• 치위생과학회지
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• 제11권4호
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• pp.339-344
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• 2011

본 연구는 흡연군, 흡연중단군, 비흡연군의 치은열구액 내 MMP-9을 측정하여 흡연과 치은열구액 내 MMP-9의 관계를 조사하고자 2009년부터 9월부터 2010년 7월까지 본 연구에 동의한 332명을 대상으로 기초설문조사와 치면세균막지수, 치주낭측정 등을 실시하고 치은열구액을 상악전치부 치간 사이 채취하여 치은열구액 내 MMP-9의 농도를 측정하여 분석하였다. 그 결과, 1. 연령대에 따른 치은열구액 내 평균 MMP-9의 농도는 10대 7.54ng/ml, 20대 15.98 ng/ml, 30대 28.47ng/ml, 40대 36.78ng/ml, 50대 이상은 45.06ng/ml로 집단간의 차이는 유의하였다(p<0.001). 2. 치은지수에 따른 치은열구액 내 평균 MMP-9의 농도는 0점 16.15ng/ml, 1점 20.97ng/ml, 2점 48.79ng/ml로 치은지수가 증가함에 따라 치은열구액 내 MMP-9의 농도가 증가하는 경향을 보였으나 유의하지는 않았다(p>0.05). 3. CPI에 따른 치은열구액 내 평균 MMP-9의 농도는 0점 14.74ng/ml, 1점 6.57ng/ml, 2점 10.29ng/ml, 3점 29.71ng/ml, 4점 56.52ng/ml였으며 군간 유의한 차이가 있었다(p<0.001). 4. 흡연여부에 따른 치은열구액 내 MMP-9의 평균 농도는 흡연군이 30.86ng/ml, 흡연중단군이 29.82ng/ml, 11.33ng/ml이었으며 연령, 치은지수, CPI을 공변량으로 보정한 전, 후 모두에서 각 군간 유의한 차이를 나타내었다(p<0.001). 흡연, 흡연중단군이 비흡연군에 비해 치은열구액내 MMP-9의 농도가 높은 것으로 나타나 흡연은 치은열구액 내 MMP-9의 농도를 증가시키고 있는 것으로 보이며 MMP-9은 치조골 파괴 및 치주질환에 영향을 미치므로 흡연자에서 치주질환 발생 및 발생가능성이 높을 것으로 사료되었다.

• Journal of Periodontal and Implant Science
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• 제30권2호
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• pp.305-324
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• 2000

This study compared the short-term(4 months) clinical results of regenerative therapy with bioabsorbable membranes($BioMesh^{(R)}$) and bone allograft for the treatment of periodontal(intrabony and furcation) defects in smokers and nonsmokers.(16 smokers) 32 subjects with 92 defects participated in the study(46 in smokers and 46 in non-smokers). This study also evaluated a bioresorbable barrier with and without decalcified freeze-dried bone allograft(DFDBA). The 92 periodontal defects were randomly treated with either the resorbable barrier alone or resorbable barrier in combination with DFDBA following thorough defect debridement and root preparation with tetracycline. Each patient received both types of treatment modalities. Clinical examinations(probing depth, gingival recession, clinical attachment level, plaque index and gingival index) were carried out immediately before and 4 months after surgery. Significant(p<0.001) gains in mean attachment level were observed for both smokers(2.93mm) and non-smokers(3.30mm) but there were not significant difference between two groups. Similarly, significant reductions in mean probing depthshowed for smokers(4.52mm) and non-smokers(4.26mm). However, when comparing gingival recession, smokers were found to exhibit significantly poorer treatment results(1.59mm vs 0.96mm, p<0.05). Using the split-mouth-design, no statistically significant difference between the two modalities could be detected with regard to pocket depth reduction, gingival recession, or attachment gain. These results illustrate that the attachment gain is better in the non-smoker and the best in the non-smoker with the combination therapy of resorbable barrier and DFDBA than with resorbable barrier alone but smoking had no significant effect on clinical treatment outcome, even though smokers show more significant gingival recession. In addition, both treatments, either resorbable barrier plus DFDBA or resorbable barrier alone, promoted significant resolution of periodontal defects but the addition of DFDBA with a bioabsorbable membrane appears to add no extra benefit to the only membrane treatment.

