• Bulletin of the Korean Chemical Society
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• v.33 no.9
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• pp.2930-2936
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• 2012

A three-dimensional pharmacophore hypothesis was developed for atypical antipsychotics in order to map common structural features of highly active compounds by using HipHop in CATALYST program. The pharmacophore hypotheses were generated using 12 compounds as training set and validated using 11 compounds as test set. The most predictive hypothesis (Hypo1) comprises five features viz. two hydrophobic regions, two hydrogen bond acceptor lipid and one aromatic ring. In the absence of information like crystallized structure of 5-$HT_{2A}$ receptor and binding mode of antipsychotics with 5-$HT_{2A}$ receptor, this hypothesis will serve as a potentially valuable tool in the design of novel atypical antipsychotics acting primarily at 5-$HT_{2A}$ and $D_2$ receptors.

• Journal of Korean Elementary Science Education
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• v.35 no.2
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• pp.137-149
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• 2016

The purpose of this study is to develop a descriptive paper test item which can evaluate elementary school students' HGA (scientific Hypothesis Generating Ability) and to propose a counting formula that can easily assess student's HGA objectively and quantitatively. To make the test item can possibly evaluate all the students from 6th graders to 3rd graders, the 'rabbit's ear' item is developed. Developed test item was distributed to four different elementary schools in Seoul. Total 280 students who were in the 6th grade solved the item. All the students' reponses to the item were analyzed. Based on the analyzed data evaluation factors and evaluation criteria are extracted to design a Hypothesis Generating ability Quotient (HGQ). As the result 'Explican's Degree of Likeness' and 'Hypothesis' Degree of Explanation' are chosen as evaluation factors. Also precedent evaluation criteria were renewed. At first, Explican's Degree of Likeness evaluation criterion was turned four levels into three levels and each content of evaluation criterion is also modified. Secondly, new evaluation factor 'Hypothesis' Degree of Explanation' was developed as combined three different evaluation criteria, 'level of explican', 'number of explican' and 'structure of explican'. This evaluation factor was designed to assess how the suggested hypothesis can elaborately explain the cause of one phenomenon. Newly designed evaluation factors and evaluation criteria can assess HGA more in detail and reduce the scoring discordant through the markers. Lastly, Developed counting formula is much more simple than precedent Kwon's equation for evaluating the Hypothesis Explanation Quotient. So it could help easily distinguish one student's scientific hypothesis generating ability.

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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• 2014.10a
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• pp.347-349
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• 2014

Model verification and validation (V&V) is a current research topic to build computational models with high predictive capability by addressing the general concepts, processes and statistical techniques. The hypothesis test for validity check is one of the model validation techniques and gives a guideline to evaluate the validity of a computational model when limited experimental data only exist due to restricted test resources (e.g., time and budget). The hypothesis test for validity check mainly employ Type I error, the risk of rejecting the valid computational model, for the validity evaluation since quantification of Type II error is not feasible for model validation. However, Type II error, the risk of accepting invalid computational model, should be importantly considered for an engineered products having high risk on predicted results. This paper proposes a technique named as the response-adaptive experimental design to reduce Type II error by adaptively designing experimental conditions for the validation experiment. A tire tread block problem and a numerical example are employed to show the effectiveness of the response-adaptive experimental design for the validity evaluation.

• Journal of Korean Academy of Nursing
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• v.37 no.6
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• pp.994-1002
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• 2007

Purpose: This study was to identify the effects of hope intervention on hope and depression of cancer patients staying at home. Methods: The study design was a randomized control group design. The subjects consisted of forty cancer patients randomly selected who were registered at S-Gu Public Health Center. Hope intervention, which was composed of hope assessment, hope objective setting, positive self identity formation, therapeutic relationships, spiritual & transcendental process improvement, positive environmental formation and hope evaluation, was provided from November 20, 2006 to January 26, 2007. Results: The 1-1 hypothesis, "The experimental group which received hope intervention will have a higher score of hope than the control group", was supported(t=-3.253, p= .003). The 1-2 hypothesis, "The experimental group which received hope intervention will have a higher level of hope index than the control group", was supported (t=-4.001, p= .000). Therefore the 1st hypothesis, "The experimental group which received hope intervention will have a higher level of hope than the control group" was supported. The 2nd hypothesis, "The experimental group which received hope intervention will have a lower level of depression than the control group", was not supported (t=1.872, p= .070). Conclusion: Hope intervention is an effective nursing intervention to enhance hope for patient with cancer.

