• 대한지역사회영양학회지
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• 제17권5호
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• pp.664-675
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• 2012

This study was conducted to investigate the cross-sectional associations between dietary factors and the risk of metabolic syndrome (MetS) in 12,755 subjects (males 5,146, females 7,609) aged 19 years or above using data from the 4th (2007-2009) Korea National Health and Nutrition Examination Survey (KNHANES). The prevalence of MetS in Korean adults was 23.6% (males 26.1%, females 20.9%) with the criteria for modified National Cholesterol Education Program Adult Treatment Panel III. While males had a higher prevalence of abdominal obesity, hyperglycemia, hypertriglyceridemia, and high blood pressure than females, the prevalence of low HDL-cholesterol level was higher in females than in males. Among dietary guidelines, the response of 'yes' for asking practice of 'avoiding salty foods', and 'eating moderately and increasing physical activity for healthy weight' were significantly associated with the decreased risk of MetS in both males and in females. Especially, the risk of MetS was significantly lower in the subjects that responded the practice of all items of Korean Dietary Guidelines. Significantly negative associations with MetS were also found in the responding for practice of 'limiting consumption of alcoholic beverages' in males, and taking dietary supplements in females. Skipping breakfast was positively associated with the risk of MetS. In conclusion, dietary behaviors such as having breakfast, practice of dietary guidelines, and food consumption in moderation could modify the prevalence of MetS, and our findings could be useful for establishing guidelines for preventing MetS.

• 동아시아식생활학회지
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• 제20권4호
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• pp.502-508
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• 2010

The purpose of this study was to investigate the blood concentrations of lipids, insulin and ascorbic acid, and their correlations in obese college men in Gyeongnam area. The blood pressure was significantly higher (p<0.001) in the obese group($127.8{\pm}7.2/86.7{\pm}9.2\;mmHg$) than the control group($112.8{\pm}6.6/71.9{\pm}6.6\;mmHg$). The serum triglyceride (p<0.01), total cholesterol (p<0.01), LDL-cholesterol (p<0.05), insulin (p<0.001) concentrations and atherogenic index (AI) (p<0.001) were significantly higher in the obese group ($158.8{\pm}79.7\;{\mu}U/L$, $185.0{\pm}26.8\;{\mu}U/L$, $111.9{\pm}28.1\;{\mu}U/L$, $15.2{\pm}5.6\;{\mu}U/L$, $3.6{\pm}1.0$) than the control group($111.9{\pm}35.8\;{\mu}U/L$, $165.9{\pm}19.4\;{\mu}U/L$, $97.0{\pm}16.4\;{\mu}U/L$, $8.9{\pm}4.4\;{\mu}U/L$, $2.6{\pm}0.3$), but HDL-cholesterol concentration was significantly higher (p<0.01) in the control group($46.5{\pm}7.2\;{\mu}U/L$) than the obese group($41.3{\pm}6.9\;{\mu}U/L$). On the other hand, there was no significant difference in the plasma ascorbic acid concentration in both groups. The ascorbic acid concentration was negatively correlated with total cholesterol level in the control group, and with triglyceride, total cholesterol levels and diastolic blood pressure in the obese group (p<0.05). These data show that young adult obesity might be related to hyperlipidemia, atherosclerosis, hypertension and diabetes mellitus, and that the nutrition of ascorbic acid is more important for obese males than normal weight males.

• 농촌의학ㆍ지역보건
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• 제32권1호
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• pp.13-26
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• 2007

Objectives: This study was conducted to investigate the association between health risk factors and mortality in Juam cohort. Methods: The subjects were 1,447 males and 1,889 females who had been followed up for 68.5 months to 1 January 2001. Whether they were alive or not was confirmed by the mortality data of the National Statistical Office. A total of 289 persons among them died during the follow-up period. The Cox's proportional hazard regression model was used for survival analysis. Results: Age, type of medical insurance, self cognitive health level, habit of alcohol drinking, smoking, exercise and BMI level were included in Cox's proportional hazard model by gender. The hazard ratio of age was 1.07(95% CI: 1.05-1.10) in men, 1.09(95% CI: 1.06-1.12) in women. The hazard ratio of medical aid(lower socioeconomic state) was 1.43(95% CI 1.02-2.19) in women. The hazard ratios of current alcohol drinking and current smoking were respectively 1.69(95% CI: 1.01-2.98), 1.52(95% CI: 1.02-2.28) in women. The hazard ratio of underweight was 1.56(95% CI 1.08-2.47) in men. The hazard ratios of underweight, normoweight, overweight, and obesity were respectively 1.63(95% CI: 1.02-2.67), 1.0(referent), 0.62(95% CI: 0.32-1.63), 1.27(95% CI: 0.65-3.06), which supported the U-shaped relationship between body mass index and mortality among the men over 65. Conclusions: The health risk factors increasing mortality were age, underweight in male, age, lower socioeconomic state, current alcohol drinking, current smoking in female. To evaluate long-term association between health risk factors and mortality, further studies need to be carried out.

