• Interdisciplinary Bio Central
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• v.3 no.4
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• pp.15.1-15.11
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• 2011

Background: Histone deacetylase (HDAC) 8 is one of its family members catalyzes the removal of acetyl groups from N-terminal lysine residues of histone proteins thereby restricts transcription factors from being expressed. Inhibition of HDAC8 has become an emerging and effective anti-cancer therapy for various cancers. Application computational methodologies may result in identifying the key components that can be used in developing future potent HDAC8 inhibitors. Results: Facilitating the discovery of novel and potential chemical scaffolds as starting points in the future HDAC8 inhibitor design, quantitative structure-activity relationship models were generated with 30 training set compounds using genetic function approximation (GFA) and Bayesian algorithms. Six GFA models were selected based on the significant statistical parameters calculated during model development. A Bayesian model using fingerprints was developed with a receiver operating characteristic curve cross-validation value of 0.902. An external test set of 54 diverse compounds was used in validating the models. Conclusions: Finally two out of six models based on their predictive ability over the test set compounds were selected as final GFA models. The Bayesian model has displayed a high classifying ability with the same test set compounds and the positively and negatively contributing molecular fingerprints were also unveiled by the model. The effectively contributing physicochemical properties and molecular fingerprints from a set of known HDAC8 inhibitors were identified and can be used in designing future HDAC8 inhibitors.

• Journal of Korean Academy of Nursing
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• v.49 no.4
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• pp.449-460
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• 2019

Purpose: This study aims to provide base data for designing education and counseling programs for child-raising by identifying the types, characteristics and predictors of parenting behaviors of married immigrant women. Methods: We used a self-report questionnaire to survey 126 immigrant mothers of young children, who agreed to participate, and who could speak Korean, Vietnamese, Chinese, Filipino, or English, at two children's hospitals and two multicultural support centers. Statistical analysis was conducted using descriptive analysis, K-means clustering, ${\chi}^2$ test, Fisher's exact test, one-way ANOVA, $Sch{\acute{e}}ffe^{\prime}s$ test, and multinominal logistic regression. Results: We identified three clusters of parenting behaviors: 'affectionate acceptance group' (38.9%), 'active engaging group' (26.2%), and 'passive parenting group' (34.9%). Passive parenting and affectionate acceptance groups were distinguished by the conversation time between couples (p=.028, OR=5.52), ideology of motherhood (p=.032, OR=4.33), and parenting stress between parent and child (p=.049, OR=0.22). Passive parenting was distinguished from active engaging group by support from spouses for participating in multicultural support centers or relevant programs (p=.011, OR=2.37), and ideology of motherhood (p=.001, OR=16.65). Ideology of motherhood was also the distinguishing factor between affectionate acceptance and active engaging groups (p=.041, OR=3.85). Conclusion: Since immigrant women's parenting type depends on their ideology of motherhood, parenting stress, and spousal relationships in terms of communication and support to help their child-raising and socio-cultural adaptation, it is necessary to provide them with systematic education and support, as well as interventions across personal, family, and community levels.

• Korean Journal of Human Ecology
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• v.10 no.4
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• pp.357-363
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• 2001

The purpose of this study was to provide buying condition of women focusing on age groups and satisfaction with ready-to-wear and basic data in designing ready-to-wear for women. The questionnaire method was used and one-to-one interviews were held for residents in Iksan, Jonju areas. Total 252 subjects were surveyed and used for statistical analysis and were analyzed by Frequency, ANOVA, CROSSTABS, $x^2-test$. Women for this study were classified 3 groups(young women, middle aged women, obesity women). The results of this study were as follows; 1) Both BMI and Rohrer index are significantly different according to 3 groups. 2) In the buying method, more than 97% of the middle aged women and obesity women had purchased ready-to-wear apparel. 3) While young women purchased their clothing in the Bose store, middle aged women and obesity women purchased their clothing in the department store. 4) In young women and middle aged women group, the most important criteria of buying were design. In obesity women, the most important criteria of buying were design, size (fitness), price. 5) For the satisfaction of ready-to-wear with aging, 34.1% of all respondents showed dissatisfaction. There was significant difference according to the age. 6) In the fit of ready-to wear, When ready-to-wear is not fit, more than 40% was purchased big or small.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.13 no.4
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• pp.1866-1883
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• 2019

