• 대한원격탐사학회:학술대회논문집
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• 대한원격탐사학회 2007년도 춘계학술대회 논문집
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• pp.76-81
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• 2007

융설 모형의 중요 매개변수인 적설분포면적은 실제 우리나라에서 적설과 관련한 관측 자료의 부족으로 인해 매개변수 추정이 어렵다. 이러한 문제점 해결을 위해 원격탐사기법을 활용하여 적설분포면적을 추출하였다. 본 연구에서는 1997년 부터 2006년 까지의 겨울철 NOAA (National Oceanic and Atmospheric Administration)의 AVHRR(Advanced Very High Resolution Radiometer) 위성영상의 8 sets의 총 108개 영상을 이용하여 적설분포면적을 추출하였고，기상청의 지상기상관측소의 최섬적설심 자료를 이용하여 GIS 자료를 구축함으로써 적설심의 공간적 분포를 추출하였다. 이를 국내 5대유역인 한강，낙동강，금강，영산강，섬진강 유역에 대하여 융설모형의 주요 매개변수인 적설분포면적，유역 평균， 최대 적설심과 적설분포감소비곡선을 구축하였다. 그 중 적설분포면적감소곡선 (SDC : Snow cover Depletion Curve)는 적설분포면적의 감소형태를 나타내 주는 지표로써 융설의 가장 민감한 매개변수이다. 이를 국내 5대 강 유역에 대해 구축하여 정량화 하였다.

• 한국자기학회지
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• 제3권3호
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• pp.221-228
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• 1993

고밀도기록용 박막재료로서의 충족조건은 높은 보자력, 높은 포화자화, 생산성, 그리고 화학적 안정성으로써 수직자기기록매체 CoCrMo 자성박막을 RF 스퍼터링 방법으로 제조한 후, 부식 특성을 전기화학적 측정, acceleration corrosion test 및 부식후 박막의 표면분석을 통하여 조사 하였다. CoCrMo 박막의 부식특성은 스퍼터링 조건에 따라서 다르게 나타났으며, Mo의 함량이 증가 할수록 내식성은 향상되었다. 전기화학부식실험 결과 박막의 Mo 함량이 증가할수록 뚜렷한 활성- 불활성 전이를 나타내었으며 부동태전류밀도의 감소를 나타내었다. Accelerated corrosion test에 서 CoCrMo 박막의 부식은 전기화학반응에 의하여 일어났으며 Mo첨가에 따라 부식이 일어난 곳의 수는 감소하였다. AES분석결과 부식 장소에는 많은 양의 $Cl_{-}$ 이온이 존재하였고, Cr의 고갈이 부식의 원인이었다.

• 한국정보디스플레이학회:학술대회논문집
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• 한국정보디스플레이학회 2005년도 International Meeting on Information Displayvol.II
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• pp.1284-1287
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• 2005

Peripheral pentacene region gives a significant influence on C-V characteristics of metal-oxide-pentacene capacitor structure. When the gate voltage goes toward negative, the effect of peripheral pentacene region becomes larger. Remaining gate DC bias constant and changing small signal frequency, the capacitance of peripheral pentacene changes along with frequency so that the total capacitance value also changes. The influence of peripheral pentacene region should be removed to measure accurate C-V characteristics, because it is hard to take into account the effect of the region quantitatively. After removing the influence of peripheral pentacene region, acceptor concentration, flat band voltage and depletion width of pentacene thin film are extracted from an accurate C-V curve as $1.58{\times}10^{17}cm^{-3}$, -1.54 V and 39.4 nm, respectively.

• Journal of Advanced Marine Engineering and Technology
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• 제30권6호
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• pp.709-715
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• 2006

The effects of thermal cycle condition and applied stress on the intergranular corrosion in austenitic 316 type stainless steels were investigated. Specimens were solution-treated at 1100$^{\circ}C$ for one hour and then sensitized in the temperature range of $500{\sim}800^{\circ}C$ by holding $2{\sim}300s$ with a various applied stresses of $0{\sim}8kg/mm^2$. Degree of sensitization. DOS %, was measured through polarization curve by electrochemical DL-EPR test. Microstructural observations were also conducted DOS % increased with an increase of sensitization temperature and/or holding time. Increase of applied stress resulted in increase of DOS % and more corroded surface because of acceleration of intergranular corrosion and fine grain size due to the stress. Cr depleted zone near grain boundary was observed. The amount of depletion was profounded with an increase of sensitization temperature, holding time and applied stress. $M_{23}C_6$ carbides were precipitated discontinuously at grain boundary. However, its amount was relatively small in the thermal cycle condition of 800$^{\circ}C$, 300sec and 4kg/mm$^2$.

