• 한국생물정보학회:학술대회논문집
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• 한국생물정보시스템생물학회 2003년도 제2차 연례학술대회 발표논문집
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• pp.277-287
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• 2003

Acetolactate synthase (ALS, EC 4.1.3.18; also referred to as acetohydroxy acid synthase) catalyzes the first common step in the biosynthesis of valine, leucine, and isoleucine in microorganisms and plants. Recently X-ray structure of yeast ALS was available. Pair-wise alignment of yeast and tobacco ALS sequences revealed 63% sequence similarity. Using Deep View and automatic modeling on Swiss model server, we have generated reliable models of tobacco ALS based on yeast ALS template with a calculated pair-wise RMSD of 0.86 Angstrom. Functional roles of four residues located on the subunit interface (H142, El43, M350, and R376) were examined by site-directed mutagenesis. Seven mutants were generated and purified, of which three mutants (H142T, M350V, and R376F) were found to be inactivated under various assay conditions. The H142k mutant showed moderately altered kinetic properties. The E143A mutant increased 10-fold in K$_m$ value while other parameters remained unchanged. The M350C mutant was strongly resistant to three tested herbicides, while the R376k mutant can bind with herbicide carder at similar affinity to that of wild type enzyme, as determined by tryptophan quenching study. Except M350V mutant, all other mutants were ate to bind with cofactor FAD. Taken together, it is likely that residues H142 and E143 are located at the active site, while residues M350 and R376 are possibly located at the overlapping region of active site and herbicide binding site of the enzyme. Our data also allows us to hypothesize that the interaction between side chains of residues M350 and R376 are probably essential for the correct conformation of the active site. It remains to be elucidated that, whether the herbicide, upon binding with enzyme, inactivates the enzyme by causing change in the active site allosterically, which is unfavorable for catalytic activity.

• 대한물리의학회지
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• 제11권1호
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• pp.71-82
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• 2016

PURPOSE: The purpose of this case report was to determine the effect of therapeutic exercise on posture, pain, and muscle activity in two patients with forward head posture (FHP). METHODS: A-31-year-old male (patient A) and a 19-year-old women (patient B) presented with FHP, neck pain, and headache. The therapeutic exercise program consisted of cervical mobilization, deep cervical flexors strengthening, and cervical extensors stretching, for 40 min/d, 2 d/week, for 8 weeks. Neck pain (VAS), neck disability (NDI), cervical range of motion (CROM), lateral view of cervical spine X-ray (indicating the FHP), and asymmetrical neck and shoulder muscular activity ratio were measured before, after 4 weeks, and after 8 weeks of corrective exercise. RESULTS: VAS and NDI decreased in patients A and B after exercise compared to before the program. CROM increased in patients A and B at flexion, extension, side bending, and rotation after exercise compared to before the program. FHP decreased in patients A and B at distance after exercise compared to before the program. In addition, asymmetrical neck and shoulder muscles activity ratio improved in patients A and B after exercise compared to before the program. CONCLUSION: We demonstrated in a case report that therapeutic exercise increases ROM, decreases pain and disability of neck, FHP, and asymmetry muscle activity ratio in patients with FHP. These finding have clinical implications for therapeutic exercise in patients with FHP.

• 한국실내디자인학회논문집
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• 제17권6호
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• pp.11-20
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• 2008

The purpose of this study is to find out the theoretical background of spatial fantage effects in Piranesi etching "Le Carceri" called 'Architectural Capriccio'. In a life time Piranesi created a prodigious oeuvre of dramatic and fantastic images about magnificent buildings and mysterious ruins and prison. The increasing "tourism" after the middle of the 18th century contributed a lot to Piranesi's success. He was famous for his poetic views of Rome and also his fantastic imaginary interiors. The terms "Capriccio" and "Veduta" are strongly connected with Piranesi's work. The term Veduta describes a form of landscape depiction in print with close to reality imitation of the scenery, whereas the "Capriccio" contains the elements of invention in artificial architectural landscape. Trained in Venice as an engineer and architect, his studies had included perspective and stage design. These skills, allied to his deep knowledge of archaeology, provided the substance for his Veduta, etchings of ancient Rome. But his most remarkable etchings are those of imaginary interiors, the Carceri d'Invenzione(Imaginary Prisons), a series of capric plates issued in 1750. It appears to Piranesi etching 'Le Carceri' that 18th century experimental scenography's effect very strongly. Also, it can understand about "Scena per Angolo" which was revealed by Ferdinando Galli Bibiena that Piranesi spatial view and viewpoint deconstruction operate motive and cause. Piranesi's spatial fortification was influence by Filippo Juvarra's spatial concept. As a result of this research will be foundation of understanding deeply that Piranesi etching has been affect to present architecture and art.