• Tuberculosis and Respiratory Diseases
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• 제49권5호
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• pp.576-584
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• 2000

연구배경 : 흡연이 폐암발생의 중요한 원인이라는 사실은 분명하지만 흡연 양이나 흡연기간 뿐만 아니라 흡연과 관련된 여러 요소들의 역할도 중요하게 고려해야 한다. 본 연구는 남녀별 흡연력 및 흡연과 관련된 요소들에 대한 폐암의 발생위험도를 구하여 담배 속 발암물질에 대한 남녀별 감수성 차이를 알아보았다. 방법 : 본 연구는 환자-대조군 연구로 영남대학교 의과대학 부속병원 내과를 방문하여 폐 기능 검사를 받았던 사람들을 대상으로 흡연력 및 흡연량, 흡연습관에 관한 설문조사를 하였다. 조직학적으로 원발성 폐암이 확인된 경우를 대상환자로 하였고, 다변량 회귀분석을 이용하여 교차비를 구하고, 이를 폐암발생의 상대적인 발생위험도로 인정하였다. 결과 : 흡연력이 있었던 여자는 흡연력이 없는 경우에 비하여 교차비는 1.9이었으며, 특히 Kreyberg I의 경우 교차비는 3.8로 증가하였다. 또한 여자 중 현재흡연자의 교차비는 4.0으로 남자의 2.3보다 훨씬 높았다. Kreyberg I 여자 환자로 20갑 년 이상 흡연하였을 때 교차비는 5.4(남자 : 1.6), 하루 1갑 이상 흡연 하였을 경우 교차비는 6.9(남자 : 5.0)로 남자보다 훨씬 높았다. 흡입정도에 따른 교차비는 중등도 이상 흡입한 경우 여자 6.7, 남자 2.4로 여자에서 현저하게 높았으며, 한 개피 당 동일한 길이의 담배를 피웠을 때도 폐암의 발생 위험도는 여자가 높았다(여자 3.7:남자 2.0). 또한 필터 유 무에 따른 폐암 발생위험도의 차이는 남녀 모두에게 있었으나 여자에서 더 뚜렷하였다. 결론 : 흡연에 따른 폐암발생의 감수성은 여자가 남자보다 더 높았으며, 이러한 성별간 감수성의 차이는 흡연 양이나 흡연습관, 또는 환경적인 요인 뿐만 아니라 발암물질의 활성이나 제거 등과 같은 대사의 차이에도 그 원인이 있을 것으로 생각된다.

• 한국학교보건학회지
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• 제29권3호
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• pp.132-139
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• 2016

Purpose: In this study, we analyzed the correlation between high-caffeine energy drink intake and mental health in high school students. Methods: Analyses were conducted using the data of 27,097 responses from the 2015 Korea Youth Risk Behavior Web-based Survey of general high school students. Data were analyzed by logistic regression based on a complex sample design. Results: High-caffeine energy drink intake was positively correlated with the rates of smoking, alcohol consumption, violence, depression, and suicidal thoughts and negatively correlated with the sense of happiness. Conclusion: High-caffeine energy drink intake has a significant impact on the mental health of high school students. Therefore, in-depth research and policies on high-caffeine energy drink intake and the mental health of young individuals are required.

• Journal of Periodontal and Implant Science
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• 제49권2호
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• pp.60-75
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• 2019

The primary aim of this systematic review was to assess the evidence on periodontal disease progression after treatment in patients receiving supportive periodontal therapy (SPT) and to identify predictors of clinical attachment level (CAL) loss. A protocol was developed to answer the following focused question: In adult patients treated for periodontitis, what is the disease progression in terms of CAL loss after surgical or non-surgical treatment? Randomized controlled clinical trials, prospective cohort studies, and longitudinal observational human studies with a minimum of 5 years of follow-up after surgical or non-surgical treatment that reported CAL and probing depth changes were selected. Seventeen publications reporting data from 14 investigations were included. Data from 964 patients with a follow-up range of 5-15 years was evaluated. When the CAL at the latest follow-up was compared to the CAL after active periodontal therapy, 10 of the included studies reported an overall mean CAL loss of ${\leq}0.5mm$, 3 studies reported a mean CAL loss of 0.5-1 mm, and 4 studies reported a mean CAL loss of >1 mm. Based on 7 publications, the percentage of sites showing a CAL loss of ${\geq}2mm$ varied from 3% to 20%, and a high percentage of sites with CAL loss was associated with poor oral hygiene, smoking, and poor compliance with SPT. The outcomes after periodontal therapy remained stable over time. Disease progression occurred in a reduced number of sites and patients, mostly associated with poor oral hygiene, poor compliance with SPT, and smoking.

