• Wind and Structures
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• v.7 no.5
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• pp.345-357
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• 2004

In the 1990s, four strong typhoons hit the Kyushu area of Japan and inflicted severe damage on power transmission facilities, houses, and so on. Maximum gust speeds exceeding 60 m/s were recorded in central Kyushu. Although the wind speeds were very high, the gust factors were over 2.0. No meteorological stations are located in mountainous areas, creating a deficiency of meteorological station data in the area where the towers were damaged. Since 1995 the authors have operated a network for wind measurement, NeWMeK, that measures wind speed and direction, covering these mountainous areas, segmenting the Kyushu area into high density arrays. Maximum gusts exceeding 70 m/s were measured at several NeWMeK sites when Typhoon Bart (1999) approached. The gust factors varied widely in southerly winds. The mean wind speeds increased due to effects of the local terrain, thus further increasing gust speeds.

• Earthquakes and Structures
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• v.3 no.3_4
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• pp.231-248
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• 2012

In this study, a systematic investigation is carried out on the seismic behaviour of plane moment resisting steel frames (MRF) to repeated strong ground motions. Such a sequence of earthquakes results in a significant damage accumulation in a structure because any rehabilitation action between any two successive seismic motions cannot be practically materialised due to lack of time. In this work, thirty-six MRF which have been designed for seismic and vertical loads according to European codes are first subjected to five real seismic sequences which are recorded at the same station, in the same direction and in a short period of time, up to three days. Furthermore, the examined frames are also subjected to sixty artificial seismic sequences. This investigation shows that the sequences of ground motions have a significant effect on the response and, hence, on the design of MRF. Additionally, it is concluded that ductility demands, behaviour factor and seismic damage of the repeated ground motions can be satisfactorily estimated using appropriate combinations of the corresponding demands of single ground motions.

• Radiation Oncology Journal
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• v.6 no.2
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• pp.155-161
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• 1988

The usefulness of hypertermia for cancer therapy have well been established. The purpose of the present investigation was to ascess the effect of step-up $(42^{\circ}{\rightarrow}44^{\circ}C$ sequence) and step-down $(44^{\circ}{\rightarrow}42^{\circ}C$ sequence) heating on the skin of the hind foot of the mouse. Hyperthermic treatments were given by immersion the hind foot of the mouse in circulating water baths. Skin response was studied by the leg reaction, which was scored according to a numerical scoring system proposed by Urano et al (1980). The results were as follows 1. The skin damage of $44^{\circ}C$ control group was more severe than $42^{\circ}C$ control group (P<0.05), except for 15 min. heating group. 2. The Skin damage of step-down group was more severe than step-up group (P<0.05). 3. The skin damage of $44^{\circ}C$ control group was more severe than step-up group when there is no difference in $44^{\circ}C$ heating time of step-up group from $44^{\circ}C$ control group (P<0.05). 4. In step-down group, the skin damage was more severe than $44^{\circ}C$ control group after preheating 45 min at $44^{\circ}C$ (P<0.05). Therefore, the above findings suggest the normal tissue damage by step-up heating was correlated with heating time of post step-up. The dropping of heating temperature in late phase had more severe damage of the skin than that in early phase during hyperthermia, and so contineous control of satisfactory temperature should be considered as the one of the most important factor for prognosis, complications of clinical hyperthermia

• Journal of the Korea Institute of Military Science and Technology
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• v.17 no.1
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• pp.82-89
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• 2014

The damage in germanium (Ge) optical window irradiated by a near-infrared continuous wave (CW) laser was studied. Laser-induced heating and melting process were surveyed, and the specific laser power and the irradiance time to melt were estimated by numerical simulation. The experiments were also carried out to investigate the macro and micro structure change on Ge window. Results showed that the surface deformation was formed by melting and resolidification process, the damaged surface had a polycrystalline phase, and the transmittance as an optical performance factor in mid-infrared region was decreased. We confirmed that an abnormal polycrystalline phase and surface deformation effect such as hillock formation and roughness increase reduced the transmittance of Ge window and were the damage mechanism of CW laser induced damage on Ge window.

