• 산업융합연구
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• 제19권6호
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• pp.177-186
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• 2021

본고는 인지적 과제를 수행하는 동안 우울 및 불안 환자의 정신병리적 과정과 이의 치료접근 방식에 대한 통합적 이해를 위해 최근 제시된 신경인지 연결망을 토대로 인지과정 및 정서조절의 비정상적 기능 연결성을 재해석 할 수 있는 모델을 제안하고자 하였다. 재구성된 우울과 불안장애 신경인지 연결망 모델을 통해, 우울증은 불이행방식 연결망(default mode network; DMN)의 과다 활성화에 기인하는 '자기참조적 사고로의 과몰입'으로, 불안장애는 불이행방식 연결망의 과소 활성화에 기인하는 '자기참조적 사고와의 단절'로 규정해 볼 수 있음을 확인하였다. 신경인지 연결망 중 자기의식 및 투사와 관련되는 자기참조 처리가 주요 기능인 DMN의 비정상적 활성화와 병리적 기능의 체계적 연결시도는 우울와 불안에 대한 통합적 해석과 치료적 접근에 시사점을 줄 수 있는 또 다른 출발점이 될 수 있을 것이다.

• 대한불안의학회지
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• 제14권2호
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• pp.63-70
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• 2018

It has been suggested that aberrant self-referential processing (SRP) is one of the important components of the explanatory models of social anxiety disorder (SAD). The default mode network (DMN), which reflects intrinsic brain functions, is known to play a critical role in SRP. Recently, resting state functional magnetic resonance imaging (fMRI) research on the functional connectivity in the brain network has gained greater attention as a tool to elucidate the neurobiological basis of various psychiatric disorders. We reviewed resting state fMRI studies that investigated the resting state functional connectivity (RSFC) of the DMN in SAD. Despite of the heterogeneity of the analytic methods and occasional negative findings, most studies consistently reported abnormalities of RSFC within the DMN, suggesting that the DMN may be significant neural correlates of aberrant SRP in SAD. Also, changes in RSFC of the DMN are associated with clinical improvements of therapeutic interventions. Moreover, emerging findings provide the basis for potential use of RSFC as a complementary method in diagnosis of SAD. Ongoing and future research to investigate RSFC of the DMN could broaden our understanding regarding the neurobiological basis of SAD, and contribute to the development of novel treatments for SAD.

• 한국멀티미디어학회논문지
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• 제24권5호
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• pp.684-694
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• 2021

Resting-state Functional Magnetic Resonance Imaging(fMRI) data detects the temporal correlations in Blood Oxygen Level Dependent(BOLD) signal and these temporal correlations are regarded to reflect intrinsic cortical connectivity, which is deactivated during attention demanding, non-self referential tasks, called Default Mode Network(DMN). The relationship between fMRI and anatomical connectivity has not been studied in detail, however, the preceded studies have tried to clarify this relationship using Diffusion Tensor Imaging(DTI) and fMRI. These studies use method that fMRI data assists DTI data or vice versa and it is used as guider to perform DTI tractography on the brain image. In this study, we hypothesized that functional connectivity in resting state would reflect anatomical connectivity of DMN and the combined images include information of fMRI and DTI showed visible connection between brain regions related in DMN. In the previous study, functional connectivity was determined by subjective region of interest method. However, in this study, functional connectivity was determined by objective and advanced method through Independent Component Analysis. There was a stronger connection between Posterior Congulate Cortex(PCC) and PHG(Parahippocampa Gyrus) than Anterior Cingulate Cortex(ACC) and PCC. This technique might be used in several clinical field and will be the basis for future studies related to aging and the brain diseases, which are needed to be translated not only functional connectivity, but structural connectivity.

• Journal of Korean Neurosurgical Society
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• 제54권6호
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• pp.453-460
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• 2013

Objective : There is a rich literature confirming the default mode network found compatible with task-induced deactivation regions in normal subjects, but few investigations of alterations of the motor deactivation in patients with intracranial lesions. Therefore, we hypothesized that an intracranial lesion results in abnormal changes in a task-induced deactivation region compared with default mode network, and these changes are associated with specific attributes of allocated regions. Methods : Blood oxygenation level dependent (BOLD) functional magnetic resonance imaging (fMRI) during a motor task were obtained from 27 intracranial lesion patients (mean age, 57.3 years; range 15-78 years) who had various kinds of brain tumors. The BOLD fMRI data for each patient were evaluated to obtain activation or deactivation regions. The distinctive deactivation regions from intracranial lesion patients were evaluated by comparing to the literature reports. Results : There were additive deactivated regions according to intracranial lesions : fusiform gyrus in cavernous hemangioma; lateral occipital gyrus in meningioma; crus cerebri in hemangiopericytoma; globus pallidus, lateral occipital gyrus, caudate nucleus, fusiform gyrus, lingual gyrus, claustrum, substantia nigra, subthalamic nucleus in GBM; fusiform gyrus in metastatic brain tumors. Conclusion : There is increasing interest in human brain function using fMRI. The authors report the brain function migrations and changes that occur in patients with intracranial lesions.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• 제23권2호
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• pp.57-62
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• 2012

