• Journal of Digital Contents Society
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• v.9 no.1
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• pp.125-130
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• 2008

User web service is increasing by development of internet technology. Quantity of encrypted data that transmitted through the network are increasing by development of encipherment technology. We have many problems; it is caused by technical development and service increase of user requests. It is like that, we have reliability of contents and illegality copy problem of internet contents in web application system. It is contents protection skills in web that encipherment technology, authentication and digital signature. We need message encoding and secret key for solve vulnerability of encipherment in web application system. In this paper, we propose a distributed secure system that can data confidentiality and user authentication. It prevent performance degradation from bottle neck in encipherment server, and improve service quality.

• Genomics & Informatics
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• v.10 no.2
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• pp.69-73
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• 2012

The explosive development of genomics technologies including microarrays and next generation sequencing (NGS) has provided comprehensive maps of cancer genomes, including the expression of mRNAs and microRNAs, DNA copy numbers, sequence variations, and epigenetic changes. These genome-wide profiles of the genetic aberrations could reveal the candidates for diagnostic and/or prognostic biomarkers as well as mechanistic insights into tumor development and progression. Recent efforts to establish the huge cancer genome compendium and integrative omics analyses, so-called "integromics", have extended our understanding on the cancer genome, showing its daunting complexity and heterogeneity. However, the challenges of the structured integration, sharing, and interpretation of the big omics data still remain to be resolved. Here, we review several issues raised in cancer omics data analysis, including NGS, focusing particularly on the study design and analysis strategies. This might be helpful to understand the current trends and strategies of the rapidly evolving cancer genomics research.

• BMB Reports
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• v.40 no.2
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• pp.226-231
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• 2007

Housekeeping genes are widely used as internal controls in a variety of study types, including real time RT-PCR, microarrays, Northern analysis and RNase protection assays. However, even commonly used housekeeping genes may vary in stability depending on the cell type or disease being studied. Thus, it is necessary to identify additional housekeeping-type genes that show sample-independent stability. Here, we used statistical analysis to examine a large human microarray database, seeking genes that were stably expressed in various tissues, disease states and cell lines. We further selected genes that were expressed at different levels, because reference and target genes should be present in similar copy numbers to achieve reliable quantitative results. Real time RT-PCR amplification of three newly identified reference genes, CGI-119, CTBP1 and GOLGAl, alongside three well-known housekeeping genes, B2M, GAPD, and TUBB, confirmed that the newly identified genes were more stably expressed in individual samples with similar ranges. These results collectively suggest that statistical analysis of microarray data can be used to identify new candidate housekeeping genes showing consistent expression across tissues and diseases. Our analysis identified three novel candidate housekeeping genes (CGI-119, GOLGA1, and CTBP1) that could prove useful for normalization across a variety of RNA-based techniques.

• The Transactions of The Korean Institute of Electrical Engineers
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• v.67 no.5
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• pp.656-662
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• 2018

Pattern matching algorithm is widely used in many application fields such as bio-informatics, intrusion detection, etc. Among many string matching algorithms, KMP (Knuth-Morris-Pratt) algorithm is commonly used because of its fast execution time when using large texts. However, the processing speed of KMP algorithm is also limited when the text size increases significantly. In this paper, we propose a high throughput parallel KMP algorithm considering CPU-GPU memory hierarchy based on OpenCL in GPGPU (General Purpose computing on Graphic Processing Unit). We focus on the optimization for the allocation of work-times and work-groups, the local memory copy of the pattern data and the failure table, and the overlapping of the data transfer with the string matching operations. The experimental results show that the execution time of the optimized parallel KMP algorithm is about 3.6 times faster than that of the non-optimized parallel KMP algorithm.

• The Journal of the Society of Korean Medicine Diagnostics
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• v.12 no.2
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• pp.61-73
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• 2008

Background: Yukmijiwhang-tang is one of the most common herbal formulas in Oriental Medicine. Yukmijiwhang-tang has been widely used as a herbal medicine to replenish Yin and tonify the kidneys for hundred years in Asian countries. Because of insufficiency in data, objective judgements about remedial effects have been difficult. In order to make objectivity diagnostic data, this research is developed. Purpose: The aim of the research is to make a pilot questionnaire for clinical use of Yukmijiwhang-tang. Methods: The questionnaire which includes symptoms and signs for Yukmijiwhang-tang is studied by the Delphi method. Results: By the Delphi method and score evaluation, 30 items of the initial copy of questionnaire are chosen for the research. Conclusions: By the Delphic survey among clinicians, a reference questionnaire for Yukmijiwhang-tang applications was suggested. Further research is necessary for modification of questionnaire by statistics and certification by clinical trial. research.

