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녹용약침(鹿茸藥鍼)이 CIA 모델 생쥐의 염증인자 생성억제에 미치는 영향 (The Ability of Cervus Elaphus Sibiricus Herbal Acupuncture to Inhibit the Generation of Inflammatory Enzymes on Collagen-induced Arthritis Mice)

  • 황종순;황지혜;이현진;이동건;강민주;백성욱;조현석;김경호;김갑성
    • Journal of Acupuncture Research
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    • 제24권6호
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    • pp.1-14
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    • 2007
  • Backgrounds : Rheumatoid Arthritis(RA) is known as the chronic inflammatory diseasethat induces persistent inflammation in the joint cavity. The destruction of cartilage occurs as the result of bones destoyed by pannus, several influential cytokines induced by the synovial capsulitis, varieties of proteinases, $O_2$ radicals, and the secondary degenerative changes of articular cartilage. The type 2 collagen-induced arthritis model is used in recent experimental research on rheumatoid arthritis. Cervus elaphus sibiricus (Nockyong) has the effect of relieving pain by nourishing the muscles, joints, and bones. It is also known to be efficacious in promoting and enhancing the immune system. The objective of this study was to investigate the effect of Cervus elaphus sibiricus herbal acupuncture to inhibit the generation of proinflammatory enzyme on type 2 collagen-induced arthritis. I investigated the inhibition of mRNA transcription of MIF(macrophage migration inhibitory factor), $TNF-{\alpha}$(Tumor necrosis $factor-{\alpha}$) and MMP-9 (matrix metalloproteinase-9) of Cervus elaphus sibiricus herbal acupuncture using an in vitro test. Also investigated was the inhibition of differentiation of Th 1 cells and activation of cytokines(MIF, $TNF-{\alpha}$, IL-6, MMP-9), which are known to cause initial RA ,and are also related to the morphology of the synovial membranes of the joint capsule, by an in vivo test, using CIA(collagen induced arthritis) model mice. Materials & methods : The laboratory animals used in this experiment were 4 week-old DBA female mice, weighing approximately 20 grams, and adjusted to the laboratory environment. The experiment was divided into the normal group(NOR)-no treated group, control group(CON)-CIA induced group, and sample group(SAM)-Cervus elaphus sibiricus herbal acupuncture treated group. RA was induced in the mice via injection of $50{\mu}{\ell}$ C II mixed CFA. The Cervus elaphus sibiricus herbal acupuncture solution was applied on $GB_{35}$(陽陵泉) for 26 days from the 3rd day of RA inducement. The concentration of the solution was determined via a MTT assay. To research the effect on the expression of MIF, $TNF-{\alpha}$ and MMP-9 mRNA, RT-PCR was performed on synovial membrane cells from the knee joint of CIA mice. C II induced RA knee joint's histo-chemical synovial membrane was observed using a specimen model via the Hematoxilin and Eosin dying technique. Results : The expression of mRNA of RA-related cytokines such as MIF, $TNF-{\alpha}$, and MMP-9 dosedependently decreased in the cell from the synovial membranes of the joint, which is treated with Cervus elaphus sibiricus herbal acupuncture solution. In mice treated with Cervus elaphus sibiricusherbal acupuncture, the damage of synovial membranes of the joint was lessened, and differentiation of Th 1 cells was suppressed. The activation of RA-related cytokines such as MIF was suppressed, and the generation of $TNF-{\alpha}$ and MMP-9 showed a statistically significant decreas. Conclusions : It is speculated that Cervus elaphus sibiricus herbal acupuncture has the therapeutic effect of palliating the damage of the tissue impaired by RA by inhibition of the initial RA progression and by regulating excessive differentiation of Th 1 cell as it suppresses the generation of RA-related cytokines during the highest stage of RA by acting on pro-inflammatory enzymes.

