• Proceedings of the Plant Resources Society of Korea Conference
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• 2023.04a
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• pp.54-54
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• 2023

Nypa fruticans Wurmb (N. fruticans) is a plant that belongs to Araceae and N. fruticans is mainly found in tropical mangrove systems. The parts (leaves, stems, and roots) of N. fruticans are traditionally used for asthma, sore throat, and liver disease. N. fruticans contains flavonoids and polyphenols, which are substances that have inhibitory effects on cancer and oxidant. In previous studies, some pharmaceutical effects of N. fruticans on melanogenesis and inflammation have been reported. The present study is conducted to investigate the effect of the ethyl acetate fraction of N. fruticans (ENF) on oxidative DNA damage and UVB-induced DNA damage. DNA damage response (DDR) pathway is important in research on cancer, apoptosis, and so on. DDR pathways are considered a crucial factor affecting the alleviation of cellular damage. ENF could reduce oxidative DNA damage derived from reactive oxygen species by the Fenton reaction. Also, ENF reduced the intensity of intracellular ROS in the live cell image by DCFDA assay. UVB is known to cause skin and cellular damage, then finally contribute to causing the formation of tumors. As for the strategies of reducing DNA damage by UVB, inhibition of p53, H2AX, and Chk2 can be important indexes to protect the human body from DNA damage. As a result of confirming the protective effect of ENF for UVB damage, MMPs significantly decreased, and the expression of apoptosis-related factors tended to decrease. In conclusion, ENF can provide protective effects against double-stranded DNA break (DSB) caused by oxidative DNA damage and UVB-induced DNA damage. These results are considered to be closely related to the protective effect against radicals based on catechin, epicatechin, and isoquercitrin contained in ENF. Based on these results, it is thought that additional mechanism studies for inhibiting cell damage are needed.

• Journal of Society of Preventive Korean Medicine
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• v.19 no.2
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• pp.83-101
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• 2015

Objective : In order to establish the scientific research methods to prove the effects of korean traditional medicine about ultraviolet induced skin damage, we investigated the research on ultraviolet induced skin damage in the korean traditional medicine field. Method : We searched the papers about ultraviolet induced skin damage published in the journals of korean traditional medicine. The searching end date was on June 29, 2015. Results : Thirty papers about ultraviolet induced skin damage were found. Twenty nine papers were experimental research, and one paper was clinical research. Sixty-three percent of papers were written the years after 2011. Fifty-seven percent of papers were published in the korean journal of oriental physiology & pathology and the journal of korean oriental medical ophthalmology & otolaryngology & dermatology. Main outcome measures of experimental research were anti-wrinkle effects, anti-oxidant capacity, anti-apoptosis effects, whitening effects and anti-inflammatory effects. Conclusion : We need more systematic research in order to prove the effects of korean traditional medicine, and use extensively.

• Proceedings of the Korean Geotechical Society Conference
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• 2006.03a
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• pp.249-256
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• 2006

New infrastructures and buildings are being constructed increasingly in congested urban areas, and excavation-induced ground movements often cause distortion and damage to adjacent buildings. Protection of adjacent structures occupies a major part of the cost, schedule and third-party impacts of urban development. To limit damage or mitigate their effects on nearby structures, it is highly important to understand the whole mechanism from excavation to building damage, and to estimate building damage reliably before excavation and provide appropriate measures. This paper investigates the effects of excavation-induced ground movements on nearby structures, considering soil-structure interactions for ground and structures, and a building damage criterion, which is based on the state of strain, is proposed. The criterion is compared with other existing damage estimation criteria and a procedure is finally provided for estimating building damage due to excavation-induced ground movements.

• Composites Research
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• v.28 no.4
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• pp.182-190
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• 2015

The phenomenological evolution laws of damage can be defined either based on residual life or residual strength. The failure of a specimen can be defined immediately after or before fracture. The former is called in this paper by "failure defined by approach I" and the latter "failure defined by approach II." Usually at failure there is a discontinuity of loading variables and, because of this, damage at failure is discontinuous. Therefore the values of damage at failure by two different approaches are not the same. Based on this idea the sequence effects of the phenomenological evolution law of damage given by $dD/dN=g(D)f({\Phi})$ were studied. Thin-walled graphite/epoxy tubes consisting of four of $[{\pm}45]_s$ laminates were used for the experimental study of sequence effects and the effects of mean stress on fatigue life. It was found that the sequence effects in two step uniaxial fatigue for $[{\pm}45]_s$ graphite/epoxy tubular specimen showed that a high-low block loading sequence was less damaging than a low-high one.

• Structural Monitoring and Maintenance
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• v.9 no.2
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• pp.179-200
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• 2022

This paper proposes a data-driven methodology for online early damage identification under changing environmental conditions. The proposed method relies on two data analysis methods: feature-based method and hybrid principal component analysis (PCA) and kernel PCA to separate damage from environmental influences. First, spectral sub-band features, namely, spectral sub-band centroids (SSCs) and log spectral sub-band energies (LSSEs), are proposed as damage-sensitive features to extract damage information from measured structural responses. Second, hybrid modeling by integrating PCA and kernel PCA is performed on the spectral sub-band feature matrix for data normalization to extract both linear and nonlinear features for nonlinear procedure monitoring. After feature normalization, suppressing environmental effects, the control charts (Hotelling T² and SPE statistics) is implemented to novelty detection and distinguish damage in structures. The hybrid PCA-KPCA technique is compared to KPCA by applying support vector machine (SVM) to evaluate the effectiveness of its performance in detecting damage. The proposed method is verified through numerical and full-scale studies (a Bridge Health Monitoring (BHM) Benchmark Problem and a cable-stayed bridge in China). The results demonstrate that the proposed method can detect the structural damage accurately and reduce false alarms by suppressing the effects and interference of environmental variations.

