• 약학회지
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• 제27권2호
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• pp.155-161
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• 1983

The rates of deterioration of contractile forces of isolated hearts from ginseng component treated rats were determined. Rat papillary muscles were also used to study the influence of ginseng on the mechanical performance of heart. Rats weighing 200-300g were administered orally with ginseng ethanol extract (100mg/kg/day), ginseng total saponin (50mg/kg/day) and ginsenoside Rbl (5mg/kg/ day) for a week respectively. The isolated hearts from rats were perfused with Krebs-Henseleit solution by Langendorff perfusion apparatus. The force-velocity relation was clearly seen with the load-generator equipped isotonic shortening recording apparatus. The control group was only able to maintain 60% of their initial contractile forces after 120 minutes of perfusion, whereas ginseng ethanol extract treated group was able to sustain nearly their initial strength even after 120 minutes of perfusion. The similar effects were seen in the hearts treated with total ginseng saponin and ginsenoside Rb$_{1}$. Ginseng ethanol extract did alter mechanical performance of rat ventricular myocardium. It increased both maximum velocity(Vmax) of isotonic shortening and isometric force (P$_{0}$) and showed increased velocity of shortening significantly (P<0,05) at any one afterload.d.

• 한국보건간호학회지
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• 제12권1호
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• pp.103-115
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• 1998

As the studies that smoking can be a major cause to various diseases have been made, many following researches on the outcome of stop-smoking education were in progress. Even though researches based on the knowledge about smoking and status about the teenagers were prevalent, the research based on the outcomes in long time basis were not in progress. Therefore, I tracked the people who went through 5-Day Stop-Smoking School that has taught through complexed structure of behavioral, intellectual, and psychological education. I made researches on the average of success and the hardest point during their efforts to stop just to show the necessity of going through re-education. The objectives of this study were the ones who have completed the education on the years 1990, 1991. 47 were selected from 364 people that completed the training, and who were able to be contacted on the phone line. This study was conducted from 27 Oct. to 7 Nov. 1997 through verbal interviews based on the questionnaire. The questionnaire used here was made by myself, assisted by my professor. Analysis was made through unstructured open questions. The data was analyzed using SPSS program. The major results were as follows ; 1) General characteristics of the objectives are $97.0\%$ were male, $17\%$ ages below 40s, $34\%$ in the age group of 40s, and $48.9\%$ over 50s. Religiously christian 340/0, buddhist $19.1\%$, no religion or any other reason $46.8\%$. Status married $93.6\%$, unmarried $6.4\%$. There is someone smoking in the family $36.2\%$, no one smokes $63.8\%$. Reputation salary men $55.3\%$, personal business $27.7\%$. 2) The average of success is $42.6\%(20/47)$, the failure is $57.4\%$. 3) The results from the study 'When was the hardest point in the process of stop smoking' : For the successors the first week $33.3\%$, after the first week $66.7\%$. For the failures the first week $55\%$, after first week $45\%$(Statistics not precisely done), the most effective element that helped through the hardest point was the family $40\%$, personal determination $30\%$. 4) The necessity of re-education : Successors needed $55\%$, not needed $45\%$. Failures needed $48.1\%$, not needed $51.9\%$(Statistics not precisely done). The perfect time for reeducation : Successors in 6 months $50\%$, irregular time basis $50\%$. Failures in six months $36.4\%$, after six months $27.3\%$, irregular time basis $36.4\%$(Statistics not precisely done). Synthesizing the result of the study can't generalize the long-term effect of the stop-smoking due to the number of the objectives,. but recognize the fact that 47.6 have experienced success, and also the self-determination and the support from the family are desirable. Seeing the fact that both are great motivation to stop smoking. Since the first week is necessary. The necessity of re-education is rather high, so this education should be planned to be done repeatedly in a long term along with close observation, instead of short education.

• 성인간호학회지
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• 제18권5호
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• pp.781-789
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• 2006

Purpose: This study is to examine the effect of auricular acupressure therapy on smoking cessation for male adult in rural areas. Method: Research design was nonequivalent control pretest-posttest design. The samples were 90 male adults(Experimental: 40, Control: 40) in a community. Measures were the number of cigarette smoking per day, dependency on nicotine, and need for smoking. Auricular acupressure therapy, experimental treatment was applied for 2 weeks, 2 times/week, 3 day/time. Data were collected from June 2005 to December 2005. Data were analyzed using SPSS PC+ 12 version. Descriptive statistics, independent t-test, ${\chi}^2-test$, were used for each aim of this study. Results: The number of cigarette smoking per day (t= 13.230, p=.000), dependency on nicotine (t=-29.743, p=.000), and need for smoking (t=-19.799, p=.000) were significantly decreased in the experimental group by application of the auricular acupressure therapy. Conclusion: Auricular Acupressure Therapy can be a better effective primary nursing intervention on smoking cessation for male adults in rural areas through reverification by a study of repetition.

