• Biomolecules & Therapeutics
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• 제8권2호
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• pp.199-205
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• 2000

On the inter-order protoplast fusants of Lentinus edodes and Ganoderma lucidum was the antitumor activity test performed and the fusant P22 was selected. The hot water extract of the cultured mycelia of P22 were purified by DEAE-cellulose chromatographya and the resulting purified fraction was designated as P22A. It was found to be a proteoglycan whose molecular weight was 47 kDa. When examined for immunopotentiation activity, P22A increased the number of colony forming unit in the bone marrow stem cells to 3-folds. It also potentiated the secretion of nitric oxide in activated macrophages to 2-folds. In humoral immune response, it increased the activities of the alkaline phosphatase in differentiated B cells to 1.6-folds and the number of plaque forming cells to 1.8-folds. In cellular immune response, it restored the depressed response of delayed type hypersensitivity in tumor bearing mice to normal level. These results suggest that P22A have potential to restore the decreased immune activity of the tumor bearing mice to normal level.

• Journal of Information Science Theory and Practice
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• 제4권1호
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• pp.6-20
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• 2016

Scholarly communication plays a significant role in the development and dissemination of research outputs in library and information science (LIS). This study presents findings from a survey which examines the key attributes that characterize the publishing by Pakistani LIS scholars, i.e. academics and professionals, in national journals. A pilot-tested, electronic questionnaire was used to collect the data from the target population. 104 respondents (or 69.3% of target) provided feedback on areas such as number of articles published, number of citations, and the nature of any collaboration with other authors. The findings of this survey revealed that, among the various designated regions of Pakistan, the Punjab region was the most highly represented. In articles published in national journals, there was a clear preference among all respondents to collaborate with at least one other author. The citation metrics for LIS articles in national journals were relatively low (30.22%), which aligns with Scimago’s Journal and Country Rankings. The uptake of social scholarly networks mirrors international trends. Respondents were asked to score factors which could impact negatively on their ability to undertake research and/or publish the results. The study recommends that concerned stakeholders work together, as appropriate, to address concerns. In addition, it recommends that further research be undertaken to define patterns of Pakistani co-authorship in the social sciences.

• 조명전기설비학회논문지
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• 제28권12호
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• pp.90-94
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• 2014

Recently, various types of trains are being operated in the same railroad whose designated stop stations are not the same. In other words, each train does not stop at every station. This could cause the pass-through accidents in which a train passes a station where it is supposed to stop. Although the number of train accidents is on the decrease, this type of error is still an important problem to be resolved. It is true that the burdens of train drivers are growing because the number of high speed trains and non-stop stations is increasing in the current railway system. However, another major reason for this accident is that there is no prevention system for these errors in the current train control system although it is being constantly improved. The purpose of this study is to reinforce the train stop system with wireless communication equipment in order to decrease this type of accident and to maximize the safety of railway transportation.

• 산업공학
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• 제16권spc호
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• pp.144-148
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• 2003

A group of digital human models with various sizes which properly represents a population under consideration is needed in the design process of an ergonomic product in virtual environment. The present study proposes a two-step method which produces a representative group of human models in terms of stature and weight. The proposed method first generates a designated number of pairs of stature and weight within an accommodation range from the bivariate normal distribution of stature and weight of the target population. Then, from each pair of stature and weight, the method determines the sizes of body segments by using 'hierarchical' regression models and corresponding prediction distributions of individual values. The suggested method was applied to the 1988 US Army anthropometric survey data and implemented to a web-based system which generates a representative group of human models for the following parameters: nationality, gender, accommodation percentage, and number of human models.

• 인터넷정보학회논문지
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• 제22권6호
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• pp.41-49
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• 2021

Due to the COVID-19 pandemic, issues related to quarantine are emerging. There are various infection prevention methods, but among them, it is certain to frequently disinfect the surface or the entire space of an object that has come into contact with the virus. However, the reality is that the number of times such disinfection is legally designated and the required number of personnel are very different depending on the building and facility. For this reason, there are no companies and systems that can professionally receive orders for disinfection work. In order to solve the aforementioned problems, this paper presents a method to design a disinfection service platform based on the MVC pattern, and implements the required functions based on this. Through this, it is possible to build a more systematic system, and it is hoped that it will be of great help to quarantine with an orderly process for disinfection work.

• 한국항공운항학회지
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• 제31권2호
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• pp.18-24
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• 2023

According to the results of a survey by Boeing, LOC-I (Loss of Control in Flight) was the highest in the number of deaths by fatality accident category in the past 10 years from 2012 to 2021, and the number of deaths worldwide due to LOC-I accidents was 757. It turned out to be the biggest cause of aircraft fatalities, with a figure close to twice the sum of UNK (Unknown or Undetermined), which is the 2nd place, and CFIT (Controlled Flight Into or Toward Terrain), which is the 3rd place. This study set six scenarios related to spatial disorientation that may occur during sensory-dependent flight targeting student pilots and instructor pilots at domestic designated specialized educational institutions using flight simulation training equipment, and in each scenario, the pilot's. The need for SDRT (Spatial Disorientation Recovery Training) is verified by analyzing the flight experience and recovery ability by qualification, and SDRT is repeatedly performed to verify and present the training cycle and time.

