• 대한물리의학회지
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• 제11권2호
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• pp.115-121
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• 2016

PURPOSE: Many studies have reported the improvement of cognition through physical activity among subject with dementia. This study aimed to whether the current studies supports that physical activity intervention is efficacious on cognitive performance in subject with dementia. METHODS: Two independent reviewers searched National assembly library, RISS, KISS (2005-2015) using the concepts of dementia, exercise, and physical activity. We included randomized controlled trials that examined the efficacy of physical activity in subject with dementia. A meta-analysis was performed to estimate the effect sizes cognition with CMA (Comprehensive Meta-Analysis, version 2.2.064) soft-ware program. Nine randomized controlled trials were included, providing data from 133 individuals and excluding those failing to criteria of this study. RESULTS: The meta-analysis showed that physical activity intervention had a rather small effect sizes of 0.36 (95% confidence interval 0.14-0.59) on cognition performance in subject with dementia. Outcome measurement were MMSE-K (Mini-mental state examination Korean version) and LOCTA (Loewenstein Occupational Therapy Cognitive Assessment). We found heterogeneous among studies and there was difference between the studies (Q = 19.63, d(f)=12, $I^2= 38.88$). CONCLUSION: The present analysis suggests that physical activity interventions have the low effect sizes on cognition performance in subject with dementia Further studies will be required to develop the various programs for improving the cognitive performance in subject with dementia.

• 대한한의학회지
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• 제38권3호
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• pp.111-123
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• 2017

Objectives: To develop and investigate the reliability of the pathologic aging scale based on korean medical theory and korean medical pattern identification for dementia. Methods: We searched the textbook of korean neurophychiatry and Donguibogam and selected items through professional consensus. We compared between dementia(n=40) and normal elderly(n=38) and tested the reliability of two scales. Results: After professional consensus, we drafted the Korean Medical Pathologic Aging Scale(12 items, Likert 3 scale) and Korean Medical Pattern Identification for Dementia(4 patterns, 28 items, Likert 5 scale). On Korean Medical Pathologic Aging Scale, There is no significant difference between two groups. We had good internal consistency(Cronbach's alpha = 0.6) and test-retest reliability(r=0.631) but low inter-rater reliability(r=0.430). On Korean Medical Pattern Identification for Dementia, dementia patients diagnosed with Qi deficiency are significantly more than those in normal group. We had fairly good internal consistency(Cronbach's alpha = 0.574) and excellent test-retest(kappa= .800) and inter-rater reliability(kappa = .733). Conclusions: Korean Medical Pattern Identification for Dementia is appropriate for diagnosing korean medical pattern. But Korean Medical Pathologic Aging Scale isn't appropriate to discriminate dementia from normal elderly because of many subjective items. Therefore objective measurement of sensory dysfunction would be needed to measure pathologic aging based on korean medical theory.

• 인간식물환경학회지
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• 제21권6호
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• pp.515-521
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• 2018

The purpose of this study was to investigate the effects of horticultural activities with reminiscence materials and singing songs on the ability to recall words and depression in the elderly with mild dementia. A total of 20 sessions of a horticultural therapy program was held once or twice a week from July 14, 2015 to November 3, 2015 for the elderly with mind dementia at the social welfare center in D city. The subjects of this study were 13 women and the mean age was 81.2 years. The ability to recall words significantly improved from $8.6{\pm}1.8$ before the program to $9.4{\pm}0.6$ after the program (p=.012). However, there was no significant difference in the score of depression after the program. Synergistic effects were generated by applying horticultural activities, singing and reminiscence therapy activities simultaneously, and it was effective in recalling memories. As emotional functions were associated with hormones in vivo, there were emotional ups and downs at each session and short-term alternative therapies were not sufficient to completely eliminate neurotoxic substances caused by dementia.

