• 설비공학논문집
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• 제14권4호
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• pp.332-340
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• 2002

In these days, environmental concerns have been increased throughout the industry and community worldwide. To prevent the ozone depletion, ozone depletion potential of a refrigerant must be zero. Simultaneously, a refrigerant with low GWP (global warming potential) is very demanding to induce green house effect. Chlorine-free HFC-l34a is a refrigerant widely used for automotive air-conditioning system because its destruction potential is ecologically zero. Although HFC-l34a has no ozone depletion potential, its global warming potential is so high that it is not considered as a perfect alternative refrigerant that is acceptable for long-term use. In this paper, experimental measurement has been carried out to analyze the performance characteristics of automotive air-conditioning system using HFC-152a, which has low GWP and zero ODP. Also mixed refrigerant that is composed of HFC-152a and $CF_3$ was applied to investigate an alternative possibility for the automotive airconditioning system. As a result of this study, we could draw following conclusions; With respect to the variation of the rotational speed of compressor, outside air temperature and flow rate, the heat amount of evaporator and compressor and performance coefficient was varied.

• 한국세라믹학회지
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• 제45권5호
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• pp.280-284
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• 2008

In order to investigate residence time effect on the growth of ZrC film, the ZrC films grew with various system total pressure (P) and total flow rate (Q) by low pressure chemical vapor deposition because residence time is function of system total pressure and total flow rate. Thermodynamic calculations predict that the decomposition of source gases ($ZrCl_4$ and $CH_4$) would be low as increasing the residence time. Thermodynamic calculations results were proved by investigating deposition rate with various residence time. Deposition rate decreased with residence time of source gas increased. Besides, depletion effect accelerated diminution of deposition rate at high residence time. On the other hands, the deposition rated was increased as decreasing the residence time because fast moving of intermediate gas species decrease the depletion effect. The crystal structure was not changed with residence time. However, the largest size of faceted grain showed up to specific residence time and the size of grain was decreased whether residence time increase or not.

• BMB Reports
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• 제33권3호
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• pp.202-207
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• 2000

The depletion of intracellular calcium stores by thapsigargin treatment evoked extracellular calcium-dependent membrane currents in Xenopus laevis oocytes. These currents have been compared to those evoked by microinjection of a calcium influx factor (CIF) purified from Jurkat T lymphocytes. The membrane currents elicited by thapsigargin treatment (peak current, $163{\pm}60$ nA) or CIF injection (peak current, $897{\pm}188$ nA) were both dependent on calcium entry, based on their eradication by the removal of extracellular calcium. The currents were, in both cases, attributed primarily to well-characterized $Ca^{2+}-dependent$ $Cl^-$ currents, based on their similar reversal potentials (-24 mV vs. -28 mV) and their inhibition by niflumic acid (a $Cl^-$ channel blocker). Currents induced by either thapsigargin treatment or CIF injection exhibited an identical pattern of inhibitory sensitivity to a panel of lanthanides, suggesting that thapsigargin treatment or CIF injection evoked $Cl^-$ currents by stimulating calcium influx through pharmacologically identical calcium channels. These results indicate that CIF acts on the same calcium entry pathway activated by the depletion of calcium stores and most lanthanides are novel pharmacological tools for the study of calcium entry in Xenopus oocytes.

• 대한전자공학회논문지SD
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• 제46권12호
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• pp.10-17
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• 2009

Double-Gate MOSFET 구조를 사용한 Nano-Electro-Mechanical MOSFET (NEMFET)는 게이트 길이가 짧아지면서 나타나는 단채널 현상을 효과적으로 제어하는 새로운 구조의 차세대 소자이다. 특히 공핍형 Double-gate NEMFET (Dep-DGNEMFET)은 차단 상태에서 얇은 산화막을 가지므로 subthreshold 전류가 효과적으로 제어된다. 이러한 Dep-DGNEMFET 특성에 대한 해석적 수식을 유도하고 소자 구조가 변화하는 경우의 특성 변화를 분석하였다. 또한 ITRS (International Technology Roadmap for Semiconductors) 전류 기준값을 만족시키기 위하여 Dep-DGNEMFET 소자 구조를 최적화 하였다.

• International Journal of Air-Conditioning and Refrigeration
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• 제11권3호
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• pp.140-149
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• 2003

In these days, environmental concerns have been increased throughout the industry and community worldwide. To prevent the ozone depletion, ozone depletion potential of a refrigerant must be zero. Simultaneously, a refrigerant with low GWP (global warming potential) is very demanding to reduce green house effect. Chlorine-free HFC-l34a is a refrigerant widely used for automotive air-conditioning system because its destruction potential is ecologically zero. Although HFC-l34a has no ozone depletion potential, its global warming potential is so high that it is not considered as a perfect alternative refrigerant that is acceptable for long-term use. In this paper, experimental measurement has been carried out to analyze the performance characteristics of automotive air-conditioning system using HFC-152a, which has low GWP and zero ODP. Also mixed refrigerant that is composed of HFC-152a and $CF_3$ was applied to investigate an alternative possibility for the automotive air-conditioning system. As a result of this study, we could draw following conclusions; With respect to the variation of the rotational speed of compressor, outside air temperature and flow rate, the heat amount of evaporator and compressor and performance coefficient was varied.

