Purpose: This study carried out the Quality by Design (QbD)6σ process to verify the effectiveness and equivalence of the finished D-antigen quantitative test method, and compared the OFAT-based method validation and test result acceptance criteria with the Analytical Quality by Design (AQbD)-based method validation and test method. This is a study on how to reduce the risk of delay in permit change by increasing the reliability of permit data in the existing method by statistically analyzing the results. Methods: With the QbD6σ process, the effectiveness and equivalence of the D-antigen quantitative test method were verified with the data of the existing test method and the new test method. Results: Method validation tests are performed based on AQbD. Critical Method Parameters are identified through risk assessment, and single/combined actions are verified by designing and performing tests for Critical Method Parameters (analysis of variance, full factorial design method). Method validation can be effectively accomplished with the QbD6σ process. Conclusion: The use of QbD6σ can be used to achieve satisfactory results for both pharmaceutical companies and regulators by using appropriate statistical analytical methods for method validation as required by regulatory agencies.
Chambers, Suzanne Kathleen;Hyde, Melissa Karen;Ip, David Fu-Keung;Dunn, Jeffrey Charles;Gardiner, Robert Alexander
Asian Pacific Journal of Cancer Prevention
/
v.14
no.4
/
pp.2621-2626
/
2013
Background: To review the peer reviewed literature on the psychological aspects of the prostate cancer experience of men in Asia. Materials and Methods: Medline and PsycINFO, CINAHL, ProQuest, and Web of Science (1999 - November Week 4, 2012) were searched. Inclusion criteria were: included men with prostate cancer and/or their partners or caregivers who identify as Asian recruited in an Asian country; and assessed health-related quality of life, psychological and social adjustment relating to prostate cancer and published in English after $1^{st}$ January 1999 and prior to $30^{th}$ November, 2012. Study aims; design; quality; level of evidence, and key results were assessed. Results: 43 articles met all inclusion criteria and were retained for initial review. Of these most focussed on health-related QOL with only five evidence Level IV studies from Japan and Taiwan including a specific psychological focus. Of these, one was a cross-sectional case control study; three were cross-sectional descriptive quantitative designs; one was a cross-sectional descriptive qualitative study. From the data available, a substantive sub group of men with prostate cancer (approximately one third) in these countries experience clinically high psychological distress and decision regret. Conclusions: Research on the psychological needs of men with the increasingly prevalent condition of prostate cancer in Asian countries is scant with only a small number of low level evidence descriptive studies identified. Future research to underpin the development and evaluation of effective and culturally relevant psychological and supportive care interventions for such men is urgently needed.
The purpose of the Present research is to investigate the effect of fashion lifestyle on babies' clothing shopping attitude of housewives. In this study shopping attitude includes criteria for shop selection prefered types of shop and prefered shop atmosphere. Subjects are 447 housewives residing in Seoul Bundang Illsan and Pungchon and having child under 4 years old Data was analyzed by factor analysis cluster analysis analysis of variance and chi-square. The results of the study are as follows: 1. Housewives can be classified into four groups according to their fashion lifestyle the group of planned buying conservative/practical group the group of self-actualization/individuality and the high involved and care for shopping group. 2. Fashion lifestyle is different according to their age. The high involved and care for shopping group have the lager proportion in twenties than thirties. The conservative/practical group have a larger proportion in thirties. 3. The factors of shop selection which serve as criteria for shop the quality of service encironment anround shop quality of goods convenience to care about babies fashionable goods location of the shop and price of goods. The group of self actualization/personality prefers shops carrying fashionable and unique style of babies clothing and showing prestige. The conservative/practical group prefers shops carrying good quality clothing and having variety in size and design. The high involved and careful shopping group prefers shops having wide space as well as carrying fashionable goods. 4. Among the types of babies clothing shops. department stroe is the most preferred Low-price brand shop is followed by traditional open market. The conservative/practical group and the group of planned shopping use department strores national bran shops street shops and import shops more often than other groups. 5. The result of the study indicates there are considerable differences in housewives attitudes of babies clothing shopping acording to their own fashion lifestyle. Therefore the retailer of babies clothing should decide their marketing policy on the basis of the understanding and analysis of costomer's fashion lifestyle. And they have to reflect their costomer's shopping attitudes on their marketing policy to improve the satisfaction of both consumer and retailer as well.
