• 대한간호학회지
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• 제46권5호
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• pp.663-674
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• 2016

Purpose: The purposes of this study were to develop and test a prediction model for caregiving experiences including caregiving satisfaction and burden in dementia family caregivers. Methods: The stress process model and a two factor model were used as the conceptual frameworks. Secondary data analysis was done with 320 family caregivers who were selected from the Seoul Dementia Management Survey (2014) data set. In the hypothesis model, the exogenous variable was patient symptomatology which included cognitive impairment, behavioral problems, dependency in activity of daily living and in instrumental activity of daily living. Endogenous variables were caregiver's perception of dementia patient's unmet needs, caregiving satisfaction and caregiving burden. Data were analysed using SPSS/WINdows and AMOS program. Results: Caregiving burden was explained by patient symptomatology and caregiving satisfaction indicating significant direct effects and significant indirect effect from unmet needs. The proposed model explained 37.8% of the variance. Caregiving satisfaction was explained by patient symptomatology and unmet needs. Mediating effect of unmet needs was significant in the relationship between patient symptomatology and caregiving satisfaction. Conclusion: Results indicate that interventions focusing on relieving caregiving burden and enhancing caregiver satisfaction should be provided to caregivers with high levels of dementia patients' unmet needs and low level of caregiving satisfaction.

• 기본간호학회지
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• 제18권3호
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• pp.317-327
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• 2011

Purpose: The purpose of this study was to contribute data toward prevention from advancing dementia and also prevention of deterioration in cognitive impairment by constructing an optimal prediction model and verifying factors influencing cognitive impairment in elders with dementia who reside at home. Methods: The participants in this study were 351 elders who were registered at dementia day care centers in 11 regions of Metropolitan Incheon. Collected data were analyzed using SPSS Statistics 17.0 and SAS 9.1. Bootstrap method using the Clementine program 12.0 was applied to build an optimum prediction model. Results: Gender and education (general characteristics), alcohol, urinary/fecal incontinence, exercise, weight, and ADL (state of health), and depression (psychological state) were found to have an affect on cognitive impairment in these elders. Conclusion: Study results indicate nine key factors that affect cognitive impairment of elders with dementia who reside at home and that could be useful in prevention and management nursing plans. These factors could also be used to expand the role of nurses who are working in community day care centers, and can be applied in the development and provision of various programs to aid retention and improve cognitive function as well as preventing deterioration of cognition.

• 경영정보학연구
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• 제26권2호
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• pp.137-153
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• 2024

본 연구는 웨어러블 기기에서 수집된 라이프로그 데이터를 활용하여 고령화 사회에서 증가하고 있는 치매를 조기에 진단하여 관리할 수 있는 예측 모델을 개발하고, 이를 기반으로 한 상업적 활용전략을 제안하는 것을 목표로 하였다. 이 연구는 전문의의 병리진단을 기반으로 한 60~80대 174명의 대상자로부터 수집된 12,184개의 라이프로그 정보(수면 및 활동 정보)와 치매 진단 데이터를 활용하였다. 연구 과정에서 수면과 활동 데이터를 포함하는 다차원적인 데이터셋을 표준화 하였고 다양한 머신러닝 알고리즘으로 분석하였으며, 가장 높은 ROC-AUC점수를 보여준 랜덤 포레스트 모델이 가장 우수한 성능을 보였다. 또한 ablation test를 통해 수면과 관련된 변수들과 활동과 관련 변수들의 제외가 모델 예측력에 미치는 영향을 평가하였고, 이러한 변수들이 모델의 예측력에 유의미한 영향력을 가지고 있음을 확인하였다. 마지막으로, 개발된 모델의 상업적 활용 전략의 가능성을 탐구함으로써, 치매예방 시스템의 상업적 확산을 위한 새로운 방향을 제안하였다.

• ETRI Journal
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• 제46권1호
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• pp.96-105
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• 2024

We propose a method to automatically predict Alzheimer's disease from speech data using the ChatGPT large language model. Alzheimer's disease patients often exhibit distinctive characteristics when describing images, such as difficulties in recalling words, grammar errors, repetitive language, and incoherent narratives. For prediction, we initially employ a speech recognition system to transcribe participants' speech into text. We then gather opinions by inputting the transcribed text into ChatGPT as well as a prompt designed to solicit fluency evaluations. Subsequently, we extract embeddings from the speech, text, and opinions by the pretrained models. Finally, we use a classifier consisting of transformer blocks and linear layers to identify participants with this type of dementia. Experiments are conducted using the extensively used ADReSSo dataset. The results yield a maximum accuracy of 87.3% when speech, text, and opinions are used in conjunction. This finding suggests the potential of leveraging evaluation feedback from language models to address challenges in Alzheimer's disease recognition.