• 생명과학회지
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• 제23권6호
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• pp.825-831
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• 2013

본 연구를 통하여 streptozotocin 주사에 의한 당뇨 유발이 일반식이와 고지방식이로 키운 C57BL/6 수컷생쥐의 지방조직에서의 염증성 사이토카인 유전자 발현에 미치는 영향을 조사하였다. 네 그룹의 당뇨생쥐(일반식이 또는 고지방식이로 키운 16주령 또는 26주령 생쥐)와 네 그룹의 비당뇨 대조군을 포함한 모두 73마리의 생쥐가 이 실험에 사용되었다. Real-time PCR을 이용하여 지방조직에서의 tumor necrosis factor-${\alpha}$ (TNF-${\alpha}$)와 monocyte chemoattractant protein-1 (MCP-1)의 유전자 발현량을 측정한 결과, TNF-${\alpha}$ mRNA는 당뇨 유발에 의해 증가하는 양상을 보였다. 특히, 16주령의 일반식이 생쥐의 경우 비당뇨 대조군에 비해 당뇨가 유발된 실험군에서 유의한 증가가 관찰되었다. MCP-1 mRNA 발현은 STZ처리에 따른 당뇨유발에 의해 감소하는 경향을 나타내었다. 특히, 16주령 고지방식이의 당뇨 실험군에서의 발현이 비당뇨 대조군에서의 발현량의 26%에 해당할 정도로 큰 감소를 나타내었다. 또한, MCP-1의 발현은 인슐린 농도와 유의한 상관관계가 있음이 확인되었다. 이들 실험결과는 당뇨 모델 생쥐에서 지방조직의 염증성 사이토카인이 이상발현되고 있음을 나타내며, 비만, 인슐린저항성, 및 당뇨에서의 저준위 염증상태와 지방조직에서의 염증성 사이토카인 발현 조절의 기작을 밝히는데 유용한 정보를 제공할 것으로 기대된다.

• Asian Pacific Journal of Cancer Prevention
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• 제17권5호
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• pp.2479-2483
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• 2016

Background: This study explored the knowledge and awareness about colorectal cancer (CRC) among undergraduate students of one of the leading universities in Saudi Arabia, along with the mode of information access. Materials and Methods: The present cross-sectional study was conducted at the King Abdulaziz University, Jeddah, Saudi Arabia, among students of different faculties. The study questionnaire, containing 28 items, was adapted from surveys identified in the relevant literature. The CRC awareness questionnaire consisted of an awareness section (early CRC signs and symptoms, and risk factors) and a knowledge section. The data were analyzed using the SPSS version 21.0. Results: A total of 525 undergraduate students participated in the study. The majority were females (63.0%) and approximately half (56.8%) were medical students. The majority of the students (82.3%) were aware of CRC, and 68% thought that CRC is a preventable disease. Regarding colorectal cancer screening tests, only one-third of students (33%) had actual knowledge, while the majority of the students (77.0%) thought that there are tests which help in early detection. Only 4% of the participants had a family history of CRC. The majority of the participants (84%) thought that CRC is a disease that can be cured. Almost 50-60% participants had good awareness level regarding risk factors, and signs and symptoms. Regarding knowledge, participant responses varied for family history (52%), age (59%), chronic infection of the colon (72%), obesity and lack of exercise (66%). More than one-third of the students had received information material regarding CRC from their curriculum followed by social media (20.4%), and nearly 40% from other sources such as TV, hospital and mass media. Female participants had significantly better awareness in a few questions regarding CRC awareness as compared to their male counterparts. There was a significant difference observed between medical and non-medical students (p<0.001) in overall score of awareness and knowledge about CRC while no significant difference found in gender-wise comparison. Conclusions: Knowledge and awareness of students about CRC were not up to the mark. Medical students and female students had better knowledge in a few areas, but the overall situation is dismal.

