• Journal of Pharmaceutical Investigation
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• 제41권6호
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• pp.331-336
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• 2011

The instability of hirsutenone (HST), a potential therapeutic candidate for the treatment of atopic dermatitis (AD) and ovarian carcinoma, is one of the main concerns for the development of drug product. In the present study, aqueous stability of HST was investigated by kinetic analysis, and the effect of several factors covering temperature, nitrogen gas ($N_2$) flushing, and selection of proper antioxidant was compared. Cosolvent system composed of distilled water and methanol (9:1 v/v) was used as a vehicle to dissolve HST at the concentration of $200{\mu}g/mL$. Samples of aqueous solution were prepared under the absence or presence of antioxidants, such as ascorbic acid (AA), sodium edetate (EDTA), and ascorbyl palmitate (AP), and subjected for stability test. The degradation of HST in aqueous solution was followed by the first order kinetics with an extremely short half life of less than a week at room temperature, and was accelerated as the temperature increased. $N_2$ flushing brought a little enhancement in stability compared to control solution, but the effect was insufficient. The addition of AA and EDTA (0.1%) significantly enhanced the stability of HST at $40^{\circ}C$, but the addition of AP (0.01%) was limited due to its water insolubility and revealed no promising result. The stability of HST was increased proportionally by the amount of AA added, showing the difference in degree of stabilization as an order of magnitude. Finally, we conclude that HST was stabilized by the addition of a suitable antioxidant, suggesting AA as the most effective stabilizer.

• 정보화정책
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• 제31권2호
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• pp.65-81
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• 2024

나라장터 종합쇼핑몰 등을 비롯한 공공기관 온라인 쇼핑몰을 통한 전자조달 규모는 나날이 커지고 있다. 본 연구는 공직자들이 공공기관 온라인 쇼핑몰의 제품, 배송, 사후관리에 대하여 어떻게 평가하는지, 그리고 그들의 만족도를 제고할 수 있는 방안은 무엇인지 살펴봄으로써 전자조달 품질 평가 및 개선 방안에 대하여 살펴보고자 한다. 공공기관 온라인 쇼핑몰 이용 경험이 있는 공무원 및 공공기관 재직자를 대상으로 설문조사를 실시한 결과, 대체로 만족도가 높은 것으로 나타났다. 그러나 제품의 다양성에 대한 불만이 확인되었다. 배달 품질에 대한 인식은 전반적으로 긍정적이지만, 사후관리에서 개선의 여지가 있음도 알 수 있었다. 이어서 구조방정식 모형을 활용하여 만족도와 재이용의사에 미치는 영향을 살펴봤는데 제품품질인식, 배송품질인식, 사후관리품질인식 모두 만족도에 유의한 정의 영향을 미침이 확인되었고, 반품·교환·하자보수가 발생하지 않도록 제품에 대한 정보와 품질의 관리에 더 많은 노력을 기울이고 문제가 발생했을 경우 그 처리를 간명하고 신속하게 진행할 필요가 있음을 알 수 있었다.

• 의료ㆍ복지 건축 : 한국의료복지건축학회 논문집
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• 제30권3호
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• pp.35-44
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• 2024

Purpose: The purpose of this study is to present basic data on installation location, functional connection, and arrangement to be considered when planning a neonatal intensive care unit in a certified tertiary general hospital. Method: Review the facility standards related to the neonatal intensive care unit, such as laws and guidelines, and select a Certified Tertiary General Hospital as a case hospital among the Neonatal Intensive Care Regional Centers designated by the Ministry of Health and Welfare to analyze the placement characteristics of major NICU components such as the location of the NICU installation, the connection of movement between adjacent facilities and functions, and the treatment room and accessory room. Results and Implications: NICU is a facility for critically ill babies among newborns and needs to consider more about infection and patient management compared to adult intensive care units, which not only install close to delivery-related facilities to enable immediate action after childbirth, but also divide the treatment room into open rooms and allow access to the attached rooms through dedicated corridors to minimize movement in the treatment room.

