• Korean Journal of Biological Psychiatry
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• v.23 no.2
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• pp.63-68
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• 2016

Objectives Haenyeo are Korean professional women breath-hold divers in Jeju island. The aim of this study was to investigate the clinical characteristics of depressed Haenyeo group, compared to non-Haenyeo depressed group. Methods This study included 75 Haenyeo and 340 non-Haenyeo with depressive disorders recruited from the Dementia Early Detection Program in Jeju island. Structural diagnostic interviews were performed using the Korean version of Mini International Neuropsychiatric Interview. All patients completed the questionnaires, including the Subjective Memory Complaints Questionnaire (SMCQ), the Patient Health Questionnaire-15 (PHQ-15), and the Blessed dementia scale. Depression was evaluated by the Korean version of short form the Geriatric Depression Scale (K-SGDS) and cognition was assessed by the Korean version of the Consortium to Establish a Registry for Alzheimer's Disease (CERAD) assessment packet. Results Although the mean scores of the K-SGDS were similar between Haenyeo and non-Haenyeo depressed groups, the Haenyeo group showed a higher mean score on the PSQ-15 (p < 0.001, ANCOVA adjusting for age, the K-SGDS and education). The Haenyeo group showed poorer performance on the Korean Version of Frontal Assessment Batter (p < 0.001), the Mini-Mental State Examination in the Korean version of the CERAD Assessment Packet (p < 0.018), the word fluency test (p < 0.001), and the word list memory test (p = 0.012) in ANCOVA adjusting for age and education. The mean SMCQ score was higher in the Haenyeo depressed group than in the non-Haenyeo depressed group. Conclusions The Haenyeo depressed group shows cognitive dysfunction, especially frontal lobe dysfunction, compared to the non-Haenyeo depressed group, indicating the Haenyeo depressed group may have more severe frontolimbic dysfunction due to chronic exposure to hypoxia. The Haenyeo depressed group suffers more somatic symptoms than the non-Haenyeo depressed group.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.16 no.8
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• pp.5096-5110
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• 2015

The purpose of this study was to identify the effects of brain wave change through therapeutic recreation programs on depression, sleep disturbance and quality of life among elderly with dementia. The subjects of this quasi-experimental study consisted of two groups, one experimental group (N=14) and one control group (N=18), after excluding 8 participants from a total of 40 participants. The subjects of experimental group were randomly selected from the elderly (order than 65 years old) of senior care center in Daejoen and participated in 3-month therapeutic recreation program. On the other hand, the subjects of control group did not participated in any therapeutic recreation program. Each group's pre-post brain wave change, depression, sleep disturbance and quality of life were estimated. Through ANCOVA and Analysis of Structural Equation Modeling with SPSS window 17.0 and AMOS 7.0, this study found followings. Frist, the therapeutic recreation program group indicated significant improvement of brain waves, sleep disturbance and quality of Life. In addition, depression was significantly reduced in the therapeutic recreation program group. Second, significant causal relationships was found among brain waves, depression, sleep disturbance, and Quality of Life.

• Journal of agriculture & life science
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• v.45 no.6
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• pp.213-226
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• 2011

This study was performed to investigate the effect of essential oils and ethanolic extracts of approximately 650 plant species on acetylcholine esterase (AChE) enzyme activity using Ellman's colorimetric method in 96-well microplates. The results showed that the ethanolic extracts from twig of Sophora subprostrata, twig of Phellodendron amurense, seed of Corylopsis coreana, and essential oil (EO) from Citrus paradisi, Cupressus sempervirens, Ocimum basilicum, Pinus sylvestris and Rosmarinus officinalis inhibited more than 80% of AChE activity. Among these, EO from Pinus sylvestris, C. sempervirens and C paradisi exhibited higher values of AChE inhibitory activity, which were 75, 84 and 99% at a concentration of 50 ug/ml, respectively. Finally, EO from C paradisi (grapefruit, GEO) showed the highest inhibitory activity towards AChE, which showed 91% of inhibition at a concentration of 20 ug/ml. We also examined the anti-dementia effects of GEO in mouse by passive avoidance test and Morris water maze test. The model mouse (male, ICR) of dementia (negative control) was induced by administration of scopolamine (1 mg/kg body weight). The latency time of sample group administrated with GEO (100 mg/kg, p.o.) increased significantly as compared with negative control on passive avoidance test. There were significant recovery from the scopolamine-induced deficits on learning and memory in water maze test through daily administrations with GEO (100 mg/kg, p.o.). From these results, we conclude that GEO treatment might enhance the cognitive function, suggesting that the EO of C. paradis may be a potential candidate for improvement of perceptive ability and dementia.

