• Transactions of the Korean Society of Mechanical Engineers B
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• v.27 no.3
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• pp.326-333
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• 2003

In the measurement using DMA and CPC in series, there is some time delay for particles classified in DMA to detect in CPC. During this time, the DMA time-response changes due to the velocity profile of sampling tube and the diffusion of particles in the volume that exists between the DMA exit and the detector of ultra-fine CPC. This is called mixing effect. In the accelerated measurement methods like the TSI -SMPS, the size distribution is obtained from the correlation between the time-varying electrical potential of the DMA and the corresponding particle concentrations sampled in DMA. If the DMA time -response changes during this delay time, this can cause the error of a size distribution measured by this accelerated technique. The kernel function considering this mixing effect using the residence time distribution is proposed by Russell et al. In this study, we obtained a size distribution using this kernel to compare to the result obtained by the commercial accelerated measurement system, TSI -SMPS for verification and considered the errors that result from the mixing effect with the geometric mean diameters of originally sampled particles, using virtually calculated responses obtained with this kernel as input data.

• Journal of Biomedical Engineering Research
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• v.19 no.3
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• pp.321-325
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• 1998

This paper presents a simple, practical, and efficient method for estimating the speed of sound in reflection mode in ultrasound medical imaging. Its accurate determination is indispensable in order to obtain both good resolution and correct geometrical and volumetric information about human organs such as heart and kidney. Up to now, there have been several methods available, but they all suffer from either poor performance or high complexity. The proposed method finds out an optimum focusing delay profile in such a way that the brightness in a region of interest is maximized using continuous dynamic focusing in receive under fixed transmit focusing. Experiments carried out on a real ultrasound medical phantom reveals that the method a quite simple and effective in providing good speed of sound estimation, hence improved resolution and images, adding to dignostic utility.

• Journal of the Korean Society for Nondestructive Testing
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• v.30 no.6
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• pp.569-577
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• 2010

Nonplanar surface geometries of components are frequently encountered in real ultrasonic inspection situations. Use of rigid array transducers can lead to beam defocusing and reduction of defect image quality due to the mismatch between the planar array and the changing surface. When a flexible array is used to fit the complex surface profile, the locations of array elements should be known to compute the delay time necessary for adaptive heam focusing. An alternative method is to employ the time reversal focusing technique that does not require a prior knowledge about the properties and structures of the specimen and the transducer. In this paper, a time reversal method is applied to simulate beam focusing of flexible arrays and imaging of point-like defects contained in specimens with nonplanar surface geometry. Quantitative comparisons are made for the performance of a number of array techniques in terms of the ability to focus and image three point-like reflectors positioned at regular intervals. The sinusoidal profile array studied here exhibits almost the same image quality as the flat, reference case.

• Toxicological Research
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• v.17
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• pp.59-69
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• 2001

Arsenic exposure is associated with several human diseases, including cancers, atherosclerosis, hypertension, and cerebrovascular diseases. In cultured cells, arsenite, an inorganic arsenic com-pound, was demonstrated to interfere with many physiological functions, such as enhancement of oxidative stress, delay of cell cycle progression, and induction of structural and numerical changes of chromosomes. The objective of this study is to investigate the effects of arsenic exposure on gene expression profiles by colorimetric cDNA microarray technique. HFW (normal human diploid skin fibroblasts), CL3 (human lung adenocarcinoma cell line), and HaCaT (immortalized human keratinocyte cell line) were treated with 5 $\mu\textrm{M}$ or 10 $\mu\textrm{M}$ sodium arsenite for 6 or 16 h, respectively. By a dual-color detection system, the expression profile of arsenite-treated cultures was compared to that of control cultures. Several genes expressed differentially were identified on the microarray membranes. For example, MDM2, SWI/SNF, ubiquitin specific protease 4, MAP3K11, RecQ protein-like 5, and Ribosomal protein Ll0a were consistently induced in all three cell types by arsenite, whereas prohibitin, cyclin D1, nucleolar protein 1, PCNA, Nm23, and immediate early protein (ETR101) were apparently inhibited. The present results suggest that arsenite insults altered the expression of several genes participating in cellular responses to DNA damage, stress, transcription, and cell cycle arrest.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.30 no.11 s.254
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• pp.1027-1034
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• 2006

In order to investigate flow characteristics of chicken blood in a micro tube of 100$\mu$m in diameter, in-vitro experiments were carried out using a micro-PIV technique. The micro-PIV system consists of a microscope, 2-head Nd:YAG laser, 12 bit cooled CCD camera and a delay generator. Chicken blood with 40% hematocrit was supplied into a micro tube using a syringe pump. The blood flow shows clearly the cell free layer near the tube wall and its thickness is increased with increasing the flow speed. The hemorheological characteristics of chicken blood, including shear rate and shear stress were estimated from the PIV velocity field data obtained. Since the aggregation index of chicken blood is less than 50% of human blood, non-Newtonian flow characteristics of chicken blood are smaller than those of human blood. As the flow rate increases, the degree of flatness in the velocity profile at the center region is decreased and the parabola-shaped shear stress distribution becomes to have a linear profile. Under the same flow rate, chicken blood shows higher shear stress, compared with human blood.

