• Biomolecules & Therapeutics
• /
• 제20권6호
• /
• pp.556-561
• /
• 2012

Steroid sulfatase (STS) is responsible for the conversion of estrone sulfate to estrone that can stimulate growth in endocrine-dependent tumors such as prostate cancer. Although STS is considered as a therapeutic target for the estrogen-dependent diseases, cellular function of STS are still not clear. Previously, we found that tumor necrosis factor (TNF)-${\alpha}$ significantly enhances steroid sulfatase expression in PC-3 human prostate cancer cells through PI3K/Akt-dependent pathways. Here, we studied whether bacterial lipopolysaccharides (LPS) which are known to induce TNF-${\alpha}$ may increase STS expression. Treatment with LPS in PC-3 cells induced STS mRNA and protein in concentration- and time-dependent manners. Using luciferase reporter assay, we found that LPS enhanced STS promoter activity. Moreover, STS expression induced by LPS increased PC-3 tumor cell migration determined by wound healing assay. We investigated that LPS induced IL-6 expression and IL-6 increased STS expression. Taken together, these data strongly suggest that LPS induces STS expression through IL-6 pathway in human prostate cancer cells.

• 대한치과의사협회지
• /
• 제21권10호통권173호
• /
• pp.805-812
• /
• 1983

For the assessment of peripheral blood leukocyte chemotaxis dysfunction in rapidly progressive periodontitis, peripheral blood leukocyte of 13 patients were isolated, and tested by the method of blind well chamber technique which was recently developed by Park. Data analysis was performed from the speed of cell migration from the bottom of filter paper to the top for 18 minutes at the condition of chemo-attractant(Zymosan-activated serum). Eight of the 13 patients (62%) exhibited statistically significant inhibition of leukocyte chemotaxis, 4 patients revealed normal function and the other one patients showed elevated leukocyte chemotaxis. Four of the 8 patients in chemotaxis dysfunction showed significant inhibition of random migration and chemotaxis dysfunction both. Two of these 4 patients exhibited random migration impairment, elevation of C.D.I. and chemotaxis dysfunction. The results indicated that the progression of rapidly progressive periodontitis was influenced by the leukocyte chemotaxis dysfunction, and half of these dysfunction was associated with cell-defect of leukocyte.

• 한국인구학
• /
• 제14권1호
• /
• pp.1-25
• /
• 1991

The Purpose of this study is to analyze the contribution of the total human capital formation to economic growth in Korea. In order to assess the contribution of the total human capital formation to economic growth, aggregate production functions are estimated using two ways of ordinary least squares and polynomial distributed lags based on 1955 - 1988 time series data in Korea. The total amount of investment in human capital is calculated by adding each amount of investment in formal education, vocational training, inter-provincial migration, and health in pecuniary terms. The findings of this study could be summarized as follows ; (1) If we enumerate the variables in good order according to the importance, we get the following ; namely, total number of labor force, inter-provincial migration, vocational training, health, physical capital, and formal education. (2) The contribution of the human capital to economic growth is much more larger than that of physical capital. In particular, it appears that inter-provincial migration and vocational training make a great contribution to economic growth. (3) It appears that investment in formal education has a continuous effect for fifteen years and maximum effect is observed approximately eight years later. In the case of vocational training, the effect of investment lasts for about 12-14 years and its effect on economic growth reaches maximum with the passage of seven to eight years after initial investment. (4) Investment in vocational training contributes more in the long run compared with investment in formal education. The effect of investment in formal education lasts longer than that of vocational training, while the effect of investment in vocational training is considerably larger in the short run compared with the investment in formal education.