• The Journal of Korean society of community based occupational therapy
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• v.2 no.1
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• pp.75-84
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• 2012

Objective : This study aims to identify the effect of an occupational therapeutic intervention program including horticultural therapy on cognition and daily living performance of the elderly with dementia. Methods : For the purpose, the study measured the changes before and after the therapy, targeting sixteen women with dementia who were living in nursery facilities. We used MMSE-K to analyse the cognition, and evaluated daily living performance using K-MBI(p<.05). Results : The results of the study were presented as follows: 1. To identify changes of MMSE-K before and after the therapy between the control and test groups. As a result, it was discovered that MMSE-K of the control group was $16.25{\pm}1.38$ before the therapy and $16.00{\pm}.92$ after the therapy, which indicated no significant differences, but MMSE-K of the test group was $16.00{\pm}1.51$ before the therapy and $17.87{\pm}1.35$ after the therapy, which was statistically significant (p<.05). 2. To identify changes in daily living performance(K-MBI) between the two groups before and after the therapy, and it was discovered that scores of the control group were $74.00{\pm}1.30$ before the therapy and $74.25{\pm}1.16$ after the therapy, which showed no significant difference, but those of the test group were $73.75{\pm}1.28$ before the therapy and $76.37{\pm}1.30$ after the therapy, which was statistically significant(p<.05). Conclusion : Based on the results above, it was demonstrated that the an occupational therapeutic intervention program including horticultural therapy had a positive effect on cognition and daily living performance of elderly women with dementia and it is suggested that the results can be used as basic data for clinical intervention of the elderly with dementia.

• Proceeding of Spring/Autumn Annual Conference of KHA
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• 2011.04a
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• pp.215-219
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• 2011

Along with the rapid increase of the elderly population, our country is facing the elderly problem as a social issue due to nuclear family, the increase of female social activities and recognition changes about the elderly support. In this connection, the welfare services to protect the overall elderly is requested urgently and the countries which have been experiencing aging earlier than our country are studying a lot a community daycare method which delays moving of the elderly into facilities as long as possible, reduces costs and efficiently provides services in order to curtail the big burden to the national economy. As one of these solutions, there is the elderly daycare center and this can be considered to be a compromising service type to correspond to our social changes, make individual and social supports without damage to the sense of value about support. Therefore, the space for the elderly can keep up with the falloff of mental and physical functions, dementia and geriatric diseases according to aging and careful consideration about the space considering stability and convenience is required. At this point, this study has the purpose to plan a daycare center which reflects the characteristics of the elderly to protect them within the community safely and comfortably. As for the research method, case study was conducted to understand the overall situation on the space plan of the daycare center for 5 daycare centers located in Seoul and found out problems. In addition, interview research was conducted for the heads of daycare centers or social workers, care workers and photographing and drawing collection were performed simultaneously. From the generalization of the above study, a space plan for a daycare center considering the characteristics of the elderly was provided.