As the youngest branch of information hiding, network covert timing channels conceal the existence of secret messages by manipulating the timing information of the overt traffic. The popular model-based framework for constructing covert timing channels always utilizes cumulative distribution function (CDF) of the inter-packet delays (IPDs) to modulate secret messages, whereas discards high-order statistics of the IPDs completely. The consequence is the vulnerability to high-order statistical tests, e.g., entropy test. In this study, a rich security model of covert timing channels is established based on IPD chains, which can be used to measure the distortion of multi-order timing statistics of a covert timing channel. To achieve rich security, we propose two types of covert timing channels based on nested lattices. The CDF of the IPDs is used to construct dot-lattice and interval-lattice for quantization, which can ensure the cell density of the lattice consistent with the joint distribution of the IPDs. Furthermore, compensative quantization and guard band strategy are employed to eliminate the regularity and enhance the robustness, respectively. Experimental results on real traffic show that the proposed schemes are rich-secure, and robust to channel interference, whereas some state-of-the-art covert timing channels cannot evade detection under the rich security model.

• Tribology and Lubricants
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• v.39 no.3
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• pp.94-101
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• 2023

Automotive wheel bearings are a critical component of vehicles that support their weight and facilitate rotation. Life and stiffness are significant performance characteristics of wheel bearings. Designing wheel bearings involves finding optimal design variables that satisfy both performances. CO₂ emission reduction and fuel efficiency regulations attribute to the recent increase in design requirements for lightweight and compact automotive parts while maintaining performance. However, achieving a design that maintains performance while reducing weight poses challenges, as performance and weight are generally inversely proportional. In this study, we perform design optimization of automotive wheel bearings considering life and stiffness. We develop a program that calculates the basic rated life and modified rated life based on international standards for evaluating the life of wheel bearings. We develop a regression equation using regression analysis to address the time-consuming stiffness analysis during repetitive analysis. We perform ANOVA and main effect analyses to understand the statistical characteristics of the developed regression equation. Furthermore, we verify its reliability by comparing the predicted and test results. We perform design optimization using the developed life prediction program, stiffness regression equation and weight regression equation. We select bearing specifications and geometry as design variables, weight as the cost function, and life and stiffness as constraints. Through design optimization, we investigate the influence of design variables on the cost function and constraints by comparing the initial and optimal design values.

• Journal of the Institute of Electronics and Information Engineers
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• v.49 no.9
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• pp.215-224
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• 2012

Using password on system is easy to build and shorten the access time to authorize user, which is high in use for vary system that requires users' authorization. Many input device are able to perform the password system easily, such as PC, smart-phone, tablet PC, etc. Beside the high usability of password, physical attack occurs when user put their password on the device, known as Shoulder Surfing attack. It used to be formed in numbers, characters or mix of different kinds, but new kind of password arose. Exploiting image or making scenarios are those kinds which are able to reflect users' intentions. Not many estimation exists for new password, so there's need to be standard for those new password for highlighting usability and accessability. In this paper, we propose password system with simple image and switching key-board to test statistical method to estimate usability on the password.

• Journal of Dental Rehabilitation and Applied Science
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• v.32 no.1
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• pp.8-15
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• 2016

Purpose: The purpose of this research is to determine whether pontic metal substructures, which are currently used in clinical surgeries, are designed appropriately and identify the problems that can occur due to their shape, size, and position. Then it aimed to emphasize the importance of making and designing pontic metal substructures based on basic principles. Materials and Methods: This research measured pontic basal surface (P1) used sample metal substructures in this study, gingiva margin (P2), and the porcelain thickness of maximum infrabulge of labial surface around 1/3 of cervix dentis (P3). One-way ANOVA analysis was carried out to test the differences among groups, Tukey Honestly Significant Difference Test was conducted for statistical analysis among groups. Results: For porcelain thickness and SD value, the P1 part was $1.2-1.8({\pm}0.17)mm$ for experimental group 1, $1.2-1.7({\pm}0.17)mm$ for experimental group 2, and $0.4-2.8({\pm}0.92)mm$ for experimental group 3. Next, the P2 part was $1.4-1.6({\pm}0.07)mm$ for experimental group 1, $1.3-1.8({\pm}0.07)mm$ for experimental group 2, and $0.5-2.7({\pm}0.67)mm$ for experimental group 3. The P3 part was $1.4-1.7({\pm}0.10)mm$ for experimental group 1, $1.5-2({\pm}0.10)mm$ for experimental group 2, and $0.9-3.1mm({\pm}0.90)$ for experimental group 3. There was no significance when One-way ANOVA analysis/Tukey Honestly Significant Difference Test was conducted for statistical analysis among groups (P > 0.05). Conclusion: The suggested metal substructures can be used clinically as they meet the requirements that pontic must have.

