• KSII Transactions on Internet and Information Systems (TIIS)
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• v.9 no.7
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• pp.2354-2370
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• 2015

The advantages of employing SCTP-based Concurrent Multipath Transfer (CMT) have been demonstrated to be very useful for data delivery over multi-homed wireless networks. However, there is still significant ongoing work addressing some remaining limitations and challenges. The most important concern when applying CMT to data delivery is related to handling packet reordering and buffer blocking. Another concern on this topic is that current sender-based CMT solutions seldom consider balancing the overhead and sharing the load between the sender and receiver. This paper proposes a novel Receiver-driven Cooperation-based Concurrent Multipath Transfer solution (CMT-Rev) with the following aims: (i) to balance overhead and share load between the sender and receiver, by moving some functions including congestion and flow control from the sender onto receiver; (ii) to mitigate the data reordering and buffer blocking problems, by using an adaptive receiver-cooperative path aggregation model, (iii) to adaptively transmit packets over multiple paths according to their receiver-inspired sending rate values, by employing a new receiver-aware data distribution scheduler. Simulation results show that CMT-Rev outperforms the existing CMT solutions in terms of data delivery performance.

• Journal of Pharmaceutical Investigation
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• v.36 no.2
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• pp.115-121
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• 2006

The aim of this study was to develop new protein/peptide depot system instead of poly(DL-lactic acid-coglycolic acid) (PLGA) microspheres. Pullulan was chemically modified by the addition of acetic anhydride (pullulan acetate; PA) and then investigated as new depot system for protein/peptide delivery. PA microspheres (PAM) with lysozyme as a model protein were prepared by w/o/w double emulsion method. The microspheres had a mean size of 10-50 mm with a spherical shape. The size distributions reduced with increasing the degree of acetylation. The loading efficiency of lysozyme was also increased. Lysozyme aggregation behavior in the microsphere was monitored to estimate the change of protein stability during preparation step. The ratios of protein aggregation in PAMs are lower than that of PLGA microsphere, in particular, PA 5 showed lowest as about 16%. The result indicated that the increase of acetylation suppressed the aggregation of protein. The release profiles of lysozyme from PAMs were significantly different. High acetylation effectively improved lysozyme release kinetics by reducing initial burst release and extending continuous release over a period of time. To check the effect of preservation for structural stability of lysozyme, the activity of lysozyme released from PA 5 was also observed. The activity of lysozyme was maintained almost 100% for 25 day. Therefore, PAM may become to a useful carrier for delivery of protein/peptide drugs, if it will be supported by biocompatibility and biodegradability results.

• Journal of Pharmaceutical Investigation
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• v.32 no.4
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• pp.259-265
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• 2002

Piroxicam is one of the NSAID, which is used in the systemic and topical treatment of a variety of inflammatory conditions. Conventionally, for topical use, the drug is formulated in gel. We designed an phonophoretic drug delivery system to investigate the piroxicam permeability and the influence of ultrasound application (continuous mode, pulsed mode), frequency (1.0 MHz, 3.0 MHz) and intensity $(1.0\;w/cm^2,\;1.5\;w/cm^2,\;2.0\;w/cm^2)$ with 0.5% piroxicam gel. Per cutaneous absorption studies were performed in vitro models to determine the rate of drug absorption via the skin. Permeation study using hairless mouse skin was performed at $37^{\circ}C$ using buffered saline (pH 7.4, 10% propylene glycol solution) as the receptor solution. Anti-inflammatory activity was determined using carrageenan-induced foot edema model in rat. A pronounced effect of ultrasound on the skin absorption of the piroxicam was observed at all ultrasound energy level studied. Ultrasound was carried out for 10 hr. The highest permeation was observed at intensity of $2.0\;w/cm^2$, frequency of 1.0 MHz and continuous output. The inclusion of phonophoresis was found to improve significantly the skin permeation in vitro and the anti-inflammatory activity in vivo.

• Biomedical Science Letters
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• v.12 no.3
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• pp.177-183
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• 2006

To demonstrate the effect of formulation conditions and evaluations of structural integrity from ovalbumin containing poly lactide glycolide copolymer (PLGA) microspheres for Vaccine delivery, OVA microspheres were prepared by a W/O/W multiple emulsion solvent extraction technique. Dichloromethan (DCM) and Ethyl acetate (EA) were applied as an organic phase and poly vinyl alcohol (PVA) as a secondary emulsion stabilizer. Microspheres were characterized for particle size, morphology (optical microscopy and Scanning Electron Microscope (SEM)). Protein denaturation was evaluated by size exclusion chromatography (SEC), SDS-PAGE and isoelectric focusing (IEF). Residual organic solvent was estimated by gas chromatography (GC) and differential scanning calorimetry (DSC). Optical photomicrograph and SEM revealed that micro spheres were typically spherical but various morphologies were observed. Mean particle size $(d_{vs})$ of microspheres were in the range of $3{\sim}50{\mu}m$. Also, The protein stability was not affected by the fonnulation process and residual organic solvent was beyond the detection below 0.1ppm. These results demonstrated that micro spheres might be a good candidate for the parenteral vaccine delivery system.

