998

The presence of an enlarged transverse process on one or both sides of the last lumbar vertebra is a common congenital anomaly of the lumbar vertebra. It is thought to be a genetic or developmental anatomical variant. The first reported assimilation of the fifth lumbar vertebra into the sacrum associated with low back pain was in 1917 by Bertolotti. However, clinical significance of lumbosacral transitional vertebra has not been fully considered due to lack of scientific investigations dealing with it. We experienced a case of symptomatic lumbosacral transitional vertebra during management of low back pain. Low back pain was relieved after infiltration of local anesthetics and steroid into the false joint of lumbosacral transitional vertebra. This result may possibly indicate a significant correlation between low back pain and lumbosacral transitional vertebra.

• 한국동물번식학회:학술대회논문집
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• 한국동물번식학회 2001년도 춘계학술발표대회
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• pp.11-11
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• 2001

In this study, we examined the developmental potential of reconstructed bovine embryos and the fate of donor mitochondria during their preimplantation development after nuclear transfer. Isolated cumulus cells were used as donor cells in nuclear transfer. Cumulus cells labelled with MitoTracker Green FM fluorochrome were injected into enucleated bovine MII oocytes and cultured in vitro. MitoTracker labelling on donor cells did not have a detrimental effect on blastocyst formation following nuclear transfer. Cleavage rate was about 69%(56/81) and blastocyst formation rate was 6.2% (5/81) at 7 days after nuclear transfer. The labelled mitochondria dispersed to the cytoplasm and became distributed among blastomeres and could be identified up to the 8- to 15-cell stages. Small patches of mitochondria were detected in some 8- to 15-cell stage embryos (5/20). However, donor mitochondria were not detected in embryos at the 16-cell stage and subsequent developmental stages. In the control group, mitochondria could be identified in arrested 1-cell embryos up to 7 days after nuclear transfer These results suggest that donor mitochondria disappear from recipient cytoplasm before 16-cell stage following nuclear transfer in reconstructed bovine embryos.

• Journal of Interdisciplinary Genomics
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• 제1권1호
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• pp.10-13
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• 2019

A 10-year and 5 month-old girl with developmental delay, intellectual disability, attention deficit hyperactivity disorder, poor weight gain, and microcephaly was transferred to our pediatric clinic for genetic evaluation. Her height was within the 5-10th percentile, and her weight was under the 3rd percentile. On the social maturity scale, her developmental status was scored as 3 years 9 months for social age, and the social quotient was 35.98. A chromosomal microarray analysis was performed and the microduplication at chromosome 16p was observed: arr[GRCh37] 16p11.2 (29580020_30190029)${\times}3$. Currently, the patient is diagnosed with Grade 2 intellectual disability and is attending a computerized cognitive rehabilitation class twice weekly. In addition, nutritional support and growth follow up are also ensured in the Pediatric Gastrointestinal and Endocrinology clinic.