• Journal of Navigation and Port Research
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• v.29 no.4
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• pp.305-312
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• 2005

Pick-up/delivery of consumer goods to offices, shops, and restaurants in order to support urban lives is one of the most vital activities in a city. With economic growth and technological innovation, a greater variety of goods have come to be supplied, and pick-up/delivery of consumer goods has become more complex. Efficient urban goods movement in Central Business District(CBD} starts with an efficient system for loading/unloading, and pick-up/delivery activities. Loading/unloading activity may be carried out on-street, or on especially designated space inside or outside buildings. Therefore, purpose of this study is to clarity the efficient urban goods movement in CBD(also called the pick-up/delivery activity) from the three different types of loading/unloading facilities. For this purpose, the differences in loading/unloading and truck-trip activity time of each loading/unloading facility was compared by performing the simulation analysis.

• Journal of Korean Society on Water Environment
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• v.25 no.3
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• pp.452-458
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• 2009

This study was carried out to assess the effect of discharge loading at sewage treatment plants (STP) on water quality in Kyoungan stream. The seasonal variations of water quality (BOD, COD, SS, TN, and chl.a) at site 1(Mesanribo) were similar with those at site 2(Sehabo). BOD, COD, SS, and chl.a concentration were also similar except for TN and TP concentration which were lower than those at site 1. The BOD, COD, TN, TP and chl.a concentration at site 2 in dry period were higher than that of wet period. The ratios of BOD, TP, COD, SS discharge loading at all STP in Kyoungan stream watershed to delivery loading at site 2 were 0.69, 0.54, 0.48, 0.31, and 0.26 on average, respectively. Both site 1 and site 2, the seasonal variations of discharge loading at STP did not showed any relationship with those of water quality. The mean ratios of inflow loading at site 1 to delivery loading at site 2 were relatively high that ranged from 0.43 to 0.61. In dry period, the ratios of discharge loading at STP in Sehabo watershed to delivery loading at site 2 were below 0.2 except for BOD (0.24), and decreased <0.1 in wet period. While, SS loading from watershed between site 1 and site 2 to delivery loading at site 2 ratios increased in wet period.

• International Journal of Internet, Broadcasting and Communication
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• v.13 no.4
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• pp.90-96
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• 2021

The logistics market is continuously growing due to the development of technology and the growth of the online market. In addition, the social atmosphere that emphasizes non-face-to-face due to the pandemic situation is accelerating the growth of logistics. Delivery of goods ordered online requires delivery process through courier worker. In order for the courier worker to ship the product, the work of loading the product on the truck must be preceded. The accident caused by such delivery and loading work is increasing and it is emerging as a social problem. This study proposes a robot-based automated loading system to efficiently handle the increasing volume of courier service and to construct a more efficient and safe working environment by replacing the physical labor that was overloaded to courier workers. The proposed system replaces the loading of the courier worker and proposes the optimal loading function through the automation system.

• Journal of the Korea Safety Management & Science
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• v.25 no.2
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• pp.91-97
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• 2023

Ensuring the safe arrival of delivery cargo at its intended destination is of utmost importance. Truck drivers play a crucial role in guaranteeing the secure delivery of cargo without any mishaps. However, there are various factors that may lead to delayed arrival of trucks at their destination, such as late departures or prolonged loading operations. The timely departure of cargo transportation is contingent upon several variables, including the driver's experience, cargo volume, and loading time. If the transportation commencement is delayed, it may increase the risk of accidents due to an elevated operating speed. Consequently, we conducted a study to investigate the correlation between cargo loading time, cargo volume, driving experience, and the likelihood of accidents. Our findings indicate that both cargo volume and driver experience can impact the likelihood of vehicle accidents. Furthermore, all factors can have an interactive effect on the occurrence of accidents. However, extending the loading time may mitigate the impact on the likelihood of accidents.

• Journal of Pharmaceutical Investigation
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• v.31 no.1
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• pp.19-25
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• 2001

The purpose of this study was to use a ternary polymeric matrix system for high drug loading of a highly soluble drug for controlled release delivery. The controlled drug delivery of diltiazem HCl (solubility > 50% in water at $25^{\circ}C$) with high loading dose (the final loading dose of drug was 34%) from a ternary polymeric matrix (gelatin, pectin, HPMC) was successfully accomplished. This simple monolithic system with 240 mg drug loading provided near zero-order release over a 24 hour-period by which time the system was completely dissolved. The release kinetics of diltiazem HCl tablet with high loading dose from the designed ternary polymeric system was dependent on the ratios of HPMC : pectin binary mixture. The release rate increased as pectin : HPMC ratio were increased. Swelling behavior of the ternary system and the ionic interaction of formulation components with cationic diltiazem molecule appear to control drug diffusion and the release kinetics. Comparable release profiles between commercial product and the designed system were obtained. The binding study between gelatin with diltiazem HCl showed the presence of two binding sites for drug interaction with subsequent controlled diffusion upon swelling. This designed delivery system is easy to manufacture and drug release behavior is highly reproducible and offers advantages over the existing commercial product.

