• Earthquakes and Structures
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• 제5권1호
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• pp.23-48
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• 2013

In this study, the effect of flexibility of superstructures and nonlinear characteristics of LRB (Lead Rubber Bearing) isolator on inelastic response of base isolated structures is investigated. To demonstrate the intensity of damage in superstructures, demand response modification factor without the consideration of damping reduction factor, demand RI, is used and the N2 method is applied to compute this factor. To evaluate the influence of superstructure flexibility on inelastic response of base isolated structures, different steel intermediate moment resisting frames with different heights have been investigated. In lead rubber bearing, the rubber provides flexibility and the lead is the source of damping; variations of aforementioned characteristics are also investigated on inelastic response of superstructures. It is observed that an increase in height of superstructure leads to higher value of demand RI till 4-story frame but afterward this factor remains constant; in other words, an increase in height until 4-story frame causes more damage in the superstructure but after that superstructure's damage is equal to the 4-story frame's. The results demonstrate that the low value of second stiffness (rubber stiffness in LRBs) tends to show a significant decrease in demand RI. Increase in value of characteristic strength (yield strength of the lead in LRBs) leads to decrease in the demand RI.

• 한국자원식물학회:학술대회논문집
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• 한국자원식물학회 2023년도 임시총회 및 춘계학술대회
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• pp.54-54
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• 2023

Nypa fruticans Wurmb (N. fruticans) is a plant that belongs to Araceae and N. fruticans is mainly found in tropical mangrove systems. The parts (leaves, stems, and roots) of N. fruticans are traditionally used for asthma, sore throat, and liver disease. N. fruticans contains flavonoids and polyphenols, which are substances that have inhibitory effects on cancer and oxidant. In previous studies, some pharmaceutical effects of N. fruticans on melanogenesis and inflammation have been reported. The present study is conducted to investigate the effect of the ethyl acetate fraction of N. fruticans (ENF) on oxidative DNA damage and UVB-induced DNA damage. DNA damage response (DDR) pathway is important in research on cancer, apoptosis, and so on. DDR pathways are considered a crucial factor affecting the alleviation of cellular damage. ENF could reduce oxidative DNA damage derived from reactive oxygen species by the Fenton reaction. Also, ENF reduced the intensity of intracellular ROS in the live cell image by DCFDA assay. UVB is known to cause skin and cellular damage, then finally contribute to causing the formation of tumors. As for the strategies of reducing DNA damage by UVB, inhibition of p53, H2AX, and Chk2 can be important indexes to protect the human body from DNA damage. As a result of confirming the protective effect of ENF for UVB damage, MMPs significantly decreased, and the expression of apoptosis-related factors tended to decrease. In conclusion, ENF can provide protective effects against double-stranded DNA break (DSB) caused by oxidative DNA damage and UVB-induced DNA damage. These results are considered to be closely related to the protective effect against radicals based on catechin, epicatechin, and isoquercitrin contained in ENF. Based on these results, it is thought that additional mechanism studies for inhibiting cell damage are needed.

• 시큐리티연구
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• 제14호
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• pp.261-283
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• 2007

범죄두려움의 원인을 설명하기 위한 최근의 연구들에서는 성, 연령, 경제수준, 범죄 피해경험 등의 미시적인 개인수준과 거시적인 지역수준과의 연계를 시도하는 연구에 관심과 노력을 보이고 있다. 하지만 이 연구에서는 이러한 지역수준의 특성에 대한 개인의 관심과 해석은 개인의 특성으로서 과거의 범죄피해경험, 범죄피해의 취약성 정도, 범죄관련 정보에 대한 관심에 따라 다를 수 있다고 보며, 미시적인 수준과 거시적인 수준의 연계를 시도하기에 앞서 개인적인 수준에서 개인의 특성과 범죄두려움의 관계에 대해서 실증적인 분석을 실시하였다. 따라서 이 연구의 목적은 범죄두려움이 과연 개인의 특성에 따라서 어떻게 느끼게 되며 또한 얼마나 많은 영향을 받게 되는지를 실증적으로 검증하는 데에 그 목적이 있다. 이 연구의 조사결과 우선 범죄피해경험이 집단간의 차이가 통계적으로 유의미한 인구통계학적 특성은 연령, 결혼상태, 최종학력, 거주하는 장소였으며, 범죄피해의 취약성 정도는 성별과 결혼상태, 범죄관련 정보에 대한 관심은 성별, 연령, 최종학력, 가족 수입, 거주장소 위치에 따라서 집단 간의 통계적으로 유의미한 차이가 있는 것으로 나타났다. 둘째, 개인적 특성 요인과 범죄두려움의 상관관계 분석을 실시한 결과 독립변수 세요인 모두 범죄두려움과 통계적으로 유의미한 상관관계를 나타내고 있었으며, 특히 범죄피해에 대한 취약성 요인이 범죄두려움과 가장 상관관계가 높게 나타났다. 마지막으로 개인의 특성으로서 범죄피해의 취약성, 범죄정보에 대한 관심, 범죄피해경험은 범죄두려움에 영향을 미쳤으며, 특히 이러한 개인적 특성 요인 중 자신이 범죄피해에 대해 취약하다고 생각 하는 범죄피해의 취약성이 범죄두려움에 가장 많은 영향을 미치는 요인으로 나타났다.