• Computers and Concrete
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• v.16 no.5
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• pp.683-701
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• 2015

When approached using nonlinear finite element (FE) techniques, structural analyses generate, for real RC structures, large complex numerical problems. Damage is a major part of concrete behavior, and the discretization technique is critical to limiting the size of the problem. Based on previous work, the ${\mu}$ damage model has been designed to activate the various damage effects correlated with monotonic and cyclic loading, including unilateral effects. Assumptions are formulated to simplify constitutive relationships while still allowing for a correct description of the main nonlinear effects. After presenting classical 2D finite element applications on structural elements, an enhanced simplified FE description including a damage description and based on the use of multi-fiber beam elements is provided. Improvements to this description are introduced both to prevent dependency on mesh size as damage evolves and to take into account specific phenomena (permanent strains and damping, steel-concrete debonding). Applications on RC structures subjected to cyclic loads are discussed, and results lead to justifying the various concepts and assumptions explained.

• Journal of Advanced Marine Engineering and Technology
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• v.32 no.6
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• pp.931-937
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• 2008

The rail/wheel rolling contact affects the microstructure in the surface layer of rail. Recently. continuum damage mechanics allows us to describe the microprocesses involved during the straining of materials and structures at the macroscale. Elastic and plastic strains. the corresponding hardening effects are generally accepted to be represented by global continuum variables. The purpose of continuum damage mechanics is to introduce the possibility of describing the coupling effects between damage processes and the stress-strain behavior of materials. In this study. the continuum damage mechanics caused by elastic deformation was briefly introduced and applied to the fatigue damage of the rails under the condition of cyclic loading. The material parameter for damage analysis was first determined so that it could reproduce the life span under the compressive loading in the vicinity of fatigue limit. Some numerical studies have been conducted to show the validity of the present computational mechanics analysis.

• Nuclear Engineering and Technology
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• v.45 no.3
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• pp.311-322
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• 2013

High-Cr martensitic steel HT-9 is one of the candidate materials for advanced nuclear energy systems. Thanks to its excellent thermal conductivity and irradiation resistance, ferritic/martensitic steels such as HT-9 are considered for in-core applications of advanced nuclear reactors. The harsh neutron irradiation environments at the reactor core region pose a unique challenge for structural and cladding materials. Microstructural and microchemical changes resulting from displacement damage are anticipated for structural materials after prolonged neutron exposure. Consequently, various irradiation effects on the service performance of in-core materials need to be understood. In this work, the fundamentals of radiation damage and irradiation effects of the HT-9 martensitic steel are reviewed. The objective of this paper is to provide a background introduction of displacement damage, microstructural evolution, and subsequent effects on mechanical properties of the HT-9 martensitic steel under neutron irradiations. Mechanical test results of the irradiated HT-9 steel obtained from previous fast reactor and fusion programs are summarized along with the information of irradiated microstructure. This review can serve as a starting point for additional investigations on the in-core applications of ferritic/martensitic steels in advanced nuclear reactors.

• Journal of the Korean Society for Aviation and Aeronautics
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• v.18 no.1
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• pp.1-10
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• 2010

Structures under high temperature may have creep behavior and fatigue behavior. Durability study of the structures need the damage analysis with the creep-fatigue effects. In this paper, the damage analysis is studied for a turbine blade in the turbopump for a liquid rocket engine which is operated under high temperature condition. First of all, the load cycle is required for defining the operational characteristics of turbopump. The thermal stress analysis is done for a turbine blade of the turbopump. The stress analysis results are used to judge damage due to the creep and the fatigue. The strain-life method with miner rule is used for fatigue damage analysis. The Larson-Miller parameter master curve and robinson rule are used for the creep damage analysis. The linear damage summation method is used to consider creep-fatigue effects of turbopump turbine. Finally, the analysis results for fatigue and the influence are compared to figure out the damage phenomenon of the turbopump turbine.

• Proceedings of the Plant Resources Society of Korea Conference
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• 2021.04a
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• pp.52-52
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• 2021

Persicaria amphibia as an England native plant, is a rhizomatous perennial, one of the rather amphibious plants. Its aquatic form contains water-soluble sugars, starch, and protein. P. amphibia have up to 18% tannins in stems and rhizomes. Previous studies have confirmed the anti-inflammatory activity of live bacteria roots, but no studies on bioactivity are known. DNA damage responses (DDRs) pathways are considered a crucial factor affecting the alleviation of cellular damage. The ataxia-telangiectasia mutated and Rad3 related (ATM) and checkpoint kinase 2 (Chk2) pathways are the main pathways of DNA damage response. Also, p53 is a key integrator of cellular response to oxidative DNA damage, contributing repair, or leading transcription including apoptosis. In the present study, we conducted an investigation into the inhibitory effects of P. amphibia on oxidative DNA damage for confirming potential to complementary medicine and therapies. In conclusion, P. amphibia can provide protective effects against double-stranded DNA break (DSB) caused by oxidative DNA damage.