• Journal of the Society of Cosmetic Scientists of Korea
• /
• v.33 no.2
• /
• pp.99-104
• /
• 2007

The skin barrier function is one of the vital functions. Horny layer and epidermis among various skin layers play an important role in protecting body from environmental insults. Stratum corneum is completely formed by differentiation processes from the basal layer and newly formed corneocytes push the older ones from skin surface. In this study we investigated changes of various parameters - capacitance, transepidermal water loss (TEWL), pH and amount of removed corneocytes - according to the stratum corneum's depth. We removed the stratum corneum using tape stripping technique. We found that uppermost stratum corneum play an important role in skin surface moisturization and lower stratum corneum in protecting transepidermal water loss. In addition, skin pH is more acidic than surface pH. In the stratum corneum, skin pH is mote acidic in the deeper layer. Furthermore amount of removed corneocyte is also decreased according to depth because of stronger cell-cell union strength. From these results we suggest that stratum corneum has different characteristics depending on their position.

• Earthquakes and Structures
• /
• v.26 no.3
• /
• pp.229-237
• /
• 2024

This paper studied the subgrade spring stiffness and its influencing factors in the seismic deformation method of circular tunnel. Numerical calculations are performed for 3 influencing factors: stratum stiffness, tunnel diameter and burial depth. The results show that the stratum stiffness and tunnel diameter have great influence on the subgrade spring stiffness. The subgrade spring stiffness increases linearly with stratum stiffness increasement, and decreases with the tunnel diameter increasement. When the burial depth ratio (burial depth/tunnel diameter) exceeds to 5, the subgrade spring stiffness has little sensitivity to the burial depth. Then, a proposed formula of subgrade spring stiffness for the seismic deformation method of circular tunnel is proposed. Meanwhile, the internal force results of the seismic deformation method are larger than that of the dynamic time history method, but the internal force distributions of the two methods are consistent, that is, the structure exhibits elliptical deformation with the largest internal force at the conjugate 45° position of the circular tunnel. Therefore, the seismic deformation method based on the proposed formula can effectively reflect the deformation and internal force characteristics of the tunnel and has good applicability in engineering practice.

• Geomechanics and Engineering
• /
• v.36 no.2
• /
• pp.131-143
• /
• 2024

Shield tunneling construction commonly crosses underground pipelines in urban areas, resulting in soil loss and followed deformation of grounds and pipelines nearby, which may threaten the safe operation of shield tunneling. This paper investigated the pipeline deformation caused by double curved shield tunnels in soil-rock composite stratum in Nanjing, China. The stratum settlement equation was modified to consider the double shield tunneling. Moreover, a three dimensional finite element model was established to explore the effects of hard-layer ratio, tunnel curvature radius, pipeline buried depth and other influencing factors. The results indicate the subsequent shield tunnel would cause secondary disturbance to the soil around the preceding tunnel, resulting in increased pipeline and ground surface settlement above the preceding tunnel. The settlement and stress of the pipeline increased gradually as buried depth of the pipeline increased or the hard-layer ratio (the ratio of hard-rock layer thickness to shield tunnel diameter within the range of the tunnel face) decreased. The modified settlement calculation equation was consistent with the measured data, which can be applied to the settlement calculation of ground surface and pipeline settlement. The modified coefficients a and b ranged from 0.45 to 0.95 and 0.90 to 1.25, respectively. Moreover, the hard-layer ratio had the most significant influence on the pipeline settlement, but the tunnel curvature radius and the included angle between pipeline and tunnel axis played a dominant role in the scope of the pipeline settlement deformation.

• Journal of the Society of Cosmetic Scientists of Korea
• /
• v.44 no.4
• /
• pp.455-463
• /
• 2018

Skin elasticity has been known to be influenced by the change of dermal components such as collagen, elastic fiber, and glycosaminoglycans. However, it is unclear whether the uppermost epidermis may affect the mechanical characteristics of elasticity. In present study we tried to find the role of stratum corneum when determining the elastic property under skin bioengineering measurement with $Cutometer^{(R)}$. A total of 10 healthy volunteers aged 25-40 years were investigated by the parameters reflecting the skin elasticity from face and volar forearm. Within various ranges of suction pressure, R0 (=Uf), R7 (=Ur/Uf) and R8 (=Ua) were obtained to explore the depth-associated elasticity. In addition, these parameters were re-measured after the skin was fully hydrated. As results, we found that the measurement of depth-associated elasticity was possible as using various suction pressure. And the R7 parameter was significantly lower from face than those from forearm in before hydration (p < 0.05). Also, we found that the hydration of stratum corneum could affect skin elasticity. Especially, the R7 parameter at 300 mbar suction pressure of face skin showed significantly increased values than that of before hydration (p < 0.05). Interestingly, measured data from the face before and after hydration manifested relatively higher variation than from the forearm. These results suggest that it is possible to evaluate the skin elasticity considering the changes of stratum corneum and epidermis by using various suction pressure and skin hydration.