• 만화애니메이션 연구
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• 통권11호
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• pp.153-167
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• 2007

본 논문은 인간이 동물로 혹은 동물이 인간으로 변신한 작품을 중심으로 애니메이션의 변신 모티프에 내재된 사상적 토대는 무엇인지, 그리고 변신 모티프가 서사에 어떤 의미와 기능을 부여하는지를 살펴보았다. 변신 모티프를 중심으로 한 애니메이션 텍스트 분석의 결과 <브라더 베어>는 동물로의 변신이 징벌의 개념으로 작용하고 있으며 동물이란 인간이 돌봐야 할 대상, 즉 정복과 극복의 대상으로 보는 인간 중심적 관점이 강하게 작용하고 있다는 것을 알 수 있었다. 반면, <곰이 되고 싶어요>는 소년이 곰이 되어가는 과정을 통해 자연(동물)을 정복의 대상이 아니라 대자연의 순리를 겸허한 시선으로 바라봄으로써 삶과 자연, 자연과 인간에 대한 깊은 성찰을, <천년여우 여우비>는 금지된 것에 대한 경계를 넘고자 하는 주체적 존재에 대한 시선을 견지하는 등 각 작품마다 인간과 자연(동물)의 관계를 다양한 관점으로 표현하고 있다는 것을 알 수 있었다.

• 대한한의정보학회지
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• 제15권2호
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• pp.77-91
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• 2009

Flowery Knotweed Root is the dried tuberous root of the knotweed family wheres Auriculate Swallowwort Root is the dried tuberous root of the swallowort family. Flowery Knotweed Root is also called Red Flowery Knotweed Root in China, which is dried root of Polygonum multiflorum THUMB. Chinese Flowery Knotweed Root is better known as the dried tuberous root belonging to the family Apocynaceae whereas White Flowery Knotweed Root in Korea is the dried tuberous root of Cynanchum wilfordii(Maxim) Hemsl. Up to now, while the dried root named Red Flowery Knotweed Root has been widely used in China, Auriculate Swallowwort Root has been widely used in Korea. Both the roots contrast in a striking way with the origin, shape, botanical names, other names, and chemical constituents, so administration and dosage without discrimination of both sides can be open to question. According to the literature, it is recorded that Flowery Knotweed Root and Auriculate Swallowwort Root are similar to the characteristics, properties, and actions. From this study, the result is as follows: 1. Flowery Knotweed Root and Auriculate Swallowwort Root are divided into the family Apocynaceae and the family Polygonaceae, respectively. Accordingly 2. Flowery Knotweed Root is in shape of an irregular spindle and looks reddish- brown or deep reddish-brown and the section is light yellowish-brown, while Auriculate Swallowwort Root looks yellowish-brown and the section is white or yellow. 3. Flowery Knotweed Root is reported by the Journal of the Crude Drug that the medicinals have not the same therapeutic action as Auriculate Swallowwort Root. It is recorded that the properties, channel entry, functions of Flowery Knotweed Root and Auriculate Swallowwort Root in literature have much in common. Many works on the roots of this plant has been used traditionally as a tonic are required of. In view of the results, Flowery Knotweed Root and Auriculate Swallowwort Root varies both in nature and in shape, so that the administration and dosage of the medicinals must be taken a prudent attitude.

• 복식문화연구
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• 제11권3호
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• pp.367-374
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• 2003

When analyzing forms in the human body and clothes, we conceptualize each part into a cone, sphere, and cylinder, and the esthetic characteristics of our fashion culture and esthetic fashion characteristics of Koreans are composed by expressing with universal images such as circle, square, and triangle when forms are expressed in a plane. To determine how the structural principle of shapes that are the shapes of all things and basic to geometry, i.e., circle, square, and triangle, applies to clothes that cloth our body called the small cosmos, we discussed the symbolic meaning hidden inside the structure of Korean clothes based on the basic pattern drafting method of Korean men’s traditional trousers. We drew the conclusion that Korean men's trousers composed of circles, triangles, and squares express the five elements diagram through their plane structure, are designed in circles with cones and pyramids, and are made to well express the principle of the small cosmos of our body. Moreover, when the basic pattern of Korean men’s trousers explained with the antipathy diagram is viewed to create all things while maintaining opposite and complementary relationship with Sangsang (mutually benefitting factor), it would be correct to say that the principle of the top verse the bottom is viewed as conflicting. From the structural point of view, since the philosophy of the Samsu principle (the principle of 1, 2 and 3 in which 1 represents the heaven, 2 represents the earth, and 3 represents the people) is hidden in Korean men's trousers in which Hurimalgi (the part of trousers corresponding to the waist band of Western pants) is the circle representing the heaven, Marupok is the square representing the earth, and Sapok is the triangle representing the people, we could look at deep meaning of our ancestors expressed in our clothes.