• Korean Journal of Organic Agriculture
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• v.22 no.4
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• pp.789-799
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• 2014

We have analyzed the effect of planting site (elevation) and direction of fruiting on the frost damage (tolerance to transparent skin and blemishes) of persimmon (Diospyros kaki Thunb) 'Fuyu' fruit subjected to the early fall frost (November 2, 2012) in environment-friendly orchards of Changnyeong and Changwon (Gyeongsangnam-do Korea). In Changnyeong, the direction of fruiting showed a significant effect on the fruit weight and the fruit width (p<0.01), and the fruit firmness (p<0.05) while the planting site (elevation) did a highly significant effect on the fruit width and the frost damage (p<0.01), and fruit length (p<0.05). In particular, severe frost damage of fruit (15.2%) and leaves (about 90%) was observed in the plants located in the low elevation area of orchard. The damaged fruit had an transparent skin color and/or blemishes. In Changwon, there was no effect of the planting site and the direction of fruiting on the frost damage, and the fruit characteristics except the fruit width having been related to the planting site (p<0.05). So, the main effects for the fruit frost damage was a terrain factor around the orchards.

• Journal of the Korean Society of Hazard Mitigation
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• v.1 no.2 s.2
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• pp.85-92
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• 2001

The flood damage due to heavy rainfall caused by not only geographical factor, but also social factors. In this paper we derived the flooding potential factors, and analyzed resident's understanding of flooding through the Tokai disaster of Japan, occurred in september 2000. Furthermore, the urban rate obtained by the data comparison between 1975 and 1985 using GIS is evaluated to estimate the effect of rainfall-runoff mechanism due to the urbanization. These efforts could be served as the information of flood damage for the communication with the residents and it would be helped the minimization of flood damage.

• The Journal of Internal Korean Medicine
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• v.32 no.1
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• pp.43-55
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• 2011

Objectives : Sokmyeung-tang(SMT) has been used for treatment of CVA in traditional oriental medicine, so this study was designed to evaluate the effect of SMT's protection on brain cell damage against the oxidative stress that was affected by CVA, We also investigated the effect of motor function improvement and neurotrophic factor in ischemic cerebral damaged rats. Methods : We measured cell viability after administrating SMT, chemicals(Paraquat, SNP, rotenone, and $H_2O_2$) which cause oxidative stress, and both SMT and chemicals. We carried out neurobehavioral evaluation(Rotarod test, Beam-walking test, postural reflex test) and observed BDNF (brain-derived neurotrophic factor) expression by injecting SMT into ischemic cerebral damaged rat. Results : Through this study, we observed the following three results. First, brain cell death caused by paraquat, rotenone, and $H_2O_2$ significantly decreased with the treatment of SMT. Second, neuronal movement function in ischemic cerebral damaged rats was significantly improved by the treatment of SMT. Third, BDNF in ischemic cerebral damaged rats increased with the treatment of SMT. Conclusions : SMT protects brain cells from damage induced by oxidative stress (Paraquat, rotenone, $H_2O_2$). SMT also improves neuronal movement function and increases BDNF in ischemic cerebral damaged rats.

• Journal of Family Resource Management and Policy Review
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• v.13 no.4
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• pp.115-139
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• 2009

This study focused on the development of a scale measuring the effect of consumer education. The purposes of this study were to develop a tool which could measure consumer knowledge, consumer attitudes and consumer behavior. Data were collected from 266 college students. Analysis was done using frequency, cross tabulation analysis, reliability test, principle components factor analysis, confirmatory factor analysis (Amos 5.0), and multiple regression analysis. The results from this study were as follows: 1) Nine consumer knowledge factors (23-items) were identified: consciousness of consumer education and evaluation, consumer rights and allowance management, methods of consumer education and consumer institutions, green energy and environmental consumption, essence and content of consumer education, consumer rights and consumer duty, critical consideration and consumer's damage salvation, buying minds and decision-making, independent consumers. Total variance was 58.4%. Cronbach's alpha for the nine factors ranged from .68-.79. 2) Five consumer attitude factors (26-items) were identified: green environmental consumption, consumer's role and rights, resources saving and consumer's damage salvation, consciousness of consumers, and right consumption. Total variance was 59.2%. Cronbach's alpha for the five factors ranged from .89-.94. 3) Seven consumer behavior factors (27-items) were identified: social role and rights of consumer and consumer movement, right buying and segregated garbage collection, green environmental consumption and resources saving, altruism and decision-making, allowance management and impulse buying, consumer's damage salvation, and consciousness of consumer. The total variance was 59.1%. Cronbach's alpha for the seven factors ranged from .77-.88. Finally, a scale measuring the effect of consumer education consisting of 76 items (consumer knowledge: 23 items (9 factors), consumer attitude: 26 items (5 factors), consumer behavior: 27 items (7 factors)) was constructed.