Objectives : Characteristic symptoms, including hyperactivity and easy distractibility, in children with attention-deficit hyperactivity disorder (ADHD) suggest that their brain status, even at rest, might differ from that of healthy children. This study was conducted in order to determine whether resting state brain activity is compromised in medication-naive children with ADHD. Methods : Twenty medication-naive children with ADHD (mean age $10.3{\pm}2.5$) and 28 age- and gender-matched healthy volunteers (mean age $10.3{\pm}2.0$) underwent measurements for resting state brain activity using functional magnetic resonance imaging (fMRI). Among resting state related-independent components (RSICs) extracted from fMRI data using independent component analysis, a significant difference in RSICs was observed between groups, using a mixed Gaussian/gamma model. Results : Except for IQ, which was higher in the healthy control group, no demographic difference was observed between the two groups (p<.001). Significantly less activation of one RSIC, which includes the bilateral precuneus/posterior cingulate cortex, occipito-temporal junction, and anterior cingulate cortex, was observed in the ADHD group, compared with the control group (p<.05). Conclusion : An abnormal RSIC, posterior default mode network (DMN), was observed in the medication-naive ADHD group. Results of our study suggest that abnormality of posterior DMN is one of the main pathophysiologies of ADHD.

• 생물정신의학
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• 제24권2호
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• pp.68-74
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• 2017

Objectives It is well known that problem drinking is associated with alterations of brain structures and functions. Brain functions related to alcohol consumption can be determined by the resting state functional connectivity in various resting state networks (RSNs). This study aims to ascertain the alcohol effect on the structures forming predetermined RSNs by assessing their cortical thickness. Methods Twenty-six abstinent male patients with alcohol dependence and the same number of age-matched healthy control were recruited from an inpatient mental hospital and community. All participants underwent a 3T MRI scan. Averaged cortical thickness of areas constituting 7 RSNs were determined by using FreeSurfer with Yeo atlas derived from cortical parcellation estimated by intrinsic functional connectivity. Results There were significant group differences of mean cortical thicknesses (Cohen's d, corrected p) in ventral attention (1.01, < 0.01), dorsal attention (0.93, 0.01), somatomotor (0.90, 0.01), and visual (0.88, 0.02) networks. We could not find significant group differences in the default mode network. There were also significant group differences of gray matter volumes corrected by head size across the all networks. However, there were no group differences of surface area in each network. Conclusions There are differences in degree and pattern of structural recovery after abstinence across areas forming RSNs. Considering the previous observation that group differences of functional connectivity were significant only in networks related to task-positive networks such as dorsal attention and cognitive control networks, we can explain recovery pattern of cognition and emotion related to the default mode network and the mechanisms for craving and relapse associated with task-positive networks.

• 감성과학
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• 제21권3호
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• pp.83-102
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• 2018

The process model of emotion regulation suggests that cognitive reappraisal and expressive suppression engage at different time points in the regulation process. Although multiple brain regions and networks have been identified for each strategy, no articles have explored changes in network characteristics or network connectivity over time. The present study examined (a) the whole-brain network and six other resting-state networks, (b) their modularity and global efficiency, which is an index of the efficiency of information exchange across the network, (c) the degree and betweenness centrality for 160 brain regions to identify the hub nodes with the most control over the entire network, and (d) the intra-network and inter-network functional connectivity (FC). Such investigations were performed using a traditional large-scale FC analysis and a relatively recent sliding window correlation analysis. The results showed that the right inferior orbitofrontal cortex was the hub region of the whole-brain network for both strategies. The present findings of temporally altering functional activity of the networks revealed that the default mode network (DMN) activated at the early stage of reappraisal, followed by the task-positive networks (cingulo-opercular network and fronto-parietal network), emotion-processing networks (the cerebellar network and DMN), and sensorimotor network (SMN) that activated at the early stage of suppression, followed by the greater recruitment of task-positive networks and their functional connection with the emotional response-related networks (SMN and occipital network). This is the first study that provides neuroimaging evidence supporting the process model of emotion regulation by revealing the temporally varying network efficiency and intra- and inter-network functional connections of reappraisal and suppression.

