• Journal of the Korea Society of Computer and Information
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• v.22 no.11
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• pp.89-96
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• 2017

This study analyzed how mental health affects stress in adolescents. The subjects of the study were data of about 60,000 middle and high school students living in the country, using cross-tabulation data and chi - square test to analyze the relationship between stress and mental health of adolescents. As a result of the research, it was found that the adolescents exposed to the excessive stress showed a poor correlation with the recovery of the fatigue, while the adolescents with relatively low stress showed the good recovery of fatigue. In the case of mental illness, depression or despair, the students who answered that they were stressed showed a lot of experience. In the case of suicide ideation, suicide attempt, and suicide attempt, the number of attempts to commit suicide was high when the level of perceived stress was high similar to the result of previous analysis. This finding confirms that stress is an important factor in the quality of life in adolescent mental health. It can be used as a strategy and business to prevent the problem of youth suicide in modern society in advance by stress management.

• Economic and Environmental Geology
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• v.27 no.6
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• pp.579-592
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• 1994

A case study is presented where a fluvial system is modeled in three dimensions and compared to data gathered from a study of the Arkansas River. The data is unique in that it documents changes that affected a straight channel that was excavated within the river by the U.S. Army Corps of Engineers. Excavation plan maps and sequential aerial photographs show that the channel underwent massive deposition and channel migration as it returned to a more natural, meandering path. These records illustrate that stability of fluvial system can be disrupted either by catastrophic events such as floods or by subtle events such as the altering of a stream's equilibrium base level or sediment load. SEDSIM, Stanford's Sedimentary Basin Simulation Model, is modified and used to model the Arkansas River and the geologic processes that changed in response to changing hydraulic and geologic parameters resulting from the excavation of the channel. Geologic parameters such as fluid and sediment discharge, velocity, transport capacity, and sediment load are input into the model. These parameters regulate the frequency distribution and sizes of sediment grains that are eroded, transported and deposited. The experiments compare favorably with field data, recreating similar patterns of fluid flow and sedimentation. Therefore, simulations provide insight for understanding and spatial distribution of sediment bodies in fluvial deposits and the internal sedimentary structure of fluvial reservoirs. These techniques of graphic simulation can be contributed to support the development of the new design criteria compatible with natural stream processes, espacially drainage problem to minimize environmental disruption.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2021.05a
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• pp.646-648
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• 2021

Sensors with wireless communication functions are essential for acquiring and transmitting spatio-temporal data that is not easily accessible in sensor network environments. However, these sensors lack adaptability to large amounts of sensing data processing or dynamic environments, resulting in over-consumption of power and network overhead. This paper proposes a mobile agent that can acquire, transmit, and process only the necessary data by applying thresholds, and presents methods for autonomous migration and communication processing of mobile agents.

• Journal of Soil and Groundwater Environment
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• v.20 no.6
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• pp.133-139
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• 2015

Attention to munitions constituents such as 2,4,6-trinitrotoluene (TNT) and hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) in the firing ranges is increasing due to their toxicity and high mobility to the environment. It is helpful to use a systemic model to predict the amount of contaminants for the establishment of environmental management of firing ranges. This study employed Training Range Environmental Evaluation and Characterization System (TREECS) program to estimate the mobility characteristics of TNT and RDX via groundwater leaching, soil erosion and surface water runoff. The prediction results of the TNT and RDX migration with TREECS showed that 68% of initial TNT and 21% of initial RDX were discharged through the soil erosion and the 20% of initial TNT and 54% of initial RDX ran out the firing range via the groundwater leaching. The rest of the initial TNT and RDX moved to adjacent surface water via surface runoff. The data suggest that soil erosion and surface runoff occupying 80% of TNT to the total amount are important migration pathways. On the other hand, groundwater leachning occupying 54% to the total amount was also important pathway for RDX.