• Journal of the Korean Home Economics Association
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• v.12 no.2
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• pp.621-631
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• 1974

The objective of the study was to obtain standard sizes of body of the high school girls for designing clothes and developing pattern grading of clothes. In 1972, 342 students, selected by the stratified cluster random sampling method, at three high schools in Seoul were measured on forty-one items by the R. Martin method. Statistical techniques of mean, standard deviation, coefficient variable, maximum and minimum, range, t-test were utilized to analyze the data. The findings of the study were as follows ; 1. No differences were found among the age groups in the all measured variables. 2. Stature, bust girth, hip girth, acromion width, posterior waist girth/stature ratio of the high school girls were significantly smaller than those sizes of adult women. This result implies that those sizes will be increased as the students grow up. But upper arm girth, upper arm girth/bust girth ratio, and thigh girth/bust girth ratio were bigger than those sizes of adult women. Waist girth, thigh girth, total head height/stature ratio, acromion width/stature ratio, and foot length/stature ratio were nearly similiar to those of adult women. 3. According to the result of t-test, waist breadth, spinailiaca anterior height/stature ratio, thigh girth/bust girth ratio, and thigh/hip girth ratio of the 15 year old group were significantly different from those of the 16 year old group at the level of 0.05. Bust girth, weight, foot breadth, posterior croth length, and cervical height/stature ratio of the 16 year old group were significantly different from those of the 17 year old group at the level of 0.01. Hip girth, upper arm girth, waist breadth/stature ratio, and neck base girth/bust girth ratio of the 16 year old group were significantly different from those of the 17 year old group at the level of 0.05.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.11 no.3
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• pp.1146-1152
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• 2010

The Korean healthcare industry is rapidly changing along with the competition among hospitals. In the past, hospitals could make profit without designing competitive management strategies. Thus, they did not find importance in listening to customers' voices and identifying their wants. However, nowadays, the increasingly intense competition is encouraging hospitals to seriously consider competitive management strategies and Customer Relationship Management (CRM) activities to gain a competitive advantage and prosper. It tries to compare the expected satisfaction with the satisfaction of out-patient and in-patient and analysis of VOC(Voice of Customer). This survey was done from 27th, April, 2009 to 8th May and each 100 in-patients and out-patients. The paired t-test and descriptive analysis was used to analysis between before and after satisfaction. The result, the replied out-patients were the highest of I.M department, 43% and in-patients, surgery and other department are the highest each 22.0%. Nurses kindness is statistical significant in out-patients. Doctor, Nurse and staff's kindness and rounding service was statistical significant in in-patients. Totally, the satisfaction was lower than expected satisfaction, so the medical care institutions should analyst detailed the patient's satisfaction by VOC.

• Journal of Wetlands Research
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• v.12 no.2
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• pp.13-23
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• 2010

According to recent researches on climate change, the global warming is obvious to increase rainfall intensity. Damage caused by extreme hydrologic events due to global change is steadily getting bigger and bigger. Recently, frequently occurring heavy rainfalls surely affect the trend of rainfall observations. Probability precipitation estimation method used in designing and planning hydrological resources assumes that rainfall data is stationary. The stationary probability precipitation estimation method could be very weak to abnormal rainfalls occurred by climate change, because stationary probability precipitation estimation method cannot reflect increasing trend of rainfall intensity. This study analyzed temporal variation of trend in rainfall time series at 51 stations which are not significant for statistical trend tests. After modeling rainfall time series with maintaining observed statistical characteristics, this study also estimated whether rainfall data is significant for the statistical trend test in near future. It was found that 13 stations among sample stations will have trend within 10 years. The results indicate that non-stationary probability precipitation estimation method must be applied to sufficiently consider increase trend of rainfall.