• 한국항해항만학회:학술대회논문집
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• 한국항해항만학회 2015년도 춘계학술대회
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• pp.296-298
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• 2015

자율적인 행위자들로서 서로 영향을 끼치며 상호작용하는 선박들을 관제하는 VTSO는 불확실성으로 인한 위험을 극복하기 위해서는 적극적으로 상황을 파악하여 최선의 의사결정을 하여야 한다. VTSO는 항상 미래의 상황을 예측하면서 업무를 수행하여야 하는데 이때 VTSO에게 요구되는 것이 바로 시뮬레이션 능력이다. 시뮬레이션은 삽화기억의 구성적 성격을 활용하는 것으로서 삽화기억의 메커니즘은 미래 계획에도 그대로 활용된다. 본고에서는 반사실적 사고가 시뮬레이션에 어떻게 작동되는가를 살펴보고, VTS 상황에 이를 적용하여 보았다. 특히 반사실적 사고와 시뮬레이션을 통해서 VTSO가 업무역량을 향상시키기 위해서 어떻게 학습하여야 하는가를 고찰하였다.

• 한국도서관정보학회지
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• 제21권
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• pp.253-289
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• 1994

The purpose of this study is about the search pattern of LINNET (Library Information Network System) OPAC users by transaction log, maintained by POSTECH(Pohang University of Science and Technology) Central Library, to provide feedback information of OPAC system design. The results of this study are as follows. First, for the period of this analysis, there were totally 11, 218 log-ins, 40, 627 transaction logs and 3.62 retrievals per a log-in. Title keyword was the most frequently used, but accession number, bibliographic control number or call number was very infrequently used. Second, 47.02% of OPAC, searches resulted in zero retrievals. Bibliographic control number was the least successful search. User displayed 2.01% full information and 64.27% local information per full information. Third, special or advanced retrieval features are very infrequently used. Only 22.67% of the searches used right truncation and 0.71% used the qualifier. Only 1 boolean operator was used in every 22 retrievals. The most frequently used operator is 'and (&)' with title keywords. But 'bibliographical control number (N) and accessionnumber (R) are not used at all with any operators. The causes of search failure are as follows. 1. The item was not used in the database. (15, 764 times : 79.42%). 2. The wrong search key was used. (3, 761 times : 18.95%) 3. The senseless string (garbage) was entered. (324 times : 1.63%) On the basis of these results, some recommendations are suggested to improve the search success rate as follows. First, a n.0, ppropriate user education and online help function let users retrieve LINNET OPAC more efficiently. Second, several corrections of retrieval software will decrease the search failure rate. Third, system offers right truncation by default to every search term. This methods will increase success rate but should considered carefully. By a n.0, pplying this method, the number of hit can be overnumbered, and system overhead can be occurred. Fourth, system offers special boolean operator by default to every keyword retrieval when user enters more than two words at a time. Fifth, system assists searchers to overcome the wrong typing of selecting key by automatic korean/english mode change.

• Investigative Magnetic Resonance Imaging
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• 제21권4호
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• pp.223-232
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• 2017

Purpose: To report the use of multiband accelerated echo-planar imaging (EPI) for resting-state functional MRI (rs-fMRI) to achieve rapid high temporal resolution at 3T compared to conventional EPI. Materials and Methods: rs-fMRI data were acquired from 20 healthy right-handed volunteers by using three methods: conventional single-band gradient-echo EPI acquisition (Data 1), multiband gradient-echo EPI acquisition with 240 volumes (Data 2) and 480 volumes (Data 3). Temporal signal-to-noise ratio (tSNR) maps were obtained by dividing the mean of the time course of each voxel by its temporal standard deviation. The resting-state sensorimotor network (SMN) and default mode network (DMN) were estimated using independent component analysis (ICA) and a seed-based method. One-way analysis of variance (ANOVA) was performed between the tSNR map, SMN, and DMN from the three data sets for between-group analysis. P < 0.05 with a family-wise error (FWE) correction for multiple comparisons was considered statistically significant. Results: One-way ANOVA and post-hoc two-sample t-tests showed that the tSNR was higher in Data 1 than Data 2 and 3 in white matter structures such as the striatum and medial and superior longitudinal fasciculus. One-way ANOVA revealed no differences in SMN or DMN across the three data sets. Conclusion: Within the adapted metrics estimated under specific imaging conditions employed in this study, multiband accelerated EPI, which substantially reduced scan times, provides the same quality image of functional connectivity as rs-fMRI by using conventional EPI at 3T. Under employed imaging conditions, this technique shows strong potential for clinical acceptance and translation of rs-fMRI protocols with potential advantages in spatial and/or temporal resolution. However, further study is warranted to evaluate whether the current findings can be generalized in diverse settings.