• Proceedings of the Korea Society of Design Studies Conference
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• 2004.10a
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• pp.10-11
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• 2004

• East Asian Journal of Business Economics (EAJBE)
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• v.8 no.1
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• pp.1-19
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• 2020

Purpose - This study is to classify quality characteristics of online environment-friendly agricultural products shopping malls into 6 categories and to empirically test their relationship with customer trust, perceived manageability, perceived utility and purchase intention. Research design, data, and methodology - This study targeted adults who have purchased ecofriendly agricultural production online malls for 4 weeks from September 3 to September 30, 2019. The survey type used was a structuralized self-report survey questionnaire made to meet the research purpose in 2019 as the time range. Out of 800 questionnaires, 500 copies are used after excluding surveys with insincere responses. Results - First, results to hypothesis 1, which was about independent variables and customer trust. Analysis showed that health, familiarity, platform reputation, reviews and product quality were found to have significant effect on customer trust; the hypothesis was adopted. On the other hand, system security did not affect customer trust significantly; it was rejected. Second, customer trust was shown to have significant effect on perceived manageability and perceived utility, so the hypothesis was adopted. Third, the hypothesis that perceived manageability moves onto perceived utility was adopted. Moreover, the hypothesis that perceived manageability moves onto purchase intention and the hypothesis that perceived utility moves onto purchase intention were adopted as well. Conclusions - Furthermore, the results of the study imply that it's imperative for online environment-friendly agricultural products shopping malls to consider their characteristics as the means to increase purchase intention of customers.

• Journal of Global Scholars of Marketing Science
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• v.10
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• pp.91-110
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• 2002

The purpose of this research is as follows; First, the reference price ads are to investigate how the price cues and prior knowledge of service products have an effect on consumers' perception by the type of information. Second, this study suggests some marketing strategy guides to service marketing managers for price promotion strategy. To achieve these research goals, the hypothesis was established through reviewing the previous studies and the data collected from the experimental design. The experiment of this study was a 2$\times$2$\times$2 among the subject factorial design in which the factors were present in price cue presentation (presentation/non- presentation), the level of prior knowledge(high/low), and the type of information(positive/negative). The major findings of this research can be summarized as follows; First, there are some significant statistical differences in the consumers' perception value by level of price cues(hypothesis 1). Second, there are some significant statistical differences in the consumers' price-quality perception by level of price cues(hypothesis 2). Third, there are some significant statistical differences in the price-quality perception by the level of prior knowledge and the type of information(hypothesis 3).

• Journal of the Korea Safety Management & Science
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• v.10 no.2
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• pp.205-210
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• 2008

The research interprets the principles of sampling error design for quality statistics models such as hypothesis test, interval estimation, control charts and acceptance sampling. Introducing the proper discussions of the design of significance level according to the use of hypothesis test, then it presents two methods to interpret significance by Neyman-Pearson and Fisher. Second point of the study proposes the design of confidence level for interval estimation by Bayesian confidence set, frequentist confidential set and fiducial interval. Third, the content also indicates the design of type I error and type II error considering both productivity and customer claim for control chart. Finally, the study reflects the design of producer's risk with operating charistictics curve, screening and switch rules for the purpose of purchasing and subcontraction.

• Proceedings of the Korea Society of Design Studies Conference
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• 2003.11a
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• pp.48-49
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• 2003

• Korean Journal of Health Education and Promotion
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• v.15 no.2
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• pp.55-66
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• 1998

The purpose of this study was to test whether adhesive taping therapy, one of rehabilitation, helps to relieve chronic low back pain. Sample were selected from 35 outpatients at oriental medicine hospital in the period from April 20 to June 20, 1998. The research design was one-group pretest - posttest design. The pretest included measuring discomfort depending on the scope and types of a range of motion, and their pain by their activity of daily living(ADL). In this research design, a treatment was to expose adhesive taping therapy to samples. The posttest included remeasuring of their discomfort and pain by ADL. The results of this study was as follows: Hypothesis I was that the discomfort score of the post-treatment group had lower than does that of the pre-treatment group. This study accepted the hypothesis (t=2.70, p=.015). Hypothesis II was that the post-treatment group had the pain score by ADL lower than does the pre-treatment group. Empirical results showed statistical significance(t=4.53, p=.000). In summary, the effect measured by the discomfort with a visual analog scale was statistically significant. The degree of pain according to postures in ADL also showed statistical significance. Consequently, these findings showed that the adhesive taping therapy was effective to alleviation of chronic low back pain.