• 지능정보연구
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• 제13권1호
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• pp.49-58
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• 2007

공급망의 물류흐름을 최적화하기 위해 여러 차고지를 기점으로 차량들이 다수의 적하와 하역장소를 거쳐 차고지로 돌아오는 최적의 배송경로를 계획하는 기존의 최적화모형 연구는 정수계획법(IP)에 기반을 둔 MDPDPTW(Multi-Depot Pickup and Delivery Problem with Time Windows) 모형이 있다. 이에 관한 연구들은 차고지의 차량들을 대상으로만 배송경로를 계획하기 때문에 운행 중인 차량을 고려할 때보다 효과적인 배송경로계획에 한계가 있다. 본 연구는 효과적인 공급망관리를 위하여 여러 차고지의 차량은 물론, 유비쿼터스 환경에서 배송화물과 운행 중인 차량상황을 포함한 배송상황을 기반으로 최적의 배송경로를 계획하는 IP기반 최적화모형인 u-MDPDPTW 모형을 제안하는데 그 목적이 있다. 또한, 기존 MDPDPTW 모형과 본 연구의 u-MDPDPTW 모형의 비교실험을 통하여 u-MDPDPTW 모형의 효과와 유용성을 보인다.

• Journal of Microbiology and Biotechnology
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• 제29권3호
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• pp.489-499
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• 2019

Subunit vaccines are safer and more stable than live vaccines although they have the disadvantage of eliciting poor immune response. To develop a subunit vaccine, an effective delivery system targeting the key elements of the protective immune response is a prerequisite. In this study, oxidized carbon nanospheres (OCNs) were used as a subunit vaccine delivery system and tuberculosis (TB) was chosen as a model disease. TB is among the deadliest infectious diseases worldwide and an effective vaccine is urgently needed. The ability of OCNs to deliver recombinant Mycobacterium tuberculosis (Mtb) proteins, Ag85B and HspX, into bone marrow derived macrophages (BMDMs) and dendritic cells (BMDCs) was investigated. For immunization, OCNs were mixed with the two TB antigens as well as the adjuvant monophosphoryl lipid A (MPL). The protective efficacy was analyzed in vaccinated mice by aerosol Mtb challenge with a virulent strain of Mtb and the bacterial burdens were measured. The results showed that OCNs are highly effective in delivering Mtb proteins into the cytosol of BMDMs and BMDCs. Upon immunization, this vaccine formula induced robust Th1 immune response characterized by cytokine profiles from restimulated splenocytes and specific antibody titer. More importantly, enhanced cytotoxic $CD8^+$ T cell activation was observed. However, it did not reduce the bacteria burden in the lung and spleen from the aerosol Mtb challenge. Taken together, OCNs are highly effective in delivering subunit protein vaccine and induce robust Th1 and $CD8^+$ T cell response. This vaccine delivery system is suitable for application in settings where cell-mediated immune response is needed.

• Medical Lasers
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• 제10권3호
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• pp.161-169
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• 2021

Background and Objectives Fractional microneedle radiofrequency systems are popular options to increase elasticity in aging skin. Laser-assisted drug delivery is a promising method for the epidermal injection of topically applied drugs and cosmetic ingredients. This study assesses the safety and efficacy of topical delivery of L-ascorbic acid, vitamin E, and ferulic acid after fractional microneedle radiofrequency treatment for reducing photodamage. Materials and Methods In this prospective, single-center, split-face, controlled pilot study, six women (mean age, 48.0 years; range, 35-57 years; Fitzpatrick skin types III and IV) exhibiting mild to moderate photodamage, underwent a single session of fractional microneedle radiofrequency treatment. The patients were instructed to apply the antioxidant formulation to only one side of the face. Patients were evaluated 3 days, 7 days, and 4 weeks thereafter, using three-dimensional imaging and ultrasound. Ex vivo, the full-thickness human skin was used for molecular and histological evaluation. Statistical analysis was achieved by applying t-tests, Mann-Whitney U tests, and one-way analyses of variance. Results Compared to the untreated side, the antioxidant-treated side exhibited a significant increase in dermal thickness (10.32% vs. 17.54%, p < 0.05), but not in skin elasticity (4.76% vs. 4.69%, p > 0.05). The difference in erythema between the sides was statistically not significant (p > 0.05). In the ex vivo model, expression of FGF2 in the skin was significantly increased after application of the antioxidant formulation, as compared to results obtained subsequent to fractional microneedle radiofrequency treatment only (p < 0.01). Conclusion This study demonstrates that for the treatment of photodamaged skin, laser-assisted delivery of the antioxidant formulation is a safe and effective adjuvant modality following fractional microneedle radiofrequency.