• 대한예방의학회:학술대회논문집
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• 대한예방의학회 1996년도 제48차 추계 학술대회 연제집
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• pp.251-252
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• 1996

• 한국산학기술학회논문지
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• 제13권12호
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• pp.5816-5825
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• 2012

인구가 고령화되면서 치매환자는 매년 급증하고 있고 이로 인한 치매환자의 치료 및 관리비용 등 사회적 비용은 크게 늘고 있어 이에 대한 대책이 절실하다. 외국에서도 국가차원에서 치매에 관한 국가전략을 수립하거나 효율적인 치매관리를 위한 국가차원의 대책을 세우거나 관련 법제도를 마련하고 있다. 치매에 대한 법제도적 대응방안으로 노인복지법, 노인장기요양보험법, 치매관리법이 존재한다. 보다 효과적인 치매관리 대책을 위해 관련법과 정책의 추진에 있어서 다음과 같은 개선이 필요하다. 첫째, 치매 검진을 65세 이상노인에 대한 국민건강보험의 건강검진 항목에 반드시 포함시키고 1차 검진에서 이상이 발견되면 진료를 계속 받을 수 있도록 하는 것이 필요하다. 둘째, 치매의 특성상 치매는 증상이 심해질수록 치료 효과가 적고 가족들의 부담도 급격히 증가한다. 치매예방사업과 조기 검진을 통해 치매 발병을 예방하거나 발병 시기를 늦추고 조기 발견하여 치료를 받도록 하여 사회적 비용을 최소화하는 것이 필요하다. 셋째, 현재와 같은 노인장기요양보험법상의 장기요양급여내용의 획일성으로는 경증 치매 등 요양노인의 욕구를 다양하게 충족시키기 어려우므로 등급판정기준 완화와 서비스 이용대상의 확대가 필요하다.

• 한국HCI학회논문지
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• 제13권4호
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• pp.5-14
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• 2018

가상현실 치매체험 프로그램(EDuVR, Empathy for Dementia using Virtual Reality)은 환자가족, 조호자, 일반인들에게 치매환자에 대한 이해와 공감을 유도하기 위해 제주특별자치도 광역치매센터에서 개발한 360도 가상현실 콘텐츠이다. 치매에 대한 인식개선도구 개발의 필요성에 따라, 치매환자가 겪는 기억력, 지남력, 언어능력, 판단력과 같은 인지기능 저하와 이로 인한 일상생활의 어려움을 환자 일인칭 시점으로 체험하도록 하였다. 본 보고의 전반부에서는 EDuVR에 대하여 소개하였고 후반부에서는 EDuVR 체험이 인식개선에 미치는 효과를 기술하였다. 총 66명의 피험자를 EDuVR 집단(34명)과 교육집단(32명)에 할당한 후, 치매태도검사, 치매인식검사를 사전과 사후에 각각 측정하였다. EDuVR 집단은 추가적으로 VR 경험에 따른 멀미감과 현실감 수준을 측정하였다. 그 결과, 치매환자에 대한 태도 및 인식은 EDuVR의 체험에 따라 긍정적으로 변화하였으며, 이러한 변화는 치매교육의 효과와 다르지 않았다. EDuVR의 체험 후 유의한 수준으로 멀미를 느낀 사람은 1명에 불과하였다. 본 결과는 EDuVR은 짧은 체험시간만으로도 교육과 유사한 수준의 인식개선 및 태도변화를 일으키며, 멀미감이 크게 유발되지 않아 일반대중이 체험하기에 용이한 콘텐츠임을 시사한다. 즉, EDuVR은 치매에 대한 이해와 공감수준을 높이는 유용한 인식개선 도구이다.

• 한국환경성돌연변이발암원학회지
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• 제25권1호
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• pp.19-24
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• 2005

The Swedish double mutation (KM670/671NL) of amyloid precursor protein (Swe-APP) is associated with early-onset familial Alzheimer's disease (FAD) and increases amyloid beta peptide production. Although APP/A/3 mediated neurotoxicity is observed both in vitro and in vivo, the relationship between mutant APP expression, A/3 production, and neuronal death observed in the brains of FAD patients remains to be elucidated. In this study, we investigated the mechanisms of Swe-APP-induced cell death in HEK293 and NGF-differentiated PC 12 cells. We found that the expression of Swe-APP induced cytochrome C relase, activation of caspase 3 in HEK 293 and NGF-differentiated PC 12 cells. We also show that the reactive oxygen species (ROS) was detected in Swe-APP expressing HEK 293 cells and NGF-differentiated PC 12 cells and that pretreatment with vitamine E attenuated the cellular death, cytochrome C release induced by Swe-APP expression, indicating the involvement of free radical in these processes. These results suggest one of possible apoptotic mechanisms of Swe-APP which could occur through cytochrome C release from mitochondria and this apoptosis inducing effects could be at least in part, due to ROS generation by Swe-APP expression.

