• Korean Journal of Optics and Photonics
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• v.17 no.6
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• pp.500-506
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• 2006

An optical fiber displacement sensor has the advantages of relatively simplicity, cheap, small probe size and immunity against environmental perturbation. The working principle of the sensor is based on the intensity modulation that is detection light intensity reflecting from the surface being measured. This paper presents the mathematical model of displacement measurement mechanism of this sensor type. The theoretical and experimental data are compared to verify the model in describing the realistic approach to sensor design. Finally, the analysis results show that displacement response characteristics such as sensitivity, measuring range are easily modified by principal design parameters such as magnitude of optical Power, diameter of optical fiber core and distance between transmitting fiber and receiving fiber.

• Nuclear Engineering and Technology
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• v.33 no.4
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• pp.409-422
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• 2001

The dynamic character of a system of the governing differential equations for the one- dimensional two-fluid model, where the momentum flux parameters are employed to consider the velocity and void fraction distribution in a flow channel, is investigated. In response to a perturbation in the form of a＇traveling wave, a linear stability analysis is peformed for the governing differential equations. The expression for the growth factor as a function of wave number and various flow parameters is analytically derived. It provides the necessary and sufficient conditions for the stability of the one-dimensional two-fluid model in terms of momentum flux parameters. It is demonstrated that the one-dimensional two-fluid model employing the physical momentum flux parameters for the whole range of dispersed flow regime, which are determined from the simplified velocity and void fraction profiles constructed from the available experimental data and $C_{o}$ correlation, is stable to the linear perturbations in all wave-lengths. As the basic form of the governing differential equations for the conventional one-dimensional two-fluid model is mathematically ill posed, it is suggested that the velocity and void distributions should be properly accounted for in the one-dimensional two-fluid model by use of momentum flux parameters.s.

• The Korean Journal of Physiology and Pharmacology
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• v.20 no.4
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• pp.367-378
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• 2016

Recently, it was reported that the role of mitochondria-reactive oxygen species (ROS) generating pathway in cisplatin-induced apoptosis is remarkable. Since a variety of molecules are involved in the pathway, a comprehensive approach to delineate the biological interactions of the molecules is required. However, quantitative modeling of the mitochondria-ROS generating pathway based on experiment and systemic analysis using the model have not been attempted so far. Thus, we conducted experiments to measure the concentration changes of critical molecules associated with mitochondrial apoptosis in both human mesothelioma H2052 and their ${\rho}^0$ cells lacking mitochondrial DNA (mtDNA). Based on the experiments, a novel mathematical model that can represent the essential dynamics of the mitochondrial apoptotic pathway induced by cisplatin was developed. The kinetic parameter values of the mathematical model were estimated from the experimental data. Then, we have investigated the dynamical properties of this model and predicted the apoptosis levels for various concentrations of cisplatin beyond the range of experiments. From parametric perturbation analysis, we further found that apoptosis will reach its saturation level beyond a certain critical cisplatin concentration.

• Physical Therapy Korea
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• v.14 no.2
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• pp.68-75
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• 2007

Reductions in strength and range of motion in older persons have been associated with decreased functional mobility and risk of falls. The purpose of this research was to investigate the effect of intensive dynamic balance exercise (DBE) during 8 weeks on onset time of medial gastrocnemius and tibialis anterior muscle contraction after perturbation in older women. Thirty subjects were randomly assigned into DBE group or control group. The DBE group participated in 50 minutes 3 days a week for 8 weeks. Surface electromyography (EMG) activity was recorded from the medial gastrocnemius and tibialis anterior muscles of left side. Outcome data were collected both groups at the pre-exercise and post-exercise. Independent t-test and paired t-test were used to determine the statistical difference. Results showed that the passive range of motion and functional reach test were significantly increased in the DBE group than the control group at the post-exercise (p<.05). The onset time of both muscles and discrepancy of onset time significantly reduced in the DBE group than the control group at the post-exercise (p<.05). The onset time of both muscles were significantly reduced in the post-exercise than the pre-exercise in the DBE group (p<.05). The discrepancy of onset time in the DBE group was significantly reduced in the post-exercise than the pre-exercise (p<.05). These findings suggest that intensive dynamic balance exercise for the eight weeks was effective in improving the postural control with older persons.

• BMB Reports
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• v.41 no.8
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• pp.609-614
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• 2008

The concentrations and catalytic activities of enzymes control metabolic rates. Previous studies have focused on enzyme concentrations because there are no genome-wide techniques used for the measurement of enzyme activity. We propose a method for evaluating the significance of enzyme activity by integrating metabolic network topologies and genome-wide microarray gene expression profiles. We quantified the enzymatic activity of reactions and report the 388 significant reactions in five perturbation datasets. For the 388 enzymatic reactions, we identified 70 that were significantly regulated (P-value < 0.001). Thirty-one of these reactions were part of anaerobic metabolism, 23 were part of low-pH aerobic metabolism, 8 were part of high-pH anaerobic metabolism, 3 were part of low-pH aerobic reactions, and 5 were part of high-pH anaerobic metabolism.

