• 산업공학
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• 제15권3호
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• pp.270-278
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• 2002

Product Liability(PL) is a legal policy to deal with global competition by improving domestic industrial competitive power and to reduce the cost of defect products. The purpose of this paper is to address the state of the art solutions to dispute on PL, in reality of a frequent occurrence of global product exchange focussing on product safety that is one of the most important functions of PL and to improve solution of the product safety and reliability responsive to PL. To minimize PL exposure, manufacturers should reflect comprehensive product safety and reliability concepts in establishing PL prevention policies. Total PL prevention policies are composed of total quality management and product safety management system in respect of safety design, risk, and reliability. These PL prevention activities should be performed consistently during the total product life cycle, especially product research and development periods.

• Journal of Genetic Medicine
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• 제5권1호
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• pp.1-6
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• 2008

Knowledge of developmental biology is essential for clinicians who seek to develop a rational approach to the diagnostic evaluation of patients with birth defects. After an accurate diagnosis, a clinician can make predictions about prognosis, recommend management options, and provide an indication of recurrence risk for the parents and relatives. In this paper, we first review the basic mechanisms of embryological development and clinical dysmorphology. We then review cellular and molecular mechanisms in development and related congenital anomalies. Developmental anomalies have a major impact on public health. Genetic counseling and prenatal diagnosis, with the option to continue or to terminate a pregnancy, are important for helping families faced with the risk of a serious congenital anomaly in their offspring. Moreover, primary prevention of birth defects, for example, supplementation of prenatal folic acid and prevention of consumption of alcohol which has teratogenic effects, can be accomplished using developmental biology knowledge.

• Childhood Kidney Diseases
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• 제27권1호
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• pp.19-25
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• 2023

Proteinuria is an important risk factor for renal and cardiovascular disease. It is associated with a risk for glomerulonephritis, chronic kidney disease, and end-stage renal disease. Therefore, if persistent proteinuria is detected, kidney biopsy is considered to diagnose and treat the underlying disease. Recently, variants in the cubilin (CUBN) gene, which is associated with albuminuria, have been reported. This gene encodes cubilin, a membrane glycoprotein receptor expressed in the renal proximal tubules. Cubilin is a component of the megalin and cubilin-amnionless complex that mediates albumin reabsorption into the proximal tubules through endocytosis. A defect in cubilin leads to a reduction in albumin reuptake, resulting in albumin-dominant proteinuria. Although numerous controversies exist, several reports suggest that cubilin defects lead to proteinuria with a high portion of albuminuria but may not impair renal filtration function. If albuminuria due to reduced cubilin function is confirmed as a benign condition, we can consider using genetic studies to detect CUBN mutations in patients with proteinuria and they may not require any treatment or kidney biopsy. Here, we review recent papers on CUBN mutations and discuss the prognosis and management of individuals with this mutation.

• 국제학술발표논문집
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• The 4th International Conference on Construction Engineering and Project Management Organized by the University of New South Wales
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• pp.52-57
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• 2011

Bridges are essential and valuable elements in road and rail transportation networks. Bridge remediation is a top priority for asset managers, but identifying the nature of true defect deterioration and associated remediation treatments remains a complex task. Nowadays Decision Support Systems (DSS) are used extensively to assist in decision-making across a wide spectrum of unstructured decision environments. In this paper a requirements-driven framework is used to develop a risk based decision support model which has the ability to quantify the bridge condition and find the best remediation treatments using Multi Attribute Utility Theory (MAUT), with the aim of maintaining a bridge within acceptable limits of safety, serviceability and sustainability.

• 대한영상의학회지
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• 제82권2호
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• pp.435-439
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• 2021

난원공개존증은 정상 성인에서 흔히 발견된다. 그러나, 임상에서 난원공개존증에 의한 기이색전증은 드물다. 심장 초음파를 이용한 이전 연구에 따르면, 기이색전증은 큰 직경이며, 유스타키오관이 동반되고, 좌우 심방의 압력차가 큰 난원공개존증에서 주로 발생하였다. 저자들은 기이색전증이 발생한 난원공개존증 환자 1예의 특징적인 CT 소견을 제시한다.

• 한국건설관리학회논문집
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• 제19권5호
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• pp.53-60
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• 2018

PSC 박스교에서 긴장재에 대한 조사는 체계적인 방법에 의해서 수행되어야 한다. 대표 긴장재 유형별로 위험 요인을 분석하고 장기적으로 위험도를 낮출 수 있도록 유지관리 계획이 수행되어야 할 예방적 유지관리 활동을 도출하는 것이 중요하다. 하지만 현 유지관리체계에서는 긴장재의 조사 및 보수보강을 위한 다양한 방법론이 연구되어 지고 있으나, 현실적으로 긴장재를 전수조사하는 것에는 어려움이 있다. 따라서 긴장재 선별에 대한 리스크 평가를 국내 PSC 박스교에 적용하기 위해 상태평가 및 유지관리체계에 맞춘 리스크 매트릭스 평가 지표를 제시하였다.

