• The Korean Journal of Physiology and Pharmacology
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• 제9권2호
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• pp.87-94
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• 2005

It is not clear whether $Ca^{2+}-induced$ $Ca^{2+}$ release from the sarcoplasmic reticulum (SR) is involved in the regulation of atrial natriuretic peptide (ANP) release. Previously, we have shown that nifedipine increased ANP release, indicating that $Ca^{2+}$ entry via voltage-gated L-type $Ca^{2+}$ channel activation decreases ANP release. The purpose of the present study was two-fold: to define the role of SR $Ca^{2+}$ release in the regulation of ANP release and whether $Ca^{2+}$ entry via L-type $Ca^{2+}$ channel is prerequisite for the SR-related effect on ANP release. Experiments were performed in perfused beating rabbit atria. Ryanodine, an inhibitor of SR $Ca^{2+}$ release, increased atrial myocytic ANP release ($8.69{\pm}3.05$, $19.55{\pm}1.09$, $27.31{\pm}3.51$, and $18.91{\pm}4.76$% for 1, 2, 3, and $6{\mu}M$ ryanodine, respectively; all P<0.01) with concomitant decrease in atrial stroke volume and pulse pressure in a dose-dependent manner. In the presence of thapsigargin, an inhibitor of SR $Ca^{2+}$ pump, ryanodine-induced increase in ANP release was not observed. Thapsigargin attenuated ryanodine-induced decrease in atrial dynamic changes. Blockade of L-type $Ca^{2+}$ channel with nifedipine abolished ryanodine-induced increase in ANP release ($0.69{\pm}5.58$% vs. $27.31{\pm}3.51$%; P＜0.001). In the presence of thapsigargin and ryanodine, nifedipine increased ANP release and decreased atrial dynamics. These data suggest that $Ca^{2+}$-induced $Ca^{2+}$ release from the SR is inversely involved in the regulation of atrial myocytic ANP release.

• 한국통신학회논문지
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• 제30권10A호
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• pp.912-921
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• 2005

Optical Burst Switched (OBS)는 If over WDM 망에서 테라비트 전송을 하기 위한 진보된 기술이다. OBS의 핵심 기술 중 하나는 데이터 버스트(DB : Data Burst)의 경쟁을 막기 위한 채널 스케쥴링 이다. OBS망에서 버스트의 제어패킷(CHP : Control Header Packet)과 데이터 버스트는 시간 간격(Time Gap)을 가지고 전송된다. 버스트 스위치 노드에 CHP가 도착하면 데이터 버스트을 위해 스케줄링 알고리즘을 사용하여 파장/채널(wavelength/channel)과 같은 자원을 예약하여 광전광(O/E/O)변환 없이 데이터 버스트를 전송해준다. 데이터 버스트를 위해 채널 스케줄링 과정에서 버스트간의 경쟁과 시간 간격이 발생되어 자원의 사용율과 버스트 손실 확률이 떨어진다. 기존에 제안된 방법들은 이러한 문제를 해결하기 위하여 많은 연구가 되어 지고 있다. 본 논문에서는 데이터 할당에서 발생되는 데이터간 간격과 데이터 손실에 중점을 두어 버스트 손실 확률과 자원 사용율을 극대화하기 위하여 버스트의 개방 시간)Release Time)을 이용한 채널 스케줄링 알고리즘 RTUC(Release Time Unscheduled Channel)을 제안한다. 시뮬레이션 결과 기존에 제안된 스케쥴링 알고리즘(LAUC, LAUC-VF)보다 버스트의 생존(Survival)과 효율적인 자원 사용 및 지연에서 개선된 성능을 확인하였다. 하지만, 로드가 적었을 경우 상대적으로 기존의 스케줄링 알고리즘보다 성능저하가 확인되었고, 로드가 증가했을 경우에는 데이터 손실 면에서 우수함을 확인하였다.