• Biomolecules & Therapeutics
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• v.23 no.6
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• pp.571-581
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• 2015

${\beta}$-asarone (BAS) is an active component of Acori graminei rhizoma, a traditional medicine used clinically in treating dementia and chronic stress in Korea. However, the cognitive effects of BAS and its mechanism of action have remained elusive. The purpose of this study was to examine whether BAS improved spatial cognitive impairment induced in rats following chronic corticosterone (CORT) administration. CORT administration (40 mg/kg, i.p., 21 days) resulted in cognitive impairment in the avoidance conditioning test (AAT) and the Morris water maze (MWM) test that was reversed by BAS (200 mg/kg, i.p). Additionally, as assessed by immunohistochemistry and RT-PCR analysis, the administration of BAS significantly alleviated memory-associated decreases in the expression levels of brain-derived neurotrophic factor (BDNF) and cAMP-response element-binding protein (CREB) proteins and mRNAs in the hippocampus. Also, BAS administration significantly restored the expression of Bax and Bcl-2 mRNAs in the hippocampus. Thus, BAS may be an effective therapeutic for learning and memory disturbances, and its neuroprotective effect was mediated, in part, by normalizing the CORT response, resulting in regulation of BDNF and CREB functions and anti-apoptosis in rats.

• Advances in Traditional Medicine
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• v.8 no.4
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• pp.365-373
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• 2008

Murraya koenigii leaves commonly known as 'curry patta' are routinely added to Indian gravy and vegetarian dishes by south Indian as a favourate condiment. The present study was undertaken to investigate the effects of Murraya koenigii leaves (MKL) on memory in rats. Elevated plus-maze and Hebb-Williams maze served as the exteroceptive behavioral models for testing memory. Diazepam-, scopolamine- and ageing-induced amnesia served as the interoceptive behavioral models. MKL fed orally to various groups of young and aged rats with diet containing 2, 4 and 8% w/w of MKL for 30 days consecutively were investigated. The MKL diets produced a significant dose-dependent improvement in memory scores of young and aged rats and significantly reduced the amnesia induced by scopolamine (0.4 mg/kg, i.p.) and diazepam (1 mg/kg, i.p.). Therefore, it would be worthwhile to specifically investigate the therapeutic potential of MKL in the management of dementia patients.

• Advances in Traditional Medicine
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• v.4 no.4
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• pp.235-242
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• 2004

The alcoholic extract of dried roots of Rubia cordifolia dose dependently reduced blood sugar level in alloxan treated rats. The extract also reduced ulcer index, plasma corticosterone in cold restrain stressed rats in dose related manner. The mice treated with alcoholic extract of Rubia cordifolia spent more time in the open arm of the elevated plus maze indicating anxiolytic activity. The extract also antagonized the amnesic effect of scopolamine in mice as indicated by reduced transfer latency in the elevated plus maze. Thus the plant bears potential for use in diabetes, stress, anxiety, and dementia.

• Food Science and Industry
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• v.54 no.4
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• pp.278-292
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• 2021

Fermented milk including yogurt, which has a long tradition of thousands of years, was first established in Korea in 1919, and the current market size has grown to over 90 billion dollars. Fermented milk, which began in the early days of liquid yogurt, appeared on the market as spoonable and drinking yogurt. Fermented milk began with research on intestinal health functions and lactobacilli, and gradually developed into various disease prevention studies such as gastrointestinal health, immunity improvement, skin beauty, and prevention of dementia. As a simple meal, it has a nutrient function element, which serves as a meal replacement, and is expanding its range from general foods to special-purpose foods and dietary supplements. Fierce market competition is taking place, and as a result, the domestic fermented milk market is developing through the development of various products for differentiation.

• Journal of Pharmacopuncture
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• v.25 no.4
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• pp.364-368
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• 2022

Objectives: Verbenalin is a compound found in herbs such as Cornus officinalis and Verbena officinalis. This study investigated whether verbenalin is safe by analyzing its mutagenicity. Methods: To examine the mutagenic potential of verbenalin, a bacterial reverse mutation test (Ames test) was conducted with Salmonella typhimurium and Escherichia coli strains. Experiments with and without metabolic activity were performed. Results: The mean colony number was less than double that of the control. Growth inhibition and precipitation of verbenalin were not apparent in all strains at different concentrations regardless of metabolic activity. Conclusion: Verbenalin did not show any signs of mutagenicity in this study. Additional toxicity studies including repeated oral toxicity, reproductive toxicity, and carcinogenicity tests are needed.