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교등원(交藤圓)이 백서(白鼠)의 산화유발(酸化誘發)을 방어(防禦)하는 작용(作用)에 관(關)한 연구(硏究) (Effect of JiaoTeng-Yuan(交藤圓) on Oxidation Stress Caused by D-galactose in Sprague-Dawley Rats)

  • 이송실;이상재;김광호
    • 대한예방한의학회지
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    • 제8권2호
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    • pp.141-156
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    • 2004
  • Objectives : JianTeng-Yuan(交藤圓) is said to be a prescription for preservation of health in ${\ulcorner}$HuaTuo ZhongZangJing(華陀 中藏經)${\lrcorner}$. It is known to have the effect of Bu-Shen(補腎: strengthening kidney) and Yi-Shou(益壽: prolonging the span of one's life). This study investigates whether JTY is effective on inhibition of oxidation stress. Methods : Sprague-Dawley Rats(12-week-old, weight $300{\pm}20g$) were divided into 3 groups. Normal group(n=8) was injected PBS(1ml/body, s.c) at the back neck's skin. Control group(n=8) was injected D-galactose(50mg/kg, 1ml PBS/body, s.c) to induce pathological animals. JTY group was injected the same treatment for the Control group, and fed containing JTY(10%). The whole groups were treated 1 time per day for 6 weeks. After rats were sacrificed and anti-oxidant enzyme(SOD, CAT, G-px) activity, GSH quantity of RBC and tissue(heart, liver and kidney), plasma Vit-C quantity were examined. Besides, the MDA levels of liver and kidney, lipofuscin of heart and endurance of erythrocyte membrane were measured. Results : In the JTY group, RBC's SOD activity decline was halted by 21% of the normal level, compared to the control group ; G-px activity(unit/g of Hb) increased significantly, compared to the normal group ; and the level of Vit-C in plasma increased by 16%. Heart's SOD activity was kept at the same level as that of the normal group ; and CAT activity decline was halted by 26%. Kidney's CAT and G-px activities were kept at the same level as that shown in the normal group, implying the existence of halting effect. Liver also showed a slight halting effect against the decline of anti-oxidant ability, but the effect was not significant(a=0.05). A comparison between the levels of peroxide in SD rats showed that the level of TBARS in plasma increased significantly in the control group and that it was normal in the JTY group. The livers in the JTY group, compared to those in the control group, showed 36% halting effect of the normal level while their kidney's indicated the level significantly lower than the normal level. Heart's lipofuscin increased significantly in the control group, but was alike in both the JTY and the normal groups. Endurance of erythrocyte membrane(%) decreased significantly in the control group while it was kept at the similar level in both the JTY and the normal groups, indicating the halting effect. Conclusions : This study suggests that JTY is effective to defend oxidation stress caused by D-galactose in the animals. It showed that the anti-oxidant ability was maintained and strengthened. On the other hand, it reduced the level of peroxide in animals. In sum, JTY appeared to have the equilibrium normal physiological function in SD rat.

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타이타늄 임플랜트 시편 내부에 설치한 자석의 자성강도에 따른 골형성 변화 (THE CHANGE OF BONE FORMATION ACCORDING TO MAGNETIC INTENSITY OF MAGNET PLACID INTO TITANIUM IMPLANT SPECIMENS)