• Animal cells and systems
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• v.15 no.1
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• pp.1-8
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• 2011

Perturbation of metabolism with increased expression of lipogenic enzymes is a common characteristic of human cancers, including prostate cancer. In the present work the overexpression of stearoyl-CoA desaturase (SCD) in LNCaP cells led to increased mRNA levels of fatty acid synthase (FAS) and acetyl-CoA-carboxylase-a, whereas micro RNA-mediated silencing of SCD inhibited the expression of these lipogenic genes in LNCaP cells. Treatment with the FAS-specific inhibitor cerulenin inhibited SCD induction of LNCaP cell proliferation. In addition, a transient transfection assay revealed the capability of cerulenin to suppress SCD and dihydrotestosterone induction of androgen receptor transcriptional activity. Furthermore, overexpression of SCD in LNCaP cells produced marked resistance to ceramide-induced cell death with reduced poly(ADP-ribose) polymerase (PARP) cleavage. In contrast, silencing of SCD expression increased Bax protein in LNCaP cells. Furthermore, addition of ceramide to SCD knockdown LNCaP cells increased cell death and caspase-3 activity with drastic increase of PARP cleavage. Together, the data indicate that SCD may provide resistance of prostate cancer cells to ceramide-induced cell death.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.15 no.2
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• pp.540-557
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• 2021

Privacy vulnerability of social networks is one of the major concerns for social science research and business analysis. Most existing studies which mainly focus on un-weighted network graph, have designed various privacy models similar to k-anonymity to prevent data disclosure of vertex attributes or relationships, but they may be suffered from serious problems of huge information loss and significant modification of key properties of the network structure. Furthermore, there still lacks further considerations of privacy protection for important sensitive edges in weighted social networks. To address this problem, this paper proposes a privacy preserving method to protect sensitive weighted edges. Firstly, the sensitive edges are differentiated from weighted edges according to the edge betweenness centrality, which evaluates the importance of entities in social network. Then, the perturbation operations are used to preserve the privacy of weighted social network by adding some pseudo-edges or modifying specific edge weights, so that the bottleneck problem of information flow can be well resolved in key area of the social network. Experimental results show that the proposed method can not only effectively preserve the sensitive edges with lower computation cost, but also maintain the stability of the network structures. Further, the capability of defending against malicious attacks to important sensitive edges has been greatly improved.

• The Bulletin of The Korean Astronomical Society
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• v.44 no.1
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• pp.74.3-75
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• 2019

Recent Integral Field Spectroscopy (IFS) studies revealed that not only late type galaxies (LTGs) but also early type galaxies (ETGs) have various kinds of kinematic rotation. (e.g. not clearly detectable rotation, disk-like rotation, kinematically distinct core (Cappellari 06)) Among the various studies about galactic kinematics, one of the most notable anomalies is the star-gas misalignment. The gas forms stars and stars release gas through mass-loss. In this process, their angular momentum is conserved. Therefore, kinematic decoupling between stars and gas can occur due to external gas inflow or perturbation of components. There are some possible origins of misalignment: cold gas from filaments, hot gas from outer halo, interaction or merging events with galaxies and environmental effects. Misalignment, the black box from mixture of internal and external gas, can be an important keyword for understanding further about galaxies' kinematics and external processes. Using both SAMI IFS data(Sydney-AAO Multi-object Integral field spectrograph Galaxy Survey, Croom+12) and Horizon-AGN simulation(Dubois+14), we examined misaligned galaxies properties and distribution. Because the simulation has lots of galaxies at various z, we were able to study history of formation, evolution and extinction of misalignment, which was hard to be done with observation only.

• Nuclear Engineering and Technology
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• v.54 no.5
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• pp.1804-1812
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• 2022

The aim of this paper is to assess the reliability and accuracy of the PSI standard method, used in many previous works, for the quantification of ND uncertainties in the SPERT-III RIA transient, by quantifying the discrepancy between the actual inserted reactivity and the original static reactivity worth and their associated uncertainties. The assessment has shown that the inherent S3K neutron source renormalization scheme, introduced before starting the transient, alters the original static reactivity worth of the transient CR and reduces the associated uncertainty due to the ND perturbation. In order to overcome these limitations, two additional methods have been developed based on CR adjustment. The comparative study performed between the three methods has showed clearly the high sensitivity of the obtained results to the selected approach and pointed out the importance of using the right procedure in order to simulate correctly the effect of ND uncertainties on the overall parameters in a RIA transient. This study has proven that the approach that allows matching the original static reactivity worth and starting the transient from criticality is the most reliable method since it conservatively preserves the effect of the ND uncertainties on the inserted reactivity during a RIA transient.

• Structural Engineering and Mechanics
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• v.87 no.5
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• pp.419-429
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• 2023

This study conducts numerical analyses of a thin-walled composite cylinder under axial compression and internal pressure of 10 kPa. Numerical vibration correlation technique and nonlinear postbuckling analyses are conducted using the nonlinear finite element analysis program, ABAQUS. The single perturbation load approach and measured imperfection data are used to represent the geometric initial imperfection of thin-walled composite cylinder. The buckling knockdown factors are derived using present initial imperfection and analysis methods under axial compression without and with the internal pressure. Furthermore, the buckling knockdown factors are compared with the buckling test and computation time are calculated. In this study, derived buckling knockdown factors in present study have difference within 10% as compared with the buckling test. It is shown that nonlinear postbuckling analysis can derive relatively accurate buckling knockdown factor of present thin-walled cylinders, however, numerical vibration correlation technique derives reasonable buckling knockdown factors compared with buckling test. Therefore, this study shows that numerical vibration correlation technique can also be considered as an effective numerical method with 21~91% reduced computation time than nonlinear postbuckling analysis for the derivation of buckling knockdown factors of present composite cylinders.