• 지질공학
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• 제25권4호
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• pp.439-447
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• 2015

In this study, specific sections vulnerable to debris flow damage were selected, and a complete enumeration survey was performed for the sections with debris flow hazards. Based on this, the characteristics of the sections with debris flow hazards and the current status of actions against debris flow were examined, and an efficient installation plan for a debris flow damage prevention method that is required in the future was suggested. The results indicated that in the Route 56 section where the residential density is relatively higher between the two model survey sections, facilities for debris flow damage reduction were insufficient compared to those in the Route 6 section which is a mountain area. It is thought that several sites require urgent preparation of a facility for debris flow damage reduction. In addition, a numerical analysis showed that for debris barriers installed as a debris flow damage prevention method, distributed installation of a number of small-scale barriers facilities within a valley part was more effective than single installation of a large-scale debris barrier at the lower part of a valley.

• Molecules and Cells
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• 제42권7호
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• pp.546-556
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• 2019

Protein phosphatase 4 (PP4) is a crucial protein complex that plays an important role in DNA damage response (DDR), including DNA repair, cell cycle arrest and apoptosis. Despite the significance of PP4, the mechanism by which PP4 is regulated remains to be elucidated. Here, we identified a novel PP4 inhibitor, protein phosphatase 4 inhibitory protein (PP4IP) and elucidated its cellular functions. PP4IP-knockout cells were generated using the CRISPR/Cas9 system, and the phosphorylation status of PP4 substrates (H2AX, KAP1, and RPA2) was analyzed. Then we investigated that how PP4IP affects the cellular functions of PP4 by immunoprecipitation, immunofluorescence, and DNA double-strand break (DSB) repair assays. PP4IP interacts with PP4 complex, which is affected by DNA damage and cell cycle progression and decreases the dephosphorylational activity of PP4. Both overexpression and depletion of PP4IP impairs DSB repairs and sensitizes cells to genotoxic stress, suggesting timely inhibition of PP4 to be indispensable for cells in responding to DNA damage. Our results identify a novel inhibitor of PP4 that inhibits PP4-mediated cellular functions and establish the physiological importance of this regulation. In addition, PP4IP might be developed as potential therapeutic reagents for targeting tumors particularly with high level of PP4C expression.

• Journal of Ecology and Environment
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• 제34권2호
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• pp.215-222
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• 2011

We evaluated the carbon (C) and nitrogen (N) status of litterfall in a natural red pine (Pinus densiflora) stand damaged by pine wilt disease in Jinju City, which was one of the areas severely affected by the disease in Korea. A significant correlation (P < 0.05) was found between tree density and basal area and the C and N status of litterfall components, but C and N status was not correlated with mean diameter at breast height in the pine wilt disease stands. Needle-litter C and N concentrations were linearly related (P < 0.05) to basal area in pine wilt disease stands. Needle-litter C concentration decreased with a decrease in damage intensity due to pine wilt disease, whereas litter N concentration increased with an increase of basal area in pine wilt disease stands. The linear regression equations developed for litterfall C and N inputs were significant (P < 0.05), with basal area accounting for 50-86% of the variation, except for cone and flower litter. The results indicated that the incidence of pine wilt disease could impact the quality and quantity of C and N in litterfall of pine stands suffering from pine wilt disease.

• 정보보호학회논문지
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• 제13권6호
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• pp.45-54
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• 2003

공개키 인증서는 유효기간 이전에도 소유자의 신원정보 변경이나 개인키의 훼손과 같은 이유로 폐지가 가능하다. 인증서는 상대적으로 긴 시간의 유효기간을 가지기 때문에 폐지될 수 있는 가능성이 높다. 공개키 기반구조에서 기술적인 중요한 문제는 인증서 상태에 대한 처리에 있다. 본 논문은 금융 네트워크의 환경에서 적합한 실시간 인증서 상태 확인 메커니즘을 제안한다. 제안 방식의 특징은 검증자목록을 이용하여 실시간으로 인증서 폐지 정보를 전송하는데 있다. 이 방식은 성능에 대한 실험에서 대표적인 상태확인 메커니즘인 실시간 인증서 상태 프로토콜(OCSP：On-line Certificate Status Protocol)과 동일한 현재성을 제공한다. 이와 동시에 감내하기 어려운 집중된 네트워크 전송에서 상태 확인의 부담을 줄인다.