• Journal of The Korean Society of Agricultural Engineers
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• v.52 no.5
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• pp.27-35
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• 2010

The characteristics of delivered nutrient loads were analyzed and the regression equations to estimate delivery ratios of nutrients (TN and TP) were developed using HSPF simulation results at six subwatersheds within the Bochung A unit watershed during 1998-2007. TN delivery ratio was higher than TP delivery ratio because significant amounts of TP was considered to be attached at soil as ${PO_4}^-$ during delivery process from discharged point of nutrient source to main stream. As a results of correlation analysis, factors related to geomorphic characteristics had not statistical correlation with TN and TP delivery ratios. TN loading rate from living and specific stream flow had statistical negative and positive correlation, respectively, with TN delivery ratio. TP loading rates from all sources and from land cover and specific stream flow had statistical negative, negative and positive correlation, respectively. The specific stream flow represents the most strong correlation with nutrient delivery ratios. The regression equations to estimate delivery ratios for TN and TP were developed by including statistical correlated factors and showed high efficiency of 0.98 and 0.95 of coefficient of determination for TN and TP, respectively.

• Proceedings of the Korean Operations and Management Science Society Conference
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• 2006.11a
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• pp.284-287
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• 2006

We consider the transportation problem of optimizing the use of trailers and tractors. Several variants with fixed loading and unloading time are discussed. We show that the variant requiring on-time delivery can be solved in polynomial time, whereas the other variant requiring time-window delivery is NP-hard. We also discuss that if the number of loading and unloading operations assigned to each trailer or tractor is limited, even the variant requiring on-time delivery becomes NP-hard.

• BMB Reports
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• v.49 no.11
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• pp.585-586
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• 2016

Extracellular vesicles (EVs) are natural carriers of biomolecules that play central roles in cell-to-cell communications. Based on this, there have been various attempts to use EVs as therapeutic drug carriers. From chemical reagents to nucleic acids, various macromolecules were successfully loaded into EVs; however, loading of proteins with high molecular weight has been huddled with several problems. Purification of recombinant proteins is expensive and time consuming, and easily results in modification of proteins due to physical or chemical forces. Also, the loading efficiency of conventional methods is too low for most proteins. We have recently proposed a new method, the so-called exosomes for protein loading via optically reversible protein-protein interaction (EXPLORs), to overcome the limitations. Since EXPLORs are produced by actively loading of intracellular proteins into EVs using blue light without protein purification steps, we demonstrated that the EXPLOR technique significantly improves the loading and delivery efficiency of therapeutic proteins. In further in vitro and in vivo experiments, we demonstrate the potential of EXPLOR technology as a novel platform for biopharmaceuticals, by successful delivery of several functional proteins such as Cre recombinase, into the target cells.

• Journal of Korean Society of Industrial and Systems Engineering
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• v.39 no.3
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• pp.56-63
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• 2016

For air express service providers offering various express delivery services such as overnight delivery and next-business day delivery services, establishing quickly cargo loading plans is one of important issues owing to the characteristics of air express business, i.e., a short amount of time is available to complete all cargo loading operations before flight departure after receiving air express containers, pallets and bulks. On the other hand, one of major concerns in the air cargo loading planning is to make a plan that insures the stability of an aircraft to avoid take-off, flight, and landing accidents. To this end, this paper considers an air cargo loading planning problem, which is the problem of determining locations in the aircraft cargo space where air containers, pallets and bulks to be loaded while insuring the aircraft stability, motivated from DHL and Air Hong Kong. The objective of the problem is to maximize the total revenue gained from loading air express containers, pallets and bulks. To solve the problem, this paper suggests a simulated annealing algorithm to overcome impracticality of the integer programming model developed by a previous study requiring excessive computation time. The results of computational experiments show that the heuristic algorithm is a viable tool for establishing express cargo loading plans as giving robust and good solutions in a short amount of computation time. Scenario analyses are performed to investigate the effect of the current activities of air express carriers on the revenue change and to draw practical implications for air express service providers.

• Journal of Pharmaceutical Investigation
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• v.36 no.6
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• pp.355-361
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• 2006

Intraarticular corticosteroid injections for therapy of rheumatic arthritis are administered with the aim of optimal local anti-inflammatory effect at the injection site. Since the side effects of corticosteroidal drug, dexamethasone(DEX), administered at hish dose limited the therapeutic efficacy, there was a need to design a new drug delivery system for controlled release of dexamethasone. As a prodrug for continuous therapeutic efficacy, dexamethasone-21-palmitate(DEX-PAL) was prepared via esterification of palmitoyl chloride and dexamethasone. DEX-PAL was identified by NMR and MASS analysis. DEX-PAL or DEX was entrapped in lipid nanosphere which could be prepared by using a self emulsification-solvent evaporation method. Physicochemical characteristics such as mean particle diameter, zeta potential and drug loading efficiency of the lipid nanospheres were investigated with variation of either the kind of lipid or the lipid composition. The lipid nanospheres had a mean diameter $83{\sim}95$ nm and DEX-PAL loading efficiency of up to 95%. The drug loading efficiency increased with the increase of aliphatic chain length attached to the phospholipid. The incorporation of cationic lipid was very efficient for both reducing particle size of lipid nanospheres and enhancing drug loading efficiency. The lipid nanospheres containing DEX-PAL may be a promising novel drug carrier for the controlled release of the poorly water-soluble drugs.