• Journal of Preventive Veterinary Medicine
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• 제42권4호
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• pp.171-176
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• 2018

A study of the tissue depletion of florfenicol (FFC) administered orally to pigs at a dose of 0.05 kg/ton feed for 7 days was performed. Sixteen healthy cross swine were administered with FFC. Four treated animals were arbitrarily selected to be sacrificed 1, 3 and 5 days after the end of treatment. FFC residue concentrations in muscle, liver, kidney, and fat were determined using high-performance liquid chromatography (HPLC) with ultraviolet photometric detector at 230 nm. The correlation coefficient ($R^2$) of the calibration curve for florfenicol amine (FFCa) was > 0.997 and the limits of detection and quantification were 0.012 and $0.040{\mu}g/mL$, respectively. Recovery rates in swine edible tissues ranged from 79.1 to 93.5%. In the FFC-treated group, FFC residues at 3 days post-treatment were below the maximum residue limits (MRLs) in muscle, kidney and fat, and those at 5 days post-administration were below the MRLs in all edible tissues. These results suggest that the withdrawal period of FFC after the drug treatment might be 5 days, which is a sufficient amount of time for reduction of the FFC residues below the MRLs in all edible tissues.

• Journal of Plant Biology
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• 제16권3_4호
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• pp.17-34
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• 1973

The physico-chemical factors, the distribution of chlorophyll and the primary production of the lakes Hwajinpo, Yongrangho, Chunchonho, Uiamho, Soyangho and Changjamot have been studied in order to make ecological comparison among these lakes during summer stagnation period of August to September of 1973. On the basis of the characteristics of these lakes, the lake types have been discussed. Thermocline is observed at 3-4m zone in the lake Changjamot and 4-5m zone in the lake Yongrangho. In the case of lake Hwajinpo and impoundments, the distinct thermal stratification is not observed at the summer stagnation period. As to vertical distribution of dissolved oxygen, a positive heterograde curve is obtained in the lakes Hwajinpo and Yongrangho. In the lake Changjamot the typical clinograde curve and the oxygen depletion in hypolimnion are observed. In the case of impoundments, however, the orthograde curve is observed in the lakes Chunchonho and Uiamho. While in the lake Soyangho, any stratification of the disssolved oxygen is not found. In the brackish lakes, such as lakes Hwajinpo and Yongragho, the salinity of hypolimnion is found to be much higher than that of epilimnion. In the lake Hwajinpo, the salinity of hypolimnion is exhibited 32.7$\textperthousand$, which is nearly the same as sea water. The distribution of nitrogenous compounds and phosphates is found to be high in the lake Changjmot. The silicate is also found in high concentration in the lake Chunchonho, and the distribution of nutrients in the brackish lakes is generally low. As to the vertical distribution of chlorophyll level, the lake Changjamot shows a stratum type and the brackish lakes L-type stratification. In the impoundments, lakes Chunchonho and Uiamho appear to be homogeneous type. Seasonal variation of chlorophyll level in the lake Changjamot is examined from January to September 1973. The vertical distribution of chlorophyll during the period of circulation from January to April is homogeneous type and is stratum type thereafter. The maximum chlorophyll level is 277.4mg/$m^2$ on June 23 and the pattern of seasonal variation of chlorophyll level is comparable to the type of eutrophy. The horizontal distribution of chlorophyll level is studied in the brackish lakes, Hwajinpo and Yongrangho. The pattern of distribution is found to be an irregular type. On the basis of measurements of primary production by means of the carbon-14 method and the distribution of chlorophyll level, it is concluded that the interior part of the lake Hwajinpo and Changjamot are eutrophic and the exterior part of the lake Hwajinpo, lake Yongrangho and the impoundments, lake Uiambo and Soyangho are mesotrophic.

• 대한전자공학회논문지SD
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• 제40권1호
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• pp.1-10
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• 2003

본 연구에서는 Metal-Ferroelecric-Semiconductor FET (MFSFET) 소자의 특성을 시뮬레이션 하였다. 시뮬레이션에서는 field-dependent polarization 모델과 square-law FET 모델이 도입되었다. MFSFET 시뮬레이전에서 C-V/sub G/ 곡선은 축적과 공핍 및 반전 영역을 확실하게 나타내었다. 게이트 전압에 따른 캐패시턴스, subthreshold 전류 그리고, 드레인 전류특성에서 강유전체 항전압이 0.5, 1V 일 때, 각각 1, 2V 의 memory window 를 나타내었다. 드레인 전류-드레인 전압 곡선은 증가영역과 포화영역으로 구성되었다. 드레인 전류-드레인 전압 곡선에서 두 부분의 문턱전압에 의해 나타난 포화드레인 전류차이는 게이트 전압이 0, 0.1, 0.2 그리고, 0.3V 일 때, 각각 1.5, 2.7, 4.0 그리고 5.7㎃ 이었다. 시간경과 후의 드레인 전류를 분석하였는데, PLZT(10/30/70) 박막은 10년 후에 약 18%의 포화 전류가 감소하여 우수한 신뢰성을 보였다. 본 모델은 MFSFET 소자의 동작을 예측하는데 중요한 역할을 할 것으로 판단된다.