• International Journal of Industrial Entomology and Biomaterials
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• v.17 no.1
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• pp.115-120
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• 2008

Recently, there has been the gradual growth of the public in rural amenities, hobby farming works, much more urbanities, and especially near-retires. However, in spite of popular preference to ruralities, little has been known about their demand on retired rural life. Therefore, this study examined urbanites' attitude to preparatory works for out-migration, preferred residential site condition and life styles in the countryside. For the purpose, data were collected from the survey with the sample of 62 urban trainees who were studying farming technology in department of training on agricultural technology of Korea National Agricultural College, RDA. We carried out the experience farming to candidate with using the abandoned sericultural facilities which are the silkworm rearing house and mulberry fields. The 71% of urban trainees, who answered in this survey, hoped to move into countryside after retirement and to make a monthly income of $1,000 from agriculture. The age distribution of sericulural farmers is about 79% more than that of 60 years old. In the experience farming works. The two candidates made 1,977$ with net income through 32 days worked in spring season. In autumn season, the couple candidates made 1,317$ with net income through 23 days worked. Knowledge of these results will be important to policy-makers and to understand the role that retirement in-migration play in stimulating economic growth of rural agricultural farmers.

• The Korean Journal of Physiology and Pharmacology
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• v.24 no.3
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• pp.223-232
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• 2020

Sesamin, a lipid-soluble lignin originally isolated from sesame seeds, which induces cancer cell apoptosis and autophagy. In the present study, has been reported that sesamin induces apoptosis via several pathways in human lung cancer cells. However, whether mitophagy is involved in sesamin induced lung cancer cell apotosis remains unclear. This study, the anticancer activity of sesamin in lung cancer was studied by reactive oxygen species (ROS) and mitophagy. A549 cells were treated with sesamin, and cell viability, migration ability, and cell cycle were assessed using the CCK8 assay, scratch-wound test, and flow cytometry, respectively. ROS levels, mitochondrial membrane potential, and apoptosis were examined by flow cytometric detection of DCFH-DA fluorescence and by using JC-1 and TUNEL assays. The results indicated that sesamin treatment inhibited the cell viability and migration ability of A549 cells and induced G₀/G₁ phase arrest. Furthermore, sesamin induced an increase in ROS levels, a reduction in mitochondrial membrane potential, and apoptosis accompanied by an increase in cleaved caspase-3 and cleaved caspase-9. Additionally, sesamin triggered mitophagy and increased the expression of PINK1 and translocation of Parkin from the cytoplasm to the mitochondria. However, the antioxidant N-acetyl-L-cysteine clearly reduced the oxidative stress and mitophagy induced by sesamin. Furthermore, we found that cyclosporine A (an inhibitor of mitophagy) decreased the inhibitory effect of sesamin on A549 cell viability. Collectively, our data indicate that sesamin exerts lethal effects on lung cancer cells through the induction of ROS-mediated mitophagy and mitochondrial apoptosis.

• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.40 no.1
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• pp.49-60
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• 2012

Synthetic aperture radar (SAR) has been employed in various fields due to its capability to generate high resolution images regardless of weather and visibility. This paper presents a performance analysis on the image formation of high resolution SAR according to various slant range distance and synthetic aperture lengths using a range migration algorithm simulator. Although the visual performance on the SAR image is more accurate, a numeric analysis resulted in a comparable measurement. More specifically, raw data were generated for an ideal point target upon imaging geometries and design parameters such as slant range distance and synthetic aperture lengths. Finally, spatial resolution, peak to sidelobe ratio and integrated sidelobe ratio are drawn to provide SAR capabilities in the initial concept design, final in-flight calibration and validation stages.

