• 원예과학기술지
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• 제33권5호
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• pp.625-632
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• 2015

Drought is a severe abiotic stress that affects global crop production. A drought model was created for 'Toyonoka' Fragaria ${\times}$ ananassa, and the effects of drought stress on contents of proline, sugars, and antioxidant enzyme activities were investigated. Strawberry transplants with identical growth were chosen for the experiments and the randomized design included four replications (10 plants per block). The experimental sets differed in the moisture level of the culture medium relative to the range of moisture content as follows: control, 70-85%; mild drought stress, 50-60%; moderate drought stress, 40-50%; and severe drought stress, 30-40%. Drought stress was imposed by limiting irrigation. Plants were sampled and physiological parameters w ere measured on 0, 2, 4, 6, 8, and 10 days after the commencement of droughts tress. The water potential of strawberry leaves decreased in the plants under mild, moderate, and severe stress during the course of the water stress treatment and exhibited a significant difference from the control. Strawberry leaves subjected to drought stress had higher accumulation of proline, sugars, and malondialdehyde, and higher activities of superoxide dismutase, peroxidase, and catalase than leaves of control plants. Malondialdehyde levels increased in parallel with the severity and duration of drought stress. By contrast, antioxidant enzyme activity displayed dynamic responses to drought stress, first increasing and subsequently decreasing as the severity and duration of drought stress increased. These results suggest that strawberry plants respond to drought stress by altering the activities of antioxidant enzymes and the levels of osmotically active metabolites. These biochemical response changes may confer adaptation to drought stress and improve the capacity of plants to withstand water-deficit conditions.

• 한국콘텐츠학회논문지
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• 제9권6호
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• pp.196-206
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• 2009

병원의 수익성이란 병원이 회계년도 기간동안 환자 진료 및 기타 경영활동을 통해 달성한 경영성과를 말한다. 본 연구는 병원의 수익성 측정 지표로 병원을 운영하여 얻은 의료수익에서 의료비용을 뺀 순수한 의료이익인 의료수익의료이익율을 사용하였다. 이를 통해 수익성에 영향을 미치는 다양한 지표를 대상으로 병원 수익성 관련 요인을 도출하였다. 이 결과를 토대로 병원의 수익성 제고 방안을 강구할 수 있는 보다 유용한 기초자료를 산출하고자 하였다. 분석결과 공공병원이 민간병원보다 수익성이 낮았다. 각 지표의 수익성을 적자병원군과 흑자병원군으로 구분하여 분석한 결과 인건비 비율, 관리비 비율, 전문의 1인당 수술건수, 의료장비 회전율와 관련한 지표에서 유의한 차이를 보였다. 관련 지표가 수익성에 미치는 영향을 보면 모형에 따라 설명력은 25%-74.5%였다.

• Journal of Acupuncture Research
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• 제36권3호
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• pp.140-146
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• 2019

Background: This study investigated the effects of Vipera lebetina turanica snake venom (SV) on cerebral infarction induced by middle cerebral artery occlusion in mice. Methods: Following cerebral infarction, SV was injected intravenously or added to BV2 cell culture. Tissue injury was detected using triphenyltetrazolium chloride (TTC) staining, neurological deficit score, NO, ROS, and GSH/GSSG assays, qPCR, Western blot, and cell viability. Results: Cerebral infarction caused by middle cerebral artery occlusion as observed by TTC staining, showed SV inhibited cell death, reducing the number of brain cells injured due to infarction. SV treatment for cerebral infarction showed a significant decrease in abnormal behavior, as determined by the neurological deficit score. The oxidation and inflammation of the cells that had cerebral infarction caused by middle cerebral artery occlusion (NO assay, ROS, GSH/GSSG assay, and qPCR), showed significant protection by SV. Western blot of brain infarction cells showed the expression of iNOS, COX-2, p-IkB-${\alpha}$, P38, p-JNK, p-ERK to be lower in the SV group. In addition, the expression of IkB increased. BV2 cells were viable when treated with SV at $20{\mu}g/mL$ or less. Western blot of BV2 cells, treated with 0.625, 1.5, $2.5{\mu}g/mL$ of SV, showed a significant decrease in the expression of p-IkB-${\alpha}$, p-JNK, iNOS, and COX-2 on BV2 cells induced by LPS. Conclusion: SV showed anti-inflammatory and anti-oxidant effects against cerebral infarction and inflammation.

