• 한국자기공명학회논문지
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• 제23권1호
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• pp.6-11
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• 2019

Parahydrogen induced hyperpolarization (PHIP) technique is extensively studied to increase the sensitivity of the conventional NMR spectroscopy and recently try to apply this advanced technique into the revolutionary future of the MRI. The other hyperpolarization technique, which is widely utilized, is DNP (Dynamic Nuclear Polarization)-based hyperpolarization one. Despite its great advances in these fields, it contains several drawbacks to overcome: fast relaxation time, expensive equipment is needed, long build-up time is required (several hours), and batch scale material is hyperpolarized. To overcome all those limitations, one can effectively harness the hyperpolarized spin state of parahydrogen. One important step for utilizing the spin state of parahydrogen is doing well-developed experiments of ALTADENA and PASADENA. Based on those concepts, we successfully obtain the hydrogenation signals of ALTADENA and PASADENA from styrene by using benchtop NMR spectrometer. Also those signals were conceptually analyzed and confirmed with different mechanisms. To our best knowledge, those experiments using 1.4T (benchtop NMR) is the first reported one. Considering these experiments, we hope that parahydrogen-based hyperpolarization transfer studies in NMR/MRI will be broadened in Korea in the future.

• 한국군사과학기술학회지
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• 제19권1호
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• pp.84-94
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• 2016

The warfighting experimentation is the most important for the weapon acquisition process because the warfighting experimentation shall support the operation effectiveness as well as acquisition logicality. Therefore, ROK Navy is starting to set up the next generation warfighting experimentation systems. According to literature studies, there have been many studies regarding the interoperability of Simulators(Virtual) and Exercising models(Constructive), but not for studies regarding interoperability between Simulators(Virtual) and Analysis models(Constructive) that is the core component of next generation maritime warfighting experimentation systems. This study is dealing with the V-C(Analysis model) interoperability test and methodology of interoperation analysis. The purpose of the study is to provide the new analysis methodology through V-C(Analysis model) interoperation, which can be applied for the concept of operations(CONOPS) of next generation maritime warfighting experimentation systems. In addition to that, the study validates the suggested analysis methodology by the case study of a naval operation.

• 한국지하수토양환경학회지:지하수토양환경
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• 제16권3호
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• pp.28-37
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• 2011

A preliminary study for energy efficient soil heating and contaminant removal using microwave was conducted. Soils sampled from floodplain were heated with microwave oven, and soil heating property and energy efficiency were compared to those heated with electrical furnace. In addition the effects of water, soil organic matter, and contaminated diesel on soil heating with microwave were investigated. Even though the electrical power consumption of electrical furnace and microwave oven were similar, temperature of soil heated with microwave oven was significantly higher than that of soil heated with electrical furnace. The increase of soil moisture content delays the raise of soil temperature during heating it with microwave oven. However, the effects of total petroleum hydrocarbon (TPH) (<10%) in contaminated soil matrix and small amount of soil organic matter (<5%) on the increase of soil temperature by microwave were not significant. Further studies for contaminated soils with different texture using pilot scale microwave reactor are required for application of this technique in the field.

• Asian Pacific Journal of Cancer Prevention
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• 제15권1호
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• pp.239-244
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• 2014

Several recent studies have showed that the n-myc downstream regulated gene 2 (NDRG2) is a new tumor suppressor gene, and that it plays an important role in tumor suppression in several cancers or cancer cell lines. However, few studies focused on its function in neuroblastoma cells. In the present investigation, we demonstrated that NDRG2 overexpression inhibited their proliferation. Using a cDNA microarray, we found that overexpression of NDRG2 inhibited the expression of cysteine-rich protein 61 (CYR61), a proliferation related gene. From our research, CYR61 may partially hinder NDRG2-mediated inhibition of cell proliferation. Overexpression of NDRG2 resulted in accumulation of cells in the G1 phase, which was accompanied by upregulation of p21 and p27 and downregulation of CDK4 and cyclin D1. Taken together, these data indicate that NDRG2 inhibits the proliferation of neuroblastoma cells partially through suppression of CYR61. Our findings offer novel insights into the physiological roles of NDRG2 in neuroblastoma cell proliferation, and NDRG2 may prove to be effective candidate for the treatment of children with neuroblastoma.

• Asian Pacific Journal of Cancer Prevention
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• 제15권6호
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• pp.2647-2650
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• 2014

Background: Colorectal cancers(CRC) are the third most common cancer in the western world, with surgery preferred for management of non-metastatic disease and post surgical treatment usually arranged according to the TNM staging system. However, there is still prognostic variation between patients who have the same stage. It is increasingly recognized that variations within disease course and clinical outcome in colorectal cancer patients are influenced by not only oncological characteristics of the tumor itself but also host response factors. Recent studies have shown correlation between the inflammatory response and clinical outcomes in various cancers. The neutrophil/lymphocyte ratio (NLR) has been described as a marker for immune response to various stimuli including cancer. Material-Methods: Two hundred eighty-one CRC patients were included in our retrospective analysis, separated into two groups according to a cut-off value for the NLR. Patient data including age, gender, vertical penetration, anatomic location, and differentiation of the tumor, TNM stage, survival rate, and disease-free survival were analyzed for correlations with the NLR. Results: Using ROC curve analysis, we determined a cut-off value of 2.2 for NLR to be best to discriminate between patient survival in the whole group. In univariate analysis, high pretreatment NLR (p=0.001, 95%CI 1.483-4.846), pathologic nodal stage (p<0.001, 95%CI 1.082-3.289) and advanced pathologic TNM stage (p<0.001, 95%CI 1.462-4.213) were predictive of shorter survival. In multivariate analysis, advanced pathologic TNM stage (p=0.001, 95%CI 1.303-26.542) and high pretreatment NLR (p=0.005, 95%CI 1.713-6.378) remained independently associated with poor survival. Conclusions: High pre-treatment NLR is a significant independent predictor of shorter survival in patients with colorectal cancer. This parameter is a simple, easily accessible laboratory value for identifying patients with poorer prognosis.