• Journal of Periodontal and Implant Science
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• 제48권4호
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• pp.251-260
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• 2018

Purpose: The aim of this retrospective cross-sectional study was to evaluate whether salivary findings of active matrix-metalloproteinase 8 (aMMP-8) chairside (point of care; POC) tests were associated with periodontal risk assessment parameters in patients receiving supportive periodontal therapy (SPT). Methods: A total of 125 patients receiving regular SPT were included, and their records were examined. The following inclusion criteria were used: a diagnosis of chronic periodontitis, at least 1 non-surgical periodontal treatment (scaling and root planning) with following regular SPT (minimum once a year), at least 6 remaining teeth, and clinical and aMMP-8 findings that were obtained at the same appointment. In addition to anamnestic factors (e.g., smoking and diabetes), oral hygiene indices (modified sulcus bleeding index [mSBI] and approximal plaque index), periodontal probing depth simultaneously with bleeding on probing, and dental findings (number of decayed, missing, and filled teeth) were recorded. Salivary aMMP-8 levels were tested using a commercial POC test system (Periomarker, Hager & Werken, Duisburg, Germany). Statistical analysis was performed using the t-test, Mann-Whitney U test, Fisher's exact test, and ${\chi}^2$ test, as appropriate (P<0.05). Results: Only the mSBI was significantly associated with positive salivary aMMP-8 findings (aMMP-8 positive: $27.8%{\pm}20.9%$ vs. aMMP-8 negative: $18.0%{\pm}14.5%$; P=0.017). No significant associations were found between aMMP-8 and smoking, diabetes, periodontal parameters, or parameters related to the maintenance interval (P>0.05). Conclusions: Salivary aMMP-8 chairside findings were not associated with common parameters used for periodontal risk assessment in patients receiving SPT. The diagnostic benefit of POC salivary aMMP-8 testing in risk assessment and maintenance interval adjustment during SPT remains unclear.

• 한국수산과학회지
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• 제1권2호
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• pp.135-137
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• 1968

1938년 A. F. Spillaus에 의하여 Bathythermograph가 고안된 이내 현재까지 수차 개량된 것이 제작판매하게 되어 해양조사 또는 어장탐색에 총중한 측기로 세계 각국에서 널리 보급되었다. 이 측기는 항해중이라도 수심 270m까지 내렸다 올림으로써 수심에 대한 수온이 동시에 연속된 일선으로 도은 또는 Smoked한 유리 판상에 기록되어 신속하게 수온의 미세한 수직분포를 알 수 있어 어장탐사에 필요한 나층의 판별과 그 수탐 및 수온의 판단에 큰 도움을 준다. 여기에서는 1, 2연전 이내 수산진흥원 산하 각 해구 시험소 및 교육기관을 비롯한 해양조사 관계기관에 다수양이 공급되어 널리 사용되고 있는 B.T의 Smoked-glass slide가 없어 사용의 곤란성 및 일본 또는 미국으로부터의 수입의 귀찮은 수속을 해소시키기 위하여 본원에서 실험 제작사용한 결과로서 간단하게 B.T Smoked glass Slide를 제작할 수 있는 방법을 소개하고자 한다.

• International Journal of Clinical Preventive Dentistry
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• 제14권4호
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• pp.264-270
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• 2018

