• Title/Summary/Keyword: Degradation of meaning

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A Study on the Relationship of Change of Mechanical Properties and Carbonyl Index Induced through Short-wavelength Ultraviolet Radiation (254 nm) for High Density Polyethylene (단파장 자외선(254 nm)에 노출된 고밀도 폴리에틸렌 수지의 카르보닐 지수(CI)와 기계적 물성 변화의 관계에 관한 연구)

  • Kim, Chang-Hwan;Shin, Jin-Yong
    • Applied Chemistry for Engineering
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    • v.24 no.2
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    • pp.138-143
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    • 2013
  • This paper studied the possibility to predict a mechanical property variation from changes in created carbonyl bands by irradiating the surface of high-density polyethylene with short-wavelength ultraviolet radiation of 254 nm to induce a fast chemical degradation. The meaning of this study lies in checking whether a mechanical property change with the same chemical property as the induced optical deterioration is caused by using a UVC lamp with high photon energy instead of optical deterioration via xenon arc light source and outdoor exposure test via natural sunlight requiring a long time. The mechanical strength of high-density polyethylene checked by a tensile test and a creep destruction test showed a similar tendency with CI changes. In particular, the yield strength and elongation had a close relationship with the exposure time to ultraviolet radiation. Accordingly, this paper presented a method to grasp the mechanical property change outdoors requiring a long time more fast through the relationship between the mechanical property change and the carbonyl index using a UVC lamp causing the fast surface degradation.

Biphasic Activity of Chloroquine in Human Colorectal Cancer Cells

  • Park, Deokbae;Lee, Youngki
    • Development and Reproduction
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    • v.18 no.4
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    • pp.225-231
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    • 2014
  • Autophagy is a homeostatic degradation process that is involved in tumor development and normal development. Autophagy is induced in cancer cells in response to chemotherapeutic agents, and inhibition of autophagy results in enhanced cancer cell death or survival. Chloroquine (CQ), an anti-malarial drug, is a lysosomotropic agent and is currently used as a potential anticancer agent as well as an autophagy inhibitor. Here, we evaluate the characteristics of these dual activities of CQ using human colorectal cancer cell line HCT15. The results show that CQ inhibited cell viability in dose- and time-dependent manner in the range between 20 to 80 uM, while CQ did not show any antiproliferative activity at 5 and 10 uM. Cotreatment of CQ with antitumor agent NVP-BEZ235, a dual inhibitor of PI3K/mTOR, rescued the cell viability at low concentrations meaning that CQ acted as an autophagy inhibitor, but CQ induced the lethal effect at high concentrations. Acridine orange staining revealed that CQ at high doses induced lysosomal membrane permeabilization (LMP). High doses of CQ produced cellular reactive oxygen species (ROS) and cotreatment of antioxidants, such as NAC and trolox, with high doses of CQ rescued the cell viability. These results suggest that CQ may exert its dual activities, as autophagy inhibitor or LMP inducer, in concentration-dependent manner.

Towards robust viscoelastic-plastic-damage material model with different hardenings/softenings capable of representing salient phenomena in seismic loading applications

  • Jehel, Pierre;Davenne, Luc;Ibrahimbegovic, Adnan;Leger, Pierre
    • Computers and Concrete
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    • v.7 no.4
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    • pp.365-386
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    • 2010
  • This paper presents the physical formulation of a 1D material model suitable for seismic applications. It is written within the framework of thermodynamics with internal variables that is, especially, very efficient for the phenomenological representation of material behaviors at macroscale: those of the representative elementary volume. The model can reproduce the main characteristics observed for concrete, that is nonsymetric loading rate-dependent (viscoelasticity) behavior with appearance of permanent deformations and local hysteresis (continuum plasticity), stiffness degradation (continuum damage), cracking due to displacement localization (discrete plasticity or damage). The parameters have a clear physical meaning and can thus be easily identified. Although this point is not detailed in the paper, this material model is developed to be implemented in a finite element computer program. Therefore, for the benefit of the robustness of the numerical implementation, (i) linear state equations (no local iteration required) are defined whenever possible and (ii) the conditions in which the presented model can enter the generalized standard materials class - whose elements benefit from good global and local stability properties - are clearly established. To illustrate the capabilities of this model - among them for Earthquake Engineering applications - results of some numerical applications are presented.