• 운동영양학회지
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• 제14권2호
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• pp.75-80
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• 2010

We evaluated the effect of the ginsenoside Re on insulin resistance of glucose transport in muscles of rats made insulin resistant with a high fat diet. After a week of adaptation period to the laboratory environment, 40 male wistar rats were randomly assigned into 2 groups (Chow diet group; CD, n = 20, High fat diet group; HFD, n = 20). After 5-week of high fat diet, Food was removed after 6:00 PM the day before the experiment. The following morning, rats were anesthetized by an intraperitoneal injection of pentobarbital sodium (50 mg/kg body wt), and the soleus muscles were removed. Before incubation, the soleus muscle was split longitudinally into strips with an average weight of 15~20 mg. After the muscle dissection was completed, the abdominal cavity was opened, and the epididymal, mesenteric, and retroperitoneal fat pads were removed and weighed. Treatment of muscles with ginsenoside Re alone had no effect on glucose transport. The high fat diet resulted in ~50% decreases glucose transport rate in soleus muscles. Treatment of muscles with ginsenoside Re in vitro for 90 min completely reversed the high fat diet-induced insulin resistance of glucose transport in soleus muscles. This effect of ginsenoside Re is specific for insulin stimulated glucose transport, as Re treatment did not reverse the high fat diet-induced resistance of skeletal muscle glucose transport to stimulation by contraction. Our results show that the ginsenoside Re induces a remarkably rapid reversal of high fat diet-induced insulin resistance of muscle glucose transport.

• Archives of Plastic Surgery
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• 제34권2호
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• pp.163-168
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• 2007

Purpose: The flap delay is a widely used technique to increase the flap survival. Dexamethasone is a well-known drug to have a positive impact on the flap survival. The objective of this study is to investigate the dual synergic effect of epinephrine as a chemical delay agent plus dexamethasone on the TRAM flap survival in rat model. Methods: Forty Sparague-Dawley rats were divided into 4 groups evenly and a right inferior epigastic vessel pedicled TRAM flap, sized $5.0{\times}3.0cm$, was elevated on each upper abdomen. In the control group(N=10), 2 ml saline was injected on transverse abdominis muscle for a week before the flap elevation. In surgical delay group(N=10) all superior pedicles and left inferior pedicle were ligated a week before the flap elevation. In epinephrine group (N=10), 1 : 50000 epinephrine mixed saline was injected to transverse abdominis muscle every day for a week before flap elevation. In epinephrine plus dexamethasone group (N=10), the same procedure as that of epinephrine group was conducted for a week and 2.5 ml/kg dexamethasone was injected transverse abdominis muscle 2 hours before the flap elevation. On the seventh day after flap elevation, the survival area of flaps were measured and the vessel numbers in upper dermis of flap were counted through histologic slides. Results: The results were as follows: the mean percentage of the flap survival area of surgical delay group ($60.5{\pm}2.44%$), epinephrine group ($75{\pm}4.43%$), and epinephrine plus dexamethasone group ($87{\pm}1.94%$) were higher than that of the control group ($35{\pm}6.06%$) significantly(p<0.05). In case of the vessel number though histologic slides, epinephrine group ($79.3{\pm}5.57$) and epinephrine plus dexamethasone group ($96.3{\pm}14.05$) were higher than that of the control group ($44.8{\pm}8.82$) significantly(p<0.05), but the surgical delay group ($54{\pm}4.23$) showed no significant difference (p>0.05) compared to that of the control group. Conclusion: The results indicated that epinephrine plus dexamethasone injection before the flap elevation could be used to increase the TRAM flap survival area in rat model.

• 한국축산시설환경학회지
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• 제22권1호
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• pp.27-34
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• 2016

The objective of this study was to increased breeding area in same size pig pen and growth performance of weaning pigs. A total of 330 crossbred ($6.68{\pm}0.36kg$) weaning pigs were subjected to a 42-day feeding trial(3 pens/treatment) in which effects of the semi-floor were compared : NC; Negative control ($0.23m^2/pig$; 40 pigs/pen), PC; Positive control($0.30m^2/pig$; 30 pigs/pen) and Semi-floor($0.30m^2/pig$; 40 pigs/pen). There was a significant effect on BW at 6 week along all treatment(P<0.01). There was a effect of Semi-floor treatment on ADG(average daily gain) only during the first 3 week after weaning(P<0.01). No significant effect was observed in the ADFI during the experiment period. NC treatment had significantly lower BUN value than other treatments(P<0.05). The results from immune and stress response with semi-floor suggest that no negative effects in their blood analysis. Consequently, semi floor treatments increased additional breeding area and also growth performance rather than other treatments in weaning pigs.