• 융합정보논문지
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• 제9권8호
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• pp.248-253
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• 2019

노인성 치매의 전 임상단계인 경도인지장애(MCI)를 조기 진단하고, 조기 개입한다면, 치매의 발병률을 줄일 수 있다. 본 연구는 우리나라 지역사회 노인의 MCI 예측 모형을 개발하고 노년기 인지장애의 예방을 위한 기초자료를 제공하였다. 연구대상은 2012년 Korean Longitudinal Survey of Aging(KLoSA)에 참여한 65세 이상 지역사회 노인 3,240명(남성 1,502명, 여성 1,738명)이다. 결과변수는 MCI유병으로 정의하였고, 설명변수는 성, 연령, 혼인상태, 교육수준, 소득수준, 흡연, 음주, 주1회 이상의 정기적인 운동, 월평균 사회활동 참여시간, 주관적 건강, 고혈압, 당뇨병을 포함하였다. 예측모형의 개발은 Restricted Boltzmann Machine(RBM) 인공신경망을 이용하였다. RMB 인공신경망을 이용하여 우리나라 지역사회 노인의 MCI 예측 모형을 구축한 결과, 유의미한 요인은 연령, 성별, 최종학력, 주관적 건강, 혼인상태, 소득수준, 흡연, 규칙적 운동이었다. 이 결과를 기초로 MCI 고위험군의 특성을 고려한 맞춤형 치매 예방 프로그램의 개발이 요구된다.

• 한국정보통신학회논문지
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• 제25권12호
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• pp.1729-1738
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• 2021

머신러닝은 인지심리, 뇌과학과 긴밀한 관계를 유지하며 함께 발전하고 있다. 본 논문은 OASIS-3 dataset을 머신러닝 기법을 이용하여 분석하고, 이를 통해 치매를 예측하는 모델을 제안한다. OASIS-3 데이터 중 각 영역의 부피를 수치화한 데이터들에 대해 PCA(Principal component analysis) 를 통한 차원 축소를 실행한 뒤, 중요한 요소(특징)들만 추출 후 이에 대해 그래디언트 부스팅, 스태킹을 포함한 다양한 머신러닝 모델들을 적용, 각각의 성능을 비교한다. 제안하는 기법은 기존 연구들과 달리 뇌 생체 데이터들은 물론 참가자의 성별 등의 기본 정보 데이터, 참여자의 의료 정보 데이터를 사용했기에 차별성이 크다. 또한, 다양한 성능평가를 통해 제안하는 기법이 다양한 수치 데이터 중 치매와 더 많은 관련성을 보이는 특징들을 찾아내어 치매를 더 잘 예측할 수 있는 모델임을 보였다.

• 생물정신의학
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• 제27권2호
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• pp.94-100
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• 2020

Objectives Amyloid β positron emission tomography (Aβ PET) is widely used as a diagnostic tool in patients who have symptoms of cognitive impairment, however, this diagnostic examination is too expensive. Thus, predicting the positivity of Aβ PET before patients undergo the examination is essential. We aimed to analyze clinical predictors of patients who underwent Aβ PET retrospectively, and to develop a predicting model of Aβ PET positivity. Methods 468 patients who underwent Aβ PET with cognitive impairment were recruited and their clinical indicators were analyzed retrospectively. We specified the primary outcome as Aβ PET positivity, and included variables such as age, sex, body mass index, diastolic blood pressure, systolic blood pressure, education, dementia family history, Mini Mental Status Examination (MMSE), Clinical Dementia Rating (CDR), Clinical Dementia Rating-Sum of Box (CDR-SB), hypertension (HTN), diabetes mellitus (DM) and presence of apolipoprotein E (ApoE) E4 as potential predictors. We developed three final models of amyloid positivity prediction for total subjects, mild cognitive impairment (MCI) and Alzheimer's disease (AD) dementia using a multivariate stepwise logistic regression analysis. Receiver operating characteristic (ROC) curve analysis was performed and the area under curve (AUC) value was calculated for the ROC curve. Results Aβ PET negative patients were 49.6% (n = 232), and Aβ PET positive patients were 50.4% (n = 236). In the final model of all subjects, older age, female sex, presence of ApoE E4 and lower MMSE are associated with Aβ PET positivity. The AUC value was 0.296. In the final model of MCI subjects (n = 244), older age and presence of ApoE E4 are associated with Aβ PET positivity. The AUC value was 0.725. In the final model of AD subjects (n = 173), lower MMSE scores, the presence of ApoE E4 and history of HTN are associated with Aβ PET positivity. The AUC value was 0.681. Conclusions The cerebral amyloid positivity model, which was based on commonly available clinical indicators, can be useful for prediction of amyloid PET positivity in MCI or AD patients.