• 한국항만경제학회지
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• 제36권3호
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• pp.39-54
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• 2020

대통령 중심제의 정치체제에서는 대통령의 언어가 국가정책의 형성과 의사결정 과정에 지대한 영향을 미치게 된다. 대통령의 이념과 중심가치에 따라 정책우선순위가 결정되고 그 우선순위에 따라 다양한 정책이 수립되고 집행된다. 그래서 대통령의 연설문을 내용분석하는 연구가 관심의 대상이 되고 있다. 대통령의 연설문은 언어 자료이기 때문에 비정형이면서 비구조화 된 텍스트를 분석하기 위해서는 기계학습과 딥러닝의 방법을 통해 빅데이터 분석이 이루어지고 있다. 본 연구에서는 1996년부터 24년간에 걸쳐 "바다의 날" 기념식의 대통령 연설문을 확보하여 텍스트마이닝 방법의 일종인 토픽모델링의 방법으로 분석하였다. 분석결과 역대 대통령은 모두 자신의 국정운영 방향에 부합되는 해양관을 가지고 연설문을 발표하였다는 것을 확인하였다. 해양의 고유가치인 해양-산업-자원 토픽은 훼손되지 않고 지속적으로 역대 대통령이 모두 강조하고 있음을 확인하였다.

• 한국전기전자재료학회:학술대회논문집
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• 한국전기전자재료학회 2008년도 추계학술대회 논문집 Vol.21
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• pp.414-414
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• 2008

Vertically well-aligned Ga-doped ZnO nanorods with different Ga contents were grown by thermal evaporation on a ZnO template. The Ga-doped ZnO nanorods synthesized with 50 wt % Ga with respect to the Zn content showed maximum compressive stress relative to the ZnO template, which led to a rapid growth rate along the c-axis due to the rapid release of stored strain energy. A further increase in the Ga content improved the conductivity of the nanorods due to the substitutional incorporation of Ga atoms in the Zn sites based on a decrease in lattice spacing. The p-n diode structure with Ga-doped ZnO nanorods, as a n-type, displayed a distinct white light luminescence from the side-view of the device, showing weak ultraviolet and various deep-level emissions.

• 사상체질의학회지
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• 제15권3호
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• pp.22-32
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• 2003

The pulse diagnosis is the basic method of oriental medicine diagnosis. But in sasang constitutional medicine, it is said that it's not a major diagnotic method. But we don't have any sasang constitutional study of the pulse diagnosis. So I made this study by research of changing concept of the pulse diagnosis in chinese medical history and Dongyi Suse Bowon (longevity and life preservation in oriental medicine). The conclusion as follows. 1. There were many kinds of the pulse diagnosis in the ancient times, it has developed to simple and effective diagnotic method. Simple and effective is the major point of medical development, the 24 pulse is abridged to Floating Pulse(浮), Deep Pulse(沈), Slow Pulse(遲), Rapid Pulse(數) 2. The latter term of Chosun, the practical study was developed. In the view of the practical study, the pulse diagnosis has a lot of cricical point. Jung Yak-Yong, in his writing Mak Lon(脈論), criticize the pulse diagnosis. 3. In the sasang constitutional medicine, the constitutional diagnosis is very important. The methods of the constitutional diagnosis are three, the way of mind and greed, knowledge and deed, external figure and physical traits. But the pulse diagnosis is one of the way of external figure and physical traits, so we can't diagnose the exact constitution by the pulse diagnosis. 4. Dong-mu conclude that the pulse diagnosis is just the diagnostic way of symptom. But in the clinical situation, the ordinary symptoms are more important than the pulse diagnosis, because it is useful to know the condition of the ingestive food metabolism and the Qi-yack metabolism

• 대한수학교육학회지:학교수학
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• 제13권3호
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• pp.405-422
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• 2011

본 연구는 행렬 연산지도의 실태를 분석하여 행렬 연산에 관한 이해의 필요성을 제시한 후, 행렬의 연산이 정의되는 이론적 배경의 탐구를 통하여 일대일 대응의 의의에 대해 고찰한다. 대수적 관점에서의 일대일 대응의 의의는 '이미 구조를 알고 있는 집합에서 일대일 대응을 통하여 새로운 집합에 대수적 체계를 도입할 수 있게 하는 수단'이라는 것이다. 즉, 동형구조를 만드는데 있어 핵심 아이디어라는 것이다. 행렬의 연산을 예로 한 일대일 대응에 관한 이러한 고찰과정은 수학적 사실의 필연성 및 개연성을 경험하게 하여, 그러한 수학적 아이디어들이 단순히 주어지는 것이 아니라, 특정의 목적성 있는 활동의 결과물임을 인식하게 한다. 또한 일대일 대응의 본질적 이해는 행렬에 대한 논의에 그치지 않고 지수법칙, 대칭차집합, 순열 등 다양한 수학적 지식을 전개하기 위한 기저가 된다. 이러한 연구의 목적은 교사와 학생들에게 수학적 개념의 의미 충실한 이해를 돕는데 있으며, 나아가 교사의 가르칠 지식에의 전문성을 높이는데 있다.