• Title/Summary/Keyword: Data Bias

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Effects of Herbal Medicines on Bone Mineral Density Score in Osteoporosis or Osteopenia: Study Protocol for a Systematic Review and Meta-Analysis (한약이 골다공증 혹은 골감소증 환자의 골밀도에 미치는 영향: 체계적 문헌고찰 및 메타분석을 위한 프로토콜)

  • Hong, Su Min;Lee, Eun Jung
    • Journal of Korean Medicine Rehabilitation
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    • v.31 no.2
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    • pp.49-55
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    • 2021
  • Objectives The impact of social and economic losses on society due to the occurrence of osteoporosis patients is serious. The purpose of this study is to identify the types and effects of herbal medicine for osteoporosis and osteopenia. Methods We will investigate 8 online databases (MEDLINE/PubMed, Cochrane library, EMbase, China National Knowledge Infrastructure [CNKI], J-stage, National Digital Science Library [NDSL], Research Information Sharing Service [RISS], Koreanstudies Information Service System [KISS]) without language, publication date limitation for the clinical study of herbal medicine for osteoporosis and osteopenia published between the start of the database and 2021. The frequency, duration and pattern of the any type of herbal medicine utilization will be analyzed. Results Randomized controlled trials about herbal medicine or herbal medicine extracts for osteoporosis and osteopenia should be included in the study. Cochrane risk in bias tools will be used to evaluate the methodological quality of the study. A risk ratio or mean difference with a 95% confidence interval will show the effects of herbal medicine or herbal medicine extracts for osteoporosis and osteopenia. Conclusions The results of the systematic review will reflect the current status of herbal medicine treatment for osteoporosis and osteopenia, and it can be expected to verify the validity of the effectiveness, and provide it as a basic data for the use of herbal medicine in clinical utilization.

Basic reproduction number of African swine fever in wild boars (Sus scrofa) and its spatiotemporal heterogeneity in South Korea

  • Lim, Jun-Sik;Kim, Eutteum;Ryu, Pan-Dong;Pak, Son-Il
    • Journal of Veterinary Science
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    • v.22 no.5
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    • pp.71.1-71.12
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    • 2021
  • Background: African swine fever (ASF) is a hemorrhagic fever occurring in wild boars (Sus scrofa) and domestic pigs. The epidemic situation of ASF in South Korean wild boars has increased the risk of ASF in domestic pig farms. Although basic reproduction number (R0) can be applied for control policies, it is challenging to estimate the R0 for ASF in wild boars due to surveillance bias, lack of wild boar population data, and the effect of ASF-positive wild boar carcass on disease dynamics. Objectives: This study was undertaken to estimate the R0 of ASF in wild boars in South Korea, and subsequently analyze the spatiotemporal heterogeneity. Methods: We detected the local transmission clusters using the spatiotemporal clustering algorithm, which was modified to incorporate the effect of ASF-positive wild boar carcass. With the assumption of exponential growth, R0 was estimated for each cluster. The temporal change of the estimates and its association with the habitat suitability of wild boar were analyzed. Results: Totally, 22 local transmission clusters were detected, showing seasonal patterns occurring in winter and spring. Mean value of R0 of each cluster was 1.54. The estimates showed a temporal increasing trend and positive association with habitat suitability of wild boar. Conclusions: The disease dynamics among wild boars seems to have worsened over time. Thus, in areas with a high elevation and suitable for wild boars, practical methods need to be contrived to ratify the control policies for wild boars.

Treatment Costs and Factors Associated with Glycemic Control among Patients with Diabetes in the United Arab Emirates