• 한국철도학회:학술대회논문집
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• 한국철도학회 2002년도 추계학술대회 논문집(II)
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• pp.1065-1073
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• 2002

A new damage identification technique using static displacement data is developed to assess the structural integrity of bridge structures. In the conventional damage assessment techniques using dynamic response, it is usually difficult to obtain a significant natural frequencies variation from the measured data because the natural frequencies variation is intrinsically not sensitive to the damage of a bridge. In this proposed identification method, the stiffness reduction of the bridges can be estimated using the static displacement data measured periodically and a specific loading test is not required. The static displacement data due to the dead load of the bridge structure can be measured by devices such as a laser displacement sensor. In this study, structural damage is represented by the reduction in the elastic modulus of the element. The damage factor of the element is introduced to estimate the stiffness reduction of the bridge under consideration. Finally, the proposed algorithm is verified using various numerical simulation and compared with other damage identification method. Also, the effect of noise and number of damaged elements on the identification are investigated. The results show that the proposed algorithm is efficient for damage identification of the bridges.

• 한국전산구조공학회:학술대회논문집
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• 한국전산구조공학회 2006년도 정기 학술대회 논문집
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• pp.914-921
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• 2006

To describe the effect of the numerous and various oriented microcracks on the compressive and tensile concrete behaviors, the directional nonlocality is defined. The plasticity model using multiple failure criteria is developed for RC planar members in tension-compression. The crack damages are defined in the pre-determined reference orientations, and then the total crack damage is calculated by integrating multi-oriented crack damages. To describe the effect of directional nonlocality on the anisotropic tensile damage, based on the existing test results, the nonlocal damage factor is defined in each reference orientation. The reduced compressive strength in the cracked concrete is defined by the multi-oriented crack damages defined as excluding the tensile normal plastic strain from the compressive equivalent plastic strain. The proposed model is implemented to finite element analysis, and it is verified by comparisons with various existing panel test results.

• 한국자원식물학회지
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• 제23권2호
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• pp.172-178
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• 2010

천연집단에 서식하는 개비자나무 개체들을 이용해 무생물 및 생물적 환경인자가homoharringtonine(HHT) 함량에 미치는 영향을 조사하여 향후 항암제 가능성이 있는 HHT의 고부가가치 산업적인 생산이 기대되는 연구에 기초자료를 제공하고자 본 연구를 수행하였다. 무생물적 환경인자(토양습도, 토양pH, 서식밀도, 기온)와 HHT 함량과의 상관관계에 있어 HHT 는 토양습도(0.77)와 토양pH(-0.68)에서 높은 상관을 보였다. 고도에 따른 무생물적 환경인자 (토양습도, 토양pH)와 HHT 의 함량 관계에 관해 다중회귀 분석을 실시한 결과, 토양 습도의 회귀계수($26.48^{***}$) 만 유의하여 토양 습도가 상대적으로 HHT 함량에 높은 영향을 미치는 것으로 나타났다. 생물적 환경인자(damage index)에 따른 HHT 함량에 미치는 영향을 살펴 본 결과, HHT는 2차곡선회귀적으로 증가하다 감소하는($H=278.23+1242D-398.87D^2$) 경향을 보였고 damage index는 HHT 함량에 높은 영향을 미치는 것으로 분석되었다. 마지막으로 HHT 의 함량에 영향을 미치는 최적환경인자를 분석한 결과, damage index와 토양 습도 모두가 2차다항회귀식으로 가장 적합하였고 결정계수는 각각 0.73와 0.67로 damage index가 상대적으로 HHT 함량에 높은 영향을 미치는 것으로 나타났다. 이는 섭식자 또는 균류와 같은 스트레스로 인한 방어기작이 HHT 의 생성에 높은 영향을 미치는 것으로 판단된다.