A study of TV Animation broadcasting for system circumference by an unguarded position and lose (TV animation 총량제에 의한 외주제작 시스템의 허와 실에 대한 방향 연구)

  • Kim, Jae-ho
    • Journal of Science of Art and Design
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    • v.11
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    • pp.37-49
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    • 2007
  • TV animation has come a long way to this date since popular animation programs were aired on TV, such as 'Run Little Tiger', 'Run Honey', 'Hurry-Scurry Yeongsimi', beginning with 'Wandering Magpie' on KBS in 1978. However, problematic production process has resulted in the degradation of quality. Consequently, the dwindling viewing rate forced animation advertisers to leave, and the animation production shrank. Under those unfavorable circumstances, the government started to heed messages transmitted from animation producers and went ahead with the 'animation broadcasting quota' in a bid to help revitalize Korean animation industry. This study aimed to identify problems and set the direction for the animation industry by analyzing its fundamental and structural problems.

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A Study on Corrosion Properties of Reinforced Concrete Structures in Subsurface Environment (지중 환경하에서의 철근콘크리트 구조물의 부식 특성 연구)

  • Kwon, Ki-jung;Jung, Haeryong;Park, Joo-Wan
    • The Journal of Engineering Geology
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    • v.26 no.1
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    • pp.79-85
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    • 2016
  • A concrete silo plays an important role in subsurface low- and intermediate-level waste facilities (LILW) by limiting the release of radionuclides from the silo geosphere. However, due to several physical and chemical processes the performance of the concrete structure decreases over time and consequently the concrete loses its effectiveness as a barrier against groundwater inflow and the release of radionuclides. Although a number of processes are responsible for degradation of the silo concrete, it is determined that the main cause is corrosion of the reinforcing steel. Therefore, the time it takes for the silo concrete to fail is calculated based on two factors: the initiation time of corrosion, defined as the time it takes for chloride ions to penetrate through the concrete cover, and the propagation time of corrosion. This paper aims to estimate the time taken for concrete to fail in a LILW disposal facility. Based on the United States Department of Energy (DOE) approach, which indicates that concrete fails completely once 50% of the volume of the reinforcing steel corrodes, the corrosion propagation time is calculated to be 640 years, which is the time it takes for corrosion to penetrate 0.640 cm into the reinforcing steel. In addition to the corrosion propagation time, a diffusion equation is used to calculate the initiation time of corrosion, yielding a time of 1284 years, which post-dates the closure time of the LILW disposal facility if we also consider the 640 years of corrosion propagation. The electrochemical conditions of the passive rebar surface were modified using an acceleration method. This is a useful approach because it can reduce the test time significantly by accelerating the transport of chlorides. Using instrumental analysis, the physicochemical properties of corrosion products were determined, thereby confirming that corrosion occurred, although we did not observe significant cracks in, or expansion of, the concrete. These results are consistent with those of Smartet al., 2006 who reported that corrosion products are easily compressed, meaning that cracks cannot be discerned by eye. Therefore, it is worth noting that rebar corrosion does not strongly influence the hydraulic conductivity of the concrete.

