• The Korean Journal of Applied Statistics
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• v.22 no.3
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• pp.607-616
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• 2009

In many epidemiological studies, the occurrence times of the event of interest are right-censored or interval censored. In certain situations such as the AIDS data, however, the incubation period which is the time between HIV infection and the diagnosis of AIDS is usually doubly censored. In this paper, we impute the interval censored HIV infection time using three imputation methods. Mid imputation, conditional mean imputation and approximate Bayesian bootstrap are implemented to obtain right censored data, and then Gibbs sampler is used to estimate the coefficient factor of the incubation period. By using Bayesian approach, flexible modeling and the use of prior information is available. We applied both parametric and semi-parametric methods for estimating the effect of the covariate and compared the imputation results incorporating prior information for the covariate effects.

• Communications for Statistical Applications and Methods
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• v.26 no.4
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• pp.411-430
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• 2019

Tumor development is driven by complex combinations of biological elements. Recent advances suggest that molecularly distinct subtypes of breast cancers may respond differently to pathway-targeted therapies. Thus, it is important to dissect pathway disturbances by integrating multiple molecular profiles, such as genetic, genomic and epigenomic data. However, missing data are often present in the -omic profiles of interest. Motivated by genomic data integration and imputation, we present a new statistical framework for pathway significance analysis. Specifically, we develop a new strategy for imputation of missing data in large-scale genomic studies, which adapts low-rank, structured matrix completion. Our iterative strategy enables us to impute missing data in complex configurations across multiple data platforms. In turn, we perform large-scale pathway analysis integrating gene expression, copy number, and methylation data. The advantages of the proposed statistical framework are demonstrated through simulations and real applications to breast cancer subtypes. We demonstrate superior power to identify pathway disturbances, compared with other imputation strategies. We also identify differential pathway activity across different breast tumor subtypes.

• Journal of Korea Multimedia Society
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• v.24 no.2
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• pp.245-254
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• 2021

We proposed the research on an analysis and prediction model that allows the identification of outliers or abnormality in the data followed by effective and rapid imputation of missing values was conducted. This model is expected to analyze efficiently the problems in the data based on the calibrated raw data. As a result, a system that can adequately utilize the data was constructed by using the introduced KNN + MLE algorithm. With this algorithm, the problems in some of the existing KNN-based missing data imputation algorithms such as ignoring the missing values in some data sections or discarding normal observations were effectively addressed. A comparative evaluation was performed between the existing imputation approaches such as K-means, KNN, MEI, and MI as well as the data missing mechanisms including MCAR, MAR, and NI to check the effectiveness/efficiency of the proposed algorithm, and its superiority in all aspects was confirmed.

• The Korean Journal of Applied Statistics
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• v.23 no.5
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• pp.909-921
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• 2010

Cross-wave regression imputation and carry-over imputation method are generally used in the analysis of panel data with missing values. Recently it is known that the BLS non-response adjust method has good statistical properties. In this paper we show that the BLS method can be considered as an imputation method with a similar formula of a ratio-estimator. In addition, we show that the carry-over imputation and BLS imputation are approximately the same under the assumption that data follow a non-stationary process with drift. Small simulation studies and real data analysis are performed. For the real data analysis, a monthly labor statistic (2007) is used.

• Journal of the Korean Statistical Society
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• v.36 no.3
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• pp.423-434
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• 2007

Imputation using a regression model is a method to preserve the correlation among variables and to provide imputed point estimators. We discuss the implementation of regression imputation using fractional imputation. By a suitable choice of fractional weights, the fractional regression imputation can take the form of hot deck fractional imputation, thus no artificial values are constructed after the imputation. A variance estimator, which extends the method of Kim and Fuller (2004), is also proposed. Results from a limited simulation study are presented.

• Proceedings of the Korean Statistical Society Conference
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• 2003.05a
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• pp.237-242
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• 2003

Various kinds of estimation methods have been developed for imputation of categorical missing data. They include modal category method, logistic regression, and association rule. In this study, we propose two imputation methods (neural network fusion and voting fusion) that combine the results of individual imputation methods. A Monte-Carlo simulation is used to compare the performance of these methods. Five factors used to simulate the missing data are (1) true model for the data, (2) data size, (3) noise size (4) percentage of missing data, and (5) missing pattern. Overall, neural network fusion performed the best while voting fusion is better than the individual imputation methods, although it was inferior to the neural network fusion. Result of an additional real data analysis confirms the simulation result.

• Journal of the Korean Data and Information Science Society
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• v.18 no.3
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• pp.585-598
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• 2007

It is so difficult to get complete data when we conduct a questionaire in actuality. And we get inefficient results if we analyze statistical tests with ignoring missing values. Therefore, we use imputation methods which evaluate quality of data. This study proposes a imputation method by decomposition and voting with ordinal data. First, data are sorted by each variable. After that, imputation methods are used by each decomposition level. And the last step is selection of values with voting. The proposed method is evaluated by accuracy and RMSE. In conclusion, missing values are related to each variable, median imputation method using decomposition and voting is powerful.

• Proceedings of the Korean Association for Survey Research Conference
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• 2000.06a
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• pp.1-14
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• 2000

We consider statistical methods for nonresponse problem in social and economic sample surveys. To create a complete data set, which does not include item nonresponse data, imputation methods are generally used. In this paper, we introduce some imputation methods and compare them with one another. Also, we consider some problems, which occur when an imputed data set is treated as a response data set. Due to the imputed values, the true variance of the estimator after imputation is increased by the imputation variance. However, since usual naive variance estimator constructed from the imputed data set does not estimate the imputation variance, the true variance of the estimator after imputation tends to be underestimated. Theoretical reason is investigated and serious results are explained through a simulation study. Finally, some adjusted variance estimation methods to compensate for underestimation are presented and discussed.

• Survey Research
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• v.1 no.2
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• pp.1-14
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• 2000

We consider statistical methods for nonresponse problem in social and economic sample surveys. To create a complete data set, which does not include item nonresponse data, imputation methods are generally used. In this paper, we introduce some imputation methods and compare them with one another. Also, we consider some problems, which occur when an imputed data set is treated as a response data set. Due to the imputed values, the true variance of the estimator after imputation is increased by the imputation variance. However, since usual naive variance estimator constructed from the imputed data set does not estimate the imputation variance, the true variance of the estimator after imputation tends to be underestimated. Theoretical reason is investigated and serious results are explained through a simulation study. Finally, some adjusted variance estimation methods to compensate for underestimation are presented and discussed.

• The Korean Journal of Applied Statistics
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• v.32 no.4
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• pp.543-559
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• 2019

Data often include missing values due to various reasons. If the missing data mechanism is not MCAR, analysis based on fully observed cases may an estimation cause bias and decrease the precision of the estimate since partially observed cases are excluded. Especially when data include many variables, missing values cause more serious problems. Many imputation techniques are suggested to overcome this difficulty. However, imputation methods using parametric models may not fit well with real data which do not satisfy model assumptions. In this study, we review imputation methods using nonlinear models such as kernel, resampling, and spline methods which are robust on model assumptions. In addition, we suggest utilizing imputation classes to improve imputation accuracy or adding random errors to correctly estimate the variance of the estimates in nonlinear imputation models. Performances of imputation methods using nonlinear models are compared under various simulated data settings. Simulation results indicate that the performances of imputation methods are different as data settings change. However, imputation based on the kernel regression or the penalized spline performs better in most situations. Utilizing imputation classes or adding random errors improves the performance of imputation methods using nonlinear models.