• 한국산학기술학회논문지
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• 제17권6호
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• pp.278-290
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• 2016

본 연구의 목적은 근로자들의 BMI 변화에 따른 혈청총콜레스테롤의 변화 및 고콜레스테롤혈증 발생비율과의 관련성을 파악하고자 시도하였다. 연구는 2002년부터 20012년까지 11년간 각 연도별로 1회 이상 정기건강검진을 받았던 30~69세 근로자 28,249명(남자 25,548명, 여자 2,701명)을 대상으로 검진기간을 전기(2002-2005), 중기(2006-2009) 및 후기(2010-2012)로 구분하여 각 기간별 BMI 구분에 따른 혈청지질의 평균치를 분석하였다. 또한, 기준년도(2002)로부터 10년간의 BMI의 변화량 구분별로 혈청총콜레스테롤의 평균변화량을 산출하였으며, 혈청총콜레스테롤 정상자에서의 BMI 구분별 10년간의 고콜레스테롤혈증 발생의 년차별 비율을 분석하였다. 연구결과, 서로 다른 3시기(전기; 2002~2005, 중기; 2006~2009 및 후기; 2010~2012)에서의 평균혈청총콜레스테롤은 BMI가 낮은 군($18.5kg/m^2$미만군)에서 중간군($18.5-25.0kg/m^2$군), 높은 군($25.0kg/m^2$ 이상군)으로 갈수록 유의하게 증가하였으며, 고콜레스테롤혈증 발생비율도 BMI가 낮은 군에서 높은 군으로 갈수록 유의하게 증가하였다. 위와 같이 10년간의 BMI 변화량에 대한 혈청총콜레스테롤의 평균변화량의 경년적 추이를 볼 때, BMI의 증가는 혈청총콜레스테롤의 증가에 유의한 영향을 미치는 것으로 밝혀졌다. 따라서 혈청지질치의 위험 관리를 위해서는 비만관리에 대한 평가와 중재가 필요함을 시사하고 있다.

• Journal of Acupuncture Research
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• 제29권4호
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• pp.7-18
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• 2012

Objectives : The purpose of this study is to evaluate the effects of Miso facial acupuncture on facial reduction and improvement of skin condition. Methods : From March to May 2012, 20 women in their twenties to forties with no facial diseases were recruited. Miso facial acupuncture was performed on the both side of their face twice a week, total seven times. The 3D face photographs of each participant were checked 5 times ; before treatment, after 1st treatment, 4th treatment, 7th treatment and 10 days from the last treatment using RS-400FL(Morpheus Co. Korea) and REAL FACE. The surface distances of the 4 lines on the face were measured using Renai MEF program. The improvement of skin condition was evaluated by water content, trans epidermal water loss(TEWL), erythema index and melanin index using MPA 5. They were checked 4 times ; before treatment, 4th treatment, 7th treatment and after 10 days from the last treatment. We analyzed data using Paired t-test(p<0.05) and Wilcoxon signed rank test(p<0.05). Results : One case was dropped out due to pain and edema after 4th treatment. The surface distances of the 4 lines on face were significantly reduced and maintained after 10 days from last treatment. Water content was significantly increased and maintained after 10 days from last treatment. TEWL was significantly decreased. Erythema index was significantly decreased from the 3rd evaluations. Melanin index was slight decreased with no significance at the 2nd evaluations. Conclusions : These results show that Miso facial acupuncture can reduce sizes of the face and improve skin condition such as water content, TEWL and erythema index except melanin index.

