• Title/Summary/Keyword: Delayed effect

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The effects of Sojagangkitang and Gamisojagangkitang on the Type I and IV hypersensitivities and on the experimental lung damage (소자강기탕(蘇子降氣湯)과 가미소자강기탕(加味蘇子降氣湯)이 I형(型) 및 IV형(型) 알레르기 반응(反應)과 폐손상(肺損傷)에 미치는 영향(影響))

  • Park, Yang-Chun;Kim, Byeong-Tak
    • The Journal of Internal Korean Medicine
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    • v.15 no.2
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    • pp.260-273
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    • 1994
  • This study attempted to investigate the effects of Sojagangkitang and Gamisojagangkitang on the variation of lung thiobarbituric acid(TBA) value, tracheal glycoprotein, serum sodium ion$(Na^+)$ contents, serum potassium ion$(K^+)$ contents ; immediatly type allergy reaction, delayed type allergy reaction in rats and mice. The results were as follows: 1. Sojagangkitang and Gami-sojagangkitang revealed significant effect on immediatly type hypersensitivity responds to histamine. 2. Sojagangkitang and Gami-sojagangkitang revealed significant effect on delayed type hypersensitivity responds to picryl chloride. 3. Sojagangkitang and Gami-sojagangkitang revealed significant effect on delayed type hypersensitivity responds to SRBC, effect of Gami-sojagangkitang was outstanding. 4. Lung thiobarbituric acid(TBA) value was decreased with statistical significance. 5. Sojagangkitang and Gami-sojagangkitang revealed decreasing effect on Tracheal glycoprotein contents, effect of Gami-sojagangkitang was outstanding. 6. Sojagangkitang and Gami-sojagangkitang revealed decreasing effect on phenol red excretion of respiratory tract. 7. Viscosity of mucine solution was decreased in proportion to increasing dosage of the Sample. 8. Serum $Na^+$ contents was not recognized significance. 9. Sojagangkitang and Gami-sojagangkitang revealed decreasing effect on Serum $K^+$ contents, effect of Gami-sojagangkitang were outstanding. According to the above results, it seems that Sojagangkitang and Gami-sojagangkitang can be applied for asthma, chronic obstructive pulmonary diseases, allergic respiratory diseases.

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The experimental study on the anti-allergic effects of Ursi fel and Ursodesoxycholic acid (UDCA) (웅담(熊膽) 및 우루소데옥시콜린 산(酸)의 항(抗)알레르기 효과(效果)에 관(關)한 실험적(實驗的) 연구(硏究))

  • Jeong Jae-Hwan;Lee Jin-Yong;Kim Deok-Gon;Jeong Gyu-Man
    • The Journal of Pediatrics of Korean Medicine
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    • v.10 no.1
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    • pp.299-321
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    • 1996
  • Experimental studies were done to research the effects of the Ursi fel and the UDCA on the anti-allergic effects. The results were obtained as follows: 1) In the experimental effects of the Ursi fel and the UDCA on the vascular permeability responses to intradermal Serotonin, though both of the Ursi fel and UDCA revealed the significant effect, the Ursi fel had stronger effect than the UDCA. 2) In the provocative effects of the Ursi fel and the UDCA on the vascular permeability responses to intradermal Histamin, though both of the Ursi powfel and UDCA showed the significant effect, the Ursi fel had moreerful effect than the UDCA. 3) In the 48 hours homologous passive cutaneous anaphylaxis provoked by the IgE-like antibody against white egg albumin, though both of the Ursi fel and UDCA revealed significant effect, the Ursi fel had stronger effect than the UDCA. 4) In the delayed type hypersensitivity response to Picryl Chlorede, though both of the Ursi fel and UDCA were proved to be effective significantly the Ursi fel showed stronger effect. 5) In the delayed type hypersensitivity responses to Sheep red blood cell, the Ursi fel revealed the significant effect, though the UDCA has no significant effect. According to above results, the Ursi fel was approved it could be used widely as antiallergic drug for immediate and delayed type allergic diseases. Although the UDCA revealed efficacy in immediated type allergic diseases, it had less powerful effects than the Ursi fel and it showed no effects in some experiment of delayed type allergy, so it would be difficult to be used clinically.

