• Nutrition Research and Practice
• /
• 제13권5호
• /
• pp.377-383
• /
• 2019

BACKGROUND/OBJECTIVES: Hyperglycemia-induced hepatic damage has been recognized as one of the major cause of complications in diabetes. Hepatic complications are associated with inflammation and oxidative stress in diabetes. In this study, we investigated the hypothesis that gamma-tocopherol (GT) supplementation ameliorates NLRP3 inflammasome associated hepatic inflammation in diabetes. MATERIALS/METHODS: Diabetes was induced by the intraperitoneal injection of alloxan (150 mg/kg. BW) in ICR mice. All mice were fed with a control diet (AIN-76A). After diabetes was induced (fasting glucose level ${\geq}250mg/dL$), the mice were treated with tocopherol-stripped corn oil or GT-supplemented (35 mg/kg) corn oil, respectively, by gavage for 2 weeks. RESULTS: GT supplementation reduced fasting blood glucose levels in diabetic mice relative to non-treated diabetic mice. Moreover, GT supplementation ameliorated hyperglycemia-induced hepatic damage by regulation of NOD-like receptor protein 3 (NLRP3)-inflammasome associated inflammation represented by NLRP3, apoptosis-associated speck-like protein containing a caspase-recruitment domain, caspase-1, nuclear $factor-{\kappa}B$ pathway as well as oxidative stress demonstrated by nuclear factor erythroid 2-related factor 2, NAD(P)H dehydrogenase quinone 1, catalase and glutathione-dependent peroxidase in diabetic mice. CONCLUSION: The findings suggested that GT supplementation ameliorated hepatic damage by attenuating inflammation and oxidative stress in alloxan-induced diabetic mice. Taken together, GT could be a beneficial nutrient that can ameliorate inflammatory responses associated with NLRP3 inflammasome in hyperglycemia-induced hepatic damage.

• Advances in concrete construction
• /
• 제9권4호
• /
• pp.413-421
• /
• 2020

For steel-concrete girders made composite using shear studs, initial damage on studs induced by weld defect, unexpected overloading, fatigue and others might degrade the service performance and even threaten the structural safety. This paper conducted a numerical study to investigate the static behavior of damaged stud shear connectors that were embedded in ultra high performance concrete (UHPC). Parameters included damage degree and damage location. The material nonlinear behavior was characterized by multi-linear stress-strain relationship and damage plasticity model. The results indicated that the shear strength was not sensitive to the damage degree when the damage occurred at 2/3d (d is the stud diameter) from the stud root. An increased stud area would be engaged in resisting shear force as the distance of damage location from stud root increased and the failure section becomes inclined, resulting in a less reduction in the shear strength and shear stiffness. The reduction factor was proposed to consider the degradation of the shear strength of the damaged stud. The reduction factor can be calculated using two approaches: a linear relationship and a square relationship with the damage degree corresponding to the shear strength dominated by the section area and the nominal diameter of the damaged stud. It was found that the proposed method is preferred to predict the shear strength of a stud with initial damage.

• 대한의생명과학회지
• /
• 제20권2호
• /
• pp.56-61
• /
• 2014

This study attempted to confirm the antioxidative potential of luteolin against tert-butyl hydroperoxide (t-BHP) induced oxidative damage and to investigate its molecular mechanism related to glutathione (GSH)-dependent enzymes in HepG2 cells. Treatment with luteolin resulted in attenuation of t-BHP induced generation of reactive oxygen species (ROS) and oxidative stress-mediated cell death. In addition, accelerated expression of GSH-dependent antioxidative enzymes, glutathione peroxidase (GPx) and glutathione reductase (GR), and heme oxygenase (HO)-1, as well as strengthened GSH content was induced by treatment with luteolin, which was in accordance with increased nuclear translocation of nuclear factor-erythroid 2 p45-related factor 2 (Nrf2), a transcription factor for phase 2 enzymes, in a dose-dependent manner. These results suggest that the cytoprotective potential of luteolin against oxidative damage can be attributed to fortified GSH-mediated antioxidative pathway and HO-1 expression through regulation of Nrf2 in HepG2 cells.

• Advances in materials Research
• /
• 제5권1호
• /
• pp.11-20
• /
• 2016

In bonded composite repair of aircraft structures, the damage of the adhesive can thus reduce significantly the efficiency and the durability of the bonded composite repair. The adhesive damage models using critical zone have proven their effectiveness due to simplicity and ap-plicability of the damage criteria in these models. The scope of this study is to analyze the effects of the patch thickness and the adhesive thickness on the damage damage in bonded composite repair of aircraft structures by using modified damage zone theory. The obtained results show that, when the thickness of adhesive increases the damage zone increases and the adhesive loses its rigidity, inversely when the patch is reduced the adhesive damage be-comes more significant.