• International Journal of Precision Engineering and Manufacturing
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• v.2 no.4
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• pp.5-11
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• 2001

Vibration and noise of gears is doc to the transmission error and the vibration exciting force caused by the periodically alternating tooth stiffness. Transmission error is the rotation delay between driving and driven gear caused by manufacturing error, alignment error in assembly and so on. Tooth stiffness changes with the proceeding mesh of teeth. The purpose of this study is to develop how to calculate simultaneously the optimum amounts of tooth profile modification. end relief and crowning by minimizing the vibration exciting force of helical gears. We estimate the vibration exciting force by the meshing analysis of gears. Formulated constraints of this problem consist of contact ratio and strengths of gear teeth such as tooth bending strength, surface durability, and scoring. ADS(Automated Design Synthesis) is used as an optimization tool. We also investigate the relation between the aspect ratio and the optimum values of tooth modification. The proposed method can calculate the optimum amount of tooth modification automatically and is expected to be practically useful to resolve the problem of vibration of helical gears.

• Current Optics and Photonics
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• v.2 no.3
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• pp.233-240
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• 2018

We proposed a two-mode fiber (TMF) design that can effectively reduce the mode overlap between $LP_{01}$ and $LP_{11}$ modes by using a W-shaped index profile core structure, which is a primary concern in uncoupled mode division multiplexing (MDM). TMF has a three-layered core structure; central circular core, inner cladding, and outer ring core. We confirmed that in an optimal structure the $LP_{01}$ mode was highly confined to the central core while the $LP_{11}$ mode was guided along the outer ring core to result in a minimum overlap integral. We used a full-vectorial finite element method to estimate effective index, differential group delay (DGD), confinement loss, chromatic dispersion, and mode overlap controlling the parameters of the W-shaped structure. The optimized W-profile fiber provided optical characteristics within the ITU-T recommended standards over the entire C+L band.

• 한국가시화정보학회:학술대회논문집
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• 2006.12a
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• pp.111-112
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• 2006

In order to investigate flow characteristics of blood flow in a micro tube ($100{\mu}m$ in diameter) according to hematocrit, in-vitro experiments were carried out using a micro-PIV technique. The micro-PIV system consists of a microscope, a 2 head Nd:YAG laser, a 12 bit cooled CCD camera and a delay generator. Blood was supplied into the micro tube using a syringe pump. Hematocrit of blood was controlled to be 20%, 30% and 40%. The blood flow has a cell free layer near the tube wall and its thickness was changed with increasing the flow rate and hematocrit. The hemorheological characteristics such as shear rate and viscosity were evaluated using the velocity field data measured. As the flow rate increased, the blunt velocity profile in the tube center was sharpened. The viscosity of blood was rapidly increased with decreasing shear rate, especially in the region of low shear rate, changing RBC rheological properties. The variation of velocity profile and blood viscosity shows typical characteristics of Non-Newtonian fluids. On the basis of inflection points, the cell free layer and two-phase flow consisting of plasma and suspensions including RBCs were clearly discriminated.

• Journal of the Korean Society for Precision Engineering
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• v.17 no.11
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• pp.199-205
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• 2000

The vibration and noise of gears is due to the vibration exciting force caused by the tooth stiffness which changes periodically as the mesh of teeth proceeds and by the transmission error, that is, the rotation delay between driving gear and driven gear caused by manufacturing error and alignment error in assembly and so on. The purpose of this study is to develop how to calculate simultaneously the optimum amounts of tooth profile modification, end relief and crowning by minimizing the vibration exciting force of helical gears. We estimate the vibration exciting force by the mesh analysis of gears. The constraints of this problem consist of contact ratio and strengths of gear teeth such as tooth fillet stress, surface durability and scoring. ADS(Automated Design Synthesis) is used as an optimization tool. And, since the aspect ratio is an important parameter of tooth modification, we investigate the relation between it and the optimum values of tooth modification. The proposed method can calculate the optimum amount of tooth modification automatically and is to be utilized to resolve the problem of vibration of helical gears.

• Journal of Information Science Theory and Practice
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• v.3 no.2
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• pp.16-30
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• 2015

The term megajournal is used to describe publication platforms, like PLOS ONE, that claim to incorporate peer review processes and web technologies that allow fast review and publishing. These platforms also publish without the constraints of periodic issues and instead publish daily. We conducted a yearlong bibliometric profile of a sample of articles published in the first several months after the launch of PeerJ, a peer reviewed, open access publishing platform in the medical and biological sciences. The profile included a study of author characteristics, peer review characteristics, usage and social metrics, and a citation analysis. We found that about 43% of the articles are collaborated on by authors from different nations. Publication delay averaged 68 days, based on the median. Almost 74% of the articles were coauthored by males and females, but less than a third were first authored by females. Usage and social metrics tended to be high after publication but declined sharply over the course of a year. Citations increased as social metrics declined. Google Scholar and Scopus citation counts were highly correlated after the first year of data collection (Spearman rho = 0.86). An analysis of reference lists indicated that articles tended to include unique journal titles. The purpose of the study is not to generalize to other journals but to chart the origin of PeerJ in order to compare to future analyses of other megajournals, which may play increasingly substantial roles in science communication.