• 간호행정학회지
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• 제3권2호
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• pp.151-165
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• 1997

A cost analysis for hospitalized patients was performed based on the KDRG classification in order to determine an appropriate nursing fee under the PPS(Prospective Payment System). The data was collected from 20 nursing units of three tertiary hospitals and two secondary hospitals from August 26 to September 15, 1996. The study consisted of 148 inpatients diagnosed for lens procedures(KDRG 03900), tonsillectomy &/or adenoidectomy(KDRG 16100), Cesarean section(KDRG 37000), or vaginal delivery(KDRG 37300) without any complications. The direct or indirect nursing hours of each patients were measured. Then, direct or indirect nursing expenditures of four nursing units, operating room and delivery room were computed. Finally, the resources used including average total nursing hours, average length of stay and average nursing cost of each KDRG were estimated as follows; 1) The average total nursing hours were 640 minutes for lens procedures, 403 minutes for tonsillectomy &/or adenoidectomy, 934 minutes for appendectomy with complicated principal diagnosis, 1,094 minutes for Cesarean section and 631 minutes for vaginal delivery. Significant differences were found in average total nursing hours among hospitals. 2) The average length of stay in lens procedures were 5 days, 4 days for tonsillectomy &/or adenoidectomy, 6 days for appendectomy with complicated principal diagnosis, 8 days for Cesarean section and 3 days for vaginal delivery. All results were within normal determined by the Ministry of Health and Welfare although significant differences existed among hospitals, especially with average length of stay for leng procedures between tertiary hospitals and secondary hospitals which was greater than for those of others. 3) The average nursing cost were 87,146 Won for lens procedures, 69,600 Won for tonsillectomy &/or adenoidectomy, 128,337 Won for appendectomy with complicated principal diagnosis, 151,769 Won for Cesarean section and 85,403 Won for vaginal delivery. These costs were 7.6%, 13.0%, 13.0%, 16.0% and 22.0%, respectively, of the official price fixed by the Ministry of Health and Welfare under the prospective payment system. Research for the analysis of nursing costs according to the severity of illness for those KDRGs shoud be carried out within the period of the PPS pilot project. In addition, a proper nursing fee schedule for a new reimbursement system based upon the result of the above research should be prepared in the near future.

• Journal of Pharmaceutical Investigation
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• 제37권5호
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• pp.281-286
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• 2007

For transdermal delivery of porcine placenta extract (PPE), various emulsion formulations were prepared and evaluated. Polysorbate surfactants were used as emulsifiers and various C-18 unsaturated fatty acids as enhancers. The skin permeation of PPE was tested using a cellulose nitrate membrane-loaded Franz cell apparatus. Among emulsifiers, Tween 20 provided higher penetration effect than did Tween 80. Meanwhile, of various fatty acids, linolenic acid (18:3) revealed the highest skin permeation of PPE than the other C-18 unsaturated fatty acids. Stability of PPE emulsions was determined by cycles of freezing and thawing processes. The stability of emulsions depended on the percentage of Tween 20. Minimum 20% of Tween 20 was required to stabilize emulsions at room temperature for several days. Taken together, our results suggest that Tween 20 and linolenic acids might be key components to formulate PPE emulsion to provide the desirable skin permeability and stability.

• 한국경영과학회:학술대회논문집
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• 한국경영과학회/대한산업공학회 1999년도 춘계공동학술대회:정보화시대의 지식경영
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• pp.209-210
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• 1999

In the case of paper plant engineering company, one of the most important critical problems is to accurately estimate the cost and the delivery time of the project. This is necessary for the company to win a bidding and to have some room for negotiation. Moreover, the company needs to have time to process all the relevant informations to make timely response to, and deal with the changing conditions of the bidding environments as quickly as possible. One of the popular methodology dealing with this kind of situation is an effective "decision support system," and may researches are currently been done on this subject. In this article, and effective decision support system is developed which can provide automatic delivery time and cost estimates from which plant engineering company may be benefited.