• Mass Spectrometry Letters
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• 제9권2호
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• pp.51-55
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• 2018

Capture of non-glycoproteins during lectin affinity chromatography is frequently observed, although it would seem to be anomalous. In actuality, lectin affinity chromatography works at post-translational modification (PTM) sites on a glycoprotein which is not involved in protein-protein interactions (PPIs). In this study, serial affinity column set (SACS) using lectins followed by proteomics methods was used to identify PPI mechanisms of captured proteins in human plasma. MetaCore, STRING, Ingenuity Pathway Analysis (IPA), and IntAct were individually used to elucidate the interactions of the identified abundant proteins and to obtain the corresponding interaction maps. The abundant non-glycoproteins were captured with the binding to the selected glycoproteins. Therefore, depletion process in sample pretreatment for abundant protein removal should be considered with more caution because it may lose precious disease-related low abundant proteins through PPIs of the removed abundant proteins in human plasma during the depletion process in biomarker discovery. Glycoproteins bearing specific glycans are frequently associated with cancer and can be specifically isolated by lectin affinity chromatography. Therefore, SACS using Lycopersicon esculentum lectin (LEL) can also be used to study disease interactomes.

• 대한전자공학회논문지TE
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• 제37권2호
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• pp.6-11
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• 2000

본 논문에서는 단채널 n형 GaAs MESFET 소자의 공핍층의 두께가 선형적으로 변한다는 근사를 적용하여 공핍층내의 2차원 프와송 방정식을 풀어 단채널 GaAs MESFET의 전류-전압 특성을 해석적으로 도출하는 모델을 제안하였다. 이 모델로부터 문턱 전압, 소오스와 드레인의 저항 및 드레인 전류식을 도출하였다 계산 결과로부터 전류-전압 특성 곡선에서 단채널 소자의 특성인 Early 효과를 설명할 수 있었고 소오스 접촉 저항과 드레인 접촉 저항에 의한 전압 강하도 설명할 수 있었다. 더욱이 본 모델은 소자 해석에 있어서 단채널 소자에만 국한되지 않고 장채널 소자의 특성을 해석하는 데에도 적용할 수 있었다.

• 대한전자공학회논문지SD
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• 제48권10호
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• pp.62-66
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• 2011

본 연구에서는 측정된 S-파라미터를 사용하여 드레인-소스 전압 Vds에 무관한 게이트-소스 overlap 캐패시턴스를 추출하고, 이를 바탕으로 deep-submicron MOSFET의 Vds 종속 게이트-벌크 캐패시턴스 곡선을 추출하는 RF 방법이 새롭게 개발 되었다. 추출된 캐패시턴스 값들을 사용한 등가회로 모델과 측정된 데이터가 잘 일치하는 것을 관찰함으로써 추출방법의 정확도가 검증되었다. 추출된 데이터로부터 overlap과 depletion 길이의 Vds 종속 곡선이 얻어졌으며, 이를 통해 drain 영역의 채널 도핑 분포를 실험적으로 측정하였다.

• BMB Reports
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• 제49권10호
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• pp.578-583
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• 2016

Special AT-rich sequence binding protein 1 (SATB1) is a nuclear matrix-associated DNA-binding protein that functions as a chromatin organizer. SATB1 is highly expressed in aggressive breast cancer cells and promotes growth and metastasis by reprograming gene expression. Through genome-wide cross-examination of gene expression and histone methylation, we identified SATB1 target genes for which expression is associated with altered epigenetic marks. Among the identified genes, long noncoding RNA urothelial carcinoma-associated 1 (UCA1) was upregulated by SATB1 depletion. Upregulation of UCA1 coincided with increased H3K4 trimethylation (H3K4me3) levels and decreased H3K27 trimethylation (H3K27me3) levels. Our study showed that SATB1 binds to the upstream region of UCA1 in vivo, and that its promoter activity increases with SATB1 depletion. Furthermore, simultaneous depletion of SATB1 and UCA1 potentiated suppression of tumor growth and cell survival. Thus, SATB1 repressed the expression of oncogenic UCA1, suppressing growth and survival of breast cancer cells.

• Journal of Advanced Marine Engineering and Technology
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• 제28권5호
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• pp.728-734
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• 2004

Environmentally friendly refrigerants with zero ozone layer depletion potential are required to be used in refrigerators and air conditioners due to the difficulties related to ozone layer depletion and global warming. A rigorous study for the system performance with new refrigerants having zero ozone layer depletion potential is inevitable before adopting that as a new fluid. The HFC(Hydrofluorocarbon) potential has been recommended as alternatives. In this paper. system performance in the heat pump facilities were studied using R-290, R-600a. R-1270 as an environment friendly refrigerant. R-22 as a HCFC's refrigerant. The experimental apparatus has been set-up as a conventional vapor compression type heat Pump system. The test section is a horizontal double pipe heat exchanger. A tube diameter of 12.70mm with 1.315mm wall thickness is used for this investigation. The test results showed that the COP of hydrocarbon refrigerants were superior to that of R-22 and the maximum increasing rate of COP was found in R-1270. The refrigeration capacity of hydrocarbon refrigerants were higher than that of R-22. The compressor work was obtained with the maximum value in R-1270 and the minimum one in R-22.