• Journal of Korea Trade
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• 제26권1호
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• pp.20-32
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• 2022

Purpose - This paper intends to make theoretical analysis and empirical test on the factors influencing China's export to South Korea, and draw conclusions about China's export efficiency and trade potential. Based on the conclusions, the reasons for China's trade deficit with South Korea are found, and a solution is put forward for solving the problem of China's trade deficit with South Korea. Design/methodology - Based on the data of 2004-2017 years in China, this paper uses the stochastic frontier gravity model to analyze the influencing factors of China's export to South Korea, as well as the export efficiency of each province and the export potential that can be explored. Findings - First, in terms of the factors affecting China's export trade to South Korea, the GDP of the provinces and cities in China, the FDI of South Korea to the provinces and cities in China, the GDP of South Korea, the population and education level of provinces and cities in China can significantly promote the export scale of Chinese provinces and cities to South Korea. The distance between Chinese provincial capitals and the South Korean capital significantly hinders Chinese exports to South Korea; Second, in terms of export trade efficiency, the trade exchange rate of the economically developed cities along the eastern coast of China and several provinces that are close to South Korea is higher than that of the cities in the central and western regions; Third, economic globalization makes trade more convenient, the average export trade efficiency of China's exports to South Korea showed an upward trend. However, under the influence of the 2008 global financial crisis, the export trade efficiency declined from 2008 to 2009, indicating that the impact of the financial crisis on the trade efficiency cannot be ignored. Originality/value - This paper finds out the influencing factors of China's export to South Korea, analyzes the export efficiency of different provinces and cities, excavates the export potential, and puts forward some suggestions for the balanced development of China and South Korea trade in the next step.

• Journal of East Asia Management
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• 제3권2호
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• pp.21-41
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• 2022

This study aims to analyze the characteristics of the management situation of the Korea Railroad Corporation(KORAIL) through the management innovation process of the KORAIL and to suggest its implications for military application. Despite stable demand, the railway passenger industry had the limitation of not being able to abolish deficit routes due to public service obligations. In addition, the launch of the Suseo High-Speed Line has introduced a competitive system, posing a threat to corporate management. KORAIL wanted to overcome this crisis by innovating its management through the utilization of big data, improvement of the freight business, decentralization of demand, the introduction of tourism railroads, and development of station influence areas. By utilizing big data, KORAIL was able to optimize the railway fare system while reducing fixed costs spent on railway maintenance. It also drastically reduced the station of cargo and created a base station to pursue economies of scale. On the other hand, the existing exclusive station system was abolished to solve the chronic saturation of the downtown area, and the railway demand was moved to Gwangmyeong Station and Suwon Station to optimize the passenger supply. In particular, it developed a new business model called the tourism railway by developing the mountain Byeokjin Line, which was a chronic deficit line, and sought to improve liquidity through the development of the station influence area. Such a process of innovation at KORAIL suggests an appropriate direction in seeking ways to innovate the military medical institutions. First of all, the necessity of improving organizational immersion through the development of a personnel structure suitable for the compulsory organization, while expanding the facilities of the division and corps, and reducing the time required for medical treatment and waiting through the establishment of a data-based medical system was suggested. Next, it was also discussed to integrate the National Health Medical College, which received accreditation as a medical facility through the designation of advanced general hospitals and is ultimately under discussion with the Medical Institution. Through this, we hope that the military medical institutions, which are facing various challenges, will overcome existing limitations and be re-lighted as innovative institution that provides comprehensive public health services.

• 한국조경학회지
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• 제51권5호
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• pp.70-83
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• 2023