• Macromolecular Research
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• 제14권4호
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• pp.461-465
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• 2006

Two types of injectable system using thermosensitive chitosan (chitosan-g-NIPAAm), hydrogel and microparticles (MPs)-embedded hydrogel were developed as drug carriers for controlled release and their pharmaceutical potentials were investigated. 5-Fluorouracil (5-FU)-loaded, biodegradable PLGA MPs were prepared by a double emulsion method and then simply mixed with an aqueous solution of thermosensitive chitosan at room temperature. All 5-FU release rates from the hydrogel matrix were faster than bovine serum albumin (BSA), possibly due to the difference in the molecular weight of the drugs. The 5-FU release profile from MPs-embedded hydrogel was shown to reduce the burst effect and exhibit nearly zero-order release behavior from the beginning of each initial stage. Thus, these MPs-embedded hydrogels, as well as thermosensitive chitosan hydrogel, have promising potential as an injectable drug carrier for pharmaceutical applications.

• 한국간호교육학회지
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• 제7권2호
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• pp.333-348
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• 2001

The study was intended to investigate the degree of satisfaction and experiences of maternity nursing practice and to examine the relationships between satisfaction and experiences. Data were collected from a college located in Inchon from April 2, 2001 to October 30, 2001. A general characteristics questionnaires, questionnaire for clinical practice satisfaction and maternity nursing clinical checklist were used to measure the satisfaction and experiences of maternity nursing practice. The subject were supposed to record their clinical experience in maternity clinical practice checklist. 153 questionnaires for satisfaction of clinical practice and 178 maternity nursing clinical practice checklists used for analysis. The data were analyzed by SPSS-PC+ program. The results of this study were as follows ; 1) The mean score of satisfaction of clinical practice was 3.34(a perfect score 5) and among the 4 categorial components from the questionnaire of satisfaction the score of 'clinical practice teaching' was high(3.85) and 'clinical practice environment(2.91)' and 'clinical practice contents(2.90)' was relatively low. 2) There was significant value between place of clinical practice and clinical practice satisfaction among 7 clinical practice hospital and the most high score of clinical practice satisfaction is 3.70 and the low score is 2.91(F=7.706, p<.001). The score of delivery room was significantly higher than the OBGY room and there was significant value among the place of clinical practice(DR : F= 6.441, p<.001, OBGY room : F=7.908, p<.001). 3) In delivery room, the frequency of observation are 2.61 day, the frequency of practice are 1.33 day and in OBGY room the frequency of observation are 1.73 day, the frequency of practice are 1.31 day for 2 week of maternity clinical practice and the most frequent practice of maternity nursing care was checking vital sign. 4) There were significant relationships between the ranking score of clinical satisfaction and clinical experiences in maternity nursing practice. Based on the results, it is suggested that the satisfaction of clinical practice was related to environment of clinical practice and it is necessary to improve environment of clinical practice and make a strategies to enhance the quality of maternity clinical experience.

• 대한안전경영과학회:학술대회논문집
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• 대한안전경영과학회 2010년도 추계학술대회
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• pp.559-580
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• 2010

General Command in the whole situation, managed effectively in order to perform the first briefing room of the reorganization plan and the personnel, the situation room of the business division of the scope(function), information exchange and delivery quickly and accurately to support the computerized Communications equipment and system construction, and various field Construction activities related to the information database construction, and should be made to secure the expertise of management personnel. Building of Computer - communication systems equipment environment for new IT technologies is necessary. From this perspective, the leadership position in the country in the Disaster Management Center in Seoul, organization and personnel, computer systems and communication system status, status of foreign countries like Dispatch managing disaster situations by identifying and analyzing the development plan is aimed to find.

• Journal of Korean Neurosurgical Society
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• 제37권6호
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• pp.453-455
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• 2005

Two young women were brought to the Emergency room with generalized tonic and clonic seizures. Seizure developed seven and ten days after delivery respectively without the clinical signs of pre-eclampsia throughout the pregnancies. Magnetic resonance(MR) image of the brain showed characteristically symmetrical abnormal signals in the parietal and occipital regions. After several days of medical treatment, they were discharged without neurologic sequelae and follow-up MR images taken three months after discharge showed complete disappearance of the previous abnormal signals.