• The Korean Journal of Physiology and Pharmacology
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• v.20 no.3
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• pp.297-304
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• 2016

Klotho functions as a tumor suppressor predominantly expressed in renal tubular cells, the origin of clear cell renal cell carcinoma (ccRCC). Altered expression and/or activity of growth factor receptor have been implicated in ccRCC development. Although Klotho suppresses a tumor progression through growth factor receptor signaling including insulin-like growth factor-1 receptor (IGF-1R), the role of Klotho acting on IGF-1R in ccRCC and its clinical relevance remains obscure. Here, we show that Klotho is favorable prognostic factor for ccRCC and exerts tumor suppressive role for ccRCC through inhibiting IGF-1R signaling. Our data shows the following key findings. First, in tumor tissues, the level of Klotho and IGF-1R expression are low or high, respectively, compared to that of adjacent non-neoplastic parenchyma. Second, the Klotho expression is clearly low in higher grade of ccRCC and is closely associated with clinical outcomes in tumor progression. Third, Klotho suppresses IGF-1-stimulated cell proliferation and migration by inhibiting PI3K/Akt pathway. These results provide compelling evidence supporting that Klotho acting on IGF-1R signaling functions as tumor suppressor in ccRCC and suggest that Klotho is a potential carcinostatis substance for ccRCC.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.12
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• pp.5071-5076
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• 2014

Cholangiocarcinoma (CCA) is one of the aggressive cancers with a very poor prognosis. Several efforts have been made to identify and develop new agents for prevention and treatment of this deadly disease. In the present study, we examined the anticancer effect of luteolin on human CCA, KKU-M156 cells. Sulforhodamine B assays showed that luteolin had potent cytotoxicity on CCA cells with IC50 values of $10.5{\pm}5.0$ and $8.7{\pm}3.5{\mu}M$ at 24 and 48 h, respectively. Treatment with luteolin also caused a concentration-dependent decline in colony forming ability. Consistent with growth inhibitory effects, luteolin arrested cell cycle progression at the G2/M phase in a dose-dependent manner as assessed by flow cytometry analysis. Protein expression of cyclin A and Cdc25A was down-regulated after luteolin treatment, supporting the arrest of cells at the G2/M boundary. Besides evident G2/M arrest, luteolin induced apoptosis of KKU-M156 cells, demonstrated by a distinct sub-G1 apoptotic peak and fluorescent dye staining. A decrease in the level of anti-apoptotic Bcl-2 protein was implicated in luteolin-induced apoptosis. We further investigated the effect of luteolin on JAK/STAT3, which is an important pathway involved in the development of CCA. The results showed that interleukin-6 (IL-6)-induced JAK/STAT3 activation in KKU-M156 cells was suppressed by treatment with luteolin. Treatment with a specific JAK inhibitor, AG490, and luteolin diminished IL-6-stimulated CCA cell migration as assessed by wound healing assay. These data revealed anticancer activity of luteolin against CCA so the agent might have potential for CCA prevention and therapy.

• Journal of Korean Neurosurgical Society
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• v.42 no.2
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• pp.118-124
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• 2007

Objective : Adipose tissue is derived from the embryonic mesoderm and contains a heterogenous stromal cell population. Authors have tried to verify the characteristics of stem cell of adipose derived stromal cells (ADSCs) and to investigate immunohistochemical findings after transplantation of ADSC into rat brain to evaluate survival, migration and differentiation of transplanted stromal cells. Methods : First ADSCs were isolated from human adipose tissue and induced adipose, osseous and neuronal differentiation under appropriate culture condition in vitro and examined phenotypes profile of human ADSCs in undifferentiated states using flow cytometry and immunohistochemical study. Human ADSCs were transplanted into the healthy rat brain to investigate survival, migration and differentiation after 4 weeks. Results : From human adipose tissue, adipose stem cells were harvested and subcultured for several times. The cultured ADSCs were differentiated into adipocytes, osteoctye and neuron-like cell under conditioned media. Flow cytometric analysis of undifferentiated ADSCs revealed that ADSCs were positive for CD29, CD44 and negative for CD34, CD45, CD117 and HLA-DR. Transplanted human ADSCs were found mainly in cortex adjacent to injection site and migrated from injection site at a distance of at least 1 mm along the cortex and corpus callosum. A few transplanted cells have differentiated into neuron and astrocyte. Conclusion : ADSCs were differentiated into multilineage cell lines through transdifferentiation. ADSCs were survived and migrated in xenograft without immunosuppression. Based on this data, ADSCs may be potential source of stem cells for many human disease including neurologic disorder.