  • Lee, Seung-Mi;Song, Inmyung;Suh, David;Chang, Chongwon;Suh, Dong-Churl
    • Journal of Obesity & Metabolic Syndrome
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    • v.27 no.4
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    • pp.238-247
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    • 2018
  • Background: We aimed to estimate the proportion of patients with diabetes who achieved target glycemic control, to estimate diabetes-related costs attributable to poor control, and to identify factors associated with them in the United Arab Emirates. Methods: This retrospective cohort study used administrative claims data handled by Abu Dhabi Health Authority (January 2010 to June 2012) to determine glycemic control and diabetes-related treatment costs. A total of 4,058 patients were matched using propensity scores to eliminate selection bias between patients with glycosylated hemoglobin (HbA1c) <7% and HbA1c ${\geq}7%$. Diabetes-related costs attributable to poor control were estimated using a recycled prediction method. Factors associated with glycemic control were investigated using logistic regression and factors associated with these costs were identified using a generalized linear model. Results: During the 1-year follow-up period, 46.6% of the patients achieved HbA1c <7%. Older age, female sex, better insurance coverage, non-use of insulin in the index diagnosis month, and non-use of antidiabetic medications during the follow-up period were significantly associated with improved glycemic control. The mean diabetes-related annual costs were $2,282 and $2,667 for patients with and without glycemic control, respectively, and the cost attributable to poor glycemic control was $172 (95% confidence interval [CI], $164-180). The diabetes-related costs were lower with mean HbA1c levels <7% (cost ratio, 0.94; 95% CI, 0.88-0.99). The costs were significantly higher in patients aged ${\geq}65$ years than those aged ${\leq}44$ years (cost ratio, 1.45; 95% CI, 1.25-1.70). Conclusion: More than 50% of patients with diabetes had poorly controlled HbA1c. Poor glycemic control may increase diabetes-related costs.

Effectiveness of Patient and Family-Centered Care interventions: A Systematic Review (환자-가족중심 의료서비스의 융합적 성과: 체계적 문헌고찰)

  • Yoo, Ji-Yeon;Ahn, Sung-Hee
    • Journal of the Korea Convergence Society
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    • v.10 no.6
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    • pp.365-379
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    • 2019
  • This review aimed to analyze characteristics and performances of patient and family-centered care interventions and evaluate the convergence effectiveness. Randomized controlled trials were searched, selected, data extracted and quality-assessed using the Risk of Bias in 15 databases. Characteristics suggested from 21 studies were provision of information, education, communication and family and friend participation. There were 89 measurement variables of performances. Patient outcome was measured by mortality, length of hospitalization, etc., indicated as significantly improved in 18 studies. This review has provided evidence that patient and family-centered care improved experience and performance of diverse patients, families and health-care providers. There is need to convergence adopt patient and family-centered care and conduct evidence-based studies for improvement of quality of healthcare and patient safety in the future.

Effect of Chuna Manual Therapy for Peripheral Facial Paralysis in Children : A Systematic Review (소아 말초성 안면마비에 대한 추나요법의 효과 : 체계적 문헌고찰)

  • Kim, Eui-Byeol;Kang, Ki-Wan;Kim, Min-Woo;Ko, Youn-Seok
    • The Journal of Churna Manual Medicine for Spine and Nerves
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    • v.14 no.1
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    • pp.1-11
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    • 2019
  • Objectives : The purpose of this study is to review clinical studies about the effect of chuna manual therapy (CMT) for peripheral facial paralysis in children. Methods : In this review, we searched 11 electronic databases (Pubmed, Cochrane Library, EMBASE, CINAHL, CAJ, Oasis, NDSL, KISS, RISS, KISTI, Dbpia); We concluded our literature search in April 23, 2019. We included only randomized controlled trials (RCTs) of testing CMT for peripheral facial paralysis in children. The methodological quality of each RCT was assessed using the Cochrane risk of bias tool. The meta-analysis was performed by synthesizing outcome data of total efficacy rate (TER). Results : After screening papers, a total of 6 RCTs were selected and analyzed. In the 6 RCTs, patients(n=15-60 per study) were randomized into groups for treatment and control. Specifically, the treatment group received CMT, while the control group was concurrently given usual care, such as acupuncture and medicine. The meta-analysis showed that the treatment group receiving CMT alone showed significant improvement in TER, compared to the control group receiving acupuncture therapy alone(P<0.05). And the treatment group receiving CMT combined with usual care showed positive results, in terms of TER, compared to the control group receiving usual care, but was not statistically significant(P>0.05). Conclusions : Our analysis suggests that CMT has therapeutic effects for peripheral facial paralysis in children. However, to confirm this result, further investigation accompanied by high quality studies is required.