• Journal of Korean Medical classics
• /
• v.27 no.4
• /
• pp.21-27
• /
• 2014

Objectives : Among the translations of the verse "Sa-gi is on the upper side, Tak-gi is on the middle side, Cheong-gi is on the under side(邪氣在上, 濁氣在中, 淸氣在下)" in the texts of Miraculous Pivot(靈樞) Nine needles and Twelve sources(九鍼十二原), the meanings of 'Ham-maek(陷脈)' and 'Joong-maek(中脈)' have contradictory versions. Methods : This study will identify the actual meaning of this verse through analysis of the phrase "夫氣之在脈也", followed by examination of the relationship between the meaning of "three-stratum puncture(三刺)" in the chapters Miraculous Pivot Handling needle(官鍼), Miraculous Pivot Jong-si(終始) and the meaning of "刺有三變" of Miraculous Pivot Longevity and character(壽夭剛柔), after which its application in later periods will be discussed. Results : The words 'Sa-gi', 'Tak-gi' and 'Cheong-gi' in the phrase "夫氣之在脈也" of Miraculous Pivot Nine needles and Twelve sources each correspond to the words 'yang pathogens(陽邪)', 'yin pathogens(陰邪)' and 'essence derived from food(穀氣)' of Miraculous Pivot 終始, respectively. Conclusions : The Upper-Middle-Lower of the phrase "夫氣之在脈也" in Nine needles and Twelve sources indicates the three levels of depth, in which 'Sa-gi', 'Tak-gi' and 'Cheong-gi' each dwell. 'Ham-maek' and 'Joong-maek' are categorizations according to the depth of needling.

• Structural Engineering and Mechanics
• /
• v.18 no.2
• /
• pp.263-276
• /
• 2004

The purpose of this paper is to determine the subsoil depth affected from the load on the plate resting on elastic foundation using stress distribution within the subsoil that will be occurred depending on the loading and dimension of the plate. An iterative method is developed in order to determine the effective depth of the subsoil under the plate. Numerical examples from the technical literature are solved by means of the method suggested herein and displacements, bending moments and shear forces are presented in graphical and tabular forms to evaluate the effects of the limit depth considered in the study. Results showed the efficiency and simplicity of the present approach for the plate resting on an elastic foundation.

• Interaction and multiscale mechanics
• /
• v.1 no.1
• /
• pp.157-175
• /
• 2008

A brief review of the research works on ground vibrations caused by trains moving in underground tunnels is first given. Then, the finite/infinite element approach for simulating the soil-tunnel interaction system with semi-infinite domain is summarized. The tunnel is assumed to be embedded in a homogeneous half-space or stratified soil medium. The train moving underground is modeled as an infinite harmonic line load. Factors considered in the parametric studies include the soil stratum depth, damping ratio and shear modulus of the soil with or without tunnel, and the thickness of the tunnel lining. As far as ground vibration is concerned, the existence of a concrete tunnel may somewhat compensate for the loss due to excavation of the tunnel. For a soil stratum resting on a bedrock, the resonance peak and frequency of the ground vibrations caused by the underground load can be rather accurately predicted by ignoring the existence of the tunnel. Other important findings drawn from the parametric studies are given in the conclusion.

• The Journal of Korean Physical Therapy
• /
• v.13 no.3
• /
• pp.719-726
• /
• 2001

Transdermal drug delivery offers various advantages over conventional drug delivery systems, such as avoidance gastrointestinal degradation and hepatic first-pass effect. encourages patient compliance. and possible sustained release of drugs. However, transdermal transport of drugs is low permeability of the stratum corneum, the superficial layer of the skin. Many physicochemical and biological factors influencing transdermal transport is described together with the corresponding experimental and clinical results. Phonophoresis is medical treatment with drugs introduced into the skin by ultrasound energy. Enhanced drug penetration is through to result from the biophysical alterations of skin structure by ultrasound waves. The frequency used for phonophoresis is usually from 20 kHz to 15MHz. Phonophoresis can be categorized in to three ranges: low-frequency range(below 1 MHz). therapeutic frequency range(1 to 3MHz), and high-frequency range(above 3 MHz). The depth of penetration of ultrasound into skin is inversely proportional to the frequency. Cavitation may cause mechanical stress. temperature elevation, or enhanced chemical reactivity causing drug transport. One theory is that ultrasound affects the permeation of the stratum corneum lipid structure as the limiting step in permeating through the skin. The range of indications for phonophoresis is wide. Aspecific classification of the range of indications is obtained by classification of pathological conditions. The continuous research is needed for many interesting issucs of phonophoretic transdermal delivory in new future.

• Proceedings of the Korea Concrete Institute Conference
• /
• 2006.05b
• /
• pp.573-576
• /
• 2006

The objective of the study is to investigate the depth of penetration of concrete water forced in under pressure. For this purpose, the experiments for the depth of penetration by selecting the factors and levels such as water pressure, pressure time were executed. The flow of water of concrete examined theoretically and experimentally. As a result, It is found that in the case of low water pressure approximately 0.15Mpa or less, the flow is Darcy seepage flow, the same as flow in an ordinary sand stratum, whereas in the case of high water pressure, the flow is diffused seepage flow accompanied by internal deformation of concrete.

• Proceedings of the Korean Geotechical Society Conference
• /
• 2005.03a
• /
• pp.49-56
• /
• 2005

The negative skin friction on piles, which are installed in currently consolidating soft deposits, creates significant problems on the stability of pile foundations. This study investigated whether or not the pile foundation designs were appropriate in soft deposits with large amount of consolidation settlement. The final settlements of the grounds along the pile depth were estimated by the soil parameters obtained from the laboratory tests and by the field-measured settlement curves, if they were available. The displacement of the piles along the pile depth was estimated by both the load transfer method and the numerical method. Both methods gave similar locations of neutral points and magnitudes of the maximum axial forces. The movements of the ground and the piles were compared to calculate the down drag acting on piles. For the piles whose bearing capacities were less than the design loads including the down drag, slip layer coatings and/or incrementing of the penetration depth into the bearing stratum were proposed to improve the piles capacities.