• Journal of Ecology and Environment
• /
• 제29권1호
• /
• pp.1-16
• /
• 2006

Environmental variables, fishing and biological data of the common squid, Todarodes pacificus were used to describe changes in structure, migration and abundance of the squid population in relation to ocean climate shifts. It was possible to consider the main groups of the squid (autumn and winter-spawned groups) as a single population to aid conservation in the waters around Korea and Japan (TWC and KOC regions). The patterns of yearly fluctuations in abundance of the squid population in the two regions were the same during 52 years of $1952{\sim}2003$. The abundance of the squid began to decrease in both regions in the early 1970s, remained low in the 1980s and the main squid groups synchronously increased in the 1990s coincident with favorable changes of thermal conditions and plankton production in those ecosystems. The mechanisms of changes in the structure, distribution and abundance of common squid population in relation to current-mediated migration circuits are explained on the basis of phenological variables responding to climate shifts.

• 대한의생명과학회지
• /
• 제25권2호
• /
• pp.149-158
• /
• 2019

The objective of this study was to evaluate the effects of thoracic mobilization (TM) on the angle of thoracic kyphosis, and static and dynamic balances by application period. The subjects of this study were 18 adult males and females (${\geq}20years\; old$) who had the angle of thoracic kyphosis equal to or higher than $40^{\circ}$. A pre-test was conducted for all subjects and TM was carried out. Data were collected before the intervention, 3 weeks after the intervention, and 6 weeks after the intervention. It was measured three times per measurement and mean values were used for the analysis. The results of this study showed that the angle of thoracic kyphosis significantly (P<.05) decreased after applying TM. However, the migration area ($mm^2$) of the center of pressure (COP) in the static balance did not vary significantly. In the case of the dynamic balance, when eyes were open, the migration area ($mm^2$) of the COP significantly (P<.05) decreased after 3 weeks. When eyes were open, the migration area ($mm^2$) of the COP significantly (P<.05) decreased after 3 weeks and 6 weeks. Therefore, an intervention for improving the human body alignment and balance should be applied for a long-term, rather than a short-term, in order to be effective.

• Molecules and Cells
• /
• 제42권8호
• /
• pp.589-596
• /
• 2019

${\beta}Pix$ is a guanine nucleotide exchange factor for the Rho family small GTPases, Rac1 and Cdc42. It is known to regulate focal adhesion dynamics and cell migration. However, the in vivo role of ${\beta}Pix$ is currently not well understood. Here, we report the production and characterization of ${\beta}Pix$-KO mice. Loss of ${\beta}Pix$ results in embryonic lethality accompanied by abnormal developmental features, such as incomplete neural tube closure, impaired axial rotation, and failure of allantois-chorion fusion. We also generated ${\beta}Pix$-KO mouse embryonic fibroblasts (MEFs) to examine ${\beta}Pix$ function in mouse fibroblasts. ${\beta}Pix$-KO MEFs exhibit decreased Rac1 activity, and defects in cell spreading and platelet-derived growth factor (PDGF)-induced ruffle formation and chemotaxis. The average size of focal adhesions is increased in ${\beta}Pix$-KO MEFs. Interestingly, ${\beta}Pix$-KO MEFs showed increased motility in random migration and rapid wound healing with elevated levels of MLC2 phosphorylation. Taken together, our data demonstrate that ${\beta}Pix$ plays essential roles in early embryonic development, cell spreading, and cell migration in fibroblasts.

• KSII Transactions on Internet and Information Systems (TIIS)
• /
• 제10권9호
• /
• pp.4207-4222
• /
• 2016

In a P2P (Peer-to-Peer) VoD (video-on-Demand) streaming system, the nodes' load is an important factor which affects the system performance. In the system, some nodes may receive too many requests, which leads to overload. On the other hand, some other nodes may receive too few requests, which leads to low utilization. Therefore, designing a reasonable load balancing strategy is important. However, existing related studies cannot handle this problem effectively, because they don't have an efficient dynamic load information management mechanism, and they don't distinguish the difference of requests when transfer the nodes' load. In this paper, to manage the dynamic load information efficiently, we design a load management table for each node. Based on the load information, we propose a load balancing strategy which uses a request migration algorithm (LBRM). Through simulations, our scheme can handle the load imbalance problem effectively and improve the users' playback fluency.