  • 황윤태;이성복;최대균;최부병
    • 대한치과보철학회지
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    • 제43권2호
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    • pp.232-247
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    • 2005
  • Purpose. The purposes of this investigation were to discover the possibility of clinical application in the areas of dental implants and bone grafts by investigating the bone formation histologically around specimen which was depending on the intensity of magnetic field of neodymium magnet inside of the specimens. Material and method. 1. Measurement of magnetic intensity - placed the magnet inside of the specimen, and measured the intensity of magnetic field around the 1st thread and 3rd thread of specimen 20 times by using a Gaussmeter(Kanetec Co., Japan). 2. Surgical Procedure - Male rabbit was anesthetised by constant amount of Ketamine (0.25ml/kg) and Rompun (0.25ml/kg). After incising the flat part of tibia, and planted the specimens of titanium implant, control group was stitched without magnet, while experimental groups were placed a magnedisc 500(Aichi Steel Co., Japan) or magnedisc 800(Aichi Steel Co., Japan) into it, fixed by pattern resin and stitched. 3. Management after the surgery - In order to prevent it from the infection of bacteria and for antiinflammation, Gentamycin and Ketopro were injected during 1 week from operation day, and dressed with potadine. 4. Preparation of histomorphometric analysis - At 2, 4 and 8 weeks after the surgery, the animals were sacrificed by excessed Ketamine, and then, specimens were obtained including the operated part and some parts of tibia, and fixed it to 10% of PBS buffer solution. After embedding specimens in Technovit 1200 and B.P solution, made a H-E stain. Samples width was 75$\mu$m . In histological findings through the optical microscope and using Kappa image base program(Olympus Co. Japan), the bone contact ratio and bone area ratio of each parts of specimens were measured and analyzed. 5. Statistical analysis - Statistical analysis was accomplished with Mann Whitney U-test. Results and conclusion. 1. In histomorphometric findings, increased new bone formation was shown in both control & experimental groups through the experiment performed for 2, 4 & 8 weeks. After 4 weeks, more osteoblasts and osteoclasts with significant bone remodeling were shown in experimental groups. 2. In histomorphometric analysis, the bone contact ratios were 38.5% for experimental group 1, 29.5% for experimental group 2 and 11.9% for control group. Experimental groups were higher than control group(p<0.05) (Fig. 6, Table IV). The bone area ratios were 60.9% for experimental group 2, 46.4% for experimental group 1 and 36.0% for control group. There was no significantly statistical difference between experimental groups and control group(p<0.05) (Fig. 8, Table VII) 3. In comparision of the bone contact ratios at each measurement sites according to magnetic intensity, experimental group 2(5.6mT) was higher than control group at the 1st thread (p<0.05) and experimental group 1 (1.8mT) was higher than control group at the 3rd thread(p<0.05) (Fig. 7, Table V, VI). 4. In comparision of the bone area ratios at each measurement sites according to magnetic intensity, experimental group 2(5.6mT) was higher than control group and experimental group 1 (4.0mT) at the 1st thread(p<0.1) and experimental group 2(4.4mT) was higher than experimental group 1 (1.8mT) at the 3rd thread(p<0.1) (Fig. 9, Table IX, X). Experiment group 2 was largest, followed by experiment group l and control group at the 3rd thread of implant. There was a significant difference at the 1st thread of control group & experiment group 2, and at 1st thread & 3rd thread of experiment group 1 & 2, and not at control group experiment group 1.(p<0.1)

대화식 데이터 마이닝 기법을 활용한 자동차 보험사의 인입 콜량 예측 사례 (A Case Study on Forecasting Inbound Calls of Motor Insurance Company Using Interactive Data Mining Technique)

  • 백웅;김남규
    • 지능정보연구
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    • 제16권3호
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    • pp.99-120
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    • 2010
  • 최근 고객들의 비대면 접점 서비스 이용도가 높아짐에 따라, 비대면 채널은 다양한 데이터의 분석을 통해 고객 만족도를 향상시킬 수 있는 유용한 창구로 인식되고 있다. 이러한 비대면 채널의 대표적 영역으로 콜센터를 들 수 있으며, 콜센터 운영에서 고객 만족도에 가장 큰 영향을 미치는 요소는 상담 인력의 규모인 것으로 알려져 있다. 즉, 일정수준 이상의 고객 만족도를 유지하기 위해서는 충분한 상담 인력을 확보하는 것이 관건이지만, 불필요하게 많은 인력을 확보하는 것은 인건비 측면에서 비용의 낭비를 초래할 수 있다. 따라서 부족하지도 않고 넘치지도 않을 정도의 적정 인력을 산출하는 능력은 콜센터 운영의 핵심 경쟁력으로 인식되고 있으며, 최근 콜센터에서는 적정 인력의 규모를 예측하기 위해 WFM(Work Force Management) 업무 전담 부서를 설치하고 콜량을 정확하게 예측하기 위한 노력을 기울이고 있다. 콜량 예측을 위해 현업에서 주로 사용되는 방법은 담당자의 직관에 의존하는 방법으로, 일정기간의 콜량 평균을 담당자가 주관적 판단에 의해 보정함으로써 이루어진다. 하지만 이러한 방식은 담당자의 주관적 성향에 크게 좌우된다는 한계를 갖고 있어서, 최근에는 다양한 예측 모형을 시스템화한 WFMS(Workforce Management System) 패키지가 널리 활용되고 있다. 하지만 이 시스템은 초기 도입 시 매우 고가의 구축비용이 발생하며, 신규 요인 발굴 시 이를 즉각적으로 시스템에 반영하기 어렵다는 한계점을 갖고 있다. 이를 극복하기 위해 본 연구에서는 데이터 마이닝의 대화식 의사결정나무 기법을 이용함으로써, 객관적이면서도 업무 배경 지식을 충분히 활용할 수 있는 예측 모형을 수립하고자 한다. 또한, 본 연구에서 수립한 모형의 정확성 평가를 위해, 국내 최대 규모의 한 자동차 보험사 콜센터의 4년 8개월 간의 실 데이터를 사용한 실험을 수행하고 그 결과를 제시하였다. 실험에서는 기존의 WFMS와 본 연구에서 제안하는 두 가지 모형인 대화식 의사결정나무 기반의 예측 모형, 일반 의사결정나무 기반의 예측 모형의 세 가지 모형에 대해, 다양한 오차 허용범위 하에서의 사고콜 및 고장콜에 대한 예측 적중률을 평가하였다.

