• Title/Summary/Keyword: Data Bias

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Clinical-pathologic profile of head and neck rhabdomyosarcoma in children: a systematic review

  • Ludimila Lemes Moura;Beatriz Della Terra Mouco Garrido;Nelson Leonel Del Hierro Polanco;Mattheus Augusto Siscotto Tobias;Viviane da Silva Siqueira;Cassia Maria Fischer Rubira;Paulo Sergio da Silva Santos
    • Journal of the Korean Association of Oral and Maxillofacial Surgeons
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    • v.49 no.2
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    • pp.61-67
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    • 2023
  • This systematic review aimed to analyze the clinicopathological profile and relevant prognostic factors of head and neck rhabdomyosarcoma in pediatric patients. The search was carried out in the electronic search portals PubMed, Lilacs, Embase, Scopus, and Web of Science. The search yielded studies that were then analyzed regarding study topic, data extraction, and risk of bias using the STROBE (Strengthening the Reporting of Observational Studies) guidelines. Finally, three studies were included for qualitative analysis. Most of the cases involved embryonic and alveolar rhabdomyosarcoma. Expression of MYOD1 was highly correlated with diagnosis of spindle cell/sclerosing rhabdomyosarcoma, which appears to have a poor prognosis in children. Furthermore, tumor size <5 cm and absence of metastasis accompanied by complete resection and administration of adjuvant therapies such as chemotherapy and radiotherapy favored a better prognosis.

Comparative Analysis of COVID-19 Outbreak and Changes in Neurosurgical Emergency Patients

  • Lee, Min Ho;Jang, Seu-Ryang;Lee, Tae-Kyu
    • Journal of Korean Neurosurgical Society
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    • v.65 no.1
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    • pp.130-137
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    • 2022
  • Objective : COVID-19 has spread worldwide since the first case was reported in Wuhan, China, in December 2019. Our institution is a regional trauma and emergency center in the northern Gyeonggi Province. The changing trend of patient care in the emergency room of this hospital likely reflects the overall trend of patients in the area. In the present study, whether changes in the surrounding social environment following the outbreak of COVID-19 changed the incidence of neurosurgical emergency patients and whether differences in practice existed were investigated. Methods : The overall trend was analyzed from January 2020 which is before the outbreak of COVID-19 to September 2020. To remove bias due to seasonal variation, the previous 2 year's records during the same period were reviewed and compared. Confirmed COVID-19 patients in the northern Gyeonggi Province were identified using data released by the government. And patients who came to the emergency department with head trauma and stroke were identified. Results : Based on the present study results, the total number of neurosurgery emergency patients decreased over the study period. In the trauma patient group, the number of patients not involved in traffic accidents significantly decreased compared with patients involved in traffic accidents. Among the stroke cases, the rate of ischemic stroke was lower than hemorrhagic stroke, although a statistically significant difference was not observed. Meanwhile, an increase in the risk of mortality associated with trauma or stroke cases was not observed during the COVID-19 outbreak compared with the same time period in the previous year. Conclusion : Due to the occurrence of COVID-19, non-essential activities have decreased and trauma cases not associated with traffic accidents appeared to decrease. Due to the decrease in overall activity, the number of stroke patients has also decreased. This trend is expected to continue even in the post-COVID-19 era, and accordingly, the results from the present study are relevant especially if the current situation continues.

Verification of the KMA Ocean Model NEMO against Argo Floats and Drift Buoys: a Comparison with the Up-to-date US Navy HYCOM (Argo 플로트와 표류부이 관측자료를 활용한 기상청 전지구 해양모델 (NEMO)의 검증: 최신 미해군 해양모델(HYCOM)과 비교)

  • Hyun, Seung-Hwon;Hwang, Seung-On;Lee, Sang-Min;Choo, Sung-Ho
    • Atmosphere
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    • v.32 no.1
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    • pp.71-84
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    • 2022
  • This paper describes verification results for the ocean analysis field produced by the Nucleus for European Modelling of the Ocean (NEMO) of the Korea Meteorological Administration (KMA) against observed Argo floats and drift buoys over the western Pacific Ocean and the equatorial Pacific during 2020~2021. This is confirmed by a comparison of the verification for the newly updated version of the HYbrid Coordinate Ocean Model/Navy Coupled Ocean Data Assimilation (HYCOM/NCODA) against same observations. NEMO shows that the vertical ocean temperature is much closer to the Argo floats than HYCOM for most seasons in terms of bias and root mean square error. On the other hand, there are overall considerable cold biases for HYCOM, which may be due to the more rapid decreasing temperature at the shallow thermocline in HYCOM. Conclusion demonstrated that the NEMO analysis for ocean temperature is more reliable than the analysis produced by the latest version of HYCOM as well as by the out-of-date HYCOM applied to the precedent study. The surface ocean current produced by NEMO also shows 14% closer to the AOML (Atlantic Oceanographic and Meteorological Laboratory) in situ drift buoys observations than HYCOM over the western Pacific Ocean. Over the equatorial Pacific, however, HYCOM shows slightly closer to AOML observation than NEMO in some seasons. Overall, this study suggests that the resulting information may be used to promote more use of NEMO analysis.

