• Journal of Life Science
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• v.14 no.6 s.67
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• pp.906-912
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• 2004

Helicobacter pylori infection is highly prevalent, as high as 2/3 of whole population infected, in Korea. H. pylori infection initiates inflammation by induction of interleukin-8 through type IV secretion of CagA. It was recently suggested that induction failure of IL-8 is not associated with defect in cag PAI but associated with cagE locus diversity. This study was designed to investigate ability of 11-8 in-duction according to sequence variation within the cagE gene, cagA TP motifs and vacA m-types in vitro study using AGS cell-line, and to evaluate its association with different clinical outcome. Seventy-four H. pylori stains were isolated from 23 patients with gastric cancer (Ca), 24 subjects with gastritis (G) and 27 patients with duodenal ulcer (Du) in Kangnam St. Mary's Hospital, Seoul, Korea. cagE gene diversity was confirmed by the PCR-RFLP methods with MboI/NlaIII and tyrosine phosphate motifs (TPMs) of cagA was determined TPM-A and C by using DdeI/Tsp5091 restriction enzyme and TPM-B was determend by Real time PCR the method of Owen et al. and IL-8 was measured by ELISA assay. IL-8 activity was positively detected in 59 among 74 strains $(79.7\%)$. IL-8 secretion was significantly increased in MboI A and MboI B type compared to MboI C type and in MboI/NlaIII A-C and B-C type than C-C type. 1L-8 activity was not associated with either the number or composition of cagA tyrosine phosphorylation motifs and vacA m-type. There was no significant difference in IL-8 activity among patient groups. cagE gene diversity is thought to be mainly associated with the induction of IL-8 in H. pylori infection.

• KDI Journal of Economic Policy
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• v.12 no.1
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• pp.3-29
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• 1990

Korean input-output tables for 1975 and 1985 are first deflated into 1975 constant domestic prices(hypothetical terms), and the constant price I-O data are used to decompose the sources of industrial growth and structural change during the 1975-85 period. Using the same methodology, our results for the 1975-85 period are then linked to the results for the earlier period(1955-75) in order to analyze and evaluate the "demand-side" sources of industrialization over the past three decades. The results from the decomposition of the whole economy indicate that over three decades(1955-85) the relative contribution of domestic demand expansion (DDE) to growth and structural change has continuously declined while the contribution of export expansion(EE) has generally continued to rise. The contribution of import-substitution(IS) which had been significantly higher than that of EE during 1955-63 declined substantially, remaining at an insignificantly low level during the period following 1963. Although it is well known that the government's industrial policy in the 1970s emphasized import-substitution in heavy and chemical industries, no significant changes in the export-oriented growth pattern could be observed even for that period, except for a minor decline in the relative contribution of EE. This may be attributed to the substantially larger, backward-linkage effects of EE than that of IS. The sources-of-growth decompositions for major branches of the manufacturing sector generally support the major conclusions derived from the decomposition for the whole economy. The IS contribution which had been significantly high in almost all manufacturing branches during the 1955-63 period declined to low levels in all but two branches, heavy industry and machinery, during the following period. On the other hand, the relative contribution of EE showed a continuous rise in almost all manufacturing branches(except food processing). Finally, the sources of growth for 1975-85 which were decomposed by detailed sub branches, are analyzed by correlating them with changes in relative prices and industrial protection rates by sub-branches for the same period. A major result is that contrary to general expectations, the EE contributions by sub-branch are not negatively correlated with the nominal rates of protection and/or the effective rates of protection for the same sub-branches. It is also found that no statistically significant, positive correlation exists between IS contributions and nominal protection rates or effective protection rates. These unexpected results may be explained by the peculiar nature of the Korean system of industrial incentives for the past period.

• Journal of Life Science
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• v.20 no.9
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• pp.1415-1419
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• 2010

Consumption of green tea has increased along with increasing concern regarding healthier lifestyles, and many brands of green tea are sold with a label indicating the region of Korea in which the tea was produced. However, there is little information on identifying the difference between the green tea cultivars according to the region they were grown. Here, 9 green tea cultivars collected from Hadong region, Bosung region, China and Japan were subjected to the STS-RFLP analysis. Using the coding and noncoding DNA regions of genes related to the phenylpropanoid pathway, such as phenylalanine ammonia-lyase, chalcone synthase and dihydroflavonol 4-reductase, we have identified the differences between green tea cultivars according to the region they were grown in. In this study, we showed a STS-RFLP method of green tea analysis which easily distinguished different kinds of tea using the primers as described. In addition, we identified that the green tea cultivars from Hadong and Bosung displayed a different profile when PAL intron was digested with Dde I, suggesting that a rapid authentication system for green tea cultivars grown in different regions in Korea is available.