Objective: This study performed a quantitative analysis using the real-time polymerase chain reaction technique to examine the oral microbial prevalence in adults and intended to examine the correlations between risk factors of periodontal disease and oral bacteria and correlation between oral test scores and oral microorganisms. Methods: We examined papillary marginal attached (PMA) index, modified patient hygiene performance (M-PHP) index, probing depth (PD), modified gingival index, and oral bacteria counts and surveyed 117, 20 years or older adult males and females who visited dental clinics in the Daejeon region to analyze the prevalence and oral health. Results: The prevalence was 100% for Fusobacterium nucleatum, meaning it was observed in all examined subject, 85.5% for Parvimonas micra, 76.1% for Prevotella intermedia, and 72.6% for Tannerella forsythia. The averages of P. gingivalis and T. forsythia increased as the examined subjects were older, and there was a statistically significant difference between T. forsythia and E. nodatum in relation to medical history, between P. intermedia and P. micra in relation to gender, and between P. intermedia and E. corrodens in relation to smoking (p<0.05). For a correlation between the oral test scores and oral microorganisms, P. gingivalis and F. nucleatum was highly correlated with PD (correlation coefficient of 0.51 and 0.41) (p<0.01) while P. gingivalis, P. micra, C. rectus, and E. nodatum were significantly correlated with M-PHP index, gingival index, PD, and PMA index (p<0.01, p<0.05). Conclusion: For oral health management of adults, the age, systemic disease, and smoking are closely related to oral bacteria, and P. gingivalis, T. forsythia, F. nucleatum, P. intermedia, P. micra, C. rectus, E. corrodens, and E. nodatum are considered to be the oral microorganisms that indicate periodontal health.

• Journal of Periodontal and Implant Science
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• 제47권5호
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• pp.328-338
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• 2017

Purpose: Chronic periodontitis is an inflammatory disease induced by pathogenic bacterial accumulation. A novel index, the periodontal inflamed surface area (PISA), represents the sum of the periodontal pocket depth of bleeding on probing (BOP)-positive sites. It is advantageous for data processing and analysis because it can be treated as a continuous variable to quantify periodontal inflammation. In the present study, we evaluated correlations between PISA and periodontal classifications, and examined PISA as an index integrating the discrete conventional periodontal indexes. Methods: This study was a cross-sectional subgroup analysis of data from a prospective cohort study investigating the association between chronic periodontitis and the clinical features of ankylosing spondylitis. Data from 84 patients without systemic diseases (the control group in the previous study) were analyzed in the present study. Results: PISA values were positively correlated with conventional periodontal classifications (Spearman correlation coefficient=0.52; P<0.01) and with periodontal indexes, such as BOP and the plaque index (PI) (r=0.94; P<0.01 and r=0.60; P<0.01, respectively; Pearson correlation test). Porphyromonas gingivalis expression and the presence of serum P. gingivalis antibodies were significant factors affecting PISA values in a simple linear regression analysis, together with periodontal classification, PI, bleeding index, and smoking, but not in the multivariate analysis. In the multivariate linear regression analysis, PISA values were positively correlated with the quantity of current smoking, PI, and severity of periodontal disease. Conclusions: PISA integrates multiple periodontal indexes, such as probing pocket depth, BOP, and PI into a numerical variable. PISA is advantageous for quantifying periodontal inflammation and plaque accumulation.

• 구강회복응용과학지
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• 제39권1호
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• pp.1-8
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• 2023

목적: 이 연구의 목적은 치주질환자를 대상으로 치주판막술 시행 5년 후 치아의 상실여부를 파악한 뒤 치아 상실과 관련된 예후 요인을 분석하는 것이다. 연구 재료 및 방법: 2017년 1월부터 12월까지 치주치료를 시행한 22명의 환자, 124개의 치아를 대상으로 하였다. 치아 관련요인은 치료 당시에 수술을 진행한 술자에 의해 임상적으로 기록된 요인으로 치주수술 당일 최대 치주낭 깊이, 치근의 수, 치근 이개부 이환, 근관치료 여부, 보철상태를 기록하였다. 내원 당시의 초진 기록을 기준으로 환자관련 요인은 성별, 나이, 흡연 여부, 첫 내원 당시 치주질환으로 상실된 치아 여부, 당뇨병 이환 여부, 5년간 유지관리 응답도가 있으며 각각 요인들을 기록하였다. 각각의 요인들의 치아 상실 여부와 관련한 영향력을 평가하였다. 결과: 치아 관련요인이 발치에 미치는 영향력을 살펴본 결과 최대 치주낭 깊이, 골 소실, 치근 이개부 이환 중 치주낭 깊이(P : 0.000), 골 소실(P : 0.021)이 발치에 유의미한 영향을 미치는 것으로 나타났다. 특히, 최대 치주낭 깊이의 영향력이 가장 높은 것으로 나타났다. 환자 관련 요인은 치아발치에 유의한 결과를 보이지 않았다. 결론: 치주판막술을 시행한 환자에서 골 소실, 최대 치주낭 깊이가 치아 상실과 관련하여 통계적으로 유의성 있는 예후 요인으로 작용하였다.