최근 산림청이 기후 변화 대응 대책으로써 지자체 바람길숲 조성 사업을 시행함에 따라 다양한 바람길에 대한 연구가 수행되어 오고 있다. 바람길숲 조성을 위해서는 바람길 기능에 대한 평가가 선행되어야 한다. 하지만, 현재 바람길을 직접적으로 평가하고, 바람길의 유형에 따라 공간을 구분할 평가 지표가 없어 간접적인 지표를 기준으로 분석을 수행하고 있다. 따라서 본 연구에서는 냉각에너지 분석을 찬공기 생성에 대한 평가 지표로 활용함으로써 바람길을 평가 및 분류하는 방법을 제안하였다. Kaltluftabflussmodell_21(KLAM_21)이라는 찬공기 분석 모형을 활용하여 냉각에너지 분석을 하였다. 그리고 시뮬레이션 분석 결과에 따라 바람길을 찬공기 생성지역, 찬공기 취약지역, 찬공기 유동지역으로 분류하였다. 냉각에너지량을 기준으로 상위 5퍼센트를 찬공기 생성지역, 하위 5퍼센트를 찬공기 취약지역으로 분류하였다. 또한 찬공기 유동지역은 찬공기 생성지역에서 이동하는 찬공기의 흐름을 파악하여 분류하였다. 분석 결과, 대구광역시의 바람길 6개의 바람 생성지역이 존재하며, 찬공기 취약지역은 시가지 내부에 집중되어 있었고, 찬공기 유동지역은 대구광역시의 주요 하천과 도로를 따라 형성되어 있었다. 본 연구의 방법론을 통해 바람길의 효과를 정량적 평가 방법으로 활용될 수 있을 것으로 기대된다. 또한 바람길숲 조성 사업지 선정에 제시할 수 있는 평가 지표로 활용될 것으로 판단된다.

• Journal of Korean Neurosurgical Society
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• 제29권9호
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• pp.1171-1178
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• 2000

Objective : The purpose of the present study was to determine the appropriate time of clinical intervention by observing and analyzing the changes in the size of infarct, penumbra and cerebral edema and the extend of neurological deficit due to reperfusion damage according to time in a reversible cerebral ischemic model of reperfusing blood flow after inducing ischemia by maintaining middle cerebral artery occlusion for 2 hours(h) in rats. Methods : The rats were divided according to reperfusion time into control group(0 h reperfusion time) and experimental groups(0.5, 1, 2, 3, 4, 5, 6, 12, and 24 h of reperfusion time). Results : Changes in the size of infarction due to reperfusion damage were 0.93, 1.48 and 1.16% at 0.5, 1 and 2 h after reperfusion, respectively, and although a statistical significance was not present compared to 1.35% of the control group, damages increased drastically up to 6 h(6.64%), and the size increased were 6.65 and 6.78% at 12 and 24 h, respectively. Also there was no significant difference after 6 h up to 24 h in the size of infarction. In the areas where infarction occurred, reperfusion damage increased significantly with time in cortex than in subcortex. Accordingly, the size of penumbra area also showed a statistically significant decrease from 2 h up to 6 h after reperfusion, and 6 h after reperfusion, the area almost disappeared, becoming permanent infarction. Thus, reperfusion damage showed a significant increase from 2 h up to 6 h after reperfusion, and became steady thereafter. As for the mean ratio of the extend of cerebral edema, the control group and reperfusion 0.5 h group were 1.073 and 1.081, respectively ; up to 2 h thereafter, the ratio decreased to 1.01 but increased again with time ; and in reperfusion 12 h and reperfusion 24 h, the ratios were 1.070 and 1.075, respectively, showing similar size with that of control group. As for neurological deficit scores, the score of the control group was 2.67, that of reperfusion 2 h was 2, those of reperfusion 3 h and 6 h groups were 3.2 and 3.8, respectively, and those of reperfusion 12 h and 24 h groups were 4.2 and 4.6, respectively. Thus, as for the test results, the neurological deficit increased with time 2 h after reperfusion, and in reperfusion 12 and 24 h groups, almost all the symptoms appeared. Conclusion : As shown in these results, although the changes in the size of infarction due to reperfusion damage did not increase up to 2 h after reperfusion in the experimental groups compared to the control group, damage increased significantly thereafter up to 6 h, and the size remained about the same from 6 h to 24 h after reperfusion, becoming permanent infarction ; thus, the appropriate time of intervention according to the present study is at least 6 h before after maintaining reperfusion, including the time of cerebral artery occlusion.