• International Journal of Aeronautical and Space Sciences
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• 제13권1호
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• pp.14-26
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• 2012

The only extraterrestrial life detection experiments ever conducted were the three which were components of the 1976 Viking Mission to Mars. Of these, only the Labeled Release experiment obtained a clearly positive response. In this experiment $^{14}C$ radiolabeled nutrient was added to the Mars soil samples. Active soils exhibited rapid, substantial gas release. The gas was probably $CO_2$ and, possibly, other radiocarbon-containing gases. We have applied complexity analysis to the Viking LR data. Measures of mathematical complexity permit deep analysis of data structure along continua including signal vs. noise, entropy vs.negentropy, periodicity vs. aperiodicity, order vs. disorder etc. We have employed seven complexity variables, all derived from LR data, to show that Viking LR active responses can be distinguished from controls via cluster analysis and other multivariate techniques. Furthermore, Martian LR active response data cluster with known biological time series while the control data cluster with purely physical measures. We conclude that the complexity pattern seen in active experiments strongly suggests biology while the different pattern in the control responses is more likely to be non-biological. Control responses that exhibit relatively low initial order rapidly devolve into near-random noise, while the active experiments exhibit higher initial order which decays only slowly. This suggests a robust biological response. These analyses support the interpretation that the Viking LR experiment did detect extant microbial life on Mars.

• Nuclear Engineering and Technology
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• 제37권1호
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• pp.101-108
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• 2005

The neutron induced nuclear cross-section data for Pd-105, Ag-109, Xe-131, and Cs-133 were calculated and evaluated from an unresolved energy to 20 MeV. The energy dependent optical model potential parameters were extracted based on recent experimental data and applied up to 20 MeV. A spherical optical model and a statistical model for the equilibrium energy, and a multistep direct and a multistep compound model for the pre-equilibrium energy were used in the calculation. The direct capture model was recently introduced for fast neutron capture. The theoretically calculated cross-sections were compared with the experimental data and the evaluated files. The total and capture cross-sections calculated using the model were in good agreement with the reference experimental data. The evaluated cross-section results were compiled in ENDF-6 format and merged with the resonance component, already adopted in the ENDF/B-VI release 8. New data library files covering from thermal to 20 MeV were created. They are at the preliminary stage of an ENDF/B- VII release.

• Water Engineering Research
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• 제1권2호
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• pp.137-146
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• 2000

A windows-based software package, named DREDGE, is developed for estimating sediment resuspension and contaminant release during dredging operations. DREDGE allows user to enter the necessary dredge information, site characteristics, operational data, and contaminant characteristics, then calculates an array of concentration using the given values. The program mainly consists of the near-field models, which are obtained empirically, for estimating sediment resuspension and the far-field models, which are obtained analytically, for suspended sediment transport. A linear equilibrium partitioning approach is applied to estimate particulate and dissolved contaminant concentrations. This software package which requires only a minimal amount of data consists of three components; user input, tabular output, and graphical output. Combining the near-field and far-field models into a user-friendly windows-based computer program can greatly save dredge operator's, planners', and regulators' efforts for estimating sediment transports and contaminant distribution.

• Nuclear Engineering and Technology
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• 제32권5호
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• pp.425-432
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• 2000

It has been an essential part for the safety assessment of nuclear power plants to understand various phenomena associated with the molten core-concrete interaction(MCCI) under severe accidents. In this study, the severe accident analysis code MELCOR was used to simulate the MCCI experiments such as SWISS and SURC test series which had been performed in Sandia National Laboratories(SNL). The calculation results were compared with corresponding experimental data such as melt temperature, concrete ablation distance, gas generation rate, and aerosol release rate. Good agreements were observed between MELCOR calculation and experimental data. The melt pool was sustained within the range of high temperature and the concrete ablation occurred continuously. The gas generation and aerosol release were under the influence of melt temperature and overlying water pool, respectively.

• 한국산학기술학회논문지
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• 제11권10호
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• pp.4047-4054
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• 2010

실험실 규모의 모사 실험을 통하여 해양 부영양화를 촉진하는 퇴적물의 용출 특성을 연구하였다. 즉 pH, ORP, 질소성분, 인성분 등 주요 환경인자를 분석하고 그에 따른 용출율을 계산하였다. 또한 산소발생제인 과산화칼슘을 이용하여 자연적 용출의 제어효과를 분석하였다. 산소발생제 처리에 따라 호기적 조건으로의 퇴적토 환경변화가 일어났으며 COD, $NH_3$-N의 용출율이 감소하고 질산화 촉진으로 NOx 성분은 증가하였다. 총인과 인산염인도 Ca 이온의 불용화 기작에 의거 감소하였다. 이에 따라 퇴적토의 용출로 인한 해양 부영양화 억제 방법론을 정립하고자한다.