• 대한한방소아과학회지
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• 제23권3호
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• pp.177-191
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• 2009

Objectives To evaluate the effect of InsamGobonHwan (IGH) on growth of rats. Methods We divided male Sprague-Dawley rats into 4 groups(IGHE1, IGHE2, IGHE3 and sham group). IGHE1, IGHE2, IGHE3 groups were administered with IGHE water extracts once a day at the dose of 1,000, 500 and 250mg/kg/$10m{ell}$ for 1 week, 2 weeks, and 3 weeks. Sham group was administered with normal saline with using the same method. We measured body weight, amount of body weight increasing, length of femur, serum Growth Hormone(GH), serum Insulin-like Growth Factor-I(IGF-I), serum Thyroid-stimulating Hormone(TSH) and serum testosterone at 1 week, 2 weeks, and 3 weeks of experiment. Results The body weight and the changes of body weight increased significantly in IGHE1 group compared to sham group after 2 and 3 weeks, and in IGHE2 group after 2 weeks. The lengths of the femur increased significantly in IGHE1 group as compared with sham group after 1, 2 and 3 weeks, and in IGHE3 group after 1 week. The level of IGF-I in the serum increased significantly in S1 group as compared tosham group after 1 and 3 weeks, and in IGHE13 group after 3 weeks. The level of TSH in the serum increased significantly in IGHE1group as compared to sham group after 2 and 3 weeks. The level of GH and testosterone in the serum does not change significantly. Conclusions SGT have an effect of promoting growth of rats and might be effect to treat various kinds of growth delay in children.

• Toxicological Research
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• 제27권3호
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• pp.153-160
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• 2011

To evaluate the whitening effect of black tea water extract (BT), BT was topically applied to artificially hyperpigmented spots on the back skins of brown guinea-pigs (weight: 450~500 g) induced by 1,500 mJ/$cm^2$ of ultraviolet B (UVB) irradiation. The test compounds of 30 ${\mu}l$ were applied twice a day, six days a week, for four weeks. The artificially hyperpigmented spots were divided into 5 groups: control (UVB + saline, C), vehicle control [UVB + propylene glycol: ethanol: water (5 : 3 : 2), VC], positive control (UVB + 2% hydroquinone, PC), experimental 1 (UVB + 1% BT), experimental 2 (UVB + 2% BT). After 4-week application, the spots were removed by biopsy punch under anesthetic condition and used as specimens for the histological examination. The total polyphenol and flavonoid contents of BT were 104 and 91 mg/g, respectively. The electron-donating ability of BT revealed a dose-dependent response, showing the excellent capacities of 86% at 800 ${\mu}g$/ml. The artificially hyperpigmented spots treated with the PC and BT were obviously lightened compared to the C and VC groups. At the fourth week, the melanin indices for the PC and BT groups were significantly lower (p < 0.001) than those of the C and VC groups. In histological examination, PC and BT groups were significantly reduced in the melanin pigmentation, the proliferation of melanocytes and the synthesis of melanosomes compared to the C and VC groups. It is found that BT inhibits the proliferation of melanocytes and synthesis of melanosomes in vivo using brown guinea pigs, thereby showing a definite skin whitening effect.

• Restorative Dentistry and Endodontics
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• 제2권1호
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• pp.7-9
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• 1976

This study was performed to reveal the effect of self-curing acrylic resin to dental pulp when the resin was used directly on the freshly cut dentin. Class V cavity preparations were made on the teeth of dogs with No. 701 carbide bur at a speed of 200,000 rpm and with an air water spray. Petrolatum jelly was coated on the inner surfaces of the cavities. After that, doughs of self-curing acrylic resin were filled in these cavities and before completely set these were removed and cemented with zinc oxide and eugenol cement. The dogs were sacrified between 1 day and 3 weeks at the intervals of one week and routinely processed with hematoxylin and eosin stain for histopathologic interpretation. The results were as followings; 1. The inflammatory changes of the pulp can be seen after the use of self-curing acrylic resin on freshly cut dentin. 2. The inflammatory changes of the pulp were not completely subsided until the end of third experimental week.

• International Journal of Contents
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• 제9권4호
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• pp.67-71
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• 2013

This study examined the effects of biofeedback postural control training on the weight distribution rate and functional ability of subjects with stroke. A total of 30 stroke patients were enrolled in this study. Subjects were divided into a biofeedback postural training group (experimental group, n=15) and a dynamic balance training group (control group, n=15). Experimental subjects received biofeedback postural training and control subjects received dynamic balance training for 30 minutes per day, 5 times per week over a 6 week period. Weight distribution rate and functional ability were measured to identify the effect of the biofeedback postural training. Significant difference in weight distribution rate was observed in the experimental group, compared with the control group (p=0.05), and a significant difference in functional ability. The results of this study provide evidence in support of incorporating a biofeedback postural training for the improvement of weight distribution rate and functional ability of stroke patients.