• Steel and Composite Structures
• /
• 제25권1호
• /
• pp.79-92
• /
• 2017

Initial damage to a stud due to corrosion, fatigue, unexpected overloading, a weld defect or other factors could degrade the shear capacity of the stud. Based on typical push-out tests, a FEM model and theoretical formulations were proposed in this study. Six specimens with the same geometric dimensions were tested to investigate the effect of the damage degree and location on the static behavior and shear capacity of stud shear connectors. The test results indicated that a reduction of up to 36.6% and 62.9% of the section area of the shank could result in a dropping rate of 7.9% and 57.2%, respectively, compared to the standard specimen shear capacity. Numerical analysis was performed to simulate the push-out test and validated against test results. A parametrical study was performed to further investigate the damage degree and location on the shear capacity of studs based on the proposed numerical model. It was demonstrated that the shear capacity was not sensitive to the damage degree when the damage section was located at 0.5d, where d is the shank diameter, from the stud root, even if the stud had a significant reduction in area. Finally, a theoretical formula with a reduction factor K was proposed to consider the reduction of the shear capacity due to the presence of initial damage. Calculating K was accomplished in two ways: a linear relationship and a square relationship with the damage degree corresponding to the shear capacity dominated by the section area and the nominal diameter of the damaged stud. This coefficient was applied using Eurocode 4, AASHTO LRFD (2014) and GB50017-2003 (2003) and compared with the test results found in the literature. It was found that the proposed method produced good predictions of the shear capacity of stud shear connectors with initial damage.

• 한국지진공학회논문집
• /
• 제13권4호
• /
• pp.57-65
• /
• 2009

본 연구에서는 HAZUS와 같은 지진위험도 추정을 위한 입력으로서 교량구조물에 대한 대표 지진취약도 함수를 도출하기 위하여 기존에 수행되었던 안전율 평가 결과를 이용하여 일련의 교량군에 대한 대표 지진취약도 함수를 도출하는 방법을 제안하였다. 지진응답해석 결과를 근거로 하여 제시된 교량 집단의 각 부재별 안전율을 정리하였으며 이 안전율 결과를 이용하여 각 파괴모드별 지진취약도 곡선을 도출하였다. 각 부재별로 평가된 지진취약도 함수를 이용하여 HAZUS의 입력으로 사용할 수 있는 손상단계별 지진취약도 함수를 도출하였다. 부재별 파괴모드를 이용하여 교량전체의 시스템 취약도를 도출하기 위하여 고장수목을 사용하였다. 결과적으로 본 연구에서는 기존의 안전율결과를 이용하여 취약도결과를 도출할 수 있는 방법을 제시하였다.

• 한국항만학회지
• /
• 제11권2호
• /
• pp.281-294
• /
• 1997

Fatigue strength analysis is one of the most important themes of ship structure design, as fatigue damages are reported on ship structures even now. But these need basic research workes which will take time. The others are the problem to apply fatigue strength analysis in design and have to be investigated in parallel with basic researches. The one of major items in the latter is the critical damage factor to define with S-N curve for fatigue strength analysis of ship structure design.

• 한국공간구조학회논문집
• /
• 제18권2호
• /
• pp.87-97
• /
• 2018

Stone pagoda structures have continued to be aged due to the combination of various damage factors. However, some studies on nonstructural damage have been carried out, but assessment studies on structural damage have not been done in various ways. Therefore, in this study, structural and nonstructural influencing factors according to the damage types are classified and the damage assessment according to the structural influencing factors affecting the behavior of the stone pagoda structure is performed. In addition, the damage rating classification criteria for each type of structural damages or damage locations are presented, and the damage index is calculated by providing the criteria for the classification of damage according to the degree of damage to which the damage is caused. Therefore, this study can evaluate quantitatively the damage status of stone pagoda structures.

• Steel and Composite Structures
• /
• 제13권4호
• /
• pp.327-341
• /
• 2012

With the advantages of large span, light deadweight and convenient construction, the steel-concrete composite beam (SCCB) has been rapidly developed as a medium span bridge. Compared with common beams, the global stiffness of SCCB is discontinuous and in a staged distribution. In this paper, the analysis model for the simply-supported SCCB is established and the vibration equations are derived. The natural vibration characteristics of a simply-supported SCCB are analyzed, and are compared with the theoretical and experimental results. A curvature mode measurement method is proposed to identify the shear connector damage of SCCB, with the stiffness reduction factor to describe the variation of shear connection stiffness. By analysis on the $1^{st}$ to $3^{rd}$ vertical modes, the distribution of shear connectors between the steel girder and the concrete slab are well identified, and the damage locations and failure degrees are detected. The results show that the curvature modes can be used for identification of the damage location.

• 대한조선학회논문집
• /
• 제43권4호
• /
• pp.494-503
• /
• 2006

Inherent damage zone model is presented to explain the fatigue properties near the fatigue limit and the crack growth threshold consistently Inherent damage zone model assumes that the stress at a point which is located at a small distance, $r_0$, an inherent length of the material that represents the size of effective damage zone, from the crack initiation position governs the fatigue characteristics regardless of the geometric configuration of the specimen; smooth specimen, notched specimen or cracked specimens with short and long crack length. A special feature of the paper is using the exact stress distributions of notched and cracked specimens at the strength evaluations. Analytical elastic solutions by Neuber and Westergaard are employed for this purpose Relationship between fatigue limit of smooth specimen and threshold stress of cracked specimen, occurrence condition of non-propagating crack at the root of elliptic notch and circular hole and relationship between stress concentration factor and fatigue notch factor are discussed quantitatively based on the proposed model.