• Structural Engineering and Mechanics
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• v.58 no.6
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• pp.1087-1107
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• 2016

A method of damage detection based on the moving harmonic excitation and continuous wavelet transforms is presented. The applied excitation is used as a moving actuator and its frequency and speed parameters can be adjusted for an amplified response. The continuous wavelet transforms, CWT, is used for cracks detection based on the resulting amplified signal. It is demonstrated that this identification procedure is largely better than the classical ones based on eigenfrequencies or on the eigenmodes wavelet transformed. For vibration responses, free and forced vibration analyses of multi-cracked beams are investigated based on both analytical and numerical methodological approaches. Cracks are modeled through rotational springs whose compliances are evaluated using linear elastic fracture mechanics. Based on the obtained forced responses, multi-cracks positions are accurately identified and the CWT identification can be highly improved by adjusting the frequency and the speed excitation parameters.

• Animal cells and systems
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• v.6 no.1
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• pp.1-12
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• 2002

A role of Src family protein Tyrosine kinases (SFK) as mediators of receptor-ligand initiated responses is well established. Well documented, but less well understood is the role of SFK in cellular reaction to stresses. Evidence from the wide variety of experimental systems indicates that SFK mediate responses to all major classes of stress, including oxidation, DNA damage, mechanical impacts, and protein denaturing. SFK may be activated by stresses directly or via regulatory circuits whose identity is not yet fully understood. Depending on the cell type and the nature of activating stimulus, SFK may activate known downstream signaling cascades leading to cell survival, proliferation, cytoskeletal rearrangement, and apoptosis; the identity of these cascades is discussed. As in the case of receptor-initiated signaling, roles of individual SFK in various stress response may be redundant or non-redundant. Although signals generated by different stresses are generally transduced via distinct SFK pathways, these pathways may overlap or exhibit crosstalk. In some cell types stress-induced activation of SFK promotes survival and inhibits apoptosis, whereas the opposite may be true for other cell types. Stress responses constitute a new and rapidly developing area of SFK-mediated signaling.

• Journal of the Korean Society for Precision Engineering
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• v.30 no.11
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• pp.1187-1192
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• 2013

In the case of 4 wheel drive (4-WD) type car, power switching occurs to 4-WD by operating lever or switch that operates power switching device attached in transfer case which can operate motor by electric signal. So if the RPM of motor is high, power switching will not exactly occur and can cause damage to gear in transfer case according to circumstances. So in this study, we applied 2 level of planet gear type motor spindle of motor drive part of a power train. And conducted decelerating to increase torque to switch power safe and accurately. Also, we researched efficiency of gear by designing reduction gear ratio and gear type and by calculating contact stress and bending strength. Based on researched content, we made drive head of power switching device and a reduction module which uses type that uses motor spindle as sun gear and ring gear as cover.

• Asian Pacific Journal of Cancer Prevention
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• v.17 no.12
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• pp.5047-5056
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• 2016

Colorectal cancer (CRC) is a major worldwide health problem owing to its high prevalence and mortality rates. Carcinogenesis in the colon is a multistage and multifactorial process. An imbalance between free radical exposure and anti-oxidant defense systems may leads to oxidative stress and attack of macromolecules which can alter signal transduction pathways and gene expression. Consequently, oxidative damage can lead to cellular dysfunction and contribute to pathophysiological processes in a variety of diseases including CRC. One factor tightly associated with CRC is chronic inflammation, which can be present from the earliest stage of tumor onset. Unpolished rice is an attractive chemoprevention in CRC due to their anti-oxidant and anti-inflammatory activities. The aim of this paper is to review evidence linking oxidative stress and inflammation to CRC and to provide essential background information for understanding future research on oxidative stress and inflammation on CRC. Mechanisms of action of unpolished rice in CRC carcinogenesis are also discussed.

• Composites Research
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• v.15 no.5
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• pp.1-6
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• 2002

When compared to other composite materials such as FRP and MMC, hybrid composite material is more attractive one due to the high specific strength and the resistance to fatigue. However, the fracture mechanism of hybrid composite material is extremely complicated because of the bonding structure of metals and FRP. Recently, nondestructive technique has been used to evaluate the fracture mechanism of these composite materials. In this study. AE technique has been used to clarify the fracture mechanism and the degree of damage for Al 7075/CFRP hybrid composite material. It was found that AE event, energy and amplitude among AE parameters were effective to evaluate fracture process of Al 7075/CFRP composite material. In addition, the relationship between the AE signal and the characteristics of failure surface using optical microscope was discussed.

• Korean Journal of Fisheries and Aquatic Sciences
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• v.47 no.6
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• pp.765-769
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• 2014

We examined the protective effects of Pyropia yezoensis glycoprotein (PYGP) against ethanol-induced gastric damage. The experimental animals were divided into four groups. They were treated with distilled water (control), ethanol alone (EtOH), ethanol + PYGP 150 mg/kg BW (EtOH+150), or ethanol + PYGP 300 mg/kg BW (EtOH+300). The groups were treated for 4 weeks. We measured mitogen-activated protein kinase (MAPK), the apoptotic signaling pathway, and PARP activity in gastric tissues obtained from the rats. Ethanol consumption increased apoptotic signal activity and ERK, JNK, and p38 phosphorylation. PYGP reduced the apoptotic signaling pathway activity and ERK, JNK, and p38 phosphorylation. Furthermore, PYGP regulated Bcl-2 family expression. In light of these findings, PYGP appears to prevent ethanol-induced gastric injury and oxidative stress.