• Journal of Korean Society of Forest Science
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• v.69 no.1
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• pp.6-12
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• 1985

A computer program for stem analysis has been prepared by using BASIC language. Annual-ring counts and other input data can be directly entered for necessary calculation, and outputs are data lists, cross-section areas, age-height relationships, growth rates, total, annual, and mean increments of height, D.B.H. and volume for an individual tree. The sectional log volumes are calculated by Huber's formula, and the growth rates by Pressler's in this program. A copy of the program listing is in appendix I.

• Proceedings of the Korean Society for Bioinformatics Conference
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• 2006.02a
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• pp.98-107
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• 2006

Chromosomal copy number changes (aneuploidies) are common in human populations. The extra chromosome can affect gene expression by whole-genome level. By gene expression microarray analysis, we want to find aberrant gene expression due to aneuploidies in Klinefelter (+X) and Down syndrome (+21). We have analyzed the inactivation status of X-linked genes in Klinefelter Syndrome (KS) by using X-linked cDNA microarray and cSNP analysis. We analyzed the expression of 190 X-linked genes by cDNA microarray from the lymphocytes of five KS patients and five females (XX) with normal males (XY) controls. cDNA microarray experiments and cSNP analysis showed the differentially expressed genes were similar between KS and XX cases. To analyze the differential gene expressions in Down Syndrome (DS), Amniotic Fluid (AF)cells were collected from 12 pregnancies at $16{\sim}18$ weeks of gestation in DS (n=6) and normal (n=6) subjects. We also analysis AF cells for a DNA microarray system and compared the chip data with two dimensional protein gel analysis of amniotic fluid. Our data may provide the basis for a more systematic identification of biological markers of fetal DS, thus leading to an improved understanding of pathogenesis for fetal DS.

• Proceedings of the Korean Society of Broadcast Engineers Conference
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• 2019.06a
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• pp.222-224
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• 2019

Light Field (LF) camera captures not only the light intensity but also the light direction coming to camera. While the rich information captured by LF camera enables many interesting applications such as digital refocusing, viewpoint changing, and 3D reconstruction, but it also requires powerful coding tools to reduce its large volume of data. In this paper, we investigate using the intra prediction scheme of the versatile video coding (VVC), which is the most recent video coding technology currently under developing, to compress the LF image. The Intra Block Copy (IBC) technique in VVC is exploited considering special LF image structure. The experimental result shows that VVC intra predict ion outperforms the H.265/HEVC intra coding technique in encoding LF data irrespective of using the IBC mode or not.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.8 no.4
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• pp.775-780
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• 2007

Rapid Prototyping (RP) is a technology that produces prototype parts from 3D computer aided design model data without intermediate processing technology rapidly. CAD model data are created from 3D object digitizing systems but presented just as 2D data when they are printed as a hard copy or displayed on a monitor. However, Rapid Prototyping Technology fabricates 3D objects the same that CAD data because it transforms designed 3D CAD data into 2D cross sectional data, and manufactures layer by layer deposition sequentially. But most of all the small and medium scale companies which produce a toothbrush, a toy and such like provisions are in difficult situations to buy RP system because it is very expensive. In this paper, we propose a 3D control system adopting open source programs for implementing Rapid Prototyping Technology in order that RP system can be purchase at a moderate price.

• Journal of Plant Biotechnology
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• v.38 no.2
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• pp.125-129
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• 2011

Environmental risk assessment (RA) is essential prior to the environmental release of GM crops. RA, however, costs at least 7 to 15 million US dollars and requires several years to complete field tests. Therefore, it is strongly suggested that developers of GM crops must consider all criteria for RA at the beginning stage of the development if it aims for commercialization. Previous review papers have pointed out that the "death valley" for the commercialization of GM crops is the screening stage of early GM events since many candidates are given up due to insufficient data on the molecular characterization of a GM event such as inserted gene's copy number, position of inserted site of a chromosome, flanking sequence of recombinant T-DNA, rearrangement of chromosome, and knock out of endogenous gene of host plant. Recently, Rural Development Administration (RDA) in South Korea has launched a Grand National Project named as "Next Generation of BioGreen 21 Project" from 2011 to 2020 and research funding for the development of global GM crops has been allocated to accelerate the commercialization of GM crops. In this regard, I strongly suggest that researchers involved in the development of GM crops for commercialization must conduct RA by themselves at the screening stage of pre-GM event based on the data for molecular characterization.