Antimicrobial Activity of Propolis Extract and Their Application as a Natural Preservative in Livestock Products: A Meta-Analysis

  • Andre, Andre;Arief, Irma Isnafia;Apriantini, Astari;Jayanegara, Anuraga;Budiman, Cahyo
    • Food Science of Animal Resources
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    • v.42 no.2
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    • pp.280-294
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    • 2022
  • This study aimed to evaluate the effectiveness of propolis extract as a natural preservative for livestock products in term of chemical and microbiological characteristics by meta-analysis. The stages carried out in this study were identification, selection, checking suitability, and the resulting selected articles were used in the meta-analysis. The selection results obtained a total of 22 selected journal articles consisting of 9 articles for analysis of the antimicrobial activity of propolis extract and 13 articles for analysis of the chemical and mirobiological characteristics of livestock products. The articles were obtained from electronic databases, namely Science Direct and Google Scholar. The model used in this study is the random-effect model involving two groups, control and experimental. Heterogeneity and effect size values were carried out in this study using Hedge's obtained through openMEE software. Forest plot tests and data validation on publication bias was obtained using Kendall's test throught JASP 0.14.1 software. The results showed that there is a significant relationship between propolis extract with the results of the antimicrobial activity (p<0.05). In addition, the results of the application of propolis extract on the livestock products for the test microbes and the value of thiobarbituric acid reactive substances (TBARs) showed significant results (p<0.05). Conclusion based on the random-effect model on the effectiveness of antimicrobial activity of propolis extract and their apllication as a natural preservative of the chemical and microbiological characteristics of livestock products is valid by Kendall's test (p>0.05). Propolis in this case effectively used as natural preservatives in livestock products.

Teaching and Learning Design for AI Value Judgment (인공지능 가치판단에 대한 교수학습 설계)

  • Jeong, Minhee;Shin, Seungki
    • 한국정보교육학회:학술대회논문집
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    • 2021.08a
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    • pp.233-237
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    • 2021
  • With the advent of the 4th industrial revolution, interest in artificial intelligence education is increasing in elementary schools. In order to nurture future talents with artificial intelligence capabilities, AI education should be actively conducted at school sites. Although basic software education is provided in the 2015 revised curriculum, there is a tendency to view the programming process that creates artificial intelligence only as a problem-solving process. However, when creating an artificial intelligence, the value of the developer who creates artificial intelligence is projected. Therefore, it is necessary to deal with the contents of artificial intelligence value judgment during SW education. This study has limitations due to the fact that Delphi research was conducted with a group of experts. In the future, it is judged that quantitative research should be conducted to supplement these limitations.

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Yukgunja-tang for Irritable Bowel Syndrome: A Protocol for a Systematic Review and Meta-Analysis

  • Kangwook Lee;Seok-Jae Ko;Minjeong Kim;Chaehyun Park;Min-Seok Cho;Jae-Woo Park
    • The Journal of Internal Korean Medicine
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    • v.44 no.3
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    • pp.285-293
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    • 2023
  • Background: Irritable bowel syndrome (IBS) is a digestive disorder characterized by abdominal discomfort or pain accompanied by a change in stool condition. Owing to its complicated mechanisms, a standard treatment for IBS has not yet been established. Yukgunja-tang (YGT) is a Korean herbal medicine known in Asia to be effective in the treatment of gastrointestinal symptoms. In this study, we will conduct a systematic review of randomized controlled trials (RCTs) to assess the efficacy and safety of YGT in IBS treatment. Methods and analysis: English databases, such as Embase, Medline (via PubMed), Allied and Complementary Medicine Database, and Cochrane Central Register of Controlled Trials, will be searched for articles published up to April 2023. Additional databases, such as five Korean, one Chinese, and one Japanese database, will be included. RCTs and quasi-RCTs will also be included in the assessment of the efficacy of YGT. The overall efficacy rate will be the primary outcome, and data such as IBS quality-of-life measurements, global symptom scores, and adverse events will be the secondary outcomes. Review Manager Version 5.3 will be used for evaluation, and the risk of bias (RoB) will be evaluated using Cochrane Collaboration's RoB tool. The Grading of Recommendations Assessment, Development, and Evaluation approach will be used to score the quality of evidence. Conclusion: This study will demonstrate the efficacy and safety of YGT for treating patients with IBS.

New approach to calculate Weibull parameters and comparison of wind potential of five cities of Pakistan