• Journal of the Korean Geotechnical Society
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• v.19 no.4
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• pp.167-178
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• 2003

Damage and overbreak of the remaining rock induced by blasting can not be avoided during tunnel construction which may result in either short-term or long-term tunnel instability. Therefore, in this paper, a methodology to take into account the effect of blast-induced damage in tunnel stability assessment is proposed. Dynamic numerical analysis was executed to evaluate damage and overbreak of the remaining rock for the most common blasting pattern in road tunnel. Rock damage was quantified by utilizing the damage variable factor which is adopted proposed in continuum damage mechanics. The damaged rock stiffness and the damaged failure criteria are used to consider the effect of rock damage in tunnel stability analysis. The damaged geological strength index of the damaged rock was newly proposed from the relationship between deformation modulus and geological strength index. Also the Hoek-Brown failure criteria of the damaged rock was obtained using the damaged geological strength index. Analysing the tunnel stability with the consideration of the blast-induced damage of remaining rock, it was found that the extend of plastic zone and deformation increased compared to the undamaged rock. Therefore the short-term or long-term tunnel stability will be threatened when the rock damage from blasting is ignored in the tunnel stability analysis.

• Journal of The Korean Society of Integrative Medicine
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• v.12 no.1
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• pp.1-10
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• 2024

Purpose: Lycopene is abundantly contained in Tomatoes and is known for diverse biological activities such as antioxidant, anti-inflammatory, and anticancer effects. In this study, the antioxidative potential of lycopene was investigated through the induction of hemeoxygenase (HO)-1 by nuclear factor-erythroid 2 p45-related factor2 (Nrf2) and upstream signaling molecules, mitogen-activated protein kinase (MAPK) and phosphoinositide 3-kinase (PI3K)/Aktin RAW 264.7 cells. Methods: The antioxidative potential of lycopene against oxidative stress and its molecular mechanisms were determined by the cell viability assay, intracellular reactive oxygen species (ROS) formation assay, and Western blot analysis in RAW 264.7 cells. Results: Lycopene treatment significantly attenuated tert-butyl hydroperoxide (t-BHP) induced intracellular ROS formation in a dose-dependent manner without any cytotoxicity. In addition, 50 µM of lycopene for 6 h treatment induced potent HO-1 expression and its transcription factor, Nrf2. MAPK and PI3K/Aktwere also analyzed due to their critical roles in the regulation of cellular redox homeostasis against oxidative damage. As a result, phosphorylation of extracellular regulated kinase (ERK) was significantly induced by lycopene treatment while the activated status of c-Jun NH2-terminal kinase (JNK), p38, and Akt, were not given any effect. To confirm the antioxidative mechanism of HO-1 mediated by ERK activation, each selective inhibitor was employed in a protection assay, in which oxidative damage occurred by t-BHP. Lycopene, SnPP, and CoPP treatments reflected accelerated HO-1 expression could be a protective role against oxidative damage-initiated cell death. A selective inhibitor for ERK significantly inhibited the lycopene-induced cytoprotective effect but selective inhibitors for other signaling molecules did not attenuate the rate of t-BHP-induced cell death. Conclusion: In conclusion, lycopene potently scavenged intracellular ROS formation and enhanced the HO-1 mediated antioxidative potential through the modulation of Nrf2, MAPK signaling pathway in RAW 264.7 cells.