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Effects of Ijintang-gamibang on the Rat Chronic Cisplatin-induced Delayed Gastrointestinal Motility (Cisplatin 유발 위배출능 지연모델에 대한 이진탕가미방의 효과)

  • Kim, Dae Jun
    • Journal of Physiology & Pathology in Korean Medicine
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    • v.27 no.2
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    • pp.225-232
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    • 2013
  • Delayed gastrointestinal (GI) motility is frequent adverse effect associated with chemotherapy, and induced by serotonin releases from enterochromaffin cells. Ijintang-gamibang (IJG) is a digestive polyherbal formula has been traditionally used in Korea and consisted of 8 types of medicinal herbs. This study was conducted to determine whether or not IJG aqueous extracts can prevent delayed GI motility induced by the antineoplastic drug cisplatin chronically administered, once per week for five consecutive weeks (2 mg/kg). 200, 100 and 50 mg/kg of IJG extracts were orally administered, once a day for 14 days from fourth cisplatin treatment, and the changes in body weight gain, fecal parameters, gastrointestinal transit ratio and histopathology were observed. In addition, pylorus gastrin and serotonin contents were also measured with immunohistochemical observations of enterochromaffin cells contains gastrin and serotonin, as compared with ondansetron, a serotonin 5-HT3 receptor antagonist, 1 mg/kg. Cisplatin treatment related body weight decreases, delayed GI motility, decreases of fecal water contents were significantly and dose-dependently inhibited by oral treatment of IJG extracts, and they also inhibited the pylorus gastrin and serotonin changes induced by cisplatin treatment. The overall effects of IJG 100 mg/kg were similar to that of ondansetron 1 mg/kg. The present results supported that IJG aqueous extracts have favorable ameliorating effect on the delayed GI motility induced by chemotheraphy, modulated the GI enterochromaffin cells, serotonin and gastrin-producing cells with antioxidant effects. This effect of IJG may help improve accompanying gastrointestinal symptoms by chemotherapy.

Effect of Ginseng Total Saponlns on the Development of Acute and Delayed Types Tolerance to Morphine (인삼사포닌이 몰핀의 급만성 내성 형성에 미치는 영향)

  • 김학생;오기완;이명구;최강주;김숙장
    • Journal of Ginseng Research
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    • v.13 no.2
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    • pp.239-241
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    • 1989
  • Naloxone partially antagonized the analgesic effect of a large dose of morphine and inhibited the development of an acute type tolerance. Ginseng total saponins did not antagonize the analgesia of a large dose of morphine but inhibited the delrelopment of acute and delayed types tolerance. The morphine analgesia and the development of acute type tolerance were affected by the opioid receptor antagonist, naloxone, but the development of acute type tolerance was not. Ginseng total saponins partially inhibited the development of the delayed type tolerance that was not inhibited by naloxone, but also partially suppressed the development of the acute type tolerance that was completely inhibited by naloxone. These results imply that the partial inhibition of the development of the acute and delayed types tolerance by ginseng total saponins is not mediated by the opioid receptors.