• 경영과학
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• 제21권3호
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• pp.101-113
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• 2004

In the rapidly propagating Internet based electronic transaction environment. the importance of real time order confirmation has been more emphasized, In this paper, using data mining techniques, we develop intelligent operations decision model to allow real time order confirmation at the time the customer places an order with required delivery terms. Among various operation plannings used for order fulfillment. mill routing is the first interface decision point to link the order receiving at the marketing with the production planning for order fulfillment. Though linear programming based mathematical optimization techniques are mostly used for mill routing problems, some early orders should wait until sufficient orders are gathered for optimization. And that could effect longer order fulfillment lead-time, and prevent instant order confirmation of delivery terms. To cope with this problem, we provide the intelligent decision model to allow instant order based mill routing decisions. Data mining techniques of decision trees and neural networks. which are more popular in marketing and financial applications, are used to develop the model. Through diverse computational trials with the industrial data from the steel company. we have reported that the performance of the proposed approach is effective compared to the present heuristic only mill routing results. Various issues of data mining techniques application to the mill routing problems having linear programming characteristics are also discussed.

• 한국건설관리학회논문집
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• 제6권4호
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• pp.91-100
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• 2005

건설 전체 프로세스를 하나의 주체가 단일 책임하에 수행하는 일괄입찰방식은 설계와 시공의 연계로 인한 기술력확보, 공기단축, 사업비절감, 품질확보 등의 예상효과로 인해 적용이 확대되리라 예상되는 발주방식의 하나이다. 한편, 국내 일괄입찰방식의 낙찰자 결정방법은 일괄입찰방식으로 수행되는 모든 프로젝트에 동일한 배점기준을 적용하도록 되어 있어, 일괄사업자 선정시 발주자의 목적과 프로젝트의 특성을 반영하기 어려운 것이 현실이다. 이에 본 연구에서는 일괄사업자 선정에 있어서 발주자의 목적과 프로젝트의 특성을 반영할 수 있는 일괄입찰방식의 적격심사 분야별 배점 결정모델을 제안함으로써, 발주자가 당해 프로젝트에 최적인 일괄사업자를 합리적으로 선정하는 것을 돕고자 하였다.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제9권5호
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• pp.1790-1806
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• 2015

Utility-based routing is a special type of routing approach using a composite utility metric when making routing decisions in ad hoc and sensor networks. Previous studies on the utility-based routing all use fixed retry limit and a very simple distance related energy model, which makes the utility maximization less efficient and the implementation separated from practice. In this paper, we refine the basic utility model by capturing the correlation of the transmit power, the retry limit, the link reliability and the energy cost. A routing algorithm based on the refined utility model with adaptive transmit power and retry limit allocation is proposed. With this algorithm, packets with different priorities will automatically receive utility-optimal delivery. The design of this algorithm is based on the observation that for a given benefit, there exists a utility-maximum route with optimal transmit power and retry limit allocated to intermediate forwarding nodes. Delivery along the utility-optimal route makes a good balance between the energy cost and the reliability according to the value of the packets. Both centralized algorithm and distributed implementations are discussed. Simulations prove the satisfying performance of the proposed algorithm.

• 한국환경과학회지
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• 제25권10호
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• pp.1433-1444
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• 2016

South Korea is a maritime nation, surrounded by water on three sides; hence, it is important to preserve in a sustainable manner. Most areas, especially those bordering the East Sea, have been suffering from severe coastal erosion. Information on the sediment yield of a river basin is an important requirement for water resources development and management. In Korea, data on suspended sediment yield are limited owing to a lack of logistic support for systematic sediment sampling activities. This paper presents an integrated approach to estimate the sediment yield for ungauged coastal basins by using a soil erosion model and a sediment delivery rate model in a geographic information system (GIS)-based platform. For applying the sediment yield model, a basin specific parameter was validated on the basis of field data, that, ranging from 0.6 to 1.2 for the 19 gauging stations. The calculated specific sediment yield ranged from 17 to $181t/km^2.yr$ in the various basin sizes of Korea. We obtained reasonable sediment yield values when comparing the measured data trends around the world with those in Korean basins.