Convective Cloud RGB Product and Its Application to Tropical Cyclone Analysis Using Geostationary Satellite Observation

  • Kim, Yuha;Hong, Sungwook
    • Journal of the Korean earth science society
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    • v.40 no.4
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    • pp.406-413
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    • 2019
  • Red-Green-Blue (RGB) imagery techniques are useful for both forecasters and public users because they are intuitively understood, have advantageous visualization, and do not lose observational information. This study presents a novel RGB convective cloud product and its application to tropical cyclone analysis using Communication, Oceanography, and Meteorology (COMS) satellite observations. The RGB convective cloud product was developed using the brightness temperature differences between WV ($6.75{\mu}m$) and IR1 ($10.8{\mu}m$), and IR2 ($12.0{\mu}m$) and IR1 ($10.8{\mu}m$) as well as the brightness temperature in the IR1 bands of the COMS, with the threshold values estimated from the Korea Meteorological Administration (KMA) radar observations and the EUMETSAT RGB recipe. To verify the accuracy of the convective cloud RGB product, the product was applied to the center positions analysis of two typhoons in 2013. Thus, the convective cloud RGB product threshold values were estimated for WV-IR1 (-20 K to 15 K), IR1 (210 K to 300 K), and IR1-IR2 (-4 K to 2 K). The product application in typhoon analysis shows relatively low bias and root mean square errors (RMSE)s of 23 and 28 km for DANAS in 2013, and 17 and 22 km for FRANCISCO in 2013, as compared to the best tracks data from the Regional Specialized Meteorological Center (RSMC) in Tokyo. Consequently, our proposed RGB convective cloud product has the advantages of high accuracy and excellent visualization for a variety of meteorological applications.

Effect of aquatic exercise on gait in persons with chronic stroke: a meta-analysis study in Korea

  • Lee, Dong-Jin;Cho, Sung-Hyoun
    • Physical Therapy Rehabilitation Science
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    • v.8 no.2
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    • pp.112-123
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    • 2019
  • Objective: Based on the results of previous studies, it is necessary to analyze gait and discuss and present the effects of aquatic exercise for chronic stroke. The purpose of this study was to present objective data on the effect of aquatic exercise on the gait of persons with stroke by performing a meta-analysis. Design: A systematic review and meta-analysis. Methods: We performed a meta-analysis of 23 studies that investigated the effects of aquatic exercise performed between 2006 and 2017. The studies were searched on the basis of the participants, intervention, comparison, outcomes standard. The quality of the research method was assessed using a tool that can assess the risks posed by each study design. A meta-analysis software program was used to calculate the mean effect size, effect size by intervention, and effect size by outcome. We also performed a meta-regression analysis and an analysis of publication bias. Results: The mean effect size of the patients' gait was 0.65 (p<0.05). The largest effect size by outcome was observed at the 6-m walk test, followed by the 6-minutes walk test, 10-m walk test, and the walking equipment test (p<0.05). The meta-regression analysis showed that the effect size increased with increased duration, number, and length of sessions. Conclusions: Aquatic exercise appears to show a moderate effect on the gait of chronic stroke survivors. Meta-analyses on the effects of aquatic exercise in other patient populations are needed. This study suggests standard criteria establishments for the effect of aquatic exercise on the walking ability of persons with chronic stroke.

A Meta-analysis for the Effects of Exercise on Pulmonary Function in Patients with Ankylosing Spondylitis (강직성 척추염 환자의 폐기능에 미치는 운동효과에 대한 메타분석)

  • Kim, Eun-Jeong;Lee, Eun-Nam;Yu, Eun-Jeong
    • Journal of muscle and joint health
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    • v.26 no.2
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    • pp.141-154
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    • 2019
  • Purpose: This study aimed to analyze the effects of exercise on pulmonary function in patients with ankylosing spondylitis (AS). Methods: Randomized controlled trials (RCTs) were identified by searching MEDLINE, EMBASE, CENTRAL, and CINAHL (through Jan 2019). Three reviewers independently retrieved articles, extracted data, and assessed methodological quality using the Cochrane's Risk of Bias for randomized studies. Results: Fourteen studies met the inclusion criteria with a total of 729 participants. CE (SMD 0.58, 95% CI 0.41~0.75, p<.001) and $VO_2peak$ (SMD 0.56, 95% CI 0.24~0.88, p=.001) had a significant effect on the most exercise interventions. As a secondary variable, BASFI (SMD -0.53, 95% CI -0.70~-0.37, p<.001), BASMI (SMD -0.75, 95% CI -0.92~-0.58, p<.001) showed an effect size of more than medium. However, PFT and QoL did not produce a significant results. Conclusion: Pulmonary involvement is common in patients with AS and might have disturbed functionality and exercise modality. Exercise can be an effective intervention to improve pulmonary function in patients with AS. More attention is needed to improve the chest and spinal mobility to maintain the appropriate pulmonary function. It is also necessary to consider how to construct a patient-tailored exercise program to increase performance, accuracy and safety of exercise.

