• Molecules and Cells
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• v.38 no.6
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• pp.540-547
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• 2015

Attention deficit/hyperactivity disorder (ADHD) is one of the most common neurodevelopmental disorders, affecting approximately 5% of children. However, the neural mechanisms underlying its development and treatment are yet to be elucidated. In this study, we report that an ADHD mouse model, which harbors a deletion in the Git1 locus, exhibits severe astrocytosis in the globus pallidus (GP) and thalamic reticular nucleus (TRN), which send modulatory GABAergic inputs to the thalamus. A moderate level of astrocytosis was displayed in other regions of the basal ganglia pathway, including the ventrobasal thalamus and cortex, but not in other brain regions, such as the caudate putamen, basolateral amygdala, and hippocampal CA1. This basal ganglia circuit-selective astrocytosis was detected in both in adult (2-3 months old) and juvenile (4 weeks old) $Git1^{\check{s}/\check{s}}$ mice, suggesting a developmental origin. Astrocytes play an active role in the developing synaptic circuit; therefore, we performed an immunohistochemical analysis of synaptic markers. We detected increased and decreased levels of GABA and parvalbumin (PV), respectively, in the GP. This suggests that astrocytosis may alter synaptic transmission in the basal ganglia. Intriguingly, increased GABA expression colocalized with the astrocyte marker, GFAP, indicative of an astrocytic origin. Collectively, these results suggest that defects in basal ganglia circuitry, leading to impaired inhibitory modulation of the thalamus, are neural correlates for the ADHD-associated behavioral manifestations in $Git1^{\check{s}/\check{s}}$ mice.

• Journal of environmental and Sanitary engineering
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• v.18 no.2
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• pp.60-66
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• 2003

This study was carried out to elucidate the preventive mechanism of molybdenum on lead-induced neuropathy, An animal model of lead neuropathy was induced by feeding diet containing lead to Sprague-Dawley rat for three weeks. Four weeks aged Sprague-Dawley rats were divided into four groups : normal control group, 10ppm-lead treated group, 1mg/kg-molybdenum treated group, 10ppm-lead and 1mg/kg-molybdenum treated group. The parameters on neuropathy were examined by measuring concentration of myo-inositol and myo-inosito uptake in sciatic nerve. In the lead-treated rats, myo-inositol concentration and myo-inositol uptake rate were reduced by from 54% to 33% respectively. This deficit results from that myo-inositol uptake system which is carrier mediated and sodium-potassium dependent was inhibited by the lead treatment. However, the molybdenum administration significantly eliminated the impairment and maintained myo-inositol concentration to about 82% of normal level. These results suggest that lead-induced neurotoxicity was significantly reduced by administration of molybdenum and the mechanism might be partly normalization of myo-inositol uptake system in sciatic nerve.

• Journal of Physiology & Pathology in Korean Medicine
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• v.16 no.2
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• pp.279-288
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• 2002

This research investigates the effect of the Crataegus pinnatifida BGE. var. major N.E. BR(CPVM) on Alzheimer's disease. The CPVM extract suppressed the expression of IL-1 β, IL-6, APP, AChE mRNA in PC-12 cells treated with CT105. The CPVM extract suppressed the AChE activity, and the production of APP significantly in PC-12 cells treated with CT105. The CPVM extract group showed a significant inhibitory effect on the memory deficit for the mice with Alzheimer's disease induced by CT105 in the Morris water maze experiment. The CPVM extract suppressed the over-expression of IL-1 β, TNF- α and ROS in the mice with Alzheimer's disease induced by CT105. This study suggests that CPVM may be effective for the prevention and treatment of Alzheimer's disease.

• Journal of Physiology & Pathology in Korean Medicine
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• v.18 no.6
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• pp.1795-1804
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• 2004

This research investigated the effect of the Chaenomelis fructus(CMF) on Alzheimer's disease. The effects of the CMF extract on the behavior in the Morris water maze experiment; the expression of IL-1β, TNF-α, ROS on the microglial cell; IL-1β mRNA, TNF-α mRNA, CD68/GFAP and MDA on the brain tissue; the infarction area of the hippocampus, and brain tissue injury in the mice with Alzheimer's disease induced by βA were investigated. The CMF extract group showed a significant inhibitory effect on the memory deficit on the mice with Alzheimer's disease induced by βA in the Morris water maze experiment. The CMF extract group suppressed the over-expression of IL-1β, TNF-α, IL-1β and TNF-α mRNA, ROS, MDA, CD68/GFAP in the mice with Alzheimer's disease induced by βA. The CMF extract reduced the infarction area of hippocampus, and controlled the injury of brain tissue in the mice with Alzheimer's disease induced by [3A. This study suggest that CMF may be effective for the prevention and treatment of Alzheimer's disease.

• Proceedings of the Korea Water Resources Association Conference
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• 2009.05a
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• pp.641-646
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• 2009

This study examines the effects of water shortage on agricultural wages in Northwest Bangladesh. For this study, meteorological data including information on the monthly temperature, precipitation, wind speed, hour of sunshine and humidity of six weather stations have been utilized during the monitoring period from 1985 to 2005. With the objective to analyze water surplus and water deficiency, a simple soil-water balance model and the modified Penman formula were applied to the Northwest Bangladesh. The seasonality of Mann-Kendell trend statistics has been used to identify the spatial variation of water surplus and deficiency throughout the region. For micro level verification of the result, a detailed field survey has been conducted within the study area. The results showed that the values of the potential evapotranspiration estimated by the modified Penmen equation were negative for certain periods. In this instance, the water deficiency of the district of Rajshahi was observed significantly in the period of pre-monsoon and post-monsoon. The field study also verified that because of such deficiency in water, the agricultural scenario of the area was widely influenced which lead to less agricultural production and less economic benefits.