• 한국멀티미디어학회논문지
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• 제24권8호
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• pp.1101-1113
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• 2021

The rapid growth of sense-and-respond applications and the emerging cloud computing model present a new challenge: providing publish/subscribe middleware as a scalable and elastic cloud service. The publish/subscribe interaction model is a promising solution for scalable data dissemination over wide-area networks. In addition, there have been some work on the publish/subscribe messaging paradigm that guarantees reliability and availability in the face of node and link failures. These publish/subscribe systems are commonly used in information-centric networks and edge-fog-cloud infrastructures for IoT. The IoT has an edge-fog cloud infrastructure to efficiently process massive amounts of sensing data collected from the surrounding environment. In this paper. we propose a quorum-based hierarchical fault-tolerant publish/subscribe systems (QHFPS) to enable reliable delivery of messages in the presence of link and node failures. The QHFPS efficiently distributes IoT messages to the publish/subscribe brokers in fog overlay layers on the basis of proposing extended stepped grid (xS-grid) quorum for providing tolerance when faced with node failures and network partitions. We evaluate the performance of QHFPS in three aspects: number of transmitted Pub/Sub messages, average subscription delay, and subscritpion delivery rate with an analytical model.

• 한국의료질향상학회지
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• 제3권2호
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• pp.52-59
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• 1997

Background : In many Nursing Delivery System, Nursing Department at D Hospital had used to traditional nursing practice model what is called functional activities based system. It has a lot of merit that carried out specialized and rapid works but tend to ignore indivisual professional responsibility and task-based work assignments. In addition this system showed high turnover rates due to heavy workload, timesum of handing over duties, lack of support from peers and interstaff communication. So we performed conversion of Nursing Delivery System to My Patients Nursing Care System for providing comprehensive nursing to patient and reducing turnover rates and increasing job satisfaction to nurse. Method : 1. 1st step(96.4.9): Detected the problem of Nursing delivery System and estabilished improving planning 2. 2nd step(96.4.26): Visited other hospital on job training 3. 3th step(96.4.29): Discussed to premonitoring problem after conversion Nursing Delivery System and prepared structure 4. 4th step(96.5.6): My Patients Nursing Care System practical application 5. 5th step(96.7.20): Held complementary meeting 6. 6th step(96. 7): The other ward application 7. 7th step(96. 10): Extended application to whole wards Results: 1. Workload: (1) reduction(55.6%) (2) addition(44.4%) 2. Strong points after conversion: (1) decreased timesum of handing overduties (35.2%) (2) increased responsibility(33%) (3) broaden nurse's outlook to duties(14.8%) 3. Shortcoming after conversion: (1) understanding difficulties except my patient(57.8%) (2) weak teamwork(23.3%) (3) intensive stress to low grade nurse(12.2%) 4. Effective complemental way: (1) manpower(76.7%) (2) conversion of though (8.9%) (3) education(14.4%) 5. Patient's satisfaction: (1) satisfaction(64%) (2) no effect(36%) 6. Physician and peer's satisfaction: (1) satisfaction(12.5%) (2) dissatisfaction(21.6%) (3) no interest(44.3%) 7. Nurse's satisfaction: (1) satisfaction(74.7%) (2) dissatisfaction(5.5%) (3) unknown(20.5%) 8. Want to continued: (1) want(76.4%) (2) try to any other system(18%) Conclusion : Even though Nursing Delivery System conversion still has many problem, we gained more merits than traditional nursing delivery system. So we suggest that My Patients Nursing Care System should be encouraged for comprehensive nursing care and satisfaction to nurses.

• 산업경영시스템학회지
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• 제14권24호
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• pp.141-147
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• 1991

This paper presents extended model for the vehicle routing problem, which allows multiple visits to a node by multiple vehicles. Multiple visits enables us split delivery. After formulating this multiple visits model mathematically, a two stage heuristic algorithm is developed by decomposition approach. This model consists of two sub-problem. The one is fixed cost transportation problem and the other is transportation problem.