• 한국컴퓨터정보학회논문지
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• 제28권11호
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• pp.53-63
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• 2023

본 연구는 고령층의 치매 예방을 위한 선별검사 수단으로 자동화된 기계학습(AutoML)을 활용하여 인지기능 장애 예측모형을 개발하였다. 연구 데이터는 한국지능정보사회진흥원의 '치매 고위험군 웨어러블 라이프로그 데이터'를 활용하였다. 분석은 구글 코랩 환경에서 PyCaret 3.0.0이 사용하여 우수한 분류성능을 보여주는 5개의 모형을 선정하고 앙상블 학습을 진행하여 모형을 통합한 뒤, 최종 성능평가를 진행하였다. 연구결과, Voting Classifier, Gradient Boosting Classifier, Extreme Gradient Boosting, Light Gradient Boosting Machine, Extra Trees Classifier, Random Forest Classifier 모형 순으로 높은 예측성능을 보이는 것으로 나타났다. 특히 '수면 중 분당 평균 호흡수'와 '수면 중 분당 평균 심박수'가 가장 중요한 특성변수(feature)로 확인되었다. 본 연구의 결과는 고령층의 인지기능 장애를 보다 효과적으로 관리하고 예방하기 위한 수단으로 기계학습과 라이프로그의 활용 가능성에 대한 고려를 시사한다.

• 한국멀티미디어학회논문지
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• 제20권2호
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• pp.205-215
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• 2017

The brain magnetic resonance images (MRI) is an important imaging biomarker in Alzheimer's disease (AD) as the cerebral atrophy has been shown to strongly associate with cognitive symptoms. The decrease of volume estimates in different structures of the medial temporal lobe related to memory correlates with the decline of cognitive functions in neurodegenerative diseases. During the past decades several methods have been developed for quantifying the disease related atrophy of hippocampus from MRI. Special effort has been dedicated to separate AD and mild cognitive impairment (MCI) related modifications from normal aging for the purpose of early detection and prediction. We trained a multi-class support vector machine (SVM) with probabilistic outputs on a sample (n = 58) of 20 normal controls (NC), 19 individuals with MCI, and 19 individuals with AD. The model was then applied to the cross-validation of same data set which no labels were known and the predictions. This study presents data on the association between MRI quantitative parameters of hippocampus and its quantitative structural changes examination use on the classification of the diseases.

• 대한간호학회지
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• 제50권2호
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• pp.191-199
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• 2020

Purpose: The purpose of this study was to compare sociodemographic characteristics of a normal cognitive group and mild cognitive impairment group, and establish prediction models of Mild Cognitive Impairment (MCI). Methods: This study was a secondary data analysis research using data from "the 4th Korea Longitudinal Study of Ageing" of the Korea Employment Information Service. A total of 6,405 individuals, including 1,329 individuals with MCI and 5,076 individuals with normal cognitive abilities, were part of the study. Based on the panel survey items, the research used 28 variables. The methods of analysis included a χ²-test, logistic regression analysis, decision tree analysis, predicted error rate, and an ROC curve calculated using SPSS 23.0 and SAS 13.2. Results: In the MCI group, the mean age was 71.4 and 65.8% of the participants was women. There were statistically significant differences in gender, age, and education in both groups. Predictors of MCI determined by using a logistic regression analysis were gender, age, education, instrumental activity of daily living (IADL), perceived health status, participation group, cultural activities, and life satisfaction. Decision tree analysis of predictors of MCI identified education, age, life satisfaction, and IADL as predictors. Conclusion: The accuracy of logistic regression model for MCI is slightly higher than that of decision tree model. The implementation of the prediction model for MCI established in this study may be utilized to identify middle-aged and elderly people with risks of MCI. Therefore, this study may contribute to the prevention and reduction of dementia.