Dzung, Nguyen Tien;Tuan, Nguyen Anh;Tinh, Do Phu Tran
The Journal of Asian Finance, Economics and Business
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v.4
no.3
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pp.27-34
/
2017
This study aims to assess the attraction of foreign direct investment in Vietnamese economic zones (including industrial zones and economic zones). The main research method used are synthesis and comparison analysis based on the data collected from the surveyed group comprising of enterprises operating in the economic zones in the Middle (Chu Lai, Nhon Hoi, Dung Quat) and the Southern (the largest island: Phu Quoc). After conducting surveys, research results show that there is a difference between the assessment and the level to meet the requirements of investors with business environment, expressed through the following criteria: (1) the infrastructure; (2) quality of public services; (3) preferential policies; (4) labor; (5) market; and (6) social services. Based on the assessment of the identified criteria, this paper had suggested six number of recommendations to promote the role of attracting foreign direct investment capital into the economic zones in Vietnam: (1) implementing the "one-stop-shop" policy; (2) continuing to improve the infrastructure of economic zones; (3) prevent and ensure the security of economic zones; (4) implementing vocational training activities to improve quality of human resources; (5) development of supporting industries; (6) raising the quality of capital invested in the economic zone.
The purposes of this study are to understand the doctors' attitude and satisfaction about the review system of national health insurance claim in Korea and to suggest the way to improve this system This study conducted a survey of the doctors registered in the medical association in Seoul city. The survey was performed as a form of self-administered questionnaire from January 2004 to February 2004. The contents of questionnaire dealt with doctors' attitude and satisfaction about the review system of medical service claim. Totally, 1,037 members replied to our survey and we analysed 981 doctors' data, excluding incomplete responses. As a result, 89.7% of repliers showed a negative attitude about the influences of the review system on improvement of medical service quality, 98.0% of repliers have had experiences that they have given distorted insufficient medical services in order to evade the curtailment of service claim. Also, 91.6% of repliers stated that they have had experiences of intentional modification or alteration of diagnostic code to shun the curtailment. Most of the doctors showed negative attitude to the curtailment procedure and the review system of service claim originally intended to be one of the quality control methods of medical service in Korea also, the development of both scientific and reasonable parameters and criteria for claim is needed. 'Through the improvement of review system for appropriate medical service, there is a need of a way to increase the satisfaction of medical service providers, and to encourage the motivation for quality control. Also, education is strongly needed to provide doctors with sufficient information about review criteria and curtailment cases.
Journal of the Korean Society of Clothing and Textiles
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v.25
no.6
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pp.1025-1036
/
2001
This paper explores the effects of price discount frequency on consumer evaluation of clothing brand equity as well as the impact on consumers who exhibit different consumer characteristics. Following a preliminary investigation, two clothing brand groups were identified according to the frequency of their price discounts, one with a high frequency of price discounts, the other with a low frequency. Each brand group consisted of three women's clothing brands. A questionnaire was developed and administered to 351 females between the ages of nineteen and thirty-four in October 2000. The questionnaire included questions on evaluations on clothing brand equity (i.e., perceived quality, brand image, perceived value, reliability and brand knowledge), on consumer characteristics (i.e., clothing knowledge, clothing evaluative criteria, price perception and demographic characteristics), as well as on price discount frequency. Statistical tests, such as factor analysis. t-test and pearson's correlation, were used to analyze the data. Results of this research showed that price discount frequency negatively impacted consumer perception of clothing brand equity. The negative influence was particularly strong on the perceived quality and brand image dimensions of brand equity. The findings also suggested the effect of price discount frequency on consumer assessment of clothing brand equity was related to consumer characteristics as well. The equity of the clothing brand group with a low frequency of price discounts was positively related to clothing knowledge, price-quality inference, price-prestige inference, sale prone-ness. price mavenism, valuing the fashionable and symbolic uses of clothing and family income. On the other hand, it was negatively related to low price consciousness. The equity of the clothing brand group with a high frequency of price discounts was positively related to utilitarian economic aspects of clothing values as well as to low price consciousness. To establish and maintain high brand equity, marketers must pay attention to the frequency of price discount as it may have a negative impact on clothing brand equity.