Adsorption Characteristics of Natural Powdered Oil Absorbent for Marine Oil Pollution (해양오염제거용 천연분말상 유흉착재의 흡착 특성에 관한 연구)

  • 김인수;이진석;김동근;고성정
    • Journal of the Korean Society of Marine Environment & Safety
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    • v.7 no.1
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    • pp.7-14
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    • 2001
  • The amount of petroleum consumption has been Increased according to the industrialization and It leads to the increase of the possibility of marine oil pollution. In Korea, some countermeasures including oil skimmer, gelling agent and herding agent of oil have been used for the remediation of the pollution. However, most of them have lets of shortcomings in the application under in-situ condition, because they are sensitive to the situation such as geographical feature, the wind and the tide. In reported literature, the natural powdered oil absorbent which is made of peat moss is an effective mean to clean spilled oil from lake or coast. However, the peat moss is a natural resource which is only Produced from a specific cold weather are like Canada. This indicates that the alternative materials which is readily obtained from everywhere are needed for powdered oil absorbent. Therefore. in the study, same natural materials including pine leaves and straw are tested as the alternative materials for the absorbent. The raw materials were dried and treated by heat at various temperature during several Periods and then. shattered by a grain cracking machine. The oil sorption capacity of the prepared materials was compared according to the methods of heat treatment and their sizes. The proportion of hydrogen cyanide to combustion of the absorbents was measured to confirm their final disposal methods. The biodegradability test of the absorbents was carried our to evaluate possibility of a side pollution in the coast. In was found that the heat treatment of pine leaves enhanced the capacity of oil sorption and decreased the water sorption. The maximum oil sorption was observed for the material treated at 18$0^{\circ}C$for 60 min. The amount of hydrogen cyanide from the combustion were 0.09ml/g, 0.07ml/g for pine leaves and straw respectively meaning that the final disposal by combustion might be feasible. The amount or organic carbon extracted from pine leaves during 7 days was up to 0.015g organic carbon from one gram of pine leaves. but the degradation was as fast as for glucose. It is concluded that the pine leaves can be served as a good raw material for the powdered oil absorbent like peat moss.

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A Comparison between the Performance Degradation of 3T APS due to Radiation Exposure and the Expected Internal Damage via Monte-Carlo Simulation (방사선 노출에 따른 3T APS 성능 감소와 몬테카를로 시뮬레이션을 통한 픽셀 내부 결함의 비교분석)

  • Kim, Giyoon;Kim, Myungsoo;Lim, Kyungtaek;Lee, Eunjung;Kim, Chankyu;Park, Jonghwan;Cho, Gyuseong
    • Journal of Radiation Industry
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    • v.9 no.1
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    • pp.1-7
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    • 2015
  • The trend of x-ray image sensor has been evolved from an amorphous silicon sensor to a crystal silicon sensor. A crystal silicon X-ray sensor, meaning a X-ray CIS (CMOS image sensor), is consisted of three transistors (Trs), i.e., a Reset Transistor, a Source Follower and a Select Transistor, and a photodiode. They are highly sensitive to radiation exposure. As the frequency of exposure to radiation increases, the quality of the imaging device dramatically decreases. The most well known effects of a X-ray CIS due to the radiation damage are increments in the reset voltage and dark currents. In this study, a pixel array of a X-ray CIS was made of $20{\times}20pixels$ and this pixel array was exposed to a high radiation dose. The radiation source was Co-60 and the total radiation dose was increased from 1 to 9 kGy with a step of 1 kGy. We irradiated the small pixel array to get the increments data of the reset voltage and the dark currents. Also, we simulated the radiation effects of the pixel by MCNP (Monte Carlo N-Particle) simulation. From the comparison of actual data and simulation data, the most affected location could be determined and the cause of the increments of the reset voltage and dark current could be found.

DNA Single Strand Breaks of Perchloroethylene and Its Bio-degradation Products by Single Cell Gel Electrophoresis Assay in Mammalian Cell System