• 응용통계연구
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• 제29권7호
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• pp.1295-1309
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• 2016

본 연구의 목적은 아동 건강에 미치는 환경의 영향을 평가하기 위하여 우리나라 환경부에서 구축한 경시적 자료인 CHEER 자료를 바탕으로 납의 벤치마크 용량 하한(BMDL)을 도출하여 Kim 등 (2014)의 결과를 재현하는 것이다. 본 연구에서는 CHEER 자료의 2005년 동집단을 사용하였는데, 벌점화 선형 스플라인을 이용한 변환공식으로 2005년 동집단의 ADHD 평가 척도를 통일하고, 경시적 자료의 특성을 반영한 두 개의 선형혼합모형을 구축하였다. 이후 구축된 모형을 바탕으로 혈중 납 농도의 BMDL을 도출하였다. 이 과정에서 Kim 등 (2014)에서 발견한 ADHD 점수의 평균으로의 회귀 현상이 재확인되었고, 2005년 동집단과 2006년 동집단의 분포 상의 특징적 차이가 발견되었다. 결과적으로 이 차이를 감안했을 때, Kim 등 (2014)과 일치적인 결과를 얻을 수 있었다.

• 응용통계연구
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• 제31권1호
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• pp.13-28
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• 2018

우리나라 환경부에서는 지난 2005년과 2006년, 매 2년마다 세 번에 걸친 추적 조사를 하여 두 개의 독립적인 자료를 구축하였고, 2010년에 두 자료를 병합하여 Children's Health and Environmental Research (CHEER) 자료라 명명하였다. 본 연구는 CHEER 자료를 이용한 Kim 등 (Journal of the Korean Data and Information Science Society, 25, 987-998, 2014)과 Lee 등 (The Korean Journal of Applied Statistics, 29, 1295-1310, 2016)의 후속 연구로서, 두 동집단을 병합한 자료에서도 기존 연구에서 보고되었던 결과가 재현되는지 확인하고 ADHD를 종점으로 한 혈중 납 농도의 95% 신뢰 하한 (BMDL) 도출하였다. Lee 등 (2016)에서 제시한 벌점화 스플라인 모형을 이용하여 모든 년도의 ADHD 척도를 통일하였고, 경시적 자료의 특성과 아동의 나이에 대한 평균으로의 회귀 현상을 반영하여 임의 기울기 모형과 AR(1) 모형을 구축하였다. 두 모형을 바탕으로 혈중 납 농도의 벤치마크 용량 하한을 공식과 모의실험을 이용하여 도출한 결과, 종전의 연구보다 작은 벤치마크 용량의 분산 값으로 인하여 벤치마크 용량 하한 값이 증가한다는 사실을 확인할 수 있었다.

• 대한지구과학교육학회지
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• 제11권1호
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• pp.1-20
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• 2018

본 연구의 목적은 세계관을 바탕으로 한 기후 변화내용에 대한 통합과학 교육전략을 제안하는데 있다. 어떤 개념이나 현상을 이해한다고 반드시 깨닫는 것이 아니다. 현재까지 대부분의 학교 교육의 정책 방향은 학생들의 결핍 모델에 기초하고 있다. 결핍 모델이란, 학습자는 늘 지식과 경험이 부족하여, 학습 내용을 제대로 이해하지 못한다고 단정하는 생각에 기초하고 있다. 그리고 학생들은 이슈가 되는 내용에 대해 깊이 있게 깨닫지 못하기 때문에 그에 대한 태도나 행동 변화가 어렵다. 예를 들면, 기후 변화의 세계관은 낙관적인 기계적인 세계관과 유기체적이고 엔트로피적 세계관이 공존한다. 이 연구는 기존의 결핍 모형의 관점에서 나아가 앎을 살아있는 충족성과 정합성을 확장하는 과정으로 의미화 하고자 한다. 서로 연결이 되지 않은 지식은 다양성을 갖기 어렵고, 지속가능하지도 않고 유연성도 없다. 따라서 이 연구의 주요 아이디어는 학문 간의 담을 없애는 것이 아니라, 서로 연결이 가능하도록 담을 낮추자는 것에 있다. 학습을 할 때, 어느 한 학문 영역에 대해 깊은 전문성을 가지고 다른 학문 영역으로 들어가지만, 연결을 위해서는 반드시 특정 목적을 가지고 있어야한다. 그러한 통합의 과정에서 문제 해결의 실마리를 의미 있게 찾을 수 있을 뿐만 아니라 동적으로 다른 영역간의 상호 피드백에 의하여 지식의 질과 양이 늘어나는 효과를 가져올 수 있다.