소규모 사업장 보건관리대행기관의 간호업무 운영관리 지원체계 (Management and Supporting System on the Occupational Health Nursing Services Provided in Group Occupational Health Agencies of Korea)

  • 유경혜
    • 한국직업건강간호학회지
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    • 제8권2호
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    • pp.193-211
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    • 1999
  • This study was carried out to investigate the management and support system affecting to the occupational health nursing services(OHNS) provided in group occupational health agencies(GOHA). Questionnaire was developed and distributed to 82 nurses who were working in GOHA and who agreed to participate in the survey. The results were as follow: 1. OH nurses responded were mostly in the age of twenty to thirties(89%), married(73.7%), technical college graduates(88.9%), worked in hospital(85.4%) and participated more than 1 year in group occupational health services (96.3%). 2. Fifty eight point four percent of the OH nurses worked in number of workplace more than 30 to less than 60 in the OHNS form. The figure of workplaces undertaken by nurses was ranged greatly from 9 to more than 100. Number of employees who cared by nurses were mostly under 5,000 peoples in 93.3%. The types of industry was mostly manufacturing and located in the order of factory complex area, suburban, urban and others. 3. Most OH nurses(87.8%) were fully involved in the OHNS for the SSE. Their working days to visit SSE was 5 days per week(77.8%) and one day in the GOHA at 41.3%. 4. The OH documents using by nurses were found in more than 23 different types. However, they were largely summarized in the types of 'Workplace Health Management Card', 'Personal Health Counselling Card', 'Daily Health Management Report', 'Visiting List of Workplace' and 'Sick Employee List'. 5. The items of laboratory test provided by GOHA were mostly achieved in the purpose of basic health examination. They were used to be the blood pressure check(98.8%), blood sugar test (98.8%), urine sugar and protein(91.4%), SGOT and SGPT(85.3% each), cholesterol (82.9%), hepa vaccine immunization(82.9%), r-GPT(81.7%), hemoglobin(79.3%) and triglyceride(75.5%). 6. The OH nurses(92.7%) followed the work pattern to visit the GOHA before and after small-scale enterprises(SSE) visit by car driven by nurses in 74.3%. They were payed by GOHA for transportation fees in certain amounts. However, nurse is the main person(75.0%) who covers up in case of traffic accident. If the GOHA has no transportation regulation for the formal workplace visit, data showed that nurses had been responsible to take charge(31.7%). 7. The personnel manager who takes in charge for nursing services was 'nurse' in 61.7% and 41.2% worked as the final decision maker related to nursing work. The OH nurses' opinions about factors affecting to the management were classified in the four areas such as 'Nature(Quality) of health professional'. 'Content of OHNS', 'Delivery system of the GOHS', and 'Others'. The factors were indicated highly in 'Authority as health professional', 'Level of perception of director on the OH' and 'Physical work condition for OHNS'. The things that this study suggests in the recommendation would be summarized in such as the management and supporting system working for SSE in the OHNS is necessary to reform thoroughly. The reconsidered aspects might be in the matters of number of workplaces undertaken by nurses, development of effectively practical health documents, preparation for guideline of the laboratory test in the workpleces, establishment of convenient and encouraging support system and cooperation between other health professionals with respect and skill.