Association Between Dental Implants and Cognitive Function in Community-dwelling Older Adults in Korea

  • Ki, Seungkook;Yun, Jihye;Kim, Jinhee;Lee, Yunhwan
    • Journal of Preventive Medicine and Public Health
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    • v.52 no.5
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    • pp.333-343
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    • 2019
  • Objectives: This study aimed to evaluate the association between dental implants and cognitive function in community-dwelling older adults. Methods: Data were collected from the baseline survey (2016-2017) of the Korean Frailty and Aging Cohort Study. The study sample comprised 1115 community-dwelling people aged 70 years to 84 years who had 0-19 natural teeth. Dental implants and natural teeth were identified by panoramic radiography, while the cognitive function was assessed by the Korean version of the Mini-Mental State Examination (MMSE-KC). The association between dental implants and cognitive function was analyzed by multiple linear regression. Sensitivity analysis was performed to test for potential bias. Results: The mean number of natural teeth in the study population was 9.50 (standard deviation [SD], 6.42), and the mean MMSE-KC score was 24.93 (SD, 3.55). In the simple univariate analysis, tooth replacement, age, sex, smoking status, alcohol consumption, body mass index, osteoporosis, number of natural teeth, periodontitis, chewing discomfort, tooth-brushing frequency, education level, monthly household income, participation in economic activity, living alone, and marital status had a significant impact on the association. After adjusting for confounders, the association between dental implants and cognitive function remained significant (B, 0.85; standard error, 0.40; p<0.05). Age, body mass index, periodontitis, tooth-brushing frequency, and education level were also significantly associated with cognitive function. The results of the sensitivity analyses were consistent with those of the primary analysis. Conclusions: Dental implants were associated with cognitive function in older adults living in the community. Dental implants as tooth replacements may play a role in preserving cognitive function.

Predictability of Northern Hemisphere Teleconnection Patterns in GloSea5 Hindcast Experiments up to 6 Weeks (GloSea5 북반구 대기 원격상관패턴의 1~6주 주별 예측성능 검증)

  • Kim, Do-Kyoung;Kim, Young-Ha;Yoo, Changhyun
    • Atmosphere
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    • v.29 no.3
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    • pp.295-309
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    • 2019
  • Due to frequent occurrence of abnormal weather, the need to improve the accuracy of subseasonal prediction has increased. Here we analyze the performance of weekly predictions out to 6 weeks by GloSea5 climate model. The performance in circulation field from January 1991 to December 2010 is first analyzed at each grid point using the 500-hPa geopotential height. The anomaly correlation coefficient and mean-square skill score, calculated each week against the ECWMF ERA-Interim reanalysis data, illustrate better prediction skills regionally in the tropics and over the ocean and seasonally during winter. Secondly, we evaluate the predictability of 7 major teleconnection patterns in the Northern Hemisphere: North Atlantic Oscillation (NAO), East Atlantic (EA), East Atlantic/Western Russia (EAWR), Scandinavia (SCAND), Polar/Eurasia (PE), West Pacific (WP), Pacific-North American (PNA). Skillful predictability of the patterns turns out to be approximately 1~2 weeks. During summer, the EAWR and SCAND, which exhibit a wave pattern propagating over Eurasia, show a considerably lower skill than the other 5 patterns, while in winter, the WP and PNA, occurring in the Pacific region, maintain the skill up to 2 weeks. To account for the model's bias in reproducing the teleconnection patterns, we measure the similarity between the teleconnection patterns obtained in each lead time. In January, the model's teleconnection pattern remains similar until lead time 3, while a sharp decrease of similarity can be seen from lead time 2 in July.