  • Ahmed Ali Rajput;Muhammad Daniyal;Muhammad Mustaqeem Zahid;Hasan Nafees;Misha Shafi;Zaheer Uddin
    • Advances in Energy Research
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    • v.8 no.2
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    • pp.95-110
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    • 2022
  • Wind energy can be utilized for the generation of electricity, due to significant wind potential at different parts of the world, some countries have already been generating of electricity through wind. Pakistan is still well behind and has not yet made any appreciable effort for the same. The objective of this work was to add some new strategies to calculate Weibull parameters and assess wind energy potential. A new approach calculates Weibull parameters; we also developed an alternate formula to calculate shape parameters instead of the gamma function. We obtained k (shape parameter) and c (scale parameter) for two-parameter Weibull distribution using five statistical methods for five different cities in Pakistan. Maximum likelihood method, Modified Maximum likelihood Method, Method of Moment, Energy Pattern Method, Empirical Method, and have been to calculate and differentiate the values of (shape parameter) k and (scale parameter) c. The performance of these five methods is estimated using the Goodness-of-Fit Test, including root mean square error, mean absolute bias error, mean absolute percentage error, and chi-square error. The daily 10-minute average values of wind speed data (obtained from energydata.info) of different cities of Pakistan for the year 2016 are used to estimate the Weibull parameters. The study finds that Hyderabad city has the largest wind potential than Karachi, Quetta, Lahore, and Peshawar. Hyderabad and Karachi are two possible sites where wind turbines can produce reasonable electricity.

Reliability Analysis of Composite Girder Designed by LRFD Method for Positive Flexure (하중저항계수설계법(LRFD)으로 설계된 강합성 거더의 휨에 대한 신뢰도해석)

  • Shin, Dong-Ku;Kim, Cheon-Yong;Paik, In-Yeol
    • KSCE Journal of Civil and Environmental Engineering Research
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    • v.26 no.3A
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    • pp.539-546
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    • 2006
  • The reliability analysis of simply-supported composite plate girder and box girder bridges under positive flexure is performed. The bridges are designed based on the AASHTO-LRFD specification. A performance function for flexural failure is expressed as a function of such random variables as flexural resistance of composite section and design moments due to permanent load and live load. For the flexural resistance, the statistical parameters obtained by analyzing over 16,000 samples of domestic structural steel products are used. Several different values of statistical parameters with the bias factor in the range of 0.95-1.05 and the coefficient of variation in the range of 0.15-0.25 are used for the live-load moment. Due to the lack of available domestic measured data on the dead load moment, the same values of statistical properties used in the calibration of AASHTO-LRFD are applied. The reliability indices for the composite plate girder and box girder bridges with various span lengths are calculated by applying the Rackwitz-Fiessler technique.

Future drought risk assessment under CMIP6 GCMs scenarios

  • Thi, Huong-Nguyen;Kim, Jin-Guk;Fabian, Pamela Sofia;Kang, Dong-Won;Kwon, Hyun-Han
    • Proceedings of the Korea Water Resources Association Conference
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    • 2022.05a
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    • pp.305-305
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    • 2022
  • A better approach for assessing meteorological drought occurrences is increasingly important in mitigating and adapting to the impacts of climate change, as well as strategies for developing early warning systems. The present study defines meteorological droughts as a period with an abnormal precipitation deficit based on monthly precipitation data of 18 gauging stations for the Han River watershed in the past (1974-2015). This study utilizes a Bayesian parameter estimation approach to analyze the effects of climate change on future drought (2025-2065) in the Han River Basin using the Coupled Model Intercomparison Project Phase 6 (CMIP6) with four bias-corrected general circulation models (GCMs) under the Shared Socioeconomic Pathway (SSP)2-4.5 scenario. Given that drought is defined by several dependent variables, the evaluation of this phenomenon should be based on multivariate analysis. Two main characteristics of drought (severity and duration) were extracted from precipitation anomalies in the past and near-future periods using the copula function. Three parameters of the Archimedean family copulas, Frank, Clayton, and Gumbel copula, were selected to fit with drought severity and duration. The results reveal that the lower parts and middle of the Han River basin have faced severe drought conditions in the near future. Also, the bivariate analysis using copula showed that, according to both indicators, the study area would experience droughts with greater severity and duration in the future as compared with the historical period.

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Effect of Herbal Medicine on Transient Synovitis of Hip in Children: A Systemic Review and Meta-analysis (소아 일과성 고관절 활액막염에 대한 한약의 효과: 체계적 문헌 고찰 및 메타분석)

  • Hong Ye Na;Lee Young Hun;Yu Sun Ae
    • The Journal of Pediatrics of Korean Medicine
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    • v.37 no.4
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    • pp.34-52
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    • 2023
  • Objective This study aimed to evaluate the effect of herbal medicines on transient hip synovitis (TSH) in children. Methods We searched 10 Korean, English, Japanese, and Chinese databases for studies published up to September 19, 2023. Randomized controlled trials (RCTs) evaluating the effect of herbal medicines on TSH levels in children were included. The Cochrane risk of bias was used to evaluate the quality of the studies. A meta-analysis was conducted according to outcome measurements, such as total effective rate (TER), visual analog score (VAS), time to pain relief, and hip joint mobility disorder disappearance time, using the Review Manager website. Results Eleven RCTs were included in this study. TER in the treatment group was significantly higher than in the control group. The duration of pain relief was significantly shorter in the treatment group than in the control group. The VAS score of the treatment group was significantly lower than that of the control group, although the statistical heterogeneity was substantial. The hip joint mobility disorder disappeared in the treatment group treated with external therapy, which was significantly shorter than in the control group. Regarding safety, two of the 11 studies reported that there were no adverse events. Conclusions Herbal medicines are effective in the treatment of TSH in children. However, the safety of herbal medicines should be carefully considered due to the lack of data.