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수도(水稻)의 발근(發根)에 미치는 묘대가리시용(苗垈加里施用)의 영향(影響) (Effects of the time, and the rate of potassium fertilization at nursery stage on the rooting activity in paddy rice plant)

  • 이은웅;이춘영;권용웅
    • Applied Biological Chemistry
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    • 제9권
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    • pp.119-124
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    • 1968
  • 묘대(苗垈) 가리시용(加里施用) 시기(時期) 및 시용량(施用量)의 차이(差異)가 수도(水稻)의 근생장(根生長) 및 후기생육(後期生育)에 미치는 영향(影響)을 알고저 수도품종(水稻品種) "재건(再建)"을 공시(供試)하여 pet 시험(試驗)을 하였다. 시험처리(試驗處理)로써는 파종(播種) 직전(直前)과 파종(播種) 후(後) 30일(日)에 각각(各各) 염화가리(鹽化加里)를 $0{\sim}100gK_{2}O/3.3m^2$ 율(率)로 시용(施用)하고, 40일묘(日苗)를 1 주일(週日) 간격(間隔)으로 3회(回)에 걸쳐 계속 전근(剪根) 후(後) 재식(栽植)하고 각각(各各) 주일(週日) 후(後)에 발근상태(發根狀態) 및 그밖의 실용형질(實用形質)에 대(對)하여 조사(調査)하였으며, 제(第) 3 회(回) 전근(剪根) 후(後) 일부(一部)는 완전재식(完全栽植)하여 수량형질(收量形質)에 관(關)하여 조사(調査)하였다. 그 결과(結果)는 다음과 같다. 1. 성묘율(成苗率)은 가리(加里)를 기비(基肥)로 소량(小量) 시용(施用)한 경우에 높았으며, $75gK_{2}O/3.3m^2$ 이상(以上) 시용구(施用區)에서는 현저(顯著)히 감소(減少)하였다. 2. 성묘(成苗)의 초장(草長), 경수(莖數), 엽수(葉數) 및 묘중(苗重)은 모두 가리시용량(加里施用量)의 증가(增加)에 따라 증대(增大)되었으나 기비(基肥)로 시용(施用)한 경우에는 $50gK_{2}O/3.3m^2$, 묘대말기(苗垈末期)의 시용(施用)에 있어서는 $75gK_{2}O/3.3m^2$를 정점(頂點)으로 감소(減少)하였다. 3. 가리시용량(加里施用量)이 많을 수록 전근(剪根) 후(後)의 발근수(發根數)가 현저(顯著)히 증가(增加)되었고 전근(剪根)을 거듭할수록 이러한 경향(傾向)은 더욱 뚜렷하였으며, 대체(大體)로 그 한계시용량(限界施用量)은 $50{\sim}75gK_{2}O/3.3m^2$ 정도(程度)이었다. 4. 전근(剪根) 후(後) 신생근(新生根)의 최장근장(最長根長)도 통계적(統計的) 유의차(有意差)는 없지만 발근수(發根數)와 비슷한 경향(傾向)을 보였다. 5. 전근묘(剪根苗)의 초장(草長), 경수(莖數) 및 지상부(地上部)와 근부(根部)의 중량변이(重量變異)도 발근수(發根數)와 동조적(同調的) 경향(傾向)이었다. 6. 수수(穗數), 정조량(精租量) 및 고중(藁重)은 처리간(處理間) 차이(差異)는 크지 않지만 역시(亦是) 이앙묘(移秧苗)의 생육상(生育狀)과 동조적(同調的) 경향(傾向)을 보이고 묘대(苗垈) 가리시용량(加里施用量)의 증가(增加)에 따라 삼소(參少) 증대(增大)되었으나 $100gK_{2}O/3.3m^2$ 처리구(處理區)에서는 무처리구(無處理區)와 비슷한 정도(程度)로 감소(減少)되었다.