• Child Health Nursing Research
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• 제20권3호
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• pp.205-214
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• 2014

목적 본 연구는 대학생을 위한 대사증후군 예방교육 프로그램을 개발하고 그 효과를 평가하기 위하여 시행되었다. 방법 비동등성대조군 사전사후설계인 유사 실험연구와 질적 자료분석인 내용분석방법을 접목한 연구 방법간 트라이앵귤레이션을 적용하였다. 서울시 노원구 소재 S대학교 재학생 49명을 대상으로 하였으며, 자료 분석방법은 SPSS WIN 18.0 프로그램을 사용하여 서술통계 $x^2$-test, t-test, Fisher's exact test를 구하였다. 결과 본 대사증후군 예방교육 프로그램의 주 메뉴는 기본교육, 영양교육, 운동교육, 식사일기, 운동체크, 팁의 총 6개로 구성되어있고, 실험군은 대조군에 비해 대사증후군 예방에 대한 인식정도가 유의하게 높았으며(F=7.919, p=.007), 대상자들은 비만, 고혈압, 당뇨 등이 대사증후군과 관련이 있으며 예방을 위한 실천방안으로 식습관 개선과 운동의 중요성에 대한 인식을 가지고 있었다. 결론 스마트폰에 친숙한 대학생에게 어플리케이션을 교육매체로 한 대사증후군 예방교육 프로그램은 매우 유의한 효과가 있음이 확인되어 그 개발의 필요성과 효용성이 입증되었다.

• Journal of Preventive Medicine and Public Health
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• 제44권5호
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• pp.226-233
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• 2011

Objectives: Being overweight or obese is central to metabolic syndrome, and these characteristics constitute dominant risk factors for chronic diseases. Although behavioral factors, including eating habits and sedentary lifestyles, are considered to be determinants of obesity, the specific childhood factors that contribute to this condition have not been clearly defined. Methods: The subjects consisted of 261 children aged 7- 9 years who were recruited from an elementary school during October 2003. Information was obtained from their parents using a questionnaire focused on eating behaviors and lifestyle factors, additional data were also collected via anthropometric measurements and biochemical examinations, including blood tests. Results: A total of 48 (18.4%) of the 261 children were overweight, and 34 (70.8%) had at least one other component of metabolic syndrome. Eating behaviors emerged as significant lifestyle-related risk factors for being overweight or obese. Those who engaged in overeating more than twice per week had three times the risk of being overweight (odds ratio [OR], 3.10, 95% confidence interval [CI], 1.39 to 6.92), and those who ate rapidly had three times the risk of being overweight (OR, 3.28; 95% CI, 1.68 to 6.41). Those who had fewer family meals (fewer than 2?3/month) had a nine times higher risk of being overweight than those who had family meals more frequently (at least 1/day) (OR, 9.51; 95% CI, 1.21 to 74.82). Conclusions: This study showed that being overweight or obese during preadolescence is associated with a higher risk of metabolic syndrome and is related to unhealthy eating behaviors. Thus, weight-control strategies and healthy eating behaviors should be developed early in life to reduce the risk for metabolic syndrome.

• 한국한의학연구원논문집
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• 제13권2호통권20호
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• pp.65-69
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• 2007

Background and Purpose : The purpose of this case-control study was to show the relationship between risk factors(past medical history, BMI, WHR, smoking, drinking), warning signs(dyscinesia, sightless, dysarthria, sensory disorder, numbness, blephalospasm, facial spasm, tension) and the incidence of stroke in korean adults. Methods : 455 stroke patients were enrolled as the case group and 180 non-stroke patients as control group from Oct. 2005 to Feb. 2006. Patients were hospitalized within 2 weeks after the onset of stroke. Obesity were defined as $BMI{\geq}25kg/m2$, $WHR{\geq}0.9$ in male and $WHR{\geq}0.8$ in female. Risk factors and warning signs were obtained from personal interview. The analysis of the data was done by chi-square test. Fisher's exact test and test-sample t-test. Results : The percentage of current smokers(or current drinkers) of case group is higher significantly than that of control group. The past medical history of risk factors were found to be transient ischemic attack(p=0.0698), facial palsy(p=0.4061), hypertension(p<0.0001), hyperlipidemia(p=0.1484), DM(p<0.0001), ischemic heart disease(p=0.0093), migraine(p=0.0014) and hypochondria(p=0.2370). $WHR{\geq}0.9$ in male had a 6.696 (3.711-12.082) odds ratio, $WHR{\geq}0.8$ in female had a 1.567 (0.659-3.726) odds ratio. $BMI{\geq}25kg/m2$ had a 2.017(1.263-3.222). The dyscinesia and sensory disorder of warning signs were found to be statistical difference between case and control group. Conclusions : According to the above results, it was found that smoking, drinking, BMI, WHR, hypertension, DM, ischemic heart disease, migraine affected to the incidence of stroke.