Journal of the Korean Society of Environmental Restoration Technology
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v.23
no.6
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pp.187-200
/
2020
Despite the eco-friendly route plan, road slopes were collapsed due to road construction, resulting in human and property damage. To solve this problem, the Ministry of Land, Transport and Maritime Affairs established guidelines in 2009 to conduct a test-bed for slope recording considering the conditions of the site and the ecological environment, and divided them into recording quality and economic evaluation. The following results were obtained by analyzing 183 construction methods of cut-soil sections at 60 sites from 2012 to 2018 for road slope afforestation research. Straw net+seedspray, vegetation media spray method 1T, 3T were used the most, and vegetation media spray method 3T(patent) was excellent in quality, and straw net+seedspray was excellent in economics. As a result of analyzing the market unit price and the construction unit price, vegetation media spray method submitted the construction unit price at up to 60% lower than the market unit price. As a result of the analysis of the key factors of the greening method evaluation, the economic assessment had the greatest influence on all evaluation items. Problems in the evaluation method of revegetation were first identified as problems in the allocation of points and secondly as problems in the evaluation criteria. As for the improvement of the economic assessment criteria, the method was proposed to evaluate the same method based on market unit price when the same method was constructed, and not to conduct an economic assessment if there was a difference in market unit price between methods, or to add weight to the scores. Based on the monitoring data of 60 road slopes, this study drew up problems and improvement measures. However, with regard to scoring, research on appropriate scoring is needed by examining the current status.
In this study, the normal group and possible sarcopenia(PS) group were divided by the criteria for sarcopenia diagnostic based on the 7th period data of the National Health and Nutrition Examination Survey. An independent t-test and logistic regression was performed for the difference between the two groups. As a result, the PS group was older, and height, weight, and BMI were all lower. The waist circumference was significantly lower in men but significantly higher in women. According to the quality of life by domain, the frequency of impairment in daily activities in exercise capacity was 8.28 fold in men and 15.52 fold in women. In addition, aerobic exercise regularity was 19% and 26% lower in the PS, and strength exercise regularity was practiced was 52% and 43% lower.
Journal of The Korean Society of Integrative Medicine
/
v.12
no.3
/
pp.237-247
/
2024
Purpose : This study aimed to systematically review the effectiveness of nursing interventions for patients receiving extracorporeal membrane oxygenation (ECMO). As the use of ECMO increases in critical care settings, it is important to understand how nursing interventions affect patient outcomes, survival, and complication rates. Methods : This systematic review followed the preferred reporting items for systematic reviews and meta-analysis guidelines. A literature search was performed using terms related to ECMO and nursing interventions in several international electronic databases including CINAHL, Embase, MEDLINE, and Web of Science. Studies were screened and selected according to predefined eligibility criteria, focusing on those that evaluated the impact of nursing interventions on adult. Data extraction and risk-of-bias assessment were independently performed by two researchers. Results : A total of 647 studies were identified, and seven met the inclusion criteria for qualitative analysis. The included studies demonstrated that high-quality nursing care significantly improves clinical outcomes and reduces complications in patients receiving ECMO. Effective nursing interventions included prone positioning combined with ECMO for patients with acute respiratory distress syndrome, meticulous infection control, comprehensive and continuous nursing protocols, skilled nursing, and multidisciplinary management. These interventions have been shown to improve oxygenation, reduce complications, such as bleeding, manage blood pressure, and enhance overall clinical outcomes. Conclusion : High-quality nursing interventions are critical to improve survival and reduce complications in patients receiving ECMO. Implementing a multidisciplinary approach and comprehensive nursing protocols, including infection control and psychological support, is essential for the effective management of these patients. The findings of this study provide a foundation for the development of practical guidelines and educational programs to improve the quality of care for patients undergoing ECMO, ultimately enhancing the effectiveness of ECMO treatment and patient outcomes.
In recent years, speedy development of Taiwan's hotel industry intensifies market competition, customers' demands on hotel services quality also increase with the increase of their consumption consciousness, and their demands on hotel types diversify, therefore hotel industry should concern on their unique management services quality brought by their different hotel types. The current designed service system or service transmission process may fail to meet customers' demands owing to emphasizing degree gap in service quality. What is worse, it is difficult for hotel industry to actualize complete customer segregation and to provide customized services, therefore comprehensive understanding of customers' demands on the service quality of different types hotels would contribute to operating management improvement of Taiwan hotel industry. This paper divides Taiwan hotels into three types: international tourism commercial type, holiday type and motel, the general hotels. It studies the emphasize degree gap in service quality between the industry and the customers. Data analysis shows that service quality gap (perceived gap) of hotels of different types exists in several quality aspects; what's more, the perceived gaps, service quality aspects, and its items of different types of hotel are also different. After an integrated analysis, this paper puts forward a general and customer-oriented quality item suitable for hotel industry to shorten the perceived gap of service quality, so that the hotel industry could design a service system and service transfer system, which could meet most lodging customers' demands in the context of pluralized customer sources.
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