• Proceedings of the Korean Society for Emotion and Sensibility Conference
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• 2003.05a
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• pp.94-100
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• 2003

Patients with schizophrenia have thinking disorders such as delusion or hallucination, because they have a deficit in the ability which to systematize and integrate information. Therefore, they cannot integrate or systemize visual, auditory and tactile stimuli. In this study we suggest a virtual reality system for the assessment of cognitive ability of schizophrenia patients, based on the brain multimodal integration model. The virtual reality system provides multimodal stimuli, such as visual and auditory stimuli, to the patient, and can evaluate the patient's multimodal integration and working memory integration abilities by making the patient interpret and react to multimodal stimuli, which must be remembered for a given period of time. The clinical study showed that the virtual reality program developed is comparable to those of the WCST and the SPM.

• Journal of environmental and Sanitary engineering
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• v.11 no.2
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• pp.21-26
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• 1996

In our previous studies, we reported that lead intoxicated nerve cell by inhibition of the Na$^{+}$-K$^{+}$ ATPase activity and reduction of myo-inositol in nerve cell. As the second series of experiments, in order to understand toxic mechanism of lead for nerve cell, the characteristics of myo-inositol transport system and the effect of lead on its system have been studied in the sciatic nerves of control and lead-treated rats. A lead intoxicated animal model was induced by feeding diet containing lead to Sprague-Dawley rat for two weeks. Four weeks aged Sprague-Dawley rats were divided into three group : normal control group, 10ppm-lead treated group, 100ppm-lead treated group. All rats were sacrified at the end of two weeks. The rate o myo-inositol transport by sciatic nerve isolated from lead-treated rat was significantly decreased compared with that of control rat. This deficit results from that myo-inositol transport system which is carrier mediated and sodium-potassium dependent was inhibited by the lead treatment (both 10ppm and 100ppm) due to increase of the Km value without affecting Vmax value for myo-inositol carrier. These observations suggest that the toxic mechanism of lead on nerve myo-inositol transport system might be a change of affinity without change of maximum transport velocity for carrier.

• 한국신재생에너지학회:학술대회논문집
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• 2011.05a
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• pp.59.2-59.2
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• 2011

Although there are many activities on the construction of wind farm to produce amount of power from the wind, in practice power productions are not as much as its expected capabilities. This is because a lack of both the prediction of wind resources and the aerodynamic analysis on turbines with far wake effects. In far wake region, there are velocity deficits and increases of the turbulence intensity which lead to the power losses of the next turbine and the increases of dynamic loadings which could reduce system's life. The analysis on power losses and the increases of fatigue loadings in the wind farm is needed to prevent these unwanted consequences. Therefore, in this study velocity deficits have been predicted and aerodynamic analysis on turbines in the far wake is carried out from these velocity profiles. Ainslie's eddy viscosity wake model is adopted to determine a wake velocity and aerodynamic analysis on wind turbines is predicted by the numerical methods such as blade element momentum theory(BEMT) and vortex lattice method(VLM). The results show that velocity recovery is more rapid in the wake region with higher turbulence intensity. Since the velocity deficit is larger when the turbine has higher thrust coefficient, there is a huge aerodynamic power loss at the downstream turbine.

• Research in Community and Public Health Nursing
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• v.12 no.2
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• pp.317-328
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• 2001

The purposes of this study were to develop the empowerment education program, to describe the experiences of diabetes patient's empowerment process and to develop a theoretical model of the diabetes patient's empowerment process. Method 1. : The development of the empowerment program for the diabetes patients: The strategies of the empowerment education program were enhancement of problem - solving, decision making, self-efficacy, self-control. participation and mutual support. Method 2. : According to the grounded theory methodology of Strauss and Corbin, the qualitative data was collected with in depth interviews and participants observations until its saturation when the 25 consented subjects were participating and interacting with the other subjects in the empowerment education program. Results: With the analysis of the data, 29 categories were generated. The core category generated, which was a central phenomenon of the empowerment process, was named powerlessness. The intervening conditions facilitating or impeding the empowerment process were discovered as supportive systems through the participation of group meeting, problem solving dialogue, and the knowledge deficit of self-care. The action/interaction strategies were developed as the paricipating, dialoguing, questioning, supporting system, self-controlling, self efficacy, enhancing self-esteem. stress relaxing and instillation of hope.

• Asian Pacific Journal of Cancer Prevention
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• v.13 no.4
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• pp.1159-1166
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• 2012

Research on radiation oncologists has indicated that there is a shortage in supply of specialist workers in this field internationally, and also within Australia. However, there are no current estimates as to what the future Australian radiotherapy workforce will look like. This paper aims to review the current status and capacity of the three main disciplines that make up the radiation oncology workforce in Australia and project the workforce supply and demand for 2014 and 2019. Using data on the workforce from a survey of all radiotherapy facilities operating in Australia in 2008 a workforce model was constructed. This study found that there will be a future shortfall of radiation oncologists, radiation therapists and radiation oncology medical physicists working in radiation oncology treatment. By 2014 there will be 109 fewer radiation oncologists than what will be demanded, and by 2019 this figure will increase to a shortfall of 155 radiation oncologists. There was a projected shortfall of 612 radiation therapists by 2014, with this figure slightly decreasing to a shortfall of 593 radiation therapists in 2019. In 2014, there was projected to be a deficit of 104 radiation oncology medical physicists with a persisting shortfall of 78 in 2019. This future projected shortage highlights the need for radiation oncology workforce planning.