• 한국체육학회지인문사회과학편
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• 제57권1호
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• pp.405-419
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• 2018

이 연구는 치매행동 관련 홀니스 프로그램 적용 및 완충효과 검증 단계로 서울시에 위치한 M1과 M2 노인복지관에 개설되어 있는 주간보호시설 참여 노인 총 40명을 대상자로 선정하였다. 선정된 대상자들의 사전조사를 실시한 후 무작위로 M1노인복지관 노인 20명을 실험군으로, M2노인복지관 노인 20명을 통제군으로 배치하였다. 치매행동 관련 홀니스 프로그램 활동은 2016년 3월 14일부터 2016년 5월 30일까지 12주간, 주 2회, 60분간 수행하였다. 측정도구는 MMSE-K와 K-MBI, GDS-K를 사용하였다. 치매행동 관련 홀니스 프로그램에 참여하는 동안 치매행동 참여 전과 참여 후 총 2회를 측정하였으며 SPSS-PC(version 21.0) 통계프로그램을 이용하여 첫째, 실험군과 통제군의 동질성여부를 파악하기 위하여 독립표본 t-검증, 둘째, MMSE-K와 K-MBI, GDS-K에 대한 효과를 알아보기 위하여 사전검사와 사후검사 간 대응표본 t-검증, 셋째, 사전·사후 간 변화량을 확인하기 위하여 ANOVA를 실시하였다. 연구결과 노인의 치매행동 관련 홀니스 프로그램은 인지능력의 변화(MMSE-K), 신체능력의 변화(K-MBI), 우울수준의 변화(GDS-K)에 모두 효과가 있는 것으로 나타났다.

• 대한간호학회지
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• 제31권1호
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• pp.139-149
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• 2001

The purpose of this study was to analyze characteristics related to the activity of Daily Living (ADL) and dementia among the elderly people who have Medicaid. The cross-sectional descriptive survey study was a nationwide randomization sampling among the population of elderly families who have Medicaid. The data were collected during the month of October, 1999 and total sample was 1,027 elderly people. There were major findings according to the studies. In the results of the ADL assessment most of elderly people were within the 24 to 45 point range. Also, 63.3% of elderly people who made 45 points do not need help when performing daily activities according to the 15 areas of activity components, and 4.9% of these people couldn't do their daily activities. The results of the Dementia assessment were 70.6% of elderly people were in the normal range, 21.7% have a mild case, and 2.8% have severe case of dementia. These were found by using instruments for mental states, which simplified to items of detection of early dementia. In the result of these tests, there was a significantly positive correlation between ADL and degree of dementia with the pearson correlation coefficients. As a result of these studies, the author recommend to strengthen function and organization of public health like a visiting nurse center for elderly people who are over 65 years old. In addition, the government should apply early detection and management system for dementia in the community continuously and cost-effectively, especially for elderly people who live alone and are vulnerable elderly as our priority.

• 한방재활의학과학회지
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• 제24권4호
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• pp.29-40
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• 2014

Objectives This study was designed to collect basic information about the herbal medicine used for dementia through analysis on Korean medicine prescriptions used in dissertations for a degree of Korean medicine related dementia (experimental study). Methods We searched dissertations in the National Assembly Library and oriental medicine advanced searching integrated system web DB by using keyword '치매' and 'dementia'. We reviewed and analyzed dissertations for the degree of Korean medicine, published from 2000 to 2013. Results As a result, We found 36 dissertations about Korean herbal medicines used for Dementia Yukmijihwang-tang, Chenwangbosim-dan were used much more than other prescriptions and Panax ginseng, Glycyrrhiza uralensis, Acorus gramineus, Polygala tenuifolia, Pachyma hoelen were used more than 10 times in these dissertations. Conclusions In relieving symptoms and the treatment of dementia, it is difficult to find tendency. Because the purpose and perspective of using each Korean medicine prescriptions and their herbs are various. However, as referred to outcome of preceding researches, Yukmijihwang-tang is considered as a potential dementia medicine.