• Management Science and Financial Engineering
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• v.18 no.1
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• pp.27-37
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• 2012

This paper is motivated by a military cargo-plane routing problem which is a pickup-and-delivery problem in which load splits and node revisits are allowed (PDPLS). Although this recent evolution of a VRP-model enhances the efficiency of routing, a solution method is more of a challenge since the node revisits entail closed walks in modeling vehicle routes. For such a case, even a compact IP-formulation is not available and an effective method had been lacking until Nowak et al. (2008b) proposed a heuristic based on a tabu search. Their method provides very reasonable solu-tions as demonstrated by the experiments not only in their paper (Nowak et al., 2008b) but also in ours. However, the computation time seems intensive especially for the class of problems with dynamic transportation requests, including the military cargo-plane routing problem. This paper proposes a more scalable algorithm hybridizing a tabu search for pricing subproblem paused as a single-vehicle routing problem, with a column generation approach based on Dantzig-Wolfe decomposition. As tested on a wide variety of instances, our algorithm produces, in average, a solution of an equiva-lent quality in 10~20% of the computation time of the previous method.

• Proceedings of the Korean Institute of Building Construction Conference
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• 2018.05a
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• pp.122-123
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• 2018

Recently, CM at Risk delivery system(CM@R) that could solve the problems of Design Bid Build delivery(DBB) system has been emerging. In the CM@R delivery system, the contractor negotiates for a maximum guaranteed price(GMP) with the client at the design stage, and the contractor carries out the construction within the GMP. In CM @ R, the construction company with expertise in construction participates from the design stage to reflects the construction know-how in the design. On the other hand, the modification design frequently occurs due to the change of the construction cost when negotiating the GMP. In addition, uncertainties are inherent in the GMP calculation because the calculation is based on unfinished drawings and documents. This study proposes a probabilistic GMP estimation method applying MCS to the BIM - based cost prediction model, in order to extract the accurate quantity information when estimating the GMP and to cope with the change of the construction cost inherent in uncertainty.

• Journal of the Korea Safety Management & Science
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• v.19 no.3
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• pp.109-115
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• 2017

In order to increase the productivity of the logistics center and transportation, we try to articulate the priority ranking factors of the productivity influenced by the personality of the field workers (logistics center workers) and functional workers (drivers) via the AHP technique Individual personality was studied by applying the Big 5 model of psychological factors (openness, Conscientiousness, extroversion, Agreeableness, neuroticism). In this paper, extraversion was critically analyzed as a priority factor. A trait of extroversion is a strongly active and individual personality. In this study, the field workers are logistics center workers and the functional workers are drivers. They are interactively influenced in the In & Out operation. For example, when it comes to 'up and down work' and 'inspection work', the functional workers perform 'up and down work' and 'delivery work' and the field workers perform 'inspection work'. Stressing on the respective work has an affect on work productivity. Inspection workforce has something to do with inventory management. Functional workforce affects the delivery workforce. Delivery work is positively correlated with customer satisfaction. Nevertheless, as a result of research, extrovert personality that has something to do with an energetic activity would not affect on the implementation of their operation. In addition, personal extraversion of workers and drivers in the warehouse can have a significant impact on job commitment and productivity improvement.

• Journal of Pharmaceutical Investigation
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• v.30 no.4
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• pp.253-258
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• 2000

In order to design the oral vaccine delivery system, we prepared the alginate micro spheres containing GFP (green fluorescent protein) as a model drug by spray method. To optimize the preparation conditions of microspheres, we investigated the effects of various parameters including nozzle pressure, nozzle opening angle, and concentrations of sodium alginate and calcium chloride. The prepared microspheres were evaluated by measuring their sizes, loading efficiency, and morphology. The particle size of microspheres was affected by the concentration of sodium alginate and calcium chloride, nozzle pressure, and nozzle opening angle. As the concentration of sodium alginate increased, GFP loading efficiency and particles size of microsphere also increased. However, it was observed to be difficult to spray the sodium alginate solution with concentration greater than 1.5% (w/v), due to high viscosity. The pressure over $3\;kgf/cm^2$ didn't affect the size of particles. As a result, the spraying method enabled us to prepare microspheres for oral vaccine delivery system. In this study, microspheres prepared with 1% (w/v) sodium alginate had greater loading efficiency and better spherical shape.

• Journal of Pharmaceutical Investigation
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• v.34 no.6
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• pp.465-469
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• 2004

Colloidal gold nanoparticles might be of use as nano scale delivery systems of various therapeutic materials in the future. Recent studies have reported the feasibility of colloidal gold nanoparticles as gene delivery systems or protein delivery systems. In this study, we aimed to develop a short-step method useful for screening the optimal coating conditions of colloidal gold nanoparticles with proteins. We observed that colloidal gold nanoparticles have properties of changing its unique color when they were exposed to NaCl solution. Taking advantage of the color changing properties of colloidal gold nanoparticles, we applied the color testing method of colloidal gold nanoparticles solutions for evaluating the protein coating nature. Using bovine serum albumin as a model protein, we tested the protein coating of colloidal gold nanoparticles via the color change upon NaCl addition. The optimal coating concentration and coating conditions of colloidal gold nanoparticles with bovine serum albumin were fixed using the color testing methods. We suggest that the color testing method might be applied to optimize the coating condition of colloidal gold nanoparticles with other therapeutic proteins.

• Journal of Korean Institute of Industrial Engineers
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• v.39 no.6
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• pp.554-561
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• 2013

As a special topic of the vehicle routing problems (VRP), VRPSDP extends the vehicle routing problem as considering simultaneous pickup and delivery for goods. The past studies have mainly dealt with a only weight constraint of a loading capacity for heterogeneous products. However. this study suggests VRPSDP considering separate loading area according to characteristics of loading species. The objective is to design a set of minimum distance routes for the vehicle routing assignment with independent capacity for heterogeneous species. And then we present a another HVRPSDP model which is easy to utilizes in a unique circumstance that is a guarantee of executing a task simultaneously from the various areas under restricted time and raising an application of vehicles that returns at the depot for the next mission like the military group. The optimal results of the suggested mathematical models are solved by the ILOG CPLEX software ver. 12.4 that is provided by IBM company.