• KCI Concrete Journal
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• 제13권2호
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• pp.26-32
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• 2001

A simple expected damage cost model is developed and a systematic approach to evaluate the economic effects of seismic hazards to reinforced concrete structures is presented. An expected damage cost function during a specific lifetime is modeled by a Poisson's process with uniform continuous cash flow assumption. It is possible that the proposed method can decouple the damage cost effect from random earthquake events. Thus, expected damage cost function can be formulated as a combination of three independent terms; a present worth factor of Poisson's process, a damage cost interpolation function and a mean occurrence rate of earthquake intensity. The validity of the proposed method is demonstrated by a comparative study of LCC evaluations with the previous study.

• 한국지반공학회논문집
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• 제21권5호
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• pp.153-161
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• 2005

시공 시 손상 및 크리프 변형의 복합효과가 지오그리드의 장기설계인장강도에 미치는 영향을 평가하기 위하여, 세 종류의 지오그리드를 대상으로 일련의 현장 내시공성시험 및 크리프시험을 수행하였다. 연구결과, 지오그리드의 시공시 손상 및 크리프 변형 특성은 지오그리드의 재질 및 제조방법에 크게 영향을 받으며, 시공 중 지오그리드의 인장강도감소가 클수록, 시공 시 손상과 크리프 변형의 복합효과가 미치는 영향이 더 큰 것으로 나타났다. 또한 지오그리드의 인장강도 감소계수를 영향인자별로 각각 산정하여 장기설계인장강도를 평가하도록 되어 있는 현행 설계법은, 지오그리드의 시공 시 손상과 크리프 변형의 복합효과를 고려하여 강도감소계수를 산정하는 방법에 비해 지오그리드의 강도감소계수를 안전측으로 산정하는 것으로 평가되었다.

• 대한임상검사과학회지
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• 제52권4호
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• pp.389-397
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• 2020

Microglial cells function as major immune cells in the brain, playing an important role in the protection and damage of neurons. BV2 microglia, activated by drug stimulation, secrete inflammatory cytokines by activating the nuclear factor kappa-light-chain-enhancer of the activated B cells pathway and are involved in neuroinflammatory and immune responses. The overactivation of microglia by stimuli can cause neuronal damage, leading to brain disease. Noni, a natural product, reduces the activity of microglia to prevent neuronal damage and is a potential natural medicine because it exerts excellent regeneration and anti-inflammatory effects on damaged cells. In this study, when noni was used to treat BV2 cells stimulated by the anti-cancer drug doxorubicin, it reduced the release of pro-inflammatory cytokines from BV2. On the other hand, neuronal damage is a side effect of doxorubicin. Therefore, the cytokines released from doxorubicin-stimulated BV2 cells treated with noni had a positive effect on the neuronal viability compared to those released from doxorubicin-stimulated BV2 cells not treated with Noni. Thus, Noni increases neuronal viability. These results suggest that noni inhibits the release of cytokines by regulating the nuclear factor kappa-light-chain-enhancer of the activated B cells pathway of BV2, thereby inhibiting neuronal damage.

• Steel and Composite Structures
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• 제25권1호
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• pp.79-92
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• 2017

Initial damage to a stud due to corrosion, fatigue, unexpected overloading, a weld defect or other factors could degrade the shear capacity of the stud. Based on typical push-out tests, a FEM model and theoretical formulations were proposed in this study. Six specimens with the same geometric dimensions were tested to investigate the effect of the damage degree and location on the static behavior and shear capacity of stud shear connectors. The test results indicated that a reduction of up to 36.6% and 62.9% of the section area of the shank could result in a dropping rate of 7.9% and 57.2%, respectively, compared to the standard specimen shear capacity. Numerical analysis was performed to simulate the push-out test and validated against test results. A parametrical study was performed to further investigate the damage degree and location on the shear capacity of studs based on the proposed numerical model. It was demonstrated that the shear capacity was not sensitive to the damage degree when the damage section was located at 0.5d, where d is the shank diameter, from the stud root, even if the stud had a significant reduction in area. Finally, a theoretical formula with a reduction factor K was proposed to consider the reduction of the shear capacity due to the presence of initial damage. Calculating K was accomplished in two ways: a linear relationship and a square relationship with the damage degree corresponding to the shear capacity dominated by the section area and the nominal diameter of the damaged stud. This coefficient was applied using Eurocode 4, AASHTO LRFD (2014) and GB50017-2003 (2003) and compared with the test results found in the literature. It was found that the proposed method produced good predictions of the shear capacity of stud shear connectors with initial damage.