• 비파괴검사학회지
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• 제23권4호
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• pp.364-371
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• 2003

In this paper, a review of the current status, on the use of long range cylindrically guided wave modes, and their interaction with cracks and corrosion damage in pipe-like structures will be discussed. Applications of cylindrically guided ultrasonic wave modes have been developed for inspection of corrosion damage in pipelines at chemical plants, flow-accelerated corrosion damage (wall thinning) in feedwater piping, and circumferential stress corrosion cracks in PWR steam generator tubes. It has been demonstrated that this inspection technique can be employed on a variety of piping geometries (diameters from 1 in. to 3 ft, and wall thickness from 0.1 to 6 in.) and a propagation distance of 100 meters or more is sometimes feasible. This technique can also be used in the inspection of inaccessible or buried regions of pipes and tubes.

• 한국전산구조공학회:학술대회논문집
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• 한국전산구조공학회 2006년도 정기 학술대회 논문집
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• pp.216-221
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• 2006

This study provides a methodology for development of the Seismic Damage Evaluation System (SDES) in Korea. Major systems and status of database related to road networks in Korea are investigated to analyze the usability of the required information for developing the SDES. In this study, the SDES is composed of four components that are the road network component, the ground motion component, the fragile structure component, and the cost component. In addition, the procedures for the construction of database which support the SDES is proposed, and a prototype of the SDES for expressway of Korea is developed based on the developed methodology. The National Geospatial Information System (NGIS) and the National Earthquake Information System (NEIS) are used to develop the road network component and ground motion component, respectively. For the fragile structure component and the cost component, Highway Bridge Management System (HEMS) was used.

• 대한안전경영과학회지
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• 제19권2호
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• pp.41-50
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• 2017

Disaster and safety budget can be characterized as a large-scale public asset on which the government has a significant role. It is of a crucial importance to properly allocate the limited national budget to various areas as necessary. Higher investment efficiency of the budget related to disaster and safety management requires distribution criteria based on relevance and efficiency. Currently, the budget related to disaster and safety management is orchestrated through the prior consultation system. However, there is still no clear framework for reviewing the investment direction and setting the priority investment areas by prior consultation. This study analyzes the status and characteristics of disaster and safety management projects by damage type and proposes a structured system for prioritization. This framework can be useful in selecting the areas that need priority investments by damage type of disaster and safety management projects, thereby contributing to improving investment efficiency.

• 한국영양학회:학술대회논문집
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• 한국영양학회 1999년도 추계학술대회 초록
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• pp.38-38
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• 1999

• The Korean Journal of Physiology and Pharmacology
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• 제21권1호
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• pp.125-131
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• 2017

Status epilepticus is the most common serious neurological condition triggered by abnormal electrical activity, leading to severe and widespread cell loss in the brain. Lithium has been one of the main drugs used for the treatment of bipolar disorder for decades, and its anticonvulsant and neuroprotective properties have been described in several neurological disease models. However, the therapeutic mechanisms underlying lithium's actions remain poorly understood. The muscarinic receptor agonist pilocarpine is used to induce status epilepticus, which is followed by hippocampal damage. The present study was designed to investigate the effects of lithium post-treatment on seizure susceptibility and hippocampal neuropathological changes following pilocarpine-induced status epilepticus. Status epilepticus was induced by administration of pilocarpine hydrochloride (320 mg/kg, i.p.) in C57BL/6 mice at 8 weeks of age. Lithium (80 mg/kg, i.p.) was administered 15 minutes after the pilocarpine injection. After the lithium injection, status epilepticus onset time and mortality were recorded. Lithium significantly delayed the onset time of status epilepticus and reduced mortality compared to the vehicle-treated group. Moreover, lithium effectively blocked pilocarpine-induced neuronal death in the hippocampus as estimated by cresyl violet and Fluoro-Jade B staining. However, lithium did not reduce glial activation following pilocarpine-induced status epilepticus. These results suggest that lithium has a neuroprotective effect and would be useful in the treatment of neurological disorders, in particular status epilepticus.

• Food Science and Biotechnology
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• 제17권3호
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• pp.457-463
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• 2008

The effects of dietary supplementation of the unrefined rice bran oil from 'Suwon 415' pigmented black rice (BRBO) on cholesterol metabolism and cellular antioxidant status were investigated in hypercholesterolemic rats. The significant reduction of total cholesterol (TC) and low density lipoprotein cholesterol (LDL-C) concentrations was observed in the plasma of rats fed BRBO. BRBO also decreased plasma and hepatic oxidative stress as a result of increased levels of hepatic thiobarbituric acid reactive substances (TBARS) levels associated with the elevations of hepatic superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px) activities together with increased plasma level of tocopherol. This study indicates that dietary BRBO supplement can leads to the improvement of overall cholesterol metabolism and antioxidant status even more effectively than 'Chuchung' white rice (WRBO). Consumption of BRBO may also protect the liver from oxidative damage caused by lipid peroxidation.