• The Korean Journal of Ecology
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• 제19권1호
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• pp.93-104
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• 1996

Ecological approach to conservation of Korea's National Parks (KNP) was reviewed. Four hundred twenty five reports on 15 national parks for 80 years (1915~1994) were analyzed in consideration of phytocoenotic information such as flora, plant community and landscape. Total species was recorded as 157 familles, 752 genera, and 2,369 species (64.3% of Korean flora), in which is included only 75 species of the protected plant species designated by the Ministry of EnvironMent. Occurrence patterns of plant species in national parks were quite similar to one another, but those of plant community were rather unique. Seventy-four of 97 plant communities were reported in only one of 15 national parks, which might be regarded as an endemic or local vegetetation type. These facts are far different from actual status of the KNP＇s ecosystem, which indicate that not only original data in previous reports are less informative, but also tools of investigation and description are too subjective, and thus these can never afford to monitor the ecosystem. From the correlation analysis between 10 ecological characteristics, the following results were obtained: (1) the species richness was positively associated with the area of national park, (2) the number of visitors was related to landscape diversity, (3) occurrence of the designated species was closely related to the vegetation diversity. Numerical analysis (cluster analysis and ordination) using dissimilarity ratio by ecological characteristics divided 15 national parks into 4 groups. The first group, composed of national parks of Chirisan, $S\v{o}laksan$, Sokrisan, Hallasan, $T\v{o}kyusan$, Odaesan, and Sobaeksan, is recognized as the best national parks in terms of ecological conservation values. Nevertheless, they have been faced with the threat of visitor stress. This study will contribute to the establishment of strategy for appropriate conservation and sustainable use of KNP.

• 한국임상약학회지
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• 제16권2호
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• pp.107-112
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• 2006

This study was aimed to investigate the current status and expectations of orphan drugs in Korea. The Korea Orphan Drug Center was established to supply many medicines for the patients with rare diseases. Among the medicines supplied by the Center, the number designated as the orphan drugs by the KFDA is quite few. However, a few of medicines are not under circulation even if the items are designated as the orphan drugs. Neoplasm-related medicines, infectious and parasitic disease-related medicines, endocrine, nutritional and metabolic disease-related medicines are the ones circulated most. There are several unapproved drugs among the medicines supplied by the Center. It's because the director of the Center can import the goods without a process to getting an approval from the KFDA. The Korea Orphan Drug Center has contributed to the selection of the medicines for treating the rare disease. On the contrary, some problems remain in the supply process. The safety and effectiveness of the medicines supplied by the Center are not guaranteed. So far, rare diseases have no specific legal definition, and therefore are only referred to in terms of the population of patients, which prevent from establishing the range of medicines. The introduction of Special Access Program or Access to Unapproved Therapeutic Goods will be the solution of these problems. In addition, it is another solution to keep intimate relations with the Rare and Intractable Disease Center and the Medicine Safety Information Center which will be open soon.

• 한국비블리아학회지
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• 제29권2호
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• pp.247-274
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• 2018

2013년 일본 서점기업 CCC가 다케오시립도서관의 지정관리자로서 도서관의 관리 운영을 수탁하였다. 관내에 상업시설을 병설하고 독자적인 분류체계를 사용하는 등 도서관 운영 및 공간구성을 종래의 공공도서관과 달리 하고, 재개관 첫 해 기존의 약 3.7배에 달하는 방문이용자를 동원하면서 일본과 국내 언론의 화제를 모았다. 본 연구에서는 다케오시립도서관에 대하여 문헌조사, 신문기사 내용분석, 인터뷰 조사를 수행함으로써 서점기업이 공공도서관을 위탁운영하게 된 배경과 언론이 어떠한 관점에서 다케오시립도서관을 논하고 있는지 이해하고자 하였다. 연구 결과, 신문기사들은 소도시 주민에게 도서관을 매개로 '복합문화공간'을 제공한 점, 방문자가 증가한 점, 지역경제 효과가 발생한 점은 긍정적으로 평가하였나, 운영적자가 계속되고 장서구입과정에 문제가 발생한 점은 한계로 평가하고 있음을 확인하였다.

• Fisheries and Aquatic Sciences
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• 제19권4호
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• pp.17.1-17.9
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• 2016

The seasonal variation of fecal coliforms (FCs) and physicochemical factors was determined in seawaters of the Hansan-Geojeman area, including a designated area for oyster, and in inland pollution sources of its drainage basin. The mean daily loads of FCs in inland pollution sources ranged from $1.2{\times}10^9$ to $3.1{\times}10^{11}$ most probable number (MPN)/day; however, the pollutants could not be reached at the designated area. FC concentrations of seawaters were closely related to season, rainfall, and inland contaminants, however, within the regulation limit of various countries for shellfish. The highest concentrations for chemical oxygen demand (COD) and $chlorophyll-{\alpha}$ in seawaters were shown in the surface layer during August with high rainfall, whereas the lowest for dissolved oxygen (DO) in the bottom layer of the same month. Therefore, it indicates that the concentrations of FC, COD, DO, and $chlorophyll-{\alpha}$ of seawaters were closely related to season and rainfall.