• 한국응용약물학회:학술대회논문집
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• 한국응용약물학회 1994년도 춘계학술대회 and 제3회 신약개발 연구발표회
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• pp.244-244
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• 1994

Cortex Mori, the root bark of mulbery tree has been used as an antiphlogistic, diuretic, and expectorant in herbal medicine. The purpose of this study is to evaluate chicken gamma globulin (CGG)-specific IgE-induced morphologic and functional changes in rat peritoneal mast cells (RPMC), and to determine whether Cortex Mori could inhibit the CGG-specific IgE-depeildent mast cell degranulation and histamine release from RPMC. Results are 1) the degranuration and histamine release from RPMC were not induced within 1 hour after addition of Cortex Mori alone, 2) the CGG and CGG-specific IgE-Induced degranulation from RPMC was observed within 10 minutes, 3) the histamine release from RPMC sensitised with CGG-specific IgE was induced by tile addition of CGG, 4) CGG-specific IgE-dependent degranulation rate in RPMC pretreated with Cortex Mori was significantly Inhibited, compared to that of control group without Cortex Mori pretreatment, and 5) the CGG-specific IgE-dependent histamine release from RPMC was significantly inhibited by pretreatment with Cortex Mori. These data suggest that Cortex Mori contains some substances with capabilities to inhibit CGG-specific IgE-dependent degranulation and histamine release from RPMC.

• The Korean Journal of Physiology
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• 제14권1호
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• pp.25-30
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• 1980

It has been well known that beta-adrenoceptor is responsible for the renin release stimulatory and alpha-adrenoceptor may be inhibitory. It has been observed accidently that alpha-adrenergic agonist can inhibit renin release by just changing the medium temperature in Vitro experiment in this laboratory. A series of experiments were performed to clarify this interesting phenomena in Vitro experiment. Rat renal slices were incubated in PSS medium under gas phase at $37^{\circ}C$. The following results were observed. 1) Isoproterenol and norepinephrine resulted in renin release stimulatory in dose-dependent by the concentrations of $10^{-9}$ to $10^{-5}\;M/L$ at $37^{\circ}C$. 2) Norepinephrine resulted in renin release inhibitory in dose dependent by the concentrations of $10^{-7}$ to $10^{-5}\;M/L$, and almost no effect by isoproterenol $10^{-6}\;M/L$ at $20^{\circ}C$. 3) Phenoxybenzamine pretreatment at $37^{\circ}C$ accentuated isoproterenol stimulatory effect at $37^{\circ}C$. 4) Phenoxybenzamine pretreatment at $20^{\circ}C$ attenuated isoproterenol stimulatory effect at $37^{\circ}C$. These data suggest that the renal adrenoceptor(s) related to renin release maybe a single entity, and can be interconverted different forms in certain conditions.

• 융합보안논문지
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• 제12권6호
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• pp.3-10
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• 2012

본 연구에서는 소프트웨어 제품을 개발하여 테스팅을 거친 후 사용자에게 인도하는 시기를 결정하는 방출문제에 대하여 연구 하였다. 소프트웨어의 결함을 제거하거나 수정 작업과정에서 학습요인을 고려한 유한고장수를 가진 비동질적인 포아송 과정에 기초하였다. 수명강도는 다양한 형상모수와 척도모수에 이용 할 수 있기 때문에 신뢰성 분야에서 많이 사용되는 로그 선형 모형을 이용한 방출시기에 관한 문제를 제시하였다. 소프트웨어 요구 신뢰도를 만족시키고 소프트웨어 개발 및 유지 총비용을 최소화 시키는 최적 소프트웨어 방출 정책에 대하여 논의 되었다. 본 논문의 수치적인 예에서는 고장 시간 자료를 적용하였으며 모수추정 방법은 최우추정법을 이용하고 최적 방출시기를 추정하였다.