• 한국운동역학회지
• /
• 제25권4호
• /
• pp.475-482
• /
• 2015

Objective : The purpose of this study was to investigate mean plantar foot pressure, maximum plantar pressure and ground reaction force, and center migration path of pressure according to the type of trekking shoes for the development of shoes. Method : Subjects of the study averaged $22.10{\pm}2.05years$ of age. Their average height was $169.27{\pm}7.62cm$ and their average weight was $64.34{\pm}10.22kg$. The method of this study was administered measuring 50 steps, at once, 3 times at a speed of 4 km/h and using the data of 30 steps. Pedar-X system measured the mean foot pressure, maximum foot pressure, mean maximum force, and center migration path of pressure by subjects' position while walking. Statistical analysis was performed by SPSS 23.0 using a paired t-test. Results : Results of the study showed Nestfit trekking shoes lower foot pressure of both feet in mean foot pressure and maximum foot pressure. Nestfit trekking shoes showed high ground reaction force (p<.001) in the midfoot, and low mean ground reaction force in the rearfoot. The center migration path of pressure showed the Nestfit trekking shoes were more stable than flat insole trekking shoes. Conclusion : It can be concluded that wearing Nestfit trekking shoes spreads pressure efficiently and induces walking stability because Nestfit trekking shoes spread the pressure of the forefoot and rearfoot to the midfoot and the center migration path of pressure shows regularly.

• 한국전자거래학회지
• /
• 제10권1호
• /
• pp.103-120
• /
• 2005

본 연구의 목적은 VAN에 기반한 EDI(Electronic Data Interchange) 트랜잭션을 사용하는 기업이 ebXML(e-business using XML), 로제타넷 (RosettaNet)이나 웹 서비스와 같은 웹 기반의 개방형 전자거래 프레임워크로 전환해 나갈 수 있도록 전략적인 지침을 제공하는 것이다. EDI가 가지고 있는 다양한 한계들과 웹 기술의 발전에 힘입어 많은 기업들이 인터넷 기반의 B2B 표준들을 채택하고자 한다. 그러나 이들은 기존의 EDI 시스템을 일시에 포기하지 않으면서도 점차적으로 B2B 프레임워크로 전환할 수 있는 방법을 찾고 있다. 따라서 이러한 상황에서 EDI 기업을 위한 효과적인 전환 전략과 지침을 마련하는 것은 매우 중요한 일이다. 본 연구에서 제시된 전략적 지침은 EDI 시스템으로부터 웹 기반의 e-비즈니스 프레임워크로 전환하고자 하는 기업에게 실제적인 가이드라인으로 사용될 수 있을 것이다.

• Biomolecules & Therapeutics
• /
• 제21권6호
• /
• pp.481-486
• /
• 2013

Macrophages play a role in innate immune responses to various foreign antigens. Many products from primary tumors influence the activation and transmigration of macrophages. Here, we investigated a migration of macrophages stimulated with cancer cell culture-conditioned medium (CM). Macrophage activation by treatment with CM of B16F10 cells were judged by the increase in protein levels of inducible nitric oxide synthase (iNOS) and cyclooxygenase 2 (COX2). The location where macrophages were at 4 h-incubation with control medium or CM was different from where they were at 5 h-incubation in culture dish. Percentage of superimposed macrophages at every 1 h interval was gradually increased by CM treatment as compared to control. Total coverage of migrated track expressed in coordinates was smaller and total distance of migration was shorter in CM-treated macrophages than that in control. Rac1 activity in CM-treated macrophages was also decreased as compared to that in control. When macrophages were treated with CM in the presence of dexamethasone (Dex), an increase in COX2 protein levels, and a decrease in Rac1 activity and total coverage of migration were reversed. In the meanwhile, biphasic changes were detected by Dex treatment in section distance of migration at each time interval, which was more decreased at early time and then increased at later time. Taken together, data demonstrate that macrophage motility could be reduced in accordance with activation in response to cancer cell products. It suggests that macrophage motility could be a novel marker to monitor cancer-associated inflammatory diseases and the efficacy of anti-inflammatory agents.