• Journal of Magnetics
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• v.19 no.2
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• pp.197-204
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• 2014

A transcranial magnetic stimulation device is a complicated appliance that employs a switching power device designed for discharging and charging a capacitor to more than 1 kV. For a simple transcranial magnetic stimulation device, this study used commercial power and controlled the firing angle using a Triac power device. AC 220V 60 Hz, the power device was used directly on the tanscranial magnetic stimulation device. The power supply device does not require a current limiting resistance in the rectifying device, energy storage capacitor or discharge circuit. To control the output power of the tanscranial magnetic stimulation device, the pulse repetition rate was regulated at 60 Hz. The change trigger of the Triac gate could be varied from $45^{\circ}$ to $135^{\circ}$. The AVR 182 (Zero Cross Detector) Chip and AVR one chip microprocessor could control the gate signal of the Triac precisely. The stimulation frequency of 50 Hz could be implemented when the initial charging voltage Vi was 1,000 V. The amplitude, pulse duration, frequency stimulation, train duration and power consumption was 0.1-2.2T, $250{\sim}300{\mu}s$, 0.1-60 Hz, 1-100 Sec and < 1 kW, respectively. Based on the results of this study, TMS can be an effective method of treating dysfunction and improving function of brain cells in brain damage caused by ischemia.

• Journal of Ginseng Research
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• v.41 no.2
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• pp.227-231
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• 2017

Background: Ginsenosides are active components of Panax ginseng that exert various health benefits including kidney protection effect. The medicinal activity of ginsenosides can be enhanced by modulating their stereospecificity by heat processing. Ginsenosides Rk2 and Rh3 represent positional isomers of the double bond at C-20(21) or C-20(22). Methods: The present study investigated the kidney-protective effects of ginsenosides Rk2 and Rh3 against cisplatin, a platinum based anticancer drug, induced apoptotic damage in renal proximal LLC-PK1 cells. Results: As a result, ginsenoside Rh3 shows a stronger protective effect than that shown by Rk2. Cisplatin-induced elevated protein levels of phosphorylated c-Jun N-terminal kinase (JNK), extracellular signal-regulated kinase (ERK), p38, and cleaved caspase-3 decreased after cotreatment with ginsenoside Rh3. The increase in the percentage of apoptotic LLC-PK1 cells induced by cisplatin treatment also significantly reduced after cotreatment with ginsenoside Rh3. Conclusion: These results demonstrate that inhibition of the JNK and ERK mitogen-activated protein kinase signaling cascade plays a critical role in mediating the renoprotective effect of ginsenoside Rh3.

• Nuclear Engineering and Technology
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• v.43 no.4
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• pp.343-354
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• 2011

It is critically important to identify unexpected loose parts in a nuclear reactor pressure vessel, since they may collide with and cause damage to internal structures. Mass estimation can provide key information regarding the kind as well as the location of loose parts. This study proposes a mass estimation method based on an artificial neural network (ANN), which can overcome several unresolved issues involved in other conventional methods. In the ANN model, input parameters are the discrete cosine transform (DCT) coefficients of the auto-power spectrum density (APSD) of the measured impact acceleration signal. The performance of the proposed method is then evaluated through application to a large-sized plate and a 1/8-scaled mockup of a reactor pressure vessel. The results are compared with those obtained using a conventional method, the frequency ratio (FR) method. It is shown that the proposed method is capable of estimating the impact mass with 30% lower relative error than the FR method, thus improving the estimation performance.

• Animal cells and systems
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• v.7 no.3
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• pp.173-186
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• 2003

The transition metal cadmium is a serious occupational and environmental toxin. To inhibit cadmium-induced damage, cells respond by increasing the expression of genes that encode stress-responsive proteins. The metal-regulatory transcription factor 1 (MTF-1) is a key regulator of heavy-metal induced transcription of metallothionein-I and II and other genes in mammals and other metazoans. Transcriptional activation of genes by MTF-1 is mediated through binding to metal-responsive elements in the target gene promoters. Phosphorylation of MTF-1 plays a critical role in the cadmium-inducible transcriptional activation of metallothionein and other responses. Studies using inhibitors indicate that multiple kinases and signal transduction cascades, including those mediated by protein kinase C, tyrosine kinase and casein kinase II, are essential for cadmium-mediated transcriptional activation. In addition, calcium signaling is also involved in regulating metal-activated transcription. In several species, cadmium induces heat shock genes. Recently much progress has been made in elucidating the cellular machinery that regulates this metal-inducible gene expression. This review summarizes these recent advances in understanding the role of some known cadmium-responsive genes and the molecular mechanisms that activate metal-responsive transcription factor, MTF-1.