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백서 설신경 압박손상모델에서 신경성장인자 유전자 주입이 신경재생에 미치는 영향 (EFFECT OF NERVE GROWTH FACTOR GENE INJECTION ON THE NERVE REGENERATION IN RAT LINGUAL NERVE CRUSH-INJURY MODEL)

  • 고은봉;정헌종;안강민;김성민;김윤희;장정원;이종호
    • Maxillofacial Plastic and Reconstructive Surgery
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    • 제28권5호
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    • pp.375-395
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    • 2006
  • Purpose: Lingual nerve (LN) damage may be caused by either tumor resection or injury such as wisdom tooth extraction, Although autologous nerve graft is sometimes used to repair the damaged nerve, it has the disadvantage of necessity of another operation for nerve harvesting. Moreover, the results of nerve grafting is not satisfactory. The nerve growth factor (NGF) is well-known to play a critical role in peripheral nerve regeneration and its local delivery to the injured nerve has been continuously tried to enhance nerve regeneration. However, its application has limitations like repeated administration due to short half life of 30 minutes and an in vivo delivery model must allow for direct and local delivery. The aim of this study was to construct a well-functioning $rhNGF-{\beta}$ adenovirus for the ultimate development of improved method to promote peripheral nerve regeneration with enhanced and extended secretion of hNGF from the injured nerve by injecting $rhNGF-{\beta}$ gene directly into crush-injured LN in rat model. Materials and Methods: $hNGF-{\beta}$ gene was prepared from fetal brain cDNA library and cloned into E1/E3 deleted adenoviral vector which contains green fluorescence protein (GFP) gene as a reporter. After large scale production and purification of $rhNGF-{\beta}$ adenovirus, transfection efficiency and its expression at various cells (primary cultured Schwann cells, HEK293 cells, Schwann cell lines, NIH3T3 and CRH cells) were evaluated by fluorescent microscopy, RT-PCR, ELISA, immunocytochemistry. Furthermore, the function of rhNGF-beta, which was secreted from various cells infected with $rhNGF-{\beta}$ adenovirus, was evaluated using neuritogenesis of PC-12 cells. For in vivo evaluation of efficacy of $rhNGF-{\beta}$ adenovirus, the LNs of 8-week old rats were exposed and crush-injured with a small hemostat for 10 seconds. After the injury, $rhNGF-{\beta}$ adenovirus($2{\mu}l,\;1.5{\times}10^{11}pfu$) or saline was administered into the crushed site in the experimental (n=24) and the control group (n=24), respectively. Sham operation of another group of rats (n=9) was performed without administration of either saline or adenovirus. The taste recovery and the change of fungiform papilla were studied at 1, 2, 3 and 4 weeks. Each of the 6 animals was tested with different solutions (0.1M NaCl, 0.1M sucrose, 0.01M QHCl, or 0.01M HCl) by two-bottle test paradigm and the number of papilla was counted using SEM picture of tongue dorsum. LN was explored at the same interval as taste study and evaluated electro-physiologically (peak voltage and nerve conduction velocity) and histomorphometrically (axon count, myelin thickness). Results: The recombinant adenovirus vector carrying $rhNGF-{\beta}$ was constructed and confirmed by restriction endonuclease analysis and DNA sequence analysis. GFP expression was observed in 90% of $rhNGF-{\beta}$ adenovirus infected cells compared with uninfected cells. Total mRNA isolated from $rhNGF-{\beta}$ adenovirus infected cells showed strong RT-PCR band, however uninfected or LacZ recombinant adenovirus infected cells did not. NGF quantification by ELISA showed a maximal release of $18865.4{\pm}310.9pg/ml$ NGF at the 4th day and stably continued till 14 days by $rhNGF-{\beta}$ adenovirus infected Schwann cells. PC-12 cells exposed to media with $rhNGF-{\beta}$ adenovirus infected Schwann cell revealed at the same level of neurite-extension as the commercial NGF did. $rhNGF-{\beta}$ adenovirus injected experimental groups in comparison to the control group exhibited different taste preference ratio. Salty, sweet and sour taste preference ratio were significantly different after 2 weeks from the beginning of the experiment, which were similar to the sham group, but not to the control group.