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Effect of Limestone Powder on Hydration of $C_{3}A-CaSO_{4}$ $\cdot$ $2H_{2}O$ system ($C_3A-CaSO_4\cdot2H_2O$ 계의 수화반응에 미치는 석회석미분말의 영향)

  • Lee Jong-Kyu;Chu Yong-Sik
    • Proceedings of the Korea Concrete Institute Conference
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    • 2005.05b
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    • pp.349-352
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    • 2005
  • In this work, effects of limestone powder on hydration of $C_3A-CaSO_4\cdot2H_2O$ system was discussed based on the XRD Quantitative analysis, and the possibility of Delayed Ettringite Formation was also discussed. The early hydration of $C_{3}A$ was delayed by addition of $CaCO_{3}$ powder. The delay effect was enhanced by increasing of $CaCO_{3}$ content and finer powder of $CaCO_{3}$ addition. After consumption of $CaSO_4\cdot2H_2O$, the reaction of $CaCO_{3}$ is started. Delayed Ettringite Formation would take place because monosulfoaluminate is not stable in presence of $CaCO_{3}$. In order to prevent the delayed ettringite formation in $C_3A-CaSO_4\cdot2H_2O-CaCo_3$ system, the reduction of monosulfoaluminate formation is important. Therefore, by increasing the amount of $CaCO_{3}$ addition and finer $CaCO_{3}$ powder addition, the delayed ettringite formation can be prevented.

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Effect of Non-metallic Inclusions on Heat Affected Zone Delayed Cracking of High Strength Steels by Hydrogen (고장력강 용접열영향부의 지연균열에 미치는 개재물의 영향)

  • 엄동석;정호신;익본공
    • Journal of Welding and Joining
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    • v.7 no.2
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    • pp.49-59
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    • 1989
  • The effect of non-metallic inclusions on the HAZ hydrogen induced cracking was investigated. Quench and temper high tensile strength steels containing various sulphur contents were employed. The sulphur contents range between 0.007% and 0.040%. Non-metallic inclusions were mainly MnS type sylphide and Mn-Al-Si type. The sensitivity of HAZ delayed cracking was evaluated by implant testing. Diffusible hydrogen content was varied by controlling the moisture absorbing condition of manual arc welding electrodes. The one was asreceived condition, the other was dipping the electrodes in the water for ten minutes. The main results obtained were as follows; 1) The results of implant test showed that critical stress increased with increasing S content up to 0.013%. But steel containing 0.040%S showed lower critical stress than that of 0.013% S. These result suggest that there will be optimum S content to prevent HAZ delayed cracking of high strength steels. 2) Under the lower D.H.C. level, critical stress was increased with rolling reduction, but higher D.H.C. level, effect of rolling reduction was not recognized.

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Delayed Anoxic Encephalopathy after Carbon Monoxide Poisoning: Evaluation of Therapeutic Effect by Serial Diffusion-Tensor Magnetic Resonance Imaging and Neurocognitive Test (일산화탄소중독 이후 발생한 지연무산소뇌병증: 확산텐서영상 및 신경인지기능검사를 이용한 치료 효과의 평가)

  • Ryu, Ho-Sung;Kim, Youngwook;Jung, Boo-Kyoung;Kim, Yong-Won
    • Journal of the Korean neurological association
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    • v.36 no.4
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    • pp.358-362
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    • 2018
  • Delayed anoxic encephalopathy after carbon monoxide (CO) poisoning is characterized by neurological deterioration that occurs after recovery from acute CO intoxication. There has been no established therapy. We report a patient recovered from acute CO intoxication developed various neurological symptoms. After the administration of high dose prednisolone and anticholinesterase inhibitor, the therapeutic effect was remarkable and confirmed by quantitative analysis of diffusion-tensor imaging (DTI). DTI could be used to evaluate the therapeutic effect for delayed anoxic encephalopathy after CO poisoning.