• Archives of Pharmacal Research
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• 제22권2호
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• pp.165-172
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• 1999

In the present work , the transport mechanism of a capsaicin derivative, DA-5018, through blood-brain barrier (BBB) has been investigated to evaluate the feasibility of potential drug development. The result of pharmacokinetic parameters obtained from the intravenous injection of plasma volume marker,$[3^H]RSA$ and $[{14}^C]DA-5018$, indicated that both AUC, area under the plasma concentration curve and VD, volume of distribution in brain of $[3^H]RSA$ agreed with those reported ($1620{\pm}10 $percentage injected dose minute per milliliter (%IDmin/ml) and $12.0{\pm}0.1{\mu}l/g$, respectively). Elimination half-life and AUC of $[{14}^C]DA-5018$is corrected by the PHLC analysis, 19.6$\pm$1.2 min and 7.69$\pm$0.85% IDmin/ml, respectively. The metabolic rate of $[{14}^C]DA-5018$was very rapid. The blood-brain barrier permeability surface area (PS) product of $[{14}^C]DA-5018$ was calculated to be 0.24$\pm$0.05 $\mu$l/min/g. The result of internal carotid artery perfusion and capillary depletion suggested that [14C]DA-5018 pass through BBB with the time increasingly. Investigation of transport mechanism of $[{14}^C]DA-5018$ using agonist and antagonist suggested that vanilloid (capsaicin) receptor did not exist in the BBB, and nutrient carrier system in the BBB has no effect on the transport of DA-5018. In conclusion, despite the fact that penetration of DA-5018 through BBB is significant, the intact drug found in the brain tissue is small because of a rapid metabolism. Therefore, for the central analgesic effect of DA-5018, the method to increase the metabolic stability in plasma and the brain permeability should be considered.

• 한국습지학회지
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• 제23권2호
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• pp.173-182
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• 2021

수자원의 보전과 관리를 위해서는 갈수시의 유량감쇄 특성을 파악하는 것이 중요한 과제 중에 하나이다. 감쇄특성을 하천 유량자료를 이용하여 표현하기 위해서 여러 복잡한 특성을 고려하여야 하므로, 편의성을 위하여 선형 감쇄분석이 주로 적용되어 왔다. 그러나, 최근의 연구에서 제시된 지하수 유출과 비피압대수층의 저장능력의 비선형성을 고려하면, 비선형 감쇄모형의 적용성이 더 높다고 할 수 있다. 따라서, 본 연구의 목적은 유출자료를 이용하여 지하수의 증발손실, 저류 및 재함양과 같은 비선형 특성을 고찰하는 데 있다. 한강의 상류인 평창강 유역의 유출자료를 이용하여 분석을 수행하였으며, 지하수 수지를 구성하는 주요한 요소인 지하수 유출, 증발손실, 저류, 재함양에 대해서 고찰하고 정량화하였다. 연구결과에 따라서, 식생에 의한 지하수 손실이 감쇄곡선을 편향시키는 것으로 나타났다. 또한, 계절적 강우와 잠재증발산 경향을 감쇄분석에 적용하여 월별 증발산 손실과 지하수 함양량을 정량화하여 제시하였다.

• BMB Reports
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• 제56권6호
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• pp.347-352
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• 2023

The protein family of poly (ADP-ribose) polymerases (PARPs) is comprised of multifunctional nuclear enzymes. Several PARP inhibitors have been developed as new anticancer drugs to combat resistance to chemotherapy. Herein, we characterized PARP4 mRNA expression profiles in cisplatin-sensitive and cisplatin-resistant ovarian cancer cell lines. PARP4 mRNA expression was significantly upregulated in cisplatin-resistant ovarian cancer cell lines, and this upregulation was associated with the hypomethylation of specific cytosine-phosphate-guanine (CpG) sites (cg18582260 and cg17117459) on its promoter. Reduced PARP4 expression was restored by treating cisplatin-sensitive cell lines with a demethylation agent, implicating the epigenetic regulation of PARP4 expression by promoter methylation. Depletion of PARP4 expression in cisplatin-resistant cell lines reduced cisplatin chemoresistance and promoted cisplatin-induced DNA fragmentation. The differential mRNA expression and DNA methylation status at specific PARP4 promoter CpG sites (cg18582260 and cg17117459) according to cisplatin responses, was further validated in primary ovarian tumor tissues. The results showed significantly increased PARP4 mRNA expressions and decreased DNA methylation levels at specific PARP4 promoter CpG sites (cg18582260 and cg17117459) in cisplatin-resistant patients. Additionally, the DNA methylation status at cg18582260 CpG sites in ovarian tumor tissues showed fairly clear discrimination between cisplatin-resistant patients and cisplatin-sensitive patients, with high accuracy (area under the curve = 0.86, P = 0.003845). Our findings suggest that the DNA methylation status of PARP4 at the specific promoter site (cg18582260) may be a useful diagnostic biomarker for predicting the response to cisplatin in ovarian cancer patients.