채석장의 부지 활용에 대한 의식 및 모델 분석 (Analysis of Consciousness and Model on Land for the Another use After Quarrying)

  • 박재현
    • 한국산림과학회지
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    • 제101권3호
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    • pp.387-394
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    • 2012
  • 이 연구는 채석장 개발 후 부지에 대한 타용도 활용에 관한 의식 분석을 통하여 타용도로 전환하는 모델을 개발함으로써 효율적으로 산림자원을 이용 개발할 수 있도록 하기 위하여 수행하였다. 설문조사 결과, 채석장 개발에 따른 경제적 발전 등 긍정적 측면보다 먼지, 소음, 산림훼손 등 부정적 시각이 약 5% 더 크게 나타나는 것으로 분석되었다. 응답자 중 42%는 채석장 개발 후 타용도 전환하여 활용하는 것이 좋다고 응답하였고, 타용도 전환은 문 화예술공간으로(25%), 타용도 활용은 인근 주민의 요구도가 큰 지역(32%), 타용도 전환시 적정한 규모는 5~10 ha의 규모(43%)가 선호도가 높았다. 폐채석지에 대하여 타용도 전환시 SWOT분석 결과, 강점요인은 국토의 효율적 활용, 근대산업유산+문화예술 융합형 콘텐츠의 개발, 인근 도시 및 휴양객의 볼거리 제공, 주변의 수려한 경관과 청정한 환경과의 조화, 주 5일 근무 증가 등에 따른 국내외 관광객의 지속적 증가이었다. 기회요인으로는 새로 개설되는 고속철도 지방도 등을 통한 획기적 교통망(접근성) 개선, 예술창작벨트 조성으로 신성장동력 창출, 관광과 교육의 접목을 통한 차별화된 문화예술공간 제공, 석재 가공품 개발을 통한 지역소득 창출, 에코시티 개발 등 지역개발 활성화이다. 약점요인으로는 심리적 원거리감과 낙후성, 체류형 관광기반의 취약이라고 분석되었다. 위협요인으로는 인근 채석장과 연계하여 개발시 지속적인 재원의 지원이 불가피하고, 폐채석지의 타용도 전환요청에 따른 법적 제도적 정비가 시급하다고 분석되었다. 폐채석지의 타용도 활용을 위한 개발형 복구모델은 조각공원, 폭포공원 및 호수공원, 암벽등산장 등의 유형, 체육공원+산림공원, 자생식물공원 유형, 문화예술공원 유형, 복합공원 유형, 저류지, 산불진화 저류지 유형, 노인병원, 농업시설지, 학교부지 등 기타 시설 유형으로 분석되었다. 토석채취 이용 후 부지에 대한 타 용도 활용은 이용자의 선호도를 고려하여 활용형태에 따른 시설 모형을 설정하는 것이 필요할 것으로 사료된다.

홧병환자의 한의학적 치료에 대한 임상적 연구 (A Clinical Study on Treatments of Hwabyung with Oriental Medicine)

  • 김종우;황의완
    • 대한한의학회지
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    • 제19권2호
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    • pp.5-16
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    • 1998
  • Hwabyung is a common emotional disorder which has symptoms expressed like firt's explosion in middle-aged after long period of emotional suppression among Koreans. It is similar in its characteristics such as neurosis, anxiety, panic attacks in Western Medicine, though the treatment method was not effective. So we have done a clinical research on Oriental Medical Method, especially on Acupuncture Therapy, and obtained following results. 1. Patients with Hwabyung complained of pressure pain around the Chunjung(?中, CV-17) point distinctively. About 70% of those were located on the CV-17 point, 25% were 1cm upper than the CV-17 point and 5% of those were 1cm lower point than the CV-17 point. 2. Degrees of pressure pain were divided into 5 grades from ade 1(feeling pain with slight pressure) to grade 5(feeling no pain with severe pressure), respectively. 3. Patients with Hwabyung showed various symptoms compared to fire's explosion such as anger, chest discomfort, difficulty in breathing. tachycardia. and feeling of epigasfric mass etc., and the degrees were divided into 5 grades according to the severities from grade 1(can't keep their usual living) to grade 5(no complaints with heavy stresses), respectively. 4. For the treatment of Hwabyung in this study, we had given Acupuncture therapy on some points such as Chunjung:?中:CV-17, Jungwan:中脘:CV-12) and Chunchu:天樞:S-25, etc. for 15 minutes a time twice a week. And Bunshimkiumgmnihang(分心氣飮加味方) was administered 3 times a day. 5. About 40% of the patients took treatment for more than 2 months, 29% of those took 1 to 2 months and 31% of those took less than 1 month. In this study, we excluded those who stopped treatment within a month without any expected effects. 6. We evaluated the changes of severity of pain according to the following categories such as - for no change, + for 1 grade, ++ for 2 grades, +++ for 3 grades, and ++++ for 4 grades of improvements. Among the patients taken 1 to 2 months of treatment. 48% of the those showed +, 7% of those showed ++, 3% of those showed +++ and 41% of those showed no change. Among the patients taken less than 2 months of treatment, 20%of those showed +, 40% of those showed ++, 28% of those showed +++ and 13% of those showed no change. 7. We evaluate the changes of symptoms according to the following categories such as - for no change, + for 1 grade, ++ for 2 grades, +++ for 3 grades and +++ for 4 grades of improvements. Among the patients taken 1 to 2 months of treatment, 34% of those showed +, 14% of those showed ++ and 52% of those showed no change. Among the patients taken more than 2 months of treatment, 20% of those showed +, 43% of those showed 20% of those showed +++, 3% of those showed +++ and 15% of those showed no change. 8. When we compare the changes of pain and symptoms according to the periods of treatment, the changes in quantity of pain in 1 to 2 months group was $0.72{\pm}0.75$, in more than 2 months group was $1.83{\pm}0.98$, and the changes in quantity of symptoms in 1 to 2 months group was $0.62{\pm}0.73$, in more than 2 months group was $1.75{\pm}1.03$. According to the above results, we have concluded that more than 2 months of treatment is more beneficial than 1 to 2 months of treatment.