The Effect of Stretching and Pre-eccentric exercise on Delayed Onset Muscle Soreness (스트레칭과 사전원심성 운동이 지연성근육통에 미치는 영향)

  • Jeong, Jin-Gyu;Ryu, Seong-Sun;Kim, Yong-Nam;Kang, Jong-Ho;Kim, Su-Hyun;Hwang, Tae-Yeon
    • Journal of the Korean Academy of Clinical Electrophysiology
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    • v.8 no.1
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    • pp.15-22
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    • 2010
  • Purpose : This study examines the effects of pre-eccentric exercise and stretch ing to bicepsbrachii to prevent delayed onset muscle soreness and recovery of muscular function depending on the training intensity with 28 normal adults in their twenties. Methods : The subjects were divided into a control group, a group without any previous eccentric exercise, and a stretching group. Pre-eccentric exercise group conducted exercise with the intensity of 25% of maximal voluntary contraction. Pre-eccentric exercise and stretching was applied before to induce delayed onset muscle soreness and after, 24 hour post, 48 hour post, and 72 hour post. Measurements were conducted to examine pain and muscular function changes before, immediately after, and after inducing delayed onset muscle soreness. After inducing delayed onset muscle soreness, measurements were taken at the 24th hour, 48th hour, and 72nd hour. Results : The pre-eccentric exercise group and stretching group showed a significant difference from the control group by isometric contract ion power and mechanical pain threshold as a result of measuring delayed onset muscle soreness. Conclusion : From these results, electrical stimulation using presynaptic inhibition mechanism of transcutaneous electrical stimulation (TES) had positive effects for walking ability on inhibition of muscle tone in lower extremity. The motor level stimulation group experienced a more significant effect than the sensory level stimulation group. Therefore, the transcutaneous electrical stimulation (TES) is considered to be effective on walking ability increasing through inhibition of muscle tone in lower extremity for rehabilitation of post stroke hemiplegic patients.

Convergence Study on Effects of Passive Stretching on Blood Fatigue and VAS after Delayed Onset Muscle Soreness (지연성근육통 유발 후 수동적 스트레칭이 혈중피로물질 및 VAS에 미치는 융합연구)

  • Kim, Jong-Hyuck;Kim, Do-Jin
    • Journal of Convergence for Information Technology
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    • v.8 no.6
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    • pp.93-99
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    • 2018
  • The purpose of this study was to prove the effect of passive stretching after delayed muscular pain induction in university students and to propose a rehabilitation exercise program for effective pain relief and prevention in case of injury. Subjects were divided into passive stretching group and control group. Passive stretching group was performed passive stretching after delayed muscular pain induction and control group did not perform any treatment after delayed muscular pain induction. The delayed muscular pain induction method was induced by bench step motion. The height of the step box was 50cm. The data were analyzed by two-way RGRM ANOVA for comparison of passive stretching group and control group. In conclusion, passive stretching after delayed myalgia has a positive effect on blood fatigue (CRP, LDH) and subjective pain scale(VAS).

The effects of sales promotion and message framing on purchase intentions: Moderating effect of time pressure (모바일 커머스 환경에서 판매촉진 형태와 메시지 프레이밍이 구매의도에 미치는 영향: 시간압박의 조절효과를 중심으로)

  • Lee, Ho-Seong;Suh, Kil-Soo;Kang, Hyun-Jeong
    • The Journal of Information Systems
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    • v.28 no.4
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    • pp.251-270
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    • 2019
  • Purpose Unlike advertising through the traditional media targeting unspecified number of people, the base of mobile environment using smartphone has expanded so that many companies can classify prospective customers according to their purpose, thereby enabling efficient targeted marketing with low cost. Design/methodology/approach This study has investigated how can marketing strategy be influenced by the price promotion type (immediate discount/delayed discount) and message framing (positive/negative) according to time pressure (low/high). Hypotheses are set through the consideration of prospect theory, endowment effect, framing effect, regulatory-focus theory, and time-pressure theory. Findings The results and interpretation of this study are as follows. First, it was found that the influence of the delayed discount on the purchase intention was larger than the immediate discount. Second, negative/loss frame messages have more influence on purchase intention than positive/profit frame messages. Third, when the price promotion type is delayed discount, the effect of the promotion message on the purchase intention when it presented by negative/loss frame is greater than the other cases. The implication of this study is that it can be used as a basic data for establishing a strategy to maximize the effectiveness of promotions effectively considering potential buyers of mobile commerce environment.