  • Jeon, Hee-Kyoung;Kim, Young-Seok;Sarma, Sailendra Nlath;Kim, Youn-Jung;Sang, Byoung-In;Ryu, Jae-Chun
    • Molecular & Cellular Toxicology
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    • v.1 no.2
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    • pp.99-105
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    • 2005
  • Perchloroethylene (tetrachloroethylene, PCE), a dry cleaning and degreasing solvent, can enter ground-water through accidental leak or spills. PCE can be degraded to trichloroethylene (TCE), 1, 1-dichloroethylene (DCE) and vinyl chloride (VC) as potential bio-product. These compounds have been reported that they can cause clinical diseases and cytotoxicity. However, only a little genotoxic information of these compounds has been known. In this study, we investigated DNA single strand breaks of PCE, TCE, DCE and VC by single cell gel electrophoresis assay, (comet assay) which is a sensitive, reliable and rapid method for DNA single strand breaks with mouse lymphoma L5178Y cells. From these results, $37.5\;{\mu}g/ml$ of PCE, $189\;{\mu}g/ml$ of TCE and $56.4\;{\mu}g/ml$ of DCE were revealed significant DNA damages in the absence of S-9 metabolic activation system meaning direct-acting mutagen. And in the presence of S-9 metabolic activation system, $41.5\;{\mu}g/ml$ of PCE, $328.7\;{\mu}g/ml$ of TCE and $949\;{\mu}g/ml$ of DCE were induced significant DNA damage. In the case of VC, it was revealed a significant DNA damage in the presence of S-9 metabolic activation system. Therefore, we suggest that chloroethylene compounds (PCE, TCE, DCE and VC) may be induced the DNA damage in a mammalian cell.

A study of how to guarantee an income policy for old people in an aging society (고령화 사회의 노인 소득보장정책에 관한 연구)

  • Kim Jae-Wan
    • Management & Information Systems Review
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    • v.16
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    • pp.139-159
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    • 2005
  • In many countries the demographics clearly informs us that an aging population represent a serious problem. To this extent senior citizens welfare does matter it has developed into a public debate and genuine concern. it seems that the social issues are focused on how the socity views the social welfare policies. In a modern welfare state where the emphasis lies in pursing a high standard of living and thereby high quality of life. This does not cover the very well the old people in society, but the government clearly carries an obligation to look after and care for the retired & old people in the society. This obligation the social and economic impact that an old person faces as he/she grows old. it is important ensure that their lives carries a meaning and that they as a group will not be estranged from the mainstream of society just because they are considered to be part of the aging population. The key issues that must be addressed are 1) The impact of reduced spending power from less income. a lower income stream; 2) increasing health problems and costs; 3) the natural degradation of ones physical & mental powers; 4) and thereby an isolation from the public in general. So clearly the social policy related to the old people in society should be developed with the consent of what they believe is important to them. To ensure their minimum income level that a beneficiary of an old person's pension will receive, the monthly pension should be reflected by the official price index and be adjusted accordingly. by making the job market open for the senior citizens, expending the mandatory retirement age, give companiesincentives to hire senior citizens, there maybe an opportunity to extend to the aging population the possibility to continue to participate in the society at large.

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Critical Discourse Analysis on Drug Addiction (마약 중독에 대한 비판적 담론 분석)

  • Shin, Seon-Hee
    • The Journal of the Korea Contents Association
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    • v.22 no.9
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    • pp.712-726
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    • 2022
  • The purpose of this study is to find out what discourse the newspaper's articles produce and distribute about 'drug addiction' and to reveal the topography and meaning of the discourse. Data were collected by searching 'drug' 'drug addiction' as keywords for news articles in four daily newspapers in Korea. As a result of analyzing using Norman Fairclough's critical discourse analysis, first, the 'crime-punishment' discourse was dominant in textual analysis. Drug addiction is a social evil and a serious crime such as sex crimes, child crimes, and violence, so it should be strictly punished. Second, in the discourse practice analysis, drug addiction is a mental disease that needs treatment, so systematic management by the state is required. Third, in the socio-cultural practice analysis, drug addiction is a means of making money for economic benefit, is related to corruption of political power, and is an object that should be strongly controlled to prevent drug crimes from threatening the foundation of the state. Culturally, drug addiction stems from the motivation of pleasure seeking, and is the result of moral degradation. Through this analysis, the conversion to the 'disease-treatment' discourse and drug policies centered on treatment and rehabilitation were suggested as alternatives.