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울산지역 중.장년층의 식생활 특성과 건강식품 섭취 실태 (Food Habits and Health Food Consumption Patterns of Adults in the Ulsan Area)

  • 유수연;김혜경
    • 대한지역사회영양학회지
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    • 제8권6호
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    • pp.889-900
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    • 2003
  • This study was carried out to obtain information regarding eating habits, including health related behavior and health food consumption patterns. The subjects of this study were 149 men and 152 women residing in the Ulsan area. We obtained results by means of a questionnaire and an interview, and these were analyzed using the SPSS package program. The results of this study are summarized as follows The average age of the men was 47.6 $\pm$ 7.3 years and of the women was 47.3 $\pm$ 7.6 years old. The average height and weight of the men were 169.4 $\pm$ 5.5 cm and 67.7 $\pm$ 8.2 kg, respectively. Those of the women were 157.6 $\pm$ 5.0 cm and 58.2 $\pm$ 7.5 kg, respectively. The BMI values of all the subjects ranged from 20.0 to 25.0, all within the normal levels. In the case of dietary patterns, 24.3% of the total population always skipped a meal. In particular, 15.9% of the total population skipped breakfast. No time to eat, no appetite, having no taste, and having poor health were themain reasons for skipping meals. With regard to health care, there was a significant difference between the men and the women with respect to smoking and drinking (p<0.001). Of the total population, 40.5% hardly exercised (less than once a week), 26.2% exercised occasionally, 13.6% frequently exercised, and 19.6% exercised almost every day. A total of 60.7% responded that they were not interested in their health. The mean eating habit score of the subjects was 65.6 $\pm$ 9.9. The women had a higher eating habit score than the men (64.0 $\pm$ 9.6 for the men and 67.2 $\pm$ 9.9 for the women). Except for one group above 60 years, the older group had a higher eating habit score than the younger one. The group having a higher income and a more specialized career had a higher eating habit score than the one having a lower income and a less specialized career. There was also a marital difference. The group of single subjects showed a lower eating habit score than the married group. The group having a higher eating habit score drank, smoked and went out for meals less, and exercised more than the group having lower scores. They also were more concerned about their health. In the older group, there were more diabetic and hypertensive individuals. The subjects who had a higher BMI index were more likely to be patients with hypertension, especially in the men's group. Those who had a higher BMI index and hypertension simultaneously took a variety of medicines and foods for promoting health. Those who worried a lot about their health and had health problems tended to take special foods for their health. Patients usually took tonics. Special foods for health included Chinese medicines, tonic foods, vitamin or mineral supplements and manufactured health food supplements. Preferences for them depended on the sex and age of the subject. In the case of tonic foods, the men liked them more than the women. Foods other than tonic foods were favorites with the women. This study may provide basic information on the eating habits and health related behaviors of middle-aged people. However, further studies are needed to improve the eating habits and to change the nutritional attitudes, so that people can make better choices of health foods.