• Journal of Korean Neurosurgical Society
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• 제54권2호
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• pp.93-99
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• 2013

Objective : Neurologic complications during carotid artery stenting (CAS) are usually associated with distal embolic event. These embolic incident during CAS are highly associated with the carotid plaque instability. The current study was undertaken to identify the angiographic characteristics of carotid plaque vulnerability, which was represented as filling defect in the cerebral protection filters during CAS. Methods : A total of 107 patients underwent CAS with use of a distal protection filter. Angiographic carotid plaque surface morphology was classified as smooth, irregular, and ulcerated. To determine predictable factors of filling defect in the protection filters, 11 variables were retrospectively analyzed which might influence filling defect in the protection filters during CAS. Results : Filling defects during CAS were presented in the 33 cerebral protection filters. In multivariate analysis, angiographic ulceration [odds ratio (OR), 6.60; 95% confidence interval (CI) : 2.24, 19.4; p=0.001], higher stenosis degree (OR, 1.06; 95% CI : 1.00, 1.12; p=0.039), and coexistent thrombus (OR, 7.58; 95% CI : 1.69, 34.05; p=0.08) were highly associated with filling defect in the cerebral protection devices during CAS. Among several variables, angiographic surface ulceration was the only significant factor associated with flow stagnation during CAS (OR, 4.11; 95% CI : 1.33, 12.72; p=0.014). Conclusion : Plaque surface morphology on carotid angiography can be a highly sensitive marker of plaque instability during CAS. The independent risk factors for filling defect in the filter devices during CAS were plaque ulceration, stenosis degree, and coexistent thrombus.

• 한국안전학회지
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• 제35권2호
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• pp.1-7
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• 2020

In this paper, we describe fire risk of Kimchi refrigerator. The Kimchi refrigerator has been widely spread and used starting from the first half of 2000 and recently fire accidents caused by the Kimchi refrigerator emerged as social concern. In particular, in products of a specific manufacturer, it is not an environmental factor, but a characteristic that the fire is caused due to a defect of the product itself is shown. These features are judged to be formed by unique defects regardless of external factor by forming electrically arc mark in the relay element. In this paper, we analyzed the cause of the fire occurring in the Kimchi refrigerator and finally confirmed the characteristic that the fire occurred mainly in the relay element due to insufficient capacity of the relay element. Therefore, when a fire occurs in a product of the same maker as the Kimchi refrigerator mentioned in this paper, it is always judged that the inspection of the relay element should be carried out.

• Archives of Reconstructive Microsurgery
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• 제23권1호
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• pp.1-7
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• 2014

Purpose: Recent studies have reported on application of fibrin glue composed of fibrinogen and thrombin to nerve anastomosis, which can be another candidate for vessel anastomosis. However, no research regarding the risk and effectiveness of thrombin in microvascular free tissue transfer has been reported. Therefore, the aim of study is to determine the risk and effectiveness of thrombin on microvascular free tissue transfer through clinical cases. Materials and Methods: Twenty-five patients underwent free flap reconstruction for soft tissue defect or bone exposure in our institute from March 2011 to February 2014. In the group using thrombin, dissolved powder thrombin (5,000 IU/amp) was mixed with 10 mL normal saline. Saline mixed with thrombin was applied on the flap, recipient, and around vessel anastomosis. In the control group, free flap was performed using the same method, except using thrombin. We analyzed the results between the two groups. Results: All flaps survived. The group using thrombin included 14 patients and the control group included 11 patients. Hematoma was found in two cases, respectively, in each group. The group using thrombin showed lower incidence of hematoma than the control group. No difference in survival rate of the flap was observed between the thrombin group and the control group. Conclusion: Results of this study showed that use of saline mixed with thrombin in free tissue transfer may be safe and effective for prevention of hematoma formation in the recipient site.

• 상하수도학회지
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• 제28권6호
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• pp.681-690
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• 2014

It is known that sewer problems are the major causes of road cave-in. The objective of this study is to analyze the risk of road cave-in due to storm sewer laterals. We investigated 174 storm sewer laterals using a zoom camera at O-dong area in Seoul. The causes of road cave-in were classified into five cases: breakage of rigid pipe, deformation of flexible pipe, out of pipeline alignment, changing pipe material or changing pipe diameter, and a poor linkage between lateral and sewer. In addition, all defects were sorted into five grades based on the severity rating at storm sewer laterals. In this study, the most fragile pipe materials were found to be concrete pipe and polyethylene pipe, which recorded 2.3 and 1.69 defect rates. With regard to the causes of road cave-in, deformation of flexible pipe has a large influence on road cave-in at present. On a long-term basis, the two causes, out of pipeline alignment and a poor linkage between lateral and sewer, could have more influence on road cave-in.