• Asian Pacific Journal of Cancer Prevention
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• 제13권2호
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• pp.579-583
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• 2012

Background: The SULT1A1 Arg213His polymorphism is reported to be associated with lung cancer risk. However, this relationship remains controversial. For better understanding a meta-analysis was therefore performed. Methods: An extensive search was performed to identify all case-control studies investigating association between SULT1A1 Arg213His polymorphism and lung cancer risk. The strength was assessed by odds ratio (OR) with the corresponding 95% confidence interval (95%CI). Results: A total of five publications covering 1,669 cases and 1,890 controls were included in this meta-analysis. No significant association between SULT1A1 Arg213His polymorphism and lung cancer risk was observed in overall comparisons in all genetic models (dominant model: OR=1.33, 95%CI=1.00-1.76, P=0.05; additive model: OR=1.30, 95%CI=0.93-1.81, P=0.12; recessive model: OR=1.21, 95%CI=0.89-1.66, P=0.23). However, on subgroup analysis, an elevated risk in mixed populations with variant His allele was revealed in the dominant model (OR=1.66, 95% CI=1.06-2.62, P=0.03). Furthermore, the SULT1A1 Arg213His polymorphism was associated with an increased risk of lung cancer in both females and males in the dominant model (females: OR=1.72, 95%CI=1.29-2.27, P=0.00; males: OR=1.46, 95%CI=1.19-1.78, P=0.00). No significant association between this polymorphism and different smoking status (smokers and non-smokers) and the other ethnicities (Asians and Caucasians) was shown. Conclusions: The results of this meta-analysis indicate that the SULT1A1 Arg213His polymorphism is not associated with lung cancer risk in Asians and Caucasians, but possible elevation for genotype (GA/AA) in mixed populations and males and females needs further investigation.

• 한국군사과학기술학회지
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• 제22권6호
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• pp.832-840
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• 2019

Recently, pollution from gunpowder due to shell shootings at military drilling sites has raised various environmental concerns. The purpose of this study is to predict the contamination level of RDX in the soil area of the firing range zone near Anwol river watershed, the study site, and the intake area, Anwol river and Imjin river, as a function of time and space. In this study, a multimedia model was developed to predict the variation of RDX contamination by rainfall. The range of the medium was limited to soil, water, and sediment, and excluded the atmosphere, taking into account the physical and chemical properties of RDX with low vapor pressure and low Henry's constant. The pollutant levels of the waters of compartments, including the last section of the Imjin River affecting the water intake, was compared with the environmental standard for RDX.

• 근관절건강학회지
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• 제16권1호
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• pp.36-45
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• 2009

Purpose: This study was to determine the effects of laughter therapy on stress response and pain of military patients with low back pain. Method: The subjects in the experimental group received 3-sessions of laughter therapy on 3 consecutive days. The primary outcome measures were state anxiety, depression, blood pressure, pulse rate and pain. Result: After 3 sessions of laughter therapy, the scores of state anxiety(p=.046), depression(p=.028) and pulse rate(p=.003) were significantly lower and diastolic blood pressure(p=.038) was significantly higher in the experimental group than those in the control group. The level of pain(p=.711) was not different significantly between two groups. Conclusion: Laughter therapy could be an effective strategic intervention for military patients with low back pain to reduce the level of anxiety and depression. Further studies are needed to determine long-term effects of laughter therapy and its effects on cardiovascular system and pain.

• BMB Reports
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• 제46권7호
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• pp.364-369
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• 2013

Endothelin-1 (ET-1) plays an indispensable role in epidermal pigmentation in hyperpigmentary disorders due to a central role in melanogenesis. Nevertheless, precise mechanism involved in ET-1-induced hyperpigmentation is still undefined. Glycoprotein (transmembrane) non-metastatic melanoma protein b (GPNMB) is a key element in melanosome formation. Therefore, we speculated that GPNMB was correlated with ET-1-induced pigmentation. After culturing with ET-1, melanin synthesis was significantly up-regulated, accompanying with increased expression of GPNMB and microphthalmia-associated transcription factor (MITF). Total number of melanosomes and melanin synthesis were sharply reduced via GPNMB-siRNA transfection, indicating ET-1-induced pigmentation by GPNMB-dependent manner. Furthermore, MITF-siRNA transfection strikingly inhibited GPNMB expression and the melanogenesis, and this suppression failed to be alleviated by ET-1 stimulation. All of these results demonstrated that ET-1 can trigger melanogenesis via the MITF-regulated GPNMB pathway. Taken together, these findings will provide a new explanation of how ET-1 induces hyperpigmentation, and possibly supply a new strategy for cosmetic studies.

• 한국전자통신학회논문지
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• 제8권11호
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• pp.1755-1762
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• 2013

본 연구는 군사시설보호법(1972년 제정)으로 인하여 제기된 민원을 분석하였다. 첫째 연구결과 민원을 해결할 수 있는 통합적인 시스템 등 개선책마련이 필요하다. 둘째 군이 지역사회에 기여하거나 함께 한다는 분위기 조성으로 상생하는 계기를 마련하여야 한다. 마지막으로 관련법이나 제도, 규정, 교리 등 다방면에서 전향적인 사고가 미흡하거나 부족한 면을 보완하여야 할 것으로 본다. 연구 자료는 국방부 관련부서에 업무에 참고가 되도록 제공하고자 한다.