• Journal of the Korean Statistical Society
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• v.35 no.2
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• pp.213-224
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• 2006

We investigate the influence of subjects or observations on regression coefficients of generalized estimating equations using the influence function and the derivative influence measures. The influence function for regression coefficients is derived and its sample versions are used for influence analysis. The derivative influence measures under certain perturbation schemes are derived. It can be seen that the influence function method and the derivative influence measures yield the same influence information. An illustrative example in longitudinal data analysis is given and we compare the results provided by the influence function method and the derivative influence measures.

• Journal of Soil and Groundwater Environment
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• v.15 no.6
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• pp.46-52
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• 2010

Derivative analysis, based on the derivative of the drawdown as a function of time (i.e., rate of drawdown change), was applied to the evaluation of hydraulic parameters of the aquifer as an aid of the aquifer test interpretation based on the Theis solutions. Pumping tests were conducted at a coastal fractured aquifer in Muan county, Korea, of which the drawdown data, measured at the two observation wells, were used for derivative analysis. Wellbore storage and transition period were hard to identify at conventional log-log and semi long plots, but was easily recognized by distinctive curves of positive unit slope, hump and negative unit slope in the derivative plot. For the observation well of OW-2 at which wellbore storage and transition lasted over an hour, conventional aquifer analysis would suffer from the uniqueness problems and in further result in erroneous hydraulic parameters. Derivative analysis was found to be effective for distinguishing the drawdown data directly reflecting the aquifer property from those reflecting non aquifer effects such as wellbore storage and transition, which offers a unified methodology to yield correct hydraulic parameters from aquifer test data.

• Journal of the Chungcheong Mathematical Society
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• v.27 no.4
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• pp.753-762
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• 2014

A three-step sextic simple-root finder is constructed with the use of weighting functions of derivative-to-derivative ratios. Their convergence and computational properties are investigated along with concrete numerical examples to verify the theoretical analysis.

• Journal of the Korean Statistical Society
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• v.30 no.3
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• pp.499-509
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• 2001

We investigate the influence of observations on a test of additional information about discrimination using the influence function and the derivative influence measures. the influence function for the test statistic is derived and this sample versions are used for influence analysis. The derivative influence measures for the test statistic under a perturbation scheme are derived. It will be seen that the influence function method and the derivative influence measures yield the same result. Furthermore, we will derive the relationships between the influence function and the derivative influence measures when the sample size is large. an illustrative example is given and we will compare the results provided by the influence function method and the derivative influence measures.

• Steel and Composite Structures
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• v.21 no.6
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• pp.1389-1410
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• 2016

This paper proposes a hybrid of topological derivative-based level set method (LSM) and isogeometric analysis (IGA) for structural topology optimization. In topology optimization a significant drawback of the conventional LSM is that it cannot create new holes in the design domain. In this study, the topological derivative approach is used to create new holes in appropriate places of the design domain, and alleviate the strong dependency of the optimal topology on the initial design. Furthermore, the values of the gradient vector in Hamilton-Jacobi equation in the conventional LSM are replaced with a Delta function. In the topology optimization procedure IGA based on Non-Uniform Rational B-Spline (NURBS) functions is utilized to overcome the drawbacks in the conventional finite element method (FEM) based topology optimization approaches. Several numerical examples are provided to confirm the computational efficiency and robustness of the proposed method in comparison with derivative-based LSM and FEM.

• The Journal of Korean Medicine
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• v.19 no.2
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• pp.337-372
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• 1998

To evaluate the effects of Injinchunggantang-derivative on cell viability, cell cycle progression, and apoptosis, MTT assay, cell cycle analysis, Cpp32 protease assay, DNA fragnemtation assay, quantitative RT-PCR, and Western blotting were performed. The results were as followes. In MTT assay, etoposide+Injinchunggantang-derivative-treated cells as well as Injinchunggantang-derivative-treated cells showed higher viability than etoposide-treated cells with no time-concentration-dependence, which implied that Injinchunggantang-derivative has hepato-protective effect Cell cycle analysis showed that Injinchunggantang-derivative has no significant effect on the cell cycle. Cpp32 protease assav and DNA fragmentation assay Injinchunggantang-derivative carry inhibitory effects on apoptosis induction. It was suggested that Injinchunggantang-delivative might regulate the cell cycle, in particular $G_1$ checkpoint by blocking p53 and Watl pathway. Injinchunggantang-derivative inhibited the mRNA expressions of Cpp32, Fas, and Bcl-2, which could result in inhibition of apoptosis. These results imply that Injinchunggantang-derivative increases hepatocyte viability, and protects hepatocyte from damage by regulating the expression of genes associated with cell cycle and apoptosis, which explains the mechanism of the clinical effect of Injinchunggantang-derivative on liver diseases.

• Journal of Mechanical Science and Technology
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• v.20 no.5
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• pp.658-667
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• 2006

Fractional derivative models, which are used to describe the viscoelastic behavior of material, have received considerable attention. Thus it is necessary to put forward the analysis solutions of dynamic systems containing a fractional derivative. Although previously reported such kind of fractional calculus-based constitutive models, it only handles the particularity of rational number in part, has great limitation by reason of only handling with particular rational number field. Simultaneously, the former study has great unreliability by reason of using the complementary error function which can't ensure uniform real number. In this paper, a new approach is proposed for an analytical scheme for dynamic system of a spring-mass-damper system of single-degree of freedom under general forcing conditions, whose damping is described by a fractional derivative of the order $0<{\alpha}<1$ which can be both irrational number and rational number. The new approach combines the fractional Green's function and Laplace transform of fractional derivative. Analytical examples of dynamic system under general forcing conditions obtained by means of this approach verify the feasibility very well with much higher reliability and universality.

• International Journal of Aeronautical and Space Sciences
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• v.17 no.2
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• pp.268-283
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• 2016

Aircraft manufacturing companies have to consider multiple derivatives to satisfy various market requirements. They modify or extend an existing aircraft to meet new market demands while keeping the development time and cost to a minimum. Many researchers have studied the derivative design process, but these research efforts consider baseline and derivative designs together, while using the whole set of design variables. Therefore, an efficient process that can reduce cost and time for aircraft derivative design is needed. In this research, a more efficient design process is proposed which obtains global changes from local changes in aircraft design in order to develop aircraft derivatives efficiently. Sensitivity analysis was introduced to remove unnecessary design variables that have a low impact on the objective function. This prevented wasting computational effort and time on low priority variables for design requirements and objectives. Additionally, uncertainty from the fidelity of analysis tools was considered in design optimization to increase the probability of optimization results. The Reliability Based Design Optimization (RBDO) and Possibility Based Design Optimization (PBDO) methods were proposed to handle the uncertainty in aircraft conceptual design optimization. In this paper, Collaborative Optimization (CO) based framework with RBDO and PBDO was implemented to consider uncertainty. The proposed method was applied for civil jet aircraft derivative design that increases cruise range and the number of passengers. The proposed process provided deterministic design optimization, RBDO, and PBDO results for given requirements.

• Archives of Pharmacal Research
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• v.11 no.1
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• pp.45-51
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• 1988

The feature of resolution enhancement by derivative operation is linked to one of the multivariate analysis, which is multiple linear regression with two options, all possible and stepwise regression. Examined samples were synthetic mixtures of 5 vitamins, thiamine mononitrate, riboflavin phosphate, nicotinamide, pyridoxine hydrochloride and ascorbic acid. All components in mixture were quantified with reasonably good accuracy and precision. Whole data processing procedure was accomplished on-line by the development of three computer programs written in APPLESOFT BASIC language.

• School Mathematics
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• v.12 no.2
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• pp.239-257
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• 2010

In school mathematics the derivative concept is intuitively taught with the tangents and the concept of instantaneous velocity. In this paper, I investigated the long historical developments of the derivative concepts and analysed the